JP2014511711A - 自動注入デバイスおよびそのサブアセンブリを組み立てるためのシステム、デバイス、および方法 - Google Patents
自動注入デバイスおよびそのサブアセンブリを組み立てるためのシステム、デバイス、および方法 Download PDFInfo
- Publication number
- JP2014511711A JP2014511711A JP2013558239A JP2013558239A JP2014511711A JP 2014511711 A JP2014511711 A JP 2014511711A JP 2013558239 A JP2013558239 A JP 2013558239A JP 2013558239 A JP2013558239 A JP 2013558239A JP 2014511711 A JP2014511711 A JP 2014511711A
- Authority
- JP
- Japan
- Prior art keywords
- component
- syringe
- force
- assembly
- housing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M5/2033—Spring-loaded one-shot injectors with or without automatic needle insertion
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B23—MACHINE TOOLS; METAL-WORKING NOT OTHERWISE PROVIDED FOR
- B23P—METAL-WORKING NOT OTHERWISE PROVIDED FOR; COMBINED OPERATIONS; UNIVERSAL MACHINE TOOLS
- B23P19/00—Machines for simply fitting together or separating metal parts or objects, or metal and non-metal parts, whether or not involving some deformation; Tools or devices therefor so far as not provided for in other classes
- B23P19/04—Machines for simply fitting together or separating metal parts or objects, or metal and non-metal parts, whether or not involving some deformation; Tools or devices therefor so far as not provided for in other classes for assembling or disassembling parts
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
- A61M2005/206—With automatic needle insertion
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2207/00—Methods of manufacture, assembly or production
- A61M2207/10—Device therefor
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/49—Method of mechanical manufacture
- Y10T29/49764—Method of mechanical manufacture with testing or indicating
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T29/00—Metal working
- Y10T29/53—Means to assemble or disassemble
- Y10T29/53022—Means to assemble or disassemble with means to test work or product
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Mechanical Engineering (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Automatic Assembly (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161454097P | 2011-03-18 | 2011-03-18 | |
| US61/454,097 | 2011-03-18 | ||
| PCT/US2012/029682 WO2012129174A1 (en) | 2011-03-18 | 2012-03-19 | Systems. devices and methods for assembling automatic injection devices and sub-asseblies thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014511711A true JP2014511711A (ja) | 2014-05-19 |
| JP2014511711A5 JP2014511711A5 (enExample) | 2015-05-07 |
Family
ID=45937593
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013558239A Ceased JP2014511711A (ja) | 2011-03-18 | 2012-03-19 | 自動注入デバイスおよびそのサブアセンブリを組み立てるためのシステム、デバイス、および方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US20120233834A1 (enExample) |
| EP (1) | EP2686036A1 (enExample) |
| JP (1) | JP2014511711A (enExample) |
| CN (1) | CN103608053B (enExample) |
| AU (1) | AU2012231178B2 (enExample) |
| BR (1) | BR112013023967A2 (enExample) |
| CA (1) | CA2829773A1 (enExample) |
| MX (1) | MX2013010699A (enExample) |
| WO (1) | WO2012129174A1 (enExample) |
Families Citing this family (49)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0414054D0 (en) | 2004-06-23 | 2004-07-28 | Owen Mumford Ltd | Improvements relating to automatic injection devices |
| CN101087625B (zh) | 2004-11-22 | 2012-02-22 | 因特利杰克特有限公司 | 用于药物供给的装置和系统 |
| US7648483B2 (en) | 2004-11-22 | 2010-01-19 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
| NZ560516A (en) | 2005-02-01 | 2010-12-24 | Intelliject Inc | A delivery system where a medicant is automatically delivered on activation as well as a recorded instruction |
| US8361026B2 (en) | 2005-02-01 | 2013-01-29 | Intelliject, Inc. | Apparatus and methods for self-administration of vaccines and other medicaments |
| US9022980B2 (en) | 2005-02-01 | 2015-05-05 | Kaleo, Inc. | Medical injector simulation device |
| US8231573B2 (en) | 2005-02-01 | 2012-07-31 | Intelliject, Inc. | Medicament delivery device having an electronic circuit system |
| US8206360B2 (en) | 2005-02-01 | 2012-06-26 | Intelliject, Inc. | Devices, systems and methods for medicament delivery |
| KR101440795B1 (ko) | 2006-06-30 | 2014-09-22 | 애브비 바이오테크놀로지 리미티드 | 자동 주사 장치 |
| US8021344B2 (en) | 2008-07-28 | 2011-09-20 | Intelliject, Inc. | Medicament delivery device configured to produce an audible output |
| USD994111S1 (en) | 2008-05-12 | 2023-08-01 | Kaleo, Inc. | Medicament delivery device cover |
| US8636704B2 (en) | 2009-04-29 | 2014-01-28 | Abbvie Biotechnology Ltd | Automatic injection device |
| KR101780210B1 (ko) | 2009-12-15 | 2017-09-21 | 애브비 바이오테크놀로지 리미티드 | 자동 주사 디바이스용 개선된 발사 버튼 |
| CN104906656B (zh) | 2010-04-21 | 2020-01-10 | 艾伯维生物技术有限公司 | 用于治疗药剂的受控输送的可佩戴自动注射装置 |
| MX336571B (es) | 2011-01-24 | 2016-01-25 | Elcam Medical Agricultural Cooperative Ass Ltd | Inyector. |
| MY166835A (en) | 2011-01-24 | 2018-07-23 | Abbvie Biotechnology Ltd | Automatic injection devices having overmolded gripping surfaces |
| CN105709312B (zh) | 2011-01-24 | 2019-11-05 | 艾伯维生物技术有限公司 | 从注射器拆卸针罩和自动注射装置 |
| US8627816B2 (en) | 2011-02-28 | 2014-01-14 | Intelliject, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
| US9173999B2 (en) | 2011-01-26 | 2015-11-03 | Kaleo, Inc. | Devices and methods for delivering medicaments from a multi-chamber container |
| US8939943B2 (en) | 2011-01-26 | 2015-01-27 | Kaleo, Inc. | Medicament delivery device for administration of opioid antagonists including formulations for naloxone |
| ES2659491T3 (es) * | 2012-09-05 | 2018-03-15 | E3D Agricultural Cooperative Association Ltd. | Dispositivo de autoinyección electrónico |
| US20150290396A1 (en) * | 2012-10-23 | 2015-10-15 | Insuline Medical Ltd. | Drug dispensing-tracking device, system and method |
| US9381647B2 (en) * | 2013-02-19 | 2016-07-05 | Seiko Epson Corporation | Force detection device, robot, and moving object |
| US20140260694A1 (en) * | 2013-03-15 | 2014-09-18 | Chevron U.S.A. Inc. | Automated Tracer Sampling and Measurement System |
| WO2015024960A1 (en) * | 2013-08-22 | 2015-02-26 | Sanofi-Aventis Deutschland Gmbh | Control unit for a drug delivery device |
| FR3014969B1 (fr) * | 2013-12-16 | 2016-01-29 | Lisi Aerospace | Fixation temporaire |
| US10625026B2 (en) | 2014-01-21 | 2020-04-21 | Parenteral Technologies, Llc | Force actuated injection device |
| US20150202373A1 (en) * | 2014-01-21 | 2015-07-23 | Parenteral Technologies, Llc | Force actuated injection device |
| US9517307B2 (en) | 2014-07-18 | 2016-12-13 | Kaleo, Inc. | Devices and methods for delivering opioid antagonists including formulations for naloxone |
| JP6859253B2 (ja) * | 2014-08-08 | 2021-04-14 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | デバイス内部に配置されたカートリッジの機械的完全性を試験するための方法、構成、および薬物送達デバイス |
| CA3009221A1 (en) | 2014-12-23 | 2016-06-30 | Automed Pty Ltd | Delivery apparatus, system and associated methods |
| CN107530502B (zh) | 2015-02-20 | 2021-01-15 | 里珍纳龙药品有限公司 | 注射器系统、活塞密封系统、塞子系统 |
| WO2017004345A1 (en) | 2015-06-30 | 2017-01-05 | Kaleo, Inc. | Auto-injectors for administration of a medicament within a prefilled syringe |
| WO2017033193A2 (en) * | 2015-08-27 | 2017-03-02 | E3D Agricultural Cooperative Association Ltd | Reusable automatic injection device |
| WO2017087888A1 (en) | 2015-11-18 | 2017-05-26 | President And Fellows Of Harvard College | Systems and methods for monitoring, managing, and treating asthma and anaphylaxis |
| CN106236319B (zh) * | 2016-09-29 | 2017-12-29 | 深圳市智屏微科技有限公司 | 一种注射器的注射端结构以及注射器 |
| AU2017379094B2 (en) | 2016-12-23 | 2023-08-24 | Kaleo, Inc. | Medicament delivery device and methods for delivering drugs to infants and children |
| WO2019012475A2 (en) | 2017-07-12 | 2019-01-17 | Insuline Medical Ltd. | DRUG MONITORING DEVICE |
| GB201718315D0 (en) * | 2017-11-06 | 2017-12-20 | Owen Mumford Ltd | Auto-injector |
| US12171990B2 (en) | 2017-12-28 | 2024-12-24 | Sanofi | Sensor device for attachment to an injection device |
| CA3099359A1 (en) | 2018-05-24 | 2019-11-28 | Novartis Ag | Automatic drug delivery device |
| WO2020140040A1 (en) | 2018-12-29 | 2020-07-02 | Kaleo, Inc. | Devices and methods for delivery of substances within a prefilled syringe |
| IL290026B1 (en) | 2019-08-09 | 2025-10-01 | Kaleo Inc | Devices and methods for transferring materials into a prefilled syringe |
| US11829795B2 (en) * | 2019-12-30 | 2023-11-28 | UiPath, Inc. | Trigger service management for robotic process automation (RPA) |
| CN115515665A (zh) * | 2020-04-06 | 2022-12-23 | 辉美医疗器械有限公司 | 用于组装用在自动注射装置中的一盒子的方法 |
| US11957542B2 (en) | 2020-04-30 | 2024-04-16 | Automed Patent Holdco, Llc | Sensing complete injection for animal injection device |
| WO2022010726A1 (en) | 2020-07-09 | 2022-01-13 | Eli Lilly And Company | Automatic injection device with reusable portion |
| US12268847B1 (en) | 2021-02-10 | 2025-04-08 | Kaleo, Inc. | Devices and methods for delivery of substances within a medicament container |
| CN118785935A (zh) * | 2022-03-11 | 2024-10-15 | 赛诺菲 | 用于注射装置的工件载体 |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3541663A (en) * | 1968-08-21 | 1970-11-24 | Roman Szpur | Syringe needle attachment device |
| US4855923A (en) * | 1988-01-06 | 1989-08-08 | Xerox Corporation | Parts assembly using signature analysis |
| US5142769A (en) * | 1988-07-14 | 1992-09-01 | Coors Brewing Company | Monitor and control assembly for use with a can end press |
| US5154046A (en) * | 1990-07-13 | 1992-10-13 | Italtractor I.T.M. S.P.A. | Method for the coupling of articulating track links with a determined tolerance by means of press fitting |
| JP2005080957A (ja) * | 2003-09-10 | 2005-03-31 | Nipro Corp | 外れ防止機構を備えたプランジャー |
| JP2008500861A (ja) * | 2004-05-28 | 2008-01-17 | シラグ・ゲーエムベーハー・インターナショナル | 注入装置 |
| JP2009542334A (ja) * | 2006-06-30 | 2009-12-03 | アボツト・バイオテクノロジー・リミテツド | 自動注射装置 |
| JP2009543698A (ja) * | 2006-07-18 | 2009-12-10 | キストラー ホールディング アクチエンゲゼルシャフト | 接合ユニット |
| JP2009544915A (ja) * | 2006-07-23 | 2009-12-17 | サジヴ アグダー シトゥフィット シャクレイト ベ’アム | パイプにパイプ継手を結合する装置および方法 |
| JP2010504778A (ja) * | 2006-09-28 | 2010-02-18 | ローベルト ボツシユ ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 注射器にニードルガードを取り付けるための装置及び方法 |
| JP2010279692A (ja) * | 2009-05-26 | 2010-12-16 | Mg2 Srl | 注射器のピストンを捩じ込むための方法及び装置 |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3910260A (en) | 1972-03-01 | 1975-10-07 | Survival Technology | Method and apparatus of treating heart attack patients prior to the establishment of qualified direct contact personal care |
| US4004577A (en) | 1972-12-04 | 1977-01-25 | Survival Technology, Inc. | Method of treating heart attack patients prior to the establishment of qualified direct contact personal care |
| US3941130A (en) | 1975-03-18 | 1976-03-02 | Tibbs Robert C | Sequential trigger release for injection device |
| US4261358A (en) | 1979-10-01 | 1981-04-14 | Walter Vargas | Automatic syringe plunger |
| US4795433A (en) | 1985-05-20 | 1989-01-03 | Survival Technology, Inc. | Automatic injector for emergency treatment |
| US4689042A (en) | 1985-05-20 | 1987-08-25 | Survival Technology, Inc. | Automatic medicament ingredient mixing and injecting apparatus |
| US5085642A (en) | 1989-07-17 | 1992-02-04 | Survival Technology, Inc. | Conveniently carried frequent use autoinjector |
| US5102393A (en) | 1989-07-17 | 1992-04-07 | Survival Technology, Inc. | Autoinjector converted from intramuscular to subcutaneous mode of injection |
| US6448380B2 (en) | 1989-08-07 | 2002-09-10 | Peptech Limited | Tumor necrosis factor antibodies |
| US5959087A (en) | 1989-08-07 | 1999-09-28 | Peptide Technology, Ltd. | Tumour necrosis factor binding ligands |
| AU630497B2 (en) | 1989-09-05 | 1992-10-29 | Immunex Corporation | Tumor necrosis factor-alpha and -beta receptors |
| US5092843A (en) | 1990-04-12 | 1992-03-03 | Survival Technology, Inc. | Dispersion multichamber auto-injector |
| US5656272A (en) | 1991-03-18 | 1997-08-12 | New York University Medical Center | Methods of treating TNF-α-mediated Crohn's disease using chimeric anti-TNF antibodies |
| US5267963A (en) | 1992-08-21 | 1993-12-07 | Nicholas Bachynsky | Medication injection device |
| JPH07504203A (ja) | 1992-09-15 | 1995-05-11 | イミュネックス・コーポレーション | 腫瘍壊死因子アンタゴニストを用いるtnf−依存性炎症の治療方法 |
| US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| DE69721548T2 (de) | 1996-02-09 | 2004-04-01 | Abbott Laboratories(Bermuda)Ltd. | HUMANE ANTIKÖRPER WELCHE AN HUMANEN TNFalpha BINDEN |
| DE19705462C2 (de) * | 1997-02-13 | 2002-01-10 | Schmidt Feinmech | Verfahren zum Betreiben einer Elektropresse |
| GB9716065D0 (en) * | 1997-07-31 | 1997-10-01 | Owen Mumford Ltd | Improvements relating to injection devices |
| US6149626A (en) | 1997-10-03 | 2000-11-21 | Bachynsky; Nicholas | Automatic injecting syringe apparatus |
| SE9803662D0 (sv) | 1998-10-26 | 1998-10-26 | Pharmacia & Upjohn Ab | Autoinjector |
| UA81743C2 (uk) | 2000-08-07 | 2008-02-11 | Центокор, Инк. | МОНОКЛОНАЛЬНЕ АНТИТІЛО ЛЮДИНИ, ЩО СПЕЦИФІЧНО ЗВ'ЯЗУЄТЬСЯ З ФАКТОРОМ НЕКРОЗУ ПУХЛИН АЛЬФА (ФНПα), ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ, ЩО ЙОГО МІСТИТЬ, ТА СПОСІБ ЛІКУВАННЯ РЕВМАТОЇДНОГО АРТРИТУ |
-
2012
- 2012-03-19 JP JP2013558239A patent/JP2014511711A/ja not_active Ceased
- 2012-03-19 MX MX2013010699A patent/MX2013010699A/es unknown
- 2012-03-19 CA CA2829773A patent/CA2829773A1/en not_active Abandoned
- 2012-03-19 AU AU2012231178A patent/AU2012231178B2/en not_active Ceased
- 2012-03-19 US US13/424,194 patent/US20120233834A1/en not_active Abandoned
- 2012-03-19 EP EP12713470.8A patent/EP2686036A1/en not_active Withdrawn
- 2012-03-19 BR BR112013023967A patent/BR112013023967A2/pt not_active Application Discontinuation
- 2012-03-19 CN CN201280023943.5A patent/CN103608053B/zh not_active Expired - Fee Related
- 2012-03-19 WO PCT/US2012/029682 patent/WO2012129174A1/en not_active Ceased
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3541663A (en) * | 1968-08-21 | 1970-11-24 | Roman Szpur | Syringe needle attachment device |
| US4855923A (en) * | 1988-01-06 | 1989-08-08 | Xerox Corporation | Parts assembly using signature analysis |
| US5142769A (en) * | 1988-07-14 | 1992-09-01 | Coors Brewing Company | Monitor and control assembly for use with a can end press |
| US5154046A (en) * | 1990-07-13 | 1992-10-13 | Italtractor I.T.M. S.P.A. | Method for the coupling of articulating track links with a determined tolerance by means of press fitting |
| JP2005080957A (ja) * | 2003-09-10 | 2005-03-31 | Nipro Corp | 外れ防止機構を備えたプランジャー |
| JP2008500861A (ja) * | 2004-05-28 | 2008-01-17 | シラグ・ゲーエムベーハー・インターナショナル | 注入装置 |
| JP2009542334A (ja) * | 2006-06-30 | 2009-12-03 | アボツト・バイオテクノロジー・リミテツド | 自動注射装置 |
| JP2009543698A (ja) * | 2006-07-18 | 2009-12-10 | キストラー ホールディング アクチエンゲゼルシャフト | 接合ユニット |
| JP2009544915A (ja) * | 2006-07-23 | 2009-12-17 | サジヴ アグダー シトゥフィット シャクレイト ベ’アム | パイプにパイプ継手を結合する装置および方法 |
| JP2010504778A (ja) * | 2006-09-28 | 2010-02-18 | ローベルト ボツシユ ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | 注射器にニードルガードを取り付けるための装置及び方法 |
| JP2010279692A (ja) * | 2009-05-26 | 2010-12-16 | Mg2 Srl | 注射器のピストンを捩じ込むための方法及び装置 |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012231178A1 (en) | 2013-05-02 |
| WO2012129174A1 (en) | 2012-09-27 |
| EP2686036A1 (en) | 2014-01-22 |
| MX2013010699A (es) | 2014-03-27 |
| CA2829773A1 (en) | 2012-09-27 |
| CN103608053A (zh) | 2014-02-26 |
| AU2012231178B2 (en) | 2015-11-05 |
| CN103608053B (zh) | 2016-06-22 |
| US20120233834A1 (en) | 2012-09-20 |
| BR112013023967A2 (pt) | 2016-01-19 |
| WO2012129174A8 (en) | 2013-03-14 |
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