JP2014511395A - Ｐｉ３キナーゼインヒビターおよびその使用 - Google Patents
Ｐｉ３キナーゼインヒビターおよびその使用 Download PDFInfo
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- JP2014511395A JP2014511395A JP2013557866A JP2013557866A JP2014511395A JP 2014511395 A JP2014511395 A JP 2014511395A JP 2013557866 A JP2013557866 A JP 2013557866A JP 2013557866 A JP2013557866 A JP 2013557866A JP 2014511395 A JP2014511395 A JP 2014511395A
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| US201161451022P | 2011-03-09 | 2011-03-09 | |
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| PCT/US2012/028293 WO2012122383A2 (en) | 2011-03-09 | 2012-03-08 | Pi3 kinase inhibitors and uses thereof |
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| JP2014511395A true JP2014511395A (ja) | 2014-05-15 |
| JP2014511395A5 JP2014511395A5 (enExample) | 2015-04-30 |
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| EP (1) | EP2683243A4 (enExample) |
| JP (1) | JP2014511395A (enExample) |
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| AU (1) | AU2012225382B2 (enExample) |
| CA (1) | CA2829558A1 (enExample) |
| WO (1) | WO2012122383A2 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018521112A (ja) * | 2015-04-30 | 2018-08-02 | ジャンスー・ヌオ−ベータ・ファーマシューティカル・テクノロジー・カンパニー・リミテッド | アルツハイマー病の治療におけるＰＩ４ＫＩＩＩαタンパク質および関連膜タンパク質複合体の利用 |
| JP2019504858A (ja) * | 2016-02-12 | 2019-02-21 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | キナーゼ活性の阻害剤としての化合物 |
| CN112189012A (zh) * | 2018-04-10 | 2021-01-05 | 神经孔疗法股份有限公司 | 作为pi3激酶和自噬途径的调节剂的三取代芳基和杂芳基衍生物 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU2013251475B2 (en) | 2012-04-26 | 2018-01-04 | The General Hospital Corporation | Agents and methods for treating and preventing seborrheic keratosis |
| US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
| PT2970101T (pt) | 2013-03-14 | 2018-10-04 | Alkermes Pharma Ireland Ltd | Pró-fármacos de fumaratos e seu uso no tratamento de várias doenças |
| TWI647220B (zh) | 2013-03-15 | 2019-01-11 | 美商西建卡爾有限責任公司 | 雜芳基化合物及其用途 |
| US9663524B2 (en) | 2013-03-15 | 2017-05-30 | Celgene Car Llc | Substituted pyrido[2,3-d]pyrimidines as protein kinase inhibitors |
| UA120248C2 (uk) | 2013-03-15 | 2019-11-11 | Селджен Кар Ллс | Гетероарильні сполуки та їх застосування |
| EA038235B1 (ru) * | 2013-05-01 | 2021-07-28 | Ф.Хоффманн-Ля Рош Аг | Бигетероарильные соединения и их применения |
| CN104140426B (zh) * | 2013-05-07 | 2017-02-01 | 上海汇伦生命科技有限公司 | 嘧啶并咪唑类化合物、其药物组合物及其制备方法和用途 |
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| CN104651368B (zh) * | 2013-11-15 | 2017-09-29 | 北京大学 | 一种核酸适配体bc15的核心序列及其类似物和应用 |
| CA2940845C (en) | 2014-02-24 | 2019-09-24 | Alkermes Pharma Ireland Limited | Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases |
| GB201712282D0 (en) | 2017-07-31 | 2017-09-13 | Nodthera Ltd | Selective inhibitors of NLRP3 inflammasome |
| EP3806833A1 (en) | 2018-06-15 | 2021-04-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of pi3kc2b inhibitors for the preservation of vascular endothelial cell barrier integrity |
| KR20210125471A (ko) | 2018-10-05 | 2021-10-18 | 안나푸르나 바이오, 인코포레이티드 | Apj 수용체 활성과 관련된 병태를 치료하기 위한 화합물 및 조성물 |
| WO2020097398A1 (en) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
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| CN115417789B (zh) * | 2022-09-03 | 2023-08-04 | 郑州大学 | 一种治疗帕金森氏病的化合物、其制备方法以及复方药物组合物和应用 |
| WO2025034858A1 (en) * | 2023-08-08 | 2025-02-13 | Theras, Inc. | Fused pyridines for the treatment of cancer and other indications |
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- 2012-03-08 WO PCT/US2012/028293 patent/WO2012122383A2/en not_active Ceased
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- 2012-03-08 US US13/414,918 patent/US20120258967A1/en not_active Abandoned
- 2012-03-08 JP JP2013557866A patent/JP2014511395A/ja active Pending
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| WO2010052569A2 (en) * | 2008-11-10 | 2010-05-14 | University Of Basel | Triazine, pyrimidine and pyridine analogs and their use as therapeutic agents and diagnostic probes |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018521112A (ja) * | 2015-04-30 | 2018-08-02 | ジャンスー・ヌオ−ベータ・ファーマシューティカル・テクノロジー・カンパニー・リミテッド | アルツハイマー病の治療におけるＰＩ４ＫＩＩＩαタンパク質および関連膜タンパク質複合体の利用 |
| JP2019504858A (ja) * | 2016-02-12 | 2019-02-21 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ | キナーゼ活性の阻害剤としての化合物 |
| CN112189012A (zh) * | 2018-04-10 | 2021-01-05 | 神经孔疗法股份有限公司 | 作为pi3激酶和自噬途径的调节剂的三取代芳基和杂芳基衍生物 |
| JP2021521178A (ja) * | 2018-04-10 | 2021-08-26 | ニューロポア セラピーズ インコーポレイテッド | Ｐｉ３キナーゼおよびオートファジー経路の調節因子としての三置換アリールおよびヘテロアリール誘導体 |
| JP7369139B2 (ja) | 2018-04-10 | 2023-10-25 | ニューロポア セラピーズ インコーポレイテッド | Ｐｉ３キナーゼおよびオートファジー経路の調節因子としての三置換アリールおよびヘテロアリール誘導体 |
| CN112189012B (zh) * | 2018-04-10 | 2024-02-13 | 神经孔疗法股份有限公司 | 作为pi3激酶和自噬途径的调节剂的三取代芳基和杂芳基衍生物 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2683243A4 (en) | 2014-12-03 |
| CA2829558A1 (en) | 2012-09-13 |
| WO2012122383A3 (en) | 2012-12-27 |
| CN103501610A (zh) | 2014-01-08 |
| AU2012225382A1 (en) | 2013-10-10 |
| WO2012122383A2 (en) | 2012-09-13 |
| EP2683243A2 (en) | 2014-01-15 |
| AU2012225382B2 (en) | 2016-10-27 |
| US20120258967A1 (en) | 2012-10-11 |
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