AU2012225382B2 - PI3 kinase inhibitors and uses thereof - Google Patents
PI3 kinase inhibitors and uses thereof Download PDFInfo
- Publication number
- AU2012225382B2 AU2012225382B2 AU2012225382A AU2012225382A AU2012225382B2 AU 2012225382 B2 AU2012225382 B2 AU 2012225382B2 AU 2012225382 A AU2012225382 A AU 2012225382A AU 2012225382 A AU2012225382 A AU 2012225382A AU 2012225382 B2 AU2012225382 B2 AU 2012225382B2
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- Australia
- Prior art keywords
- ring
- optionally substituted
- oxo
- halogen
- bivalent
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- GWNAYWCXIPBCDM-UHFFFAOYSA-N CCNC1CCC(C)CCC1 Chemical compound CCNC1CCC(C)CCC1 GWNAYWCXIPBCDM-UHFFFAOYSA-N 0.000 description 2
- UAEPNZWRGJTJPN-UHFFFAOYSA-N CC1CCCCC1 Chemical compound CC1CCCCC1 UAEPNZWRGJTJPN-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Pulmonology (AREA)
- Physical Education & Sports Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Urology & Nephrology (AREA)
- Hospice & Palliative Care (AREA)
- Rheumatology (AREA)
- Dermatology (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Ophthalmology & Optometry (AREA)
- Pain & Pain Management (AREA)
- Virology (AREA)
- Obesity (AREA)
- Psychiatry (AREA)
- Vascular Medicine (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161451022P | 2011-03-09 | 2011-03-09 | |
| US61/451,022 | 2011-03-09 | ||
| PCT/US2012/028293 WO2012122383A2 (en) | 2011-03-09 | 2012-03-08 | Pi3 kinase inhibitors and uses thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2012225382A1 AU2012225382A1 (en) | 2013-10-10 |
| AU2012225382B2 true AU2012225382B2 (en) | 2016-10-27 |
Family
ID=46798805
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2012225382A Expired - Fee Related AU2012225382B2 (en) | 2011-03-09 | 2012-03-08 | PI3 kinase inhibitors and uses thereof |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20120258967A1 (enExample) |
| EP (1) | EP2683243A4 (enExample) |
| JP (1) | JP2014511395A (enExample) |
| CN (1) | CN103501610A (enExample) |
| AU (1) | AU2012225382B2 (enExample) |
| CA (1) | CA2829558A1 (enExample) |
| WO (1) | WO2012122383A2 (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2798185T3 (es) | 2012-04-26 | 2020-12-09 | Massachusetts Gen Hospital | Agentes y métodos para el tratamiento y prevención de queratosis seborreica |
| US8669281B1 (en) | 2013-03-14 | 2014-03-11 | Alkermes Pharma Ireland Limited | Prodrugs of fumarates and their use in treating various diseases |
| UA116648C2 (uk) | 2013-03-14 | 2018-04-25 | Алкермес Фарма Айерленд Лімітед | Фумарати як проліки та їх застосування при лікуванні різних захворювань |
| EA036160B1 (ru) * | 2013-03-15 | 2020-10-08 | Селджен Кар Ллс | Гетероарильные соединения и их применение |
| AR095464A1 (es) | 2013-03-15 | 2015-10-21 | Celgene Avilomics Res Inc | Compuestos de heteroarilo y usos de los mismos |
| KR102350704B1 (ko) | 2013-03-15 | 2022-01-13 | 셀젠 카르 엘엘씨 | 헤테로아릴 화합물 및 이의 용도 |
| CR20200177A (es) | 2013-05-01 | 2020-06-28 | Hoffmann La Roche | Compuestos de biheteroarilo (divisional 2015-0589) |
| CN104140426B (zh) * | 2013-05-07 | 2017-02-01 | 上海汇伦生命科技有限公司 | 嘧啶并咪唑类化合物、其药物组合物及其制备方法和用途 |
| WO2014186663A2 (en) * | 2013-05-17 | 2014-11-20 | The General Hospital Corporation | Methods for detecting and treating variants of seborrheic keratoses |
| CN104651368B (zh) * | 2013-11-15 | 2017-09-29 | 北京大学 | 一种核酸适配体bc15的核心序列及其类似物和应用 |
| WO2015127450A1 (en) | 2014-02-24 | 2015-08-27 | Alkermes Pharma Ireland Limited | Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases |
| WO2016172952A1 (zh) * | 2015-04-30 | 2016-11-03 | 江苏挪贝肽医药科技有限公司 | PI4KIIIα蛋白及相关的膜蛋白复合体在治疗阿尔茨海默病中的应用 |
| GB201602527D0 (en) * | 2016-02-12 | 2016-03-30 | Glaxosmithkline Ip Dev Ltd | Chemical compounds |
| GB201712282D0 (en) | 2017-07-31 | 2017-09-13 | Nodthera Ltd | Selective inhibitors of NLRP3 inflammasome |
| WO2019199864A1 (en) * | 2018-04-10 | 2019-10-17 | Neuropore Therapies, Inc. | Tri-substituted aryl and heteroaryl derivatives as modulators of pi3-kinase and autophagy pathways |
| WO2019238933A1 (en) * | 2018-06-15 | 2019-12-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of pi3kc2b inhibitors for the preservation of vascular endothelial cell barrier integrity |
| BR112021006488A2 (pt) | 2018-10-05 | 2021-07-06 | Annapurna Bio Inc | compostos e composições para o tratamento de condições associadas com atividade do receptor apj |
| WO2020097398A1 (en) | 2018-11-07 | 2020-05-14 | Dana-Farber Cancer Institute, Inc. | Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof |
| US11691963B2 (en) | 2020-05-06 | 2023-07-04 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| MX2023001758A (es) * | 2020-08-11 | 2023-04-11 | Univ Michigan State | Potenciadores de proteasoma y usos de los mismos. |
| US12043632B2 (en) | 2020-12-23 | 2024-07-23 | Ajax Therapeutics, Inc. | 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors |
| TW202325289A (zh) | 2021-11-09 | 2023-07-01 | 美商雅捷可斯治療公司 | Jak2抑制劑之形式及組合物 |
| AU2022388555A1 (en) | 2021-11-09 | 2024-05-02 | Ajax Therapeutics, Inc. | 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors |
| AU2023216951A1 (en) * | 2022-02-08 | 2024-08-15 | Lawrence Livermore National Security, Llc | Compounds having a t-structure formed by at least four cycles for use in the treatment of cancer and other indications |
| CN115417789B (zh) * | 2022-09-03 | 2023-08-04 | 郑州大学 | 一种治疗帕金森氏病的化合物、其制备方法以及复方药物组合物和应用 |
| WO2025034858A1 (en) * | 2023-08-08 | 2025-02-13 | Theras, Inc. | Fused pyridines for the treatment of cancer and other indications |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005007648A2 (en) * | 2003-07-16 | 2005-01-27 | Neurogen Corporation | Biaryl piperazinyl-pyridine analogues |
| WO2006026135A2 (en) * | 2004-08-13 | 2006-03-09 | Neurogen Corporation | Substituted biaryl piperazinyl-pyridine analogues |
| WO2010052569A2 (en) * | 2008-11-10 | 2010-05-14 | University Of Basel | Triazine, pyrimidine and pyridine analogs and their use as therapeutic agents and diagnostic probes |
| WO2011031896A2 (en) * | 2009-09-09 | 2011-03-17 | Avila Therapeutics, Inc. | Pi3 kinase inhibitors and uses thereof |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200510383A (en) * | 2003-07-16 | 2005-03-16 | Neurogen Corp | Biaryl piperazinyl-pyridine analogues |
| CN101080401A (zh) * | 2004-12-13 | 2007-11-28 | 神经能质公司 | 经取代的二芳基类似物 |
| CA2671845C (en) * | 2006-12-07 | 2015-03-24 | Genentech, Inc. | Phosphoinositide 3-kinase inhibitor compounds and methods of use |
| KR20090108124A (ko) * | 2007-02-06 | 2009-10-14 | 노파르티스 아게 | Pi 3-키나제 억제제 및 그의 사용 방법 |
| EP2211615A4 (en) * | 2007-10-22 | 2010-10-13 | Glaxosmithkline Llc | PYRIDOSULFONAMIDE DERIVATIVES AS PI3 KINASE INHIBITORS |
| WO2009066084A1 (en) * | 2007-11-21 | 2009-05-28 | F. Hoffmann-La Roche Ag | 2 -morpholinopyrimidines and their use as pi3 kinase inhibitors |
| US20090149458A1 (en) * | 2007-11-27 | 2009-06-11 | Wyeth | PYRROLO[3,2-d]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND mTOR KINASE INHIBITORS |
| US7820665B2 (en) * | 2007-12-19 | 2010-10-26 | Amgen Inc. | Imidazopyridazine inhibitors of PI3 kinase for cancer treatment |
| DE102009015255A1 (de) * | 2009-04-01 | 2010-10-14 | GM Global Technology Operations, Inc., Detroit | Tankklappenmodul |
| US8835429B2 (en) * | 2009-04-17 | 2014-09-16 | Wyeth Llc | Pyrimidine compounds, their use as mTOR kinase and Pl3 kinase inhibitors, and their syntheses |
| UY32582A (es) * | 2009-04-28 | 2010-11-30 | Amgen Inc | Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero |
| WO2013033901A1 (en) * | 2011-09-08 | 2013-03-14 | Merck Sharp & Dohme Corp. | Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases |
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2012
- 2012-03-08 JP JP2013557866A patent/JP2014511395A/ja active Pending
- 2012-03-08 CA CA2829558A patent/CA2829558A1/en not_active Abandoned
- 2012-03-08 CN CN201280021536.0A patent/CN103501610A/zh active Pending
- 2012-03-08 EP EP12755552.2A patent/EP2683243A4/en not_active Withdrawn
- 2012-03-08 AU AU2012225382A patent/AU2012225382B2/en not_active Expired - Fee Related
- 2012-03-08 WO PCT/US2012/028293 patent/WO2012122383A2/en not_active Ceased
- 2012-03-08 US US13/414,918 patent/US20120258967A1/en not_active Abandoned
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005007648A2 (en) * | 2003-07-16 | 2005-01-27 | Neurogen Corporation | Biaryl piperazinyl-pyridine analogues |
| WO2006026135A2 (en) * | 2004-08-13 | 2006-03-09 | Neurogen Corporation | Substituted biaryl piperazinyl-pyridine analogues |
| WO2010052569A2 (en) * | 2008-11-10 | 2010-05-14 | University Of Basel | Triazine, pyrimidine and pyridine analogs and their use as therapeutic agents and diagnostic probes |
| WO2011031896A2 (en) * | 2009-09-09 | 2011-03-17 | Avila Therapeutics, Inc. | Pi3 kinase inhibitors and uses thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2012122383A2 (en) | 2012-09-13 |
| JP2014511395A (ja) | 2014-05-15 |
| CA2829558A1 (en) | 2012-09-13 |
| WO2012122383A3 (en) | 2012-12-27 |
| CN103501610A (zh) | 2014-01-08 |
| AU2012225382A1 (en) | 2013-10-10 |
| EP2683243A4 (en) | 2014-12-03 |
| EP2683243A2 (en) | 2014-01-15 |
| US20120258967A1 (en) | 2012-10-11 |
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| MK25 | Application lapsed reg. 22.2i(2) - failure to pay acceptance fee |