AU2012225382B2 - PI3 kinase inhibitors and uses thereof - Google Patents

PI3 kinase inhibitors and uses thereof Download PDF

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Publication number
AU2012225382B2
AU2012225382B2 AU2012225382A AU2012225382A AU2012225382B2 AU 2012225382 B2 AU2012225382 B2 AU 2012225382B2 AU 2012225382 A AU2012225382 A AU 2012225382A AU 2012225382 A AU2012225382 A AU 2012225382A AU 2012225382 B2 AU2012225382 B2 AU 2012225382B2
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ring
optionally substituted
oxo
halogen
bivalent
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AU2012225382A
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AU2012225382A1 (en
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Deqiang Niu
Russell C. Petter
Lixin Qiao
Zhendong Zhu
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Celgene Avilomics Research Inc
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Celgene Avilomics Research Inc
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    • C07ORGANIC CHEMISTRY
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    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07ORGANIC CHEMISTRY
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    • C07ORGANIC CHEMISTRY
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    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

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AU2012225382A 2011-03-09 2012-03-08 PI3 kinase inhibitors and uses thereof Expired - Fee Related AU2012225382B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161451022P 2011-03-09 2011-03-09
US61/451,022 2011-03-09
PCT/US2012/028293 WO2012122383A2 (en) 2011-03-09 2012-03-08 Pi3 kinase inhibitors and uses thereof

Publications (2)

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AU2012225382A1 AU2012225382A1 (en) 2013-10-10
AU2012225382B2 true AU2012225382B2 (en) 2016-10-27

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US (1) US20120258967A1 (enExample)
EP (1) EP2683243A4 (enExample)
JP (1) JP2014511395A (enExample)
CN (1) CN103501610A (enExample)
AU (1) AU2012225382B2 (enExample)
CA (1) CA2829558A1 (enExample)
WO (1) WO2012122383A2 (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2798185T3 (es) 2012-04-26 2020-12-09 Massachusetts Gen Hospital Agentes y métodos para el tratamiento y prevención de queratosis seborreica
US8669281B1 (en) 2013-03-14 2014-03-11 Alkermes Pharma Ireland Limited Prodrugs of fumarates and their use in treating various diseases
UA116648C2 (uk) 2013-03-14 2018-04-25 Алкермес Фарма Айерленд Лімітед Фумарати як проліки та їх застосування при лікуванні різних захворювань
EA036160B1 (ru) * 2013-03-15 2020-10-08 Селджен Кар Ллс Гетероарильные соединения и их применение
AR095464A1 (es) 2013-03-15 2015-10-21 Celgene Avilomics Res Inc Compuestos de heteroarilo y usos de los mismos
KR102350704B1 (ko) 2013-03-15 2022-01-13 셀젠 카르 엘엘씨 헤테로아릴 화합물 및 이의 용도
CR20200177A (es) 2013-05-01 2020-06-28 Hoffmann La Roche Compuestos de biheteroarilo (divisional 2015-0589)
CN104140426B (zh) * 2013-05-07 2017-02-01 上海汇伦生命科技有限公司 嘧啶并咪唑类化合物、其药物组合物及其制备方法和用途
WO2014186663A2 (en) * 2013-05-17 2014-11-20 The General Hospital Corporation Methods for detecting and treating variants of seborrheic keratoses
CN104651368B (zh) * 2013-11-15 2017-09-29 北京大学 一种核酸适配体bc15的核心序列及其类似物和应用
WO2015127450A1 (en) 2014-02-24 2015-08-27 Alkermes Pharma Ireland Limited Sulfonamide and sulfinamide prodrugs of fumarates and their use in treating various diseases
WO2016172952A1 (zh) * 2015-04-30 2016-11-03 江苏挪贝肽医药科技有限公司 PI4KIIIα蛋白及相关的膜蛋白复合体在治疗阿尔茨海默病中的应用
GB201602527D0 (en) * 2016-02-12 2016-03-30 Glaxosmithkline Ip Dev Ltd Chemical compounds
GB201712282D0 (en) 2017-07-31 2017-09-13 Nodthera Ltd Selective inhibitors of NLRP3 inflammasome
WO2019199864A1 (en) * 2018-04-10 2019-10-17 Neuropore Therapies, Inc. Tri-substituted aryl and heteroaryl derivatives as modulators of pi3-kinase and autophagy pathways
WO2019238933A1 (en) * 2018-06-15 2019-12-19 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of pi3kc2b inhibitors for the preservation of vascular endothelial cell barrier integrity
BR112021006488A2 (pt) 2018-10-05 2021-07-06 Annapurna Bio Inc compostos e composições para o tratamento de condições associadas com atividade do receptor apj
WO2020097398A1 (en) 2018-11-07 2020-05-14 Dana-Farber Cancer Institute, Inc. Benzothiazole derivatives and 7-aza-benzothiazole derivatives as janus kinase 2 inhibitors and uses thereof
US11691963B2 (en) 2020-05-06 2023-07-04 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
MX2023001758A (es) * 2020-08-11 2023-04-11 Univ Michigan State Potenciadores de proteasoma y usos de los mismos.
US12043632B2 (en) 2020-12-23 2024-07-23 Ajax Therapeutics, Inc. 6-heteroaryloxy benzimidazoles and azabenzimidazoles as JAK2 inhibitors
TW202325289A (zh) 2021-11-09 2023-07-01 美商雅捷可斯治療公司 Jak2抑制劑之形式及組合物
AU2022388555A1 (en) 2021-11-09 2024-05-02 Ajax Therapeutics, Inc. 6-he tero aryloxy benzimidazoles and azabenzimidazoles as jak2 inhibitors
AU2023216951A1 (en) * 2022-02-08 2024-08-15 Lawrence Livermore National Security, Llc Compounds having a t-structure formed by at least four cycles for use in the treatment of cancer and other indications
CN115417789B (zh) * 2022-09-03 2023-08-04 郑州大学 一种治疗帕金森氏病的化合物、其制备方法以及复方药物组合物和应用
WO2025034858A1 (en) * 2023-08-08 2025-02-13 Theras, Inc. Fused pyridines for the treatment of cancer and other indications

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005007648A2 (en) * 2003-07-16 2005-01-27 Neurogen Corporation Biaryl piperazinyl-pyridine analogues
WO2006026135A2 (en) * 2004-08-13 2006-03-09 Neurogen Corporation Substituted biaryl piperazinyl-pyridine analogues
WO2010052569A2 (en) * 2008-11-10 2010-05-14 University Of Basel Triazine, pyrimidine and pyridine analogs and their use as therapeutic agents and diagnostic probes
WO2011031896A2 (en) * 2009-09-09 2011-03-17 Avila Therapeutics, Inc. Pi3 kinase inhibitors and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200510383A (en) * 2003-07-16 2005-03-16 Neurogen Corp Biaryl piperazinyl-pyridine analogues
CN101080401A (zh) * 2004-12-13 2007-11-28 神经能质公司 经取代的二芳基类似物
CA2671845C (en) * 2006-12-07 2015-03-24 Genentech, Inc. Phosphoinositide 3-kinase inhibitor compounds and methods of use
KR20090108124A (ko) * 2007-02-06 2009-10-14 노파르티스 아게 Pi 3-키나제 억제제 및 그의 사용 방법
EP2211615A4 (en) * 2007-10-22 2010-10-13 Glaxosmithkline Llc PYRIDOSULFONAMIDE DERIVATIVES AS PI3 KINASE INHIBITORS
WO2009066084A1 (en) * 2007-11-21 2009-05-28 F. Hoffmann-La Roche Ag 2 -morpholinopyrimidines and their use as pi3 kinase inhibitors
US20090149458A1 (en) * 2007-11-27 2009-06-11 Wyeth PYRROLO[3,2-d]PYRIMIDINE COMPOUNDS AND THEIR USE AS PI3 KINASE AND mTOR KINASE INHIBITORS
US7820665B2 (en) * 2007-12-19 2010-10-26 Amgen Inc. Imidazopyridazine inhibitors of PI3 kinase for cancer treatment
DE102009015255A1 (de) * 2009-04-01 2010-10-14 GM Global Technology Operations, Inc., Detroit Tankklappenmodul
US8835429B2 (en) * 2009-04-17 2014-09-16 Wyeth Llc Pyrimidine compounds, their use as mTOR kinase and Pl3 kinase inhibitors, and their syntheses
UY32582A (es) * 2009-04-28 2010-11-30 Amgen Inc Inhibidores de fosfoinositida 3 cinasa y/u objetivo mamífero
WO2013033901A1 (en) * 2011-09-08 2013-03-14 Merck Sharp & Dohme Corp. Heterocyclic-substituted benzofuran derivatives and methods of use thereof for the treatment of viral diseases

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005007648A2 (en) * 2003-07-16 2005-01-27 Neurogen Corporation Biaryl piperazinyl-pyridine analogues
WO2006026135A2 (en) * 2004-08-13 2006-03-09 Neurogen Corporation Substituted biaryl piperazinyl-pyridine analogues
WO2010052569A2 (en) * 2008-11-10 2010-05-14 University Of Basel Triazine, pyrimidine and pyridine analogs and their use as therapeutic agents and diagnostic probes
WO2011031896A2 (en) * 2009-09-09 2011-03-17 Avila Therapeutics, Inc. Pi3 kinase inhibitors and uses thereof

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WO2012122383A2 (en) 2012-09-13
JP2014511395A (ja) 2014-05-15
CA2829558A1 (en) 2012-09-13
WO2012122383A3 (en) 2012-12-27
CN103501610A (zh) 2014-01-08
AU2012225382A1 (en) 2013-10-10
EP2683243A4 (en) 2014-12-03
EP2683243A2 (en) 2014-01-15
US20120258967A1 (en) 2012-10-11

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