JP2014511393A - イソインドリン化合物を用いた疾患の治療方法 - Google Patents

イソインドリン化合物を用いた疾患の治療方法 Download PDF

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JP2014511393A
JP2014511393A JP2013557763A JP2013557763A JP2014511393A JP 2014511393 A JP2014511393 A JP 2014511393A JP 2013557763 A JP2013557763 A JP 2013557763A JP 2013557763 A JP2013557763 A JP 2013557763A JP 2014511393 A JP2014511393 A JP 2014511393A
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disease
compound
solvate
pharmaceutically acceptable
ethoxy
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JP2014511393A5 (enExample
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エイチ.スチャフエル ペテル
シャンカル サイ
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Celgene Corp
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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/4035Isoindoles, e.g. phthalimide
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    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
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  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
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  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
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  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
JP2013557763A 2011-03-07 2012-03-02 イソインドリン化合物を用いた疾患の治療方法 Pending JP2014511393A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161449716P 2011-03-07 2011-03-07
US61/449,716 2011-03-07
PCT/US2012/027368 WO2012121988A2 (en) 2011-03-07 2012-03-02 Methods for treating diseases using isoindoline compounds

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JP2014511393A true JP2014511393A (ja) 2014-05-15
JP2014511393A5 JP2014511393A5 (enExample) 2015-04-16

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US (1) US9387195B2 (enExample)
EP (2) EP2683376B1 (enExample)
JP (1) JP2014511393A (enExample)
ES (2) ES2711100T3 (enExample)
WO (1) WO2012121988A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020505469A (ja) * 2017-01-27 2020-02-20 サルドバーヴァ フォーミュレーションズ プライベート リミテッドSarudbhava Formulations Private Limited 治療用アプレミラスト局所組成物
WO2023120466A1 (ja) * 2021-12-23 2023-06-29 沢井製薬株式会社 アプレミラスト水和物含有製剤

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2884454C (en) * 2012-10-11 2021-07-27 Nerre Therapeutics Limited Orvepitant and uses thereof
EP3010490A1 (en) * 2013-06-17 2016-04-27 Celgene Corporation Tablet formulations of (+)-2-[1 -(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione
RU2538615C1 (ru) * 2013-08-20 2015-01-10 Общество с ограниченной ответственностью "УНИФАРМ" (ООО "УНИФАРМ"). Средство для профилактики и лечения простатита и аденомы предстательной железы
CN105669478A (zh) * 2014-11-17 2016-06-15 重庆医药工业研究院有限责任公司 一种制备3-氨基邻苯二甲酸及其衍生物的方法
AU2015371308A1 (en) 2014-12-23 2017-08-03 Intellectual Property Associates, Llc Methods and formulations for transdermal administration
WO2017085568A1 (en) * 2015-11-19 2017-05-26 Alembic Pharmaceuticals Limited An improved process and novel polymorphic form of apremilast
CN105388237B (zh) * 2015-12-28 2017-02-01 成都百裕金阁莱药业有限公司 阿普斯特中3‑乙酰氨基邻苯二甲酸的检测方法
EP3435973B1 (en) * 2016-03-30 2023-11-01 Sarudbhava Formulations Private Limited Apremilast pharmaceutical compositions
JP6827113B2 (ja) * 2017-01-21 2021-02-10 広州白雲山漢方現代薬業有限公司Guangzhou Hanfang Pharmaceutical Co.,Ltd. シェーグレン症候群の治療におけるペオニフロリン−6’−o−ベンゼンスルホン酸の使用
JP2020534285A (ja) 2017-09-15 2020-11-26 アンパサンド バイオファーマシューティカルズ インコーポレイテッドAmpersand Biopharmaceuticals Inc. 投与および処置の方法
US20240252426A1 (en) * 2018-09-21 2024-08-01 Apramitha Innovations Private Limited Improved and stable apremilast pharmaceutical compositions
BR112021013174A2 (pt) 2019-01-11 2021-11-03 Novartis Ag Anticorpos anti-cd40 para uso no tratamento da hidradenite supurativa
CN115068406A (zh) * 2021-03-12 2022-09-20 浙江万晟药业有限公司 一种用于治疗斑秃的阿普斯特凝胶及其制备工艺

Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004500346A (ja) * 1999-11-12 2004-01-08 セルジーン コーポレイション 薬剤活性のあるイソインドリン誘導体
JP2005525386A (ja) * 2002-03-20 2005-08-25 セルジーン・コーポレーション (+)−2−[1−(3−エトキシ−4−メトキシフェニル)−2−メチルスルホニルエチル]−4−アセチルアミノイソインドリン−1,3−ジオン、その使用方法及び組成物
JP2005529930A (ja) * 2002-05-28 2005-10-06 アルタナ ファルマ アクチエンゲゼルシャフト 局所適用可能な薬剤学的製剤
JP2006511479A (ja) * 2002-09-27 2006-04-06 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 3,4−二置換ピロールおよび炎症性疾患の治療におけるこれらの使用
JP2007536222A (ja) * 2004-05-05 2007-12-13 セルジーン・コーポレーション 癌及び他の疾患を治療及び管理するための選択的サイトカイン阻害薬を用いた方法及び組成物
JP2008518891A (ja) * 2004-11-02 2008-06-05 スイッチ バイオテック アーゲー Tリンパ球の増殖および/またはケラチノサイトの過剰増殖を特徴とする疾患、特にアトピー性皮膚炎および乾癬を処置するための、ピルリンドールの使用
JP2008523102A (ja) * 2004-12-13 2008-07-03 セルジーン・コーポレーション Pde4モジュレーターを含有する組成物及び気道炎症の治療又は予防のためのそれらの使用
JP2009522289A (ja) * 2005-12-29 2009-06-11 セルジーン・コーポレーション アミノイソインドリン化合物を使用した皮膚狼瘡治療方法
WO2009120167A1 (en) * 2008-03-27 2009-10-01 Celgene Corporation Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
WO2010069322A1 (en) * 2008-12-19 2010-06-24 Leo Pharma A/S Triazolopyridines as phosphodiesterase inhibitors for treatment of dermal diseases
JP2010523725A (ja) * 2007-04-16 2010-07-15 レオ ファーマ アクティーゼルスカブ 皮膚疾患処置用ホスホジエステラーゼ阻害剤としてのトリアゾロピリジン
WO2010091894A2 (en) * 2009-02-16 2010-08-19 Giuliani International Limited Methods of treating hair related conditions
WO2011001212A1 (en) * 2009-06-30 2011-01-06 Piramal Life Sciences Limited Imidazo [4,5-c]quinoline derivatives and their use in the treatment of tumors and/or inflammation

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536809A (en) 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
US3845770A (en) 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
IE58110B1 (en) 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
US5073543A (en) 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5733566A (en) 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5580578A (en) 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5591767A (en) 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
IT1270594B (it) 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
US6020358A (en) 1998-10-30 2000-02-01 Celgene Corporation Substituted phenethylsulfones and method of reducing TNFα levels
US7319107B2 (en) * 2001-11-08 2008-01-15 Johnson & Johnson Consumer Companies, Inc. 1,2,4-thiadiazolium derivatives as melanocortin receptor modulators
US7893101B2 (en) * 2002-03-20 2011-02-22 Celgene Corporation Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
CN101745112A (zh) 2002-07-19 2010-06-23 艾博特生物技术有限公司 TNFα相关疾病的治疗
DE102004046235A1 (de) * 2004-09-22 2006-03-30 Altana Pharma Ag Arzneimittelzubereitung
WO2008013791A2 (en) * 2006-07-24 2008-01-31 University Of Delaware Pan-antagonists for the androgen receptor and androgen receptor mutants associated with anti-androgen withdrawal
EP2498753B1 (en) * 2009-11-10 2019-03-06 Celgene Corporation Nanosuspension of a poorly soluble drug made by microfluidization process

Patent Citations (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004500346A (ja) * 1999-11-12 2004-01-08 セルジーン コーポレイション 薬剤活性のあるイソインドリン誘導体
JP2005525386A (ja) * 2002-03-20 2005-08-25 セルジーン・コーポレーション (+)−2−[1−(3−エトキシ−4−メトキシフェニル)−2−メチルスルホニルエチル]−4−アセチルアミノイソインドリン−1,3−ジオン、その使用方法及び組成物
JP2005529930A (ja) * 2002-05-28 2005-10-06 アルタナ ファルマ アクチエンゲゼルシャフト 局所適用可能な薬剤学的製剤
JP2006511479A (ja) * 2002-09-27 2006-04-06 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 3,4−二置換ピロールおよび炎症性疾患の治療におけるこれらの使用
JP2007536222A (ja) * 2004-05-05 2007-12-13 セルジーン・コーポレーション 癌及び他の疾患を治療及び管理するための選択的サイトカイン阻害薬を用いた方法及び組成物
JP2008518891A (ja) * 2004-11-02 2008-06-05 スイッチ バイオテック アーゲー Tリンパ球の増殖および/またはケラチノサイトの過剰増殖を特徴とする疾患、特にアトピー性皮膚炎および乾癬を処置するための、ピルリンドールの使用
JP2008523102A (ja) * 2004-12-13 2008-07-03 セルジーン・コーポレーション Pde4モジュレーターを含有する組成物及び気道炎症の治療又は予防のためのそれらの使用
JP2009522289A (ja) * 2005-12-29 2009-06-11 セルジーン・コーポレーション アミノイソインドリン化合物を使用した皮膚狼瘡治療方法
JP2010523725A (ja) * 2007-04-16 2010-07-15 レオ ファーマ アクティーゼルスカブ 皮膚疾患処置用ホスホジエステラーゼ阻害剤としてのトリアゾロピリジン
WO2009120167A1 (en) * 2008-03-27 2009-10-01 Celgene Corporation Solid forms comprising (+)-2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, compositions thereof, and uses thereof
WO2010069322A1 (en) * 2008-12-19 2010-06-24 Leo Pharma A/S Triazolopyridines as phosphodiesterase inhibitors for treatment of dermal diseases
WO2010091894A2 (en) * 2009-02-16 2010-08-19 Giuliani International Limited Methods of treating hair related conditions
WO2011001212A1 (en) * 2009-06-30 2011-01-06 Piramal Life Sciences Limited Imidazo [4,5-c]quinoline derivatives and their use in the treatment of tumors and/or inflammation

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
J. EUR. ACAD. DERMATOL. VENEREOL., vol. Vol.25(4), JPN6016020104, 2011, pages 479 - 484, ISSN: 0003327285 *
NATALIE DUBCHAK & GERALD F FALASCA: "New and improved strategies for the treatment of gout", INTERNATIONAL JOURNAL OF NEPHROLOGY AND RENOVASCULAR DISEASE, vol. 3, JPN6015051343, 2010, pages 145 - 166, ISSN: 0003220859 *
SCAND. J. RHEUMATOL., vol. Vol.38(5), JPN6016020107, 2009, pages 328 - 331, ISSN: 0003327286 *
STAMATIS GREGORIOU ET AL.: "Cytokines and Other Mediators in Alopecia Areata", HINDAWI PUBLISHING CORPORATION MEDIATORS OF INFLAMMATION, vol. 2010, JPN6015051341, 28 January 2010 (2010-01-28), pages 1 - 5, ISSN: 0003220858 *
THE NEW ENGLAND JOURNAL OF MEDICINE, vol. Vol.366;16, JPN7016001365, April 2012 (2012-04-01), pages 1515 - 1525, ISSN: 0003327284 *

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2020505469A (ja) * 2017-01-27 2020-02-20 サルドバーヴァ フォーミュレーションズ プライベート リミテッドSarudbhava Formulations Private Limited 治療用アプレミラスト局所組成物
JP2023022177A (ja) * 2017-01-27 2023-02-14 サルドバーヴァ フォーミュレーションズ プライベート リミテッド 治療用アプレミラスト局所組成物
WO2023120466A1 (ja) * 2021-12-23 2023-06-29 沢井製薬株式会社 アプレミラスト水和物含有製剤

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