JP2014511173A - 選択的細胞殺滅のための生物学的有効ヌクレオチド分子、その使用及び適用キット - Google Patents

選択的細胞殺滅のための生物学的有効ヌクレオチド分子、その使用及び適用キット Download PDF

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JP2014511173A
JP2014511173A JP2013549831A JP2013549831A JP2014511173A JP 2014511173 A JP2014511173 A JP 2014511173A JP 2013549831 A JP2013549831 A JP 2013549831A JP 2013549831 A JP2013549831 A JP 2013549831A JP 2014511173 A JP2014511173 A JP 2014511173A
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cells
biologically effective
cell
nucleotide molecule
mrna
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ペールマン,トビアス
グンター,ロルフ
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フリードリヒ−シラー−ユニバーシタット イエナ
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    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/14Type of nucleic acid interfering N.A.
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    • C12N2310/00Structure or type of the nucleic acid
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    • C12N2310/18Type of nucleic acid acting by a non-sequence specific mechanism
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/318Chemical structure of the backbone where the PO2 is completely replaced, e.g. MMI or formacetal
    • C12N2310/3181Peptide nucleic acid, PNA
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    • C12N2310/32Chemical structure of the sugar
    • C12N2310/323Chemical structure of the sugar modified ring structure
    • C12N2310/3231Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
JP2013549831A 2011-01-21 2012-01-20 選択的細胞殺滅のための生物学的有効ヌクレオチド分子、その使用及び適用キット Pending JP2014511173A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102011009470A DE102011009470A1 (de) 2011-01-21 2011-01-21 Biologisch wirksame Nukleotid-Moleküle zur gezielten Abtötung von Zellen, Verwendung derselben sowie Applikationskit
DE102011009470.9 2011-01-21
PCT/EP2012/050879 WO2012098234A1 (de) 2011-01-21 2012-01-20 Biologisch wirksame nukleotid-moleküle zur gezielten abtötung von zellen, verwendung derselben sowie applikationskit

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JP2014511173A true JP2014511173A (ja) 2014-05-15

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JP2013549831A Pending JP2014511173A (ja) 2011-01-21 2012-01-20 選択的細胞殺滅のための生物学的有効ヌクレオチド分子、その使用及び適用キット

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Country Link
US (1) US20170233760A1 (zh)
EP (1) EP2665816A1 (zh)
JP (1) JP2014511173A (zh)
CN (1) CN103597075A (zh)
DE (1) DE102011009470A1 (zh)
WO (1) WO2012098234A1 (zh)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102013003869B4 (de) 2013-02-27 2016-11-24 Friedrich-Schiller-Universität Jena Verfahren zur gezielten Abtötung von Zellen durch zur mRNA-Anbindung ausgerichtete Nukleotid-Moleküle sowie Nukleotid-Moleküle und Applikationskit für solche Verwendung
MA53381A (fr) 2018-07-24 2021-06-02 Amgen Inc Association d'inhibiteurs de la voie lilrb1/2 et d'inhibiteurs de la voie pd-1
DE102019000490A1 (de) 2019-01-23 2020-07-23 HAEMES Verwaltungsgesellschaft mbH Verwendung von Oligonukleotiden für die Behandlung von Tumoren

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WO2004048511A2 (en) * 2002-11-26 2004-06-10 Rosetta Genomics Ltd. Bioinformatically detectable group of novel viral regulatory genes and uses thereof
KR20070114923A (ko) * 2006-05-30 2007-12-05 울산대학교 산학협력단 복수의 표적 mRNA에 적용 가능한 siRNA염기서열을 추출하는 방법
WO2009083790A2 (en) * 2007-12-28 2009-07-09 Qiagen Sciences, Inc 'apoptosis inducing positive control for expression modulating experiments'
JP2010538660A (ja) * 2007-09-17 2010-12-16 イントラドイグム コーポレーション STAT3siRNA含有組成物及びそれらの使用法

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US5898031A (en) 1996-06-06 1999-04-27 Isis Pharmaceuticals, Inc. Oligoribonucleotides for cleaving RNA
TR200401292T3 (tr) 2000-12-01 2004-07-21 Max@Planck@Gesellschaft�Zur�F�Rderung�Der�Wissenschaften RNAÁgirişimineÁyolÁaçanÁküçükÁRNAÁmolekülleri
EP1628993A4 (en) * 2003-05-16 2010-04-07 Rosetta Inpharmatics Llc METHOD AND COMPOSITIONS FOR RNA INTERFERENCE
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DE102007008596B4 (de) 2007-02-15 2010-09-02 Friedrich-Schiller-Universität Jena Biologisch wirksame Moleküle auf Grundlage von PNA und siRNA, Verfahren zu deren zellspezifischen Aktivierung sowie Applikationskit zur Verabreichung
WO2009020344A2 (en) * 2007-08-06 2009-02-12 Postech Acad Ind Found Small interfering rnas (sirnas) controlling multiple target genes and method for preparing the same
DE102009043743B4 (de) * 2009-03-13 2016-10-13 Friedrich-Schiller-Universität Jena Zellspezifisch wirksame Moleküle auf Grundlage von siRNA sowie Applikationskits zu deren Herstellung und Verwendung
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KR20070114923A (ko) * 2006-05-30 2007-12-05 울산대학교 산학협력단 복수의 표적 mRNA에 적용 가능한 siRNA염기서열을 추출하는 방법
JP2010538660A (ja) * 2007-09-17 2010-12-16 イントラドイグム コーポレーション STAT3siRNA含有組成物及びそれらの使用法
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EP2665816A1 (de) 2013-11-27
US20170233760A1 (en) 2017-08-17
CN103597075A (zh) 2014-02-19
WO2012098234A1 (de) 2012-07-26
DE102011009470A1 (de) 2012-08-09

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