JP2014510122A5 - - Google Patents

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Publication number
JP2014510122A5
JP2014510122A5 JP2014503105A JP2014503105A JP2014510122A5 JP 2014510122 A5 JP2014510122 A5 JP 2014510122A5 JP 2014503105 A JP2014503105 A JP 2014503105A JP 2014503105 A JP2014503105 A JP 2014503105A JP 2014510122 A5 JP2014510122 A5 JP 2014510122A5
Authority
JP
Japan
Prior art keywords
phenyl
pyrrolo
dihydro
methylmorpholino
urea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014503105A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014510122A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2012/055953 external-priority patent/WO2012136622A1/en
Publication of JP2014510122A publication Critical patent/JP2014510122A/ja
Publication of JP2014510122A5 publication Critical patent/JP2014510122A5/ja
Pending legal-status Critical Current

Links

JP2014503105A 2011-04-04 2012-04-02 ｍＴＯＲ阻害剤としてのジヒドロピロロピリミジン誘導体 Pending JP2014510122A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11160983.0 2011-04-04
EP11160983 2011-04-04
PCT/EP2012/055953 WO2012136622A1 (en) 2011-04-04 2012-04-02 Dihydropyrrolo pyrimidine derivatives as mtor inhibitors

Publications (2)

Publication Number Publication Date
JP2014510122A JP2014510122A (ja) 2014-04-24
JP2014510122A5 true JP2014510122A5 (enExample) 2015-05-21

Family

ID=44246546

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014503105A Pending JP2014510122A (ja) 2011-04-04 2012-04-02 ｍＴＯＲ阻害剤としてのジヒドロピロロピリミジン誘導体

Country Status (4)

Country Link
US (1) US20140163023A1 (enExample)
EP (1) EP2694511A1 (enExample)
JP (1) JP2014510122A (enExample)
WO (1) WO2012136622A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2542536B1 (en) 2010-03-04 2015-01-21 Cellzome Limited Morpholino substituted urea derivatives as mtor inhibitors
EP2758379B1 (en) 2011-09-21 2016-10-19 Cellzome Limited Urea and carbamate derivatives of 2-morpholino-1,3,5-triazine as mTOR inhibitors for the treatment of immunological or proliferative diseases
AU2012320465B2 (en) 2011-10-07 2016-03-03 Cellzome Limited Morpholino substituted bicyclic pyrimidine urea or carbamate derivatives as mTOR inhibitors
CA2926596C (en) * 2013-10-16 2020-07-14 Shanghai Yingli Pharmaceutical Co., Ltd Fused heterocyclic compound, preparation method therefor, pharmaceutical composition, and uses thereof
EP3478686B1 (en) * 2016-06-29 2020-04-15 H. Hoffnabb-La Roche Ag Novel dihydropyrrolopyrimidines for the treatment and prophylaxis of hepatitis b virus infection
CA3111980A1 (en) 2018-09-10 2020-03-19 Mirati Therapeutics, Inc. Combination therapies
CN111606926B (zh) * 2020-05-13 2021-10-15 大连理工大学 一种苯并咪唑[1,3]氮硫杂卓类化合物的制备方法

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DK1553097T3 (da) 1999-02-10 2010-12-13 Astrazeneca Ab Quinazolinderivat som angiogeneseinhibitor og mellemprodukter dertil
PL203782B1 (pl) 1999-11-05 2009-11-30 Astrazeneca Ab Pochodne chinazoliny,sposoby ich wytwarzania,ich kompozycje farmaceutyczne oraz ich zastosowania
DE122008000002I1 (de) 2000-02-15 2008-04-17 Sugen Inc Pyrrol substituierte indolin-2-on protein kinase inhibitoren
US7135298B2 (en) 2003-03-26 2006-11-14 The Burnham Institute For Medical Research Screening assay for agents that alter target of Rapamycin activity
DK1887359T3 (da) 2006-08-03 2009-03-02 Cellzome Ag Fremgangsmåde til identifikation af PI3K-interagerende molekyler og til rensning af PI3K
WO2008023159A1 (en) 2006-08-24 2008-02-28 Astrazeneca Ab Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders
US20080233127A1 (en) 2007-03-21 2008-09-25 Wyeth Imidazolopyrimidine analogs and their use as pi3 kinase and mtor inhibitors
US20080234262A1 (en) 2007-03-21 2008-09-25 Wyeth Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors
EP2178563A2 (en) 2007-07-06 2010-04-28 OSI Pharmaceuticals, Inc. Combination anti-cancer therapy comprising an inhibitor of both mtorc1 and mtorc2
CN101801962A (zh) 2007-07-09 2010-08-11 阿斯利康(瑞典)有限公司 用于治疗增殖疾病的三取代嘧啶衍生物
US20100227858A1 (en) 2007-07-09 2010-09-09 Astrazeneca Ab Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases
EA018708B1 (ru) 2007-07-09 2013-10-30 Астразенека Аб ПРОИЗВОДНЫЕ МОРФОЛИНОПИРИМИДИНА, ИСПОЛЬЗУЕМЫЕ ПРИ ЗАБОЛЕВАНИЯХ, СВЯЗАННЫХ С mTOR КИНАЗОЙ И/ИЛИ PI3K
CN101796048A (zh) 2007-07-09 2010-08-04 阿斯利康(瑞典)有限公司 用于治疗增殖病症的三取代的嘧啶衍生物
WO2009045174A1 (en) * 2007-10-05 2009-04-09 S*Bio Pte Ltd 2-morpholinylpurines as inhibitors of pi3k
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ES2439793T3 (es) 2009-04-17 2014-01-24 Wyeth Llc Compuestos de pirimidina, su uso como inhibidores de la mTOR quinasa y de la PI3 quinasa, y su síntesis
CA2768851A1 (en) 2009-07-23 2011-01-27 The Trustees Of Princeton University Inhibitors of mtor kinase as anti-viral agents
EP2542536B1 (en) 2010-03-04 2015-01-21 Cellzome Limited Morpholino substituted urea derivatives as mtor inhibitors

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