JP2014510122A5 - - Google Patents

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Publication number
JP2014510122A5
JP2014510122A5 JP2014503105A JP2014503105A JP2014510122A5 JP 2014510122 A5 JP2014510122 A5 JP 2014510122A5 JP 2014503105 A JP2014503105 A JP 2014503105A JP 2014503105 A JP2014503105 A JP 2014503105A JP 2014510122 A5 JP2014510122 A5 JP 2014510122A5
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JP
Japan
Prior art keywords
phenyl
pyrrolo
dihydro
methylmorpholino
urea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014503105A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014510122A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2012/055953 external-priority patent/WO2012136622A1/en
Publication of JP2014510122A publication Critical patent/JP2014510122A/ja
Publication of JP2014510122A5 publication Critical patent/JP2014510122A5/ja
Pending legal-status Critical Current

Links

JP2014503105A 2011-04-04 2012-04-02 ｍＴＯＲ阻害剤としてのジヒドロピロロピリミジン誘導体 Pending JP2014510122A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11160983.0 2011-04-04
EP11160983 2011-04-04
PCT/EP2012/055953 WO2012136622A1 (en) 2011-04-04 2012-04-02 Dihydropyrrolo pyrimidine derivatives as mtor inhibitors

Publications (2)

Publication Number Publication Date
JP2014510122A JP2014510122A (ja) 2014-04-24
JP2014510122A5 true JP2014510122A5 (enExample) 2015-05-21

Family

ID=44246546

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014503105A Pending JP2014510122A (ja) 2011-04-04 2012-04-02 ｍＴＯＲ阻害剤としてのジヒドロピロロピリミジン誘導体

Country Status (4)

Country Link
US (1) US20140163023A1 (enExample)
EP (1) EP2694511A1 (enExample)
JP (1) JP2014510122A (enExample)
WO (1) WO2012136622A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9249129B2 (en) 2010-03-04 2016-02-02 Cellzome Limited Morpholino substituted urea derivatives as mTOR inhibitors
KR20140070616A (ko) 2011-09-21 2014-06-10 셀좀 리미티드 Mtor 저해제로서의 모르폴리노 치환된 우레아 또는 카바메이트 유도체
US9242993B2 (en) 2011-10-07 2016-01-26 Cellzome Limited Morpholino substituted bicyclic pyrimidine urea or carbamate derivatives as mTOR inhibitors
JP6139789B2 (ja) 2013-10-16 2017-05-31 シャンハイ インリ ファーマシューティカル カンパニー リミティド 縮合複素環化合物、その調製方法、医薬組成物及びその使用
CN109415367B (zh) * 2016-06-29 2021-04-16 豪夫迈·罗氏有限公司 用于治疗和预防乙型肝炎病毒感染的新的二氢吡咯并嘧啶类化合物
CA3111980A1 (en) 2018-09-10 2020-03-19 Mirati Therapeutics, Inc. Combination therapies
CN111606926B (zh) * 2020-05-13 2021-10-15 大连理工大学 一种苯并咪唑[1,3]氮硫杂卓类化合物的制备方法

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AU6111298A (en) 1997-02-12 1998-09-08 Samir M. Hanash Protein markers for lung cancer and use thereof
GB9714249D0 (en) 1997-07-08 1997-09-10 Angiogene Pharm Ltd Vascular damaging agents
PL199802B1 (pl) 1999-02-10 2008-10-31 Astrazeneca Ab Pochodne chinazoliny, sposoby ich wytwarzania, ich kompozycje farmaceutyczne i ich zastosowania
EP1676845B1 (en) 1999-11-05 2008-06-11 AstraZeneca AB New quinazoline derivatives
BRPI0117360B8 (pt) 2000-02-15 2021-07-06 Upjohn Co inibidores de proteína de quinase de 2-indolinona de pirrol substituído, seus sais e composições farmacêuticas compreendendo os mesmos
US7135298B2 (en) 2003-03-26 2006-11-14 The Burnham Institute For Medical Research Screening assay for agents that alter target of Rapamycin activity
DK1887359T3 (da) 2006-08-03 2009-03-02 Cellzome Ag Fremgangsmåde til identifikation af PI3K-interagerende molekyler og til rensning af PI3K
AU2007287428B2 (en) 2006-08-24 2011-08-11 Astrazeneca Ab Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders
US20080234262A1 (en) 2007-03-21 2008-09-25 Wyeth Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors
US20080233127A1 (en) 2007-03-21 2008-09-25 Wyeth Imidazolopyrimidine analogs and their use as pi3 kinase and mtor inhibitors
US20090274698A1 (en) 2007-07-06 2009-11-05 Shripad Bhagwat Combination anti-cancer therapy
EP2178866A2 (en) 2007-07-09 2010-04-28 AstraZeneca AB Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases
CA2692720A1 (en) 2007-07-09 2009-01-15 Astrazeneca Ab Morpholino pyrimidine derivatives used in diseases linked to mtor kinase and/or pi3k
EA201000092A1 (ru) 2007-07-09 2010-06-30 Астразенека Аб Тризамещенные пиримидиновые производные для лечения пролиферативных заболеваний
AU2008273892A1 (en) 2007-07-09 2009-01-15 Astrazeneca Ab Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases
US20110009403A1 (en) * 2007-10-05 2011-01-13 S*Bio Pte Ltd. 2-morpholinylpurines as inhibitors of pi3k
CN101224207A (zh) 2007-10-12 2008-07-23 中国科学院上海有机化学研究所 具有诱导自吞噬治疗错误折叠蛋白聚集所致疾病的药物及其筛选方法
EP2410062A1 (en) 2008-02-04 2012-01-25 Cellzome Ag Selectivity profiling of PI3K interacting molecules against multiple targets
US8513221B2 (en) 2008-07-07 2013-08-20 Xcovery Holding, LLC PI3K isoform selective inhibitors
CA2729045A1 (en) * 2008-07-31 2010-02-04 Philippe Bergeron Pyrimidine compounds, compositions and methods of use
US8829011B2 (en) * 2008-10-29 2014-09-09 Janssen Pharmaceutica Nv 2-aminopyrimidine compounds as serotonin receptor modulators
US8586582B2 (en) 2008-11-11 2013-11-19 Xcovery Holding Company, Llc PI3K/mTOR kinase inhibitors
EP2406258B1 (en) * 2009-03-13 2014-12-03 Cellzome Limited PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
US8835429B2 (en) * 2009-04-17 2014-09-16 Wyeth Llc Pyrimidine compounds, their use as mTOR kinase and Pl3 kinase inhibitors, and their syntheses
WO2010120996A1 (en) 2009-04-17 2010-10-21 Wyeth Llc 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses
WO2010120987A1 (en) 2009-04-17 2010-10-21 Wyeth Llc Ring fused, ureidoaryl- and carbamoylaryl-bridged morpholino-pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses
WO2010120994A2 (en) * 2009-04-17 2010-10-21 Wyeth Llc Ureidoaryl-and carbamoylaryl-morpholino- pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their synthesis
WO2010120991A1 (en) 2009-04-17 2010-10-21 Wyeth Llc 5, 6, 7, 8-tetrahydropyrido[4,3-d]pyrimidine compounds, their use as mtor, pi3, and hsmg-1 kinase inhibitors, and their syntheses
JP2013500265A (ja) 2009-07-23 2013-01-07 ザ トラスティーズ オブ プリンストン ユニバーシティ 抗ウイルス剤として用いられるｍＴＯＲキナーゼ阻害剤
US9249129B2 (en) 2010-03-04 2016-02-02 Cellzome Limited Morpholino substituted urea derivatives as mTOR inhibitors

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