JP2014510122A5 - - Google Patents

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Publication number
JP2014510122A5
JP2014510122A5 JP2014503105A JP2014503105A JP2014510122A5 JP 2014510122 A5 JP2014510122 A5 JP 2014510122A5 JP 2014503105 A JP2014503105 A JP 2014503105A JP 2014503105 A JP2014503105 A JP 2014503105A JP 2014510122 A5 JP2014510122 A5 JP 2014510122A5
Authority
JP
Japan
Prior art keywords
phenyl
pyrrolo
dihydro
methylmorpholino
urea
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2014503105A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014510122A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2012/055953 external-priority patent/WO2012136622A1/en
Publication of JP2014510122A publication Critical patent/JP2014510122A/ja
Publication of JP2014510122A5 publication Critical patent/JP2014510122A5/ja
Pending legal-status Critical Current

Links

JP2014503105A 2011-04-04 2012-04-02 ｍＴＯＲ阻害剤としてのジヒドロピロロピリミジン誘導体 Pending JP2014510122A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11160983 2011-04-04
EP11160983.0 2011-04-04
PCT/EP2012/055953 WO2012136622A1 (en) 2011-04-04 2012-04-02 Dihydropyrrolo pyrimidine derivatives as mtor inhibitors

Publications (2)

Publication Number Publication Date
JP2014510122A JP2014510122A (ja) 2014-04-24
JP2014510122A5 true JP2014510122A5 (enExample) 2015-05-21

Family

ID=44246546

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2014503105A Pending JP2014510122A (ja) 2011-04-04 2012-04-02 ｍＴＯＲ阻害剤としてのジヒドロピロロピリミジン誘導体

Country Status (4)

Country Link
US (1) US20140163023A1 (enExample)
EP (1) EP2694511A1 (enExample)
JP (1) JP2014510122A (enExample)
WO (1) WO2012136622A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011107585A1 (en) 2010-03-04 2011-09-09 Cellzome Limited Morpholino substituted urea derivatives as mtor inhibitors
WO2013041652A1 (en) 2011-09-21 2013-03-28 Cellzome Limited Morpholino substituted urea or carbamate derivatives as mtor inhibitors
RU2609208C2 (ru) 2011-10-07 2017-01-31 Селлзоум Лимитед МОРФОЛИНО-ЗАМЕЩЕННЫЕ ПРОИЗВОДНЫЕ БИЦИКЛИЧЕСКИХ ПИРИМИДИНМОЧЕВИНЫ ИЛИ КАРБАМАТА В КАЧЕСТВЕ ИНГИБИТОРОВ mTOR
RU2663999C2 (ru) * 2013-10-16 2018-08-14 Шанхай Инли Фармасьютикал Ко., Лтд Конденсированное гетероциклическое соединение, способ его получения, его фармацевтическая композиция и применения
EP3478686B1 (en) * 2016-06-29 2020-04-15 H. Hoffnabb-La Roche Ag Novel dihydropyrrolopyrimidines for the treatment and prophylaxis of hepatitis b virus infection
CA3111980A1 (en) 2018-09-10 2020-03-19 Mirati Therapeutics, Inc. Combination therapies
CN111606926B (zh) * 2020-05-13 2021-10-15 大连理工大学 一种苯并咪唑[1,3]氮硫杂卓类化合物的制备方法

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EE05708B1 (et) 1999-02-10 2014-04-15 Astrazeneca Ab Kinasoliini derivaat angiogeneesi inhibiitorina ja selle kasutamine
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CN1329390C (zh) 2000-02-15 2007-08-01 苏根公司 吡咯取代的2－二氢吲哚酮蛋白激酶抑制剂
US7135298B2 (en) 2003-03-26 2006-11-14 The Burnham Institute For Medical Research Screening assay for agents that alter target of Rapamycin activity
ATE414281T1 (de) 2006-08-03 2008-11-15 Cellzome Ag Verfahren zur identifizierung von molekülen die mit pi3k interagieren und verfahren zur reinigung von pi3k
EP2057140B1 (en) 2006-08-24 2012-08-08 AstraZeneca AB Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders
US20080234262A1 (en) 2007-03-21 2008-09-25 Wyeth Pyrazolopyrimidine analogs and their use as mtor kinase and pi3 kinase inhibitors
US20080233127A1 (en) 2007-03-21 2008-09-25 Wyeth Imidazolopyrimidine analogs and their use as pi3 kinase and mtor inhibitors
EP2178563A2 (en) 2007-07-06 2010-04-28 OSI Pharmaceuticals, Inc. Combination anti-cancer therapy comprising an inhibitor of both mtorc1 and mtorc2
EA018708B1 (ru) 2007-07-09 2013-10-30 Астразенека Аб ПРОИЗВОДНЫЕ МОРФОЛИНОПИРИМИДИНА, ИСПОЛЬЗУЕМЫЕ ПРИ ЗАБОЛЕВАНИЯХ, СВЯЗАННЫХ С mTOR КИНАЗОЙ И/ИЛИ PI3K
US20100261723A1 (en) 2007-07-09 2010-10-14 Astrazeneca Ab Trisubstituted pyrimidine derivatives for the treatment of proliferative diseases
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EP2209785A1 (en) * 2007-10-05 2010-07-28 S*BIO Pte Ltd 2-morpholinylpurines as inhibitors of pi3k
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DK2245181T3 (da) 2008-02-04 2012-02-06 Cellzome Ag Selektivitetsprofilering af PI3K-interagerende molekyler med multiple mål
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WO2010120991A1 (en) 2009-04-17 2010-10-21 Wyeth Llc 5, 6, 7, 8-tetrahydropyrido[4,3-d]pyrimidine compounds, their use as mtor, pi3, and hsmg-1 kinase inhibitors, and their syntheses
WO2010120996A1 (en) 2009-04-17 2010-10-21 Wyeth Llc 5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine compounds, their use as mtor kinase and pi3 kinase inhibitors, and their syntheses
ES2439793T3 (es) 2009-04-17 2014-01-24 Wyeth Llc Compuestos de pirimidina, su uso como inhibidores de la mTOR quinasa y de la PI3 quinasa, y su síntesis
EP2456869A4 (en) 2009-07-23 2013-11-27 Trustees Of The University Of Princeton MTOR KINASE HEMMER AS ANTIVIRUS AGENT
WO2011107585A1 (en) 2010-03-04 2011-09-09 Cellzome Limited Morpholino substituted urea derivatives as mtor inhibitors

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