JP2014509862A5 - - Google Patents
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- Publication number
- JP2014509862A5 JP2014509862A5 JP2013558467A JP2013558467A JP2014509862A5 JP 2014509862 A5 JP2014509862 A5 JP 2014509862A5 JP 2013558467 A JP2013558467 A JP 2013558467A JP 2013558467 A JP2013558467 A JP 2013558467A JP 2014509862 A5 JP2014509862 A5 JP 2014509862A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- seq
- mitochondrial
- sequence
- acid molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000007523 nucleic acids Chemical group 0.000 claims 59
- 125000003729 nucleotide group Chemical group 0.000 claims 52
- 239000002773 nucleotide Substances 0.000 claims 51
- 108020004707 nucleic acids Proteins 0.000 claims 47
- 102000039446 nucleic acids Human genes 0.000 claims 47
- 239000000523 sample Substances 0.000 claims 27
- 230000000295 complement effect Effects 0.000 claims 25
- 230000002438 mitochondrial effect Effects 0.000 claims 25
- 238000000034 method Methods 0.000 claims 19
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 18
- 108091092584 GDNA Proteins 0.000 claims 16
- 238000001514 detection method Methods 0.000 claims 16
- 108020004414 DNA Proteins 0.000 claims 15
- 210000003527 eukaryotic cell Anatomy 0.000 claims 14
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 13
- 238000000338 in vitro Methods 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 10
- 108020005196 Mitochondrial DNA Proteins 0.000 claims 9
- 208000021642 Muscular disease Diseases 0.000 claims 6
- 201000009623 Myopathy Diseases 0.000 claims 6
- 102000053602 DNA Human genes 0.000 claims 5
- 239000012634 fragment Substances 0.000 claims 5
- ZHNUHDYFZUAESO-UHFFFAOYSA-N Formamide Chemical compound NC=O ZHNUHDYFZUAESO-UHFFFAOYSA-N 0.000 claims 4
- 230000010076 replication Effects 0.000 claims 4
- 238000013518 transcription Methods 0.000 claims 4
- 230000035897 transcription Effects 0.000 claims 4
- 208000035473 Communicable disease Diseases 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 229930040373 Paraformaldehyde Natural products 0.000 claims 3
- 238000000137 annealing Methods 0.000 claims 3
- 230000001684 chronic effect Effects 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 3
- 210000003470 mitochondria Anatomy 0.000 claims 3
- 108091064355 mitochondrial RNA Proteins 0.000 claims 3
- 208000012268 mitochondrial disease Diseases 0.000 claims 3
- 238000012544 monitoring process Methods 0.000 claims 3
- 230000001613 neoplastic effect Effects 0.000 claims 3
- 150000002894 organic compounds Chemical class 0.000 claims 3
- 229920002866 paraformaldehyde Polymers 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 238000012360 testing method Methods 0.000 claims 3
- 230000001988 toxicity Effects 0.000 claims 3
- 231100000419 toxicity Toxicity 0.000 claims 3
- 238000009396 hybridization Methods 0.000 claims 2
- 210000001822 immobilized cell Anatomy 0.000 claims 2
- 238000011065 in-situ storage Methods 0.000 claims 2
- 241000972773 Aulopiformes Species 0.000 claims 1
- 230000004543 DNA replication Effects 0.000 claims 1
- 235000010469 Glycine max Nutrition 0.000 claims 1
- 244000068988 Glycine max Species 0.000 claims 1
- 108020004682 Single-Stranded DNA Proteins 0.000 claims 1
- 229920004890 Triton X-100 Polymers 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000013043 chemical agent Substances 0.000 claims 1
- 238000010438 heat treatment Methods 0.000 claims 1
- 230000003100 immobilizing effect Effects 0.000 claims 1
- 238000010166 immunofluorescence Methods 0.000 claims 1
- 238000007901 in situ hybridization Methods 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 238000002372 labelling Methods 0.000 claims 1
- 230000025608 mitochondrion localization Effects 0.000 claims 1
- 235000019515 salmon Nutrition 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11290139.2A EP2500436B1 (en) | 2011-03-17 | 2011-03-17 | Method, probe and kit for DNA in situ hybridation and use thereof |
| EP11290139.2 | 2011-03-17 | ||
| PCT/EP2012/054739 WO2012123588A1 (en) | 2011-03-17 | 2012-03-16 | Method, probe and kit for dna in situ hybridation and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014509862A JP2014509862A (ja) | 2014-04-24 |
| JP2014509862A5 true JP2014509862A5 (https=) | 2015-05-07 |
| JP6262533B2 JP6262533B2 (ja) | 2018-01-17 |
Family
ID=45833435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013558467A Expired - Fee Related JP6262533B2 (ja) | 2011-03-17 | 2012-03-16 | Ｄｎａインサイチュハイブリダイゼーションのための方法、プローブ及びキット、並びにそれらの使用 |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9957555B2 (https=) |
| EP (2) | EP2500436B1 (https=) |
| JP (1) | JP6262533B2 (https=) |
| DK (1) | DK2500436T3 (https=) |
| WO (1) | WO2012123588A1 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3604555B1 (en) | 2011-10-14 | 2024-12-25 | President and Fellows of Harvard College | Sequencing by structure assembly |
| ES2991004T3 (es) | 2011-12-22 | 2024-12-02 | Harvard College | Métodos para la detección de analitos |
| EP4249605B1 (en) | 2011-12-22 | 2024-08-28 | President And Fellows Of Harvard College | Methods for analyte detection |
| US9914967B2 (en) | 2012-06-05 | 2018-03-13 | President And Fellows Of Harvard College | Spatial sequencing of nucleic acids using DNA origami probes |
| EP2971184B1 (en) | 2013-03-12 | 2019-04-17 | President and Fellows of Harvard College | Method of generating a three-dimensional nucleic acid containing matrix |
| SG10201913068PA (en) | 2013-06-04 | 2020-02-27 | Harvard College | Rna-guided transcriptional regulation |
| WO2016007839A1 (en) | 2014-07-11 | 2016-01-14 | President And Fellows Of Harvard College | Methods for high-throughput labelling and detection of biological features in situ using microscopy |
| AU2016349288A1 (en) | 2015-11-03 | 2018-05-31 | President And Fellows Of Harvard College | Method and apparatus for volumetric imaging of a three-dimensional nucleic acid containing matrix |
| AU2016365720B2 (en) | 2015-12-07 | 2020-11-26 | Arc Bio, Llc | Methods and compositions for the making and using of guide nucleic acids |
| EP4613756A3 (en) | 2016-04-25 | 2025-11-12 | President And Fellows Of Harvard College | Hybridization chain reaction methods for in situ molecular detection |
| CN118853848A (zh) | 2016-08-31 | 2024-10-29 | 哈佛学院董事及会员团体 | 将生物分子的检测组合到使用荧光原位测序的单个试验的方法 |
| CN118389650A (zh) | 2016-08-31 | 2024-07-26 | 哈佛学院董事及会员团体 | 生成用于通过荧光原位测序检测的核酸序列文库的方法 |
| US11185568B2 (en) | 2017-04-14 | 2021-11-30 | President And Fellows Of Harvard College | Methods for generation of cell-derived microfilament network |
| ES2994431T3 (en) | 2017-09-22 | 2025-01-23 | Univ Washington | In situ combinatorial labeling of cellular molecules |
| CN112770776B (zh) | 2018-07-30 | 2025-08-19 | 瑞德库尔有限责任公司 | 用于样品处理或分析的方法和系统 |
| WO2020076976A1 (en) | 2018-10-10 | 2020-04-16 | Readcoor, Inc. | Three-dimensional spatial molecular indexing |
| EP4097251A1 (en) | 2020-01-29 | 2022-12-07 | 10X Genomics, Inc. | Compositions and methods for analyte detection |
| US20220049303A1 (en) | 2020-08-17 | 2022-02-17 | Readcoor, Llc | Methods and systems for spatial mapping of genetic variants |
| CN114891861B (zh) * | 2022-05-05 | 2024-07-26 | 江苏省食品药品监督检验研究院 | 一种检测抗体中cho细胞残留dna的raa试剂盒及其检测方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5541308A (en) * | 1986-11-24 | 1996-07-30 | Gen-Probe Incorporated | Nucleic acid probes for detection and/or quantitation of non-viral organisms |
| WO2000061819A2 (en) * | 1999-04-14 | 2000-10-19 | California Institute Of Technology | Methods of detection and modulation of age-related mutations |
| US20070190534A1 (en) | 2001-06-11 | 2007-08-16 | Genesis Genomics Inc. | Mitochondrial sites and genes associated with prostate cancer |
| USH2220H1 (en) * | 2001-08-10 | 2008-07-01 | Snp Consortium | Identification and mapping of single nucleotide polymorphisms in the human genome |
| WO2005003766A2 (en) * | 2003-06-13 | 2005-01-13 | Whitehead Institute For Biomedical Research | Methods of regulating metabolism and mitochondrial function |
| JP2005107404A (ja) | 2003-10-01 | 2005-04-21 | Matsushita Electric Ind Co Ltd | 広角撮像光学系、並びにそれを備えた広角撮像装置、監視用撮像装置、車載用撮像装置及び投写装置 |
-
2011
- 2011-03-17 DK DK11290139.2T patent/DK2500436T3/en active
- 2011-03-17 EP EP11290139.2A patent/EP2500436B1/en not_active Not-in-force
-
2012
- 2012-03-16 US US14/005,364 patent/US9957555B2/en active Active
- 2012-03-16 JP JP2013558467A patent/JP6262533B2/ja not_active Expired - Fee Related
- 2012-03-16 EP EP12708876.3A patent/EP2686440B1/en not_active Not-in-force
- 2012-03-16 WO PCT/EP2012/054739 patent/WO2012123588A1/en not_active Ceased
-
2018
- 2018-04-27 US US15/965,681 patent/US11566280B2/en active Active
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