JP2014508511A5 - - Google Patents
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- JP2014508511A5 JP2014508511A5 JP2013545325A JP2013545325A JP2014508511A5 JP 2014508511 A5 JP2014508511 A5 JP 2014508511A5 JP 2013545325 A JP2013545325 A JP 2013545325A JP 2013545325 A JP2013545325 A JP 2013545325A JP 2014508511 A5 JP2014508511 A5 JP 2014508511A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- amino acid
- antibody molecule
- seq
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 125000003275 alpha amino acid group Chemical group 0.000 claims 20
- 102000003810 Interleukin-18 Human genes 0.000 claims 9
- 108090000171 Interleukin-18 Proteins 0.000 claims 9
- 238000006467 substitution reaction Methods 0.000 claims 7
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 238000000034 method Methods 0.000 claims 5
- 101000960954 Homo sapiens Interleukin-18 Proteins 0.000 claims 3
- 102000043959 human IL18 Human genes 0.000 claims 3
- 102000044166 interleukin-18 binding protein Human genes 0.000 claims 3
- 108010070145 interleukin-18 binding protein Proteins 0.000 claims 3
- 150000007523 nucleic acids Chemical group 0.000 claims 3
- 102000004557 Interleukin-18 Receptors Human genes 0.000 claims 2
- 108010017537 Interleukin-18 Receptors Proteins 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 101100067721 Caenorhabditis elegans gly-3 gene Proteins 0.000 claims 1
- 101100315624 Caenorhabditis elegans tyr-1 gene Proteins 0.000 claims 1
- 102100038796 E3 ubiquitin-protein ligase TRIM13 Human genes 0.000 claims 1
- 101000664589 Homo sapiens E3 ubiquitin-protein ligase TRIM13 Proteins 0.000 claims 1
- 241001465754 Metazoa Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000037430 deletion Effects 0.000 claims 1
- 238000012217 deletion Methods 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000004602 germ cell Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000037431 insertion Effects 0.000 claims 1
- 238000003780 insertion Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201061424920P | 2010-12-20 | 2010-12-20 | |
| US61/424,920 | 2010-12-20 | ||
| PCT/EP2011/073496 WO2012085015A1 (en) | 2010-12-20 | 2011-12-20 | Anti-il-18 antibodies and their uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014508511A JP2014508511A (ja) | 2014-04-10 |
| JP2014508511A5 true JP2014508511A5 (cg-RX-API-DMAC10.html) | 2015-02-12 |
Family
ID=45372272
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013545325A Pending JP2014508511A (ja) | 2010-12-20 | 2011-12-20 | 抗ｉｌ−１８抗体およびそれらの使用 |
Country Status (11)
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20200308A1 (ar) * | 2012-09-07 | 2017-06-16 | Novartis Ag | جزيئات إرتباط il-18 |
| WO2014080866A1 (ja) * | 2012-11-21 | 2014-05-30 | 一般財団法人化学及血清療法研究所 | 新規なヒト抗ｉｌ－１８抗体 |
| KR102321172B1 (ko) * | 2013-09-05 | 2021-11-05 | 에이비2 바이오 에스에이 | 염증성 질환에서 il-18 결합 단백질(ｉｌ-18ｂｐ) |
| WO2015160795A1 (en) * | 2014-04-14 | 2015-10-22 | The Regents Of The University Of California | Compositions and methods for treating inflammation |
| CA2972689A1 (en) * | 2015-03-05 | 2016-09-09 | Ab2 Bio Sa | Il-18 binding protein (il-18bp) and antibodies in inflammatory diseases |
| EP3592384B1 (en) | 2017-03-09 | 2025-07-02 | MAB Discovery GmbH | Antibodies specifically binding to human il-1r7 |
| WO2019213686A1 (en) * | 2018-05-10 | 2019-11-14 | The Council Of The Queensland Institute Of Medical Research | Therapeutic compositions and uses therefor |
| JP6892180B2 (ja) | 2018-12-03 | 2021-06-23 | 株式会社ｍＡｂＰｒｏｔｅｉｎ | 活性型インターロイキン−１８タンパク質のネオエピトープを認識する抗体、及びその応用 |
| CN109870570A (zh) * | 2018-12-29 | 2019-06-11 | 广东云天抗体生物科技有限公司 | 一种检测猴il-18的酶联免疫试剂盒 |
| GB202007404D0 (en) * | 2020-05-19 | 2020-07-01 | Nasser Syed Muhammad Tahir | Treatment for viral respiratory infections |
| WO2021247454A1 (en) * | 2020-06-01 | 2021-12-09 | Avalo Therapeutics, Inc. | Methods and treatment involving antibodies to il-18 |
| CN112415191A (zh) * | 2020-11-06 | 2021-02-26 | 郑州人福博赛生物技术有限责任公司 | 一种白细胞三烯检测试剂盒 |
| WO2023286694A1 (ja) | 2021-07-13 | 2023-01-19 | 国立大学法人東海国立大学機構 | 炎症性腸疾患を治療するための医薬組成物 |
| WO2023067348A1 (en) | 2021-10-21 | 2023-04-27 | Biosirius Ltd | Treatment for virally-induced pneumonia |
| AU2021479973A1 (en) * | 2021-12-20 | 2024-07-04 | Avalo Therapeutics, Inc. | Methods and treatment for adult-onset still's disease and systemic-onset juvenile idiopathic arthritis involving antibodies to il-18 |
| IL314346A (en) | 2022-03-15 | 2024-09-01 | Compugen Ltd | Antibodies antagonistic to IL-18BP and their use in monotherapy and combination therapy in cancer treatment |
| CN116236560A (zh) * | 2022-12-13 | 2023-06-09 | 华中科技大学同济医学院附属同济医院 | 人白细胞介素-37b在制备治疗鼻息肉的药品中的应用 |
| WO2024261470A1 (en) | 2023-06-20 | 2024-12-26 | Apollo Ap43 Limited | Anti-il-18 antibody therapy for treating atopic dermatitis |
| TW202515608A (zh) | 2023-06-26 | 2025-04-16 | 以色列商坎布根有限公司 | Ｉｌ—１８ｂｐ拮抗抗體及其於癌症治療之單一療法及組合療法的用途 |
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| US565332A (en) | 1896-08-04 | Toy for making soap-bubbles | ||
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| US4424200A (en) | 1979-05-14 | 1984-01-03 | Nuc Med Inc. | Method for radiolabeling proteins with technetium-99m |
| US4479930A (en) | 1982-07-26 | 1984-10-30 | Trustees Of The University Of Massachusetts | Amines coupled wth dicyclic dianhydrides capable of being radiolabeled product |
| GB8308235D0 (en) | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5185243A (en) | 1988-08-25 | 1993-02-09 | Syntex (U.S.A.) Inc. | Method for detection of specific nucleic acid sequences |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
| GB9206318D0 (en) | 1992-03-24 | 1992-05-06 | Cambridge Antibody Tech | Binding substances |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| US6172197B1 (en) | 1991-07-10 | 2001-01-09 | Medical Research Council | Methods for producing members of specific binding pairs |
| US5962255A (en) | 1992-03-24 | 1999-10-05 | Cambridge Antibody Technology Limited | Methods for producing recombinant vectors |
| US6492160B1 (en) | 1991-05-15 | 2002-12-10 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| DE69230142T2 (de) | 1991-05-15 | 2000-03-09 | Cambridge Antibody Technology Ltd. | Verfahren zur herstellung von spezifischen bindungspaargliedern |
| US6225447B1 (en) | 1991-05-15 | 2001-05-01 | Cambridge Antibody Technology Ltd. | Methods for producing members of specific binding pairs |
| US5858657A (en) | 1992-05-15 | 1999-01-12 | Medical Research Council | Methods for producing members of specific binding pairs |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5872215A (en) | 1991-12-02 | 1999-02-16 | Medical Research Council | Specific binding members, materials and methods |
| US5885793A (en) | 1991-12-02 | 1999-03-23 | Medical Research Council | Production of anti-self antibodies from antibody segment repertoires and displayed on phage |
| GB9203459D0 (en) | 1992-02-19 | 1992-04-08 | Scotgen Ltd | Antibodies with germ-line variable regions |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| US5639641A (en) | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
| AU690528B2 (en) | 1992-12-04 | 1998-04-30 | Medical Research Council | Multivalent and multispecific binding proteins, their manufacture and use |
| GB9624482D0 (en) | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
| JP4471404B2 (ja) | 1996-02-13 | 2010-06-02 | アストラゼネカ ユーケイ リミテッド | Ｖｅｇｆインヒビターとしてのキナゾリン誘導体 |
| KR100489174B1 (ko) | 1996-03-05 | 2005-09-30 | 제네카-파마 소시에떼아노님 | 4-아닐리노퀴나졸린유도체 |
| US5814468A (en) | 1996-03-27 | 1998-09-29 | Coulter International Corp. | Methods of enumerating receptor molecules for specific binding partners on formed bodies and in solution |
| GB9718972D0 (en) | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
| GB9714249D0 (en) | 1997-07-08 | 1997-09-10 | Angiogene Pharm Ltd | Vascular damaging agents |
| CA2276216A1 (en) * | 1998-06-24 | 1999-12-24 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | An artificial peptide capable of neutralizing the biological activity of interleukin-18 |
| JP4562286B2 (ja) | 1998-12-10 | 2010-10-13 | ブリストル−マイヤーズ スクウィブ カンパニー | 抗体模倣物および他の結合タンパク質のタンパク質骨格 |
| GB9900334D0 (en) | 1999-01-07 | 1999-02-24 | Angiogene Pharm Ltd | Tricylic vascular damaging agents |
| GB9900752D0 (en) | 1999-01-15 | 1999-03-03 | Angiogene Pharm Ltd | Benzimidazole vascular damaging agents |
| AR022952A1 (es) | 1999-03-19 | 2002-09-04 | Smithkline Beecham Corp | ANTICUERPO MONOCLONAL DE ROEDOR ESPECIFICAMENTE NEUTRALIZANTE PARA LA INTERLEUQUINA-18 HUMANA , UN FRAGMENTO FAB NEUTRALIZANTE o FRAGMENTO F(AB')2, UNA REGION DE COMPLEMENTARIEDAD DE CADENA LIGERA DE INMONOGLOBULINA(CDR), UNA MOLECULA DE ACIDO NUCLEICO, COMPOSICION FARMACEUTICA QUE LO COMPRENDE, EL |
| CN102206277A (zh) * | 2000-02-10 | 2011-10-05 | 雅培制药有限公司 | 结合人白介素-18的抗体及制备和使用方法 |
| EP1268766B1 (en) | 2000-03-31 | 2005-11-30 | Cambridge Antibody Technology Limited | Improvements to ribosome display |
| BR0111230A (pt) | 2000-05-31 | 2003-06-10 | Astrazeneca Ab | Composto, e, uso e processo para a preparação do mesmo |
| SK52003A3 (en) | 2000-07-07 | 2003-07-01 | Angiogene Pharm Ltd | Colchinol derivatives as angiogenesis inhibitors, method for their preparation and pharmaceutical composition comprising the same |
| BR0112224A (pt) | 2000-07-07 | 2003-06-10 | Angiogene Pharm Ltd | Composto, composição farmacêutica, uso de um composto ou de um sal, solvato ou pró-droga farmaceuticamente aceitável do mesmo, e, processo para preparar um composto |
| US6881557B2 (en) | 2001-07-12 | 2005-04-19 | Arrowsmith Technologies Llp | Super humanized antibodies |
| KR100988129B1 (ko) | 2003-04-30 | 2010-10-18 | 쥬리디컬 파운데이션 더 케모-세로-쎄라퓨틱 리서치 인스티튜트 | 인간 항인간 인터루킨-18 항체와 그 단편, 및 이들의이용방법 |
| US20050100965A1 (en) | 2003-11-12 | 2005-05-12 | Tariq Ghayur | IL-18 binding proteins |
| US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| ATE548386T1 (de) | 2005-01-05 | 2012-03-15 | Star Biotechnologische Forschungs Und Entwicklungsges M B H F | Synthetische immunglobulindomänen mit in regionen des moleküls, die sich von den die komplementarität bestimmenden bereichen unterscheiden, modifizierten bindeeigenschaften |
| GB0500099D0 (en) | 2005-01-05 | 2005-02-09 | Cambridge Antibody Tech | Methods and means relating to protein variants |
| EP2604628A3 (en) * | 2007-12-21 | 2013-08-21 | Medimmune Limited | Binding members for interleukin-4 receptor alpha (IL-4R) - 173 |
| EP2247310A4 (en) * | 2008-01-30 | 2012-06-27 | Abbott Lab | COMPOSITIONS AND METHODS FOR CRYSTALLIZING ANTIBODY FRAGMENTS |
| US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
-
2011
- 2011-12-20 US US13/993,537 patent/US9255144B2/en active Active
- 2011-12-20 KR KR1020137018576A patent/KR20140003467A/ko not_active Withdrawn
- 2011-12-20 CN CN2011800612426A patent/CN103339147A/zh active Pending
- 2011-12-20 JP JP2013545325A patent/JP2014508511A/ja active Pending
- 2011-12-20 RU RU2013133846/10A patent/RU2013133846A/ru not_active Application Discontinuation
- 2011-12-20 MX MX2013007067A patent/MX2013007067A/es not_active Application Discontinuation
- 2011-12-20 BR BR112013015508-6A patent/BR112013015508B1/pt active IP Right Grant
- 2011-12-20 AU AU2011347354A patent/AU2011347354A1/en not_active Abandoned
- 2011-12-20 CA CA2822515A patent/CA2822515C/en active Active
- 2011-12-20 WO PCT/EP2011/073496 patent/WO2012085015A1/en not_active Ceased
- 2011-12-20 EP EP11799104.2A patent/EP2655416A1/en not_active Withdrawn
-
2017
- 2017-03-06 AU AU2017201512A patent/AU2017201512A1/en not_active Abandoned
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