JP2014508511A - 抗ｉｌ−１８抗体およびそれらの使用 - Google Patents
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Images
Classifications
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- C—CHEMISTRY; METALLURGY
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- C07K2299/00—Coordinates from 3D structures of peptides, e.g. proteins or enzymes
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- C—CHEMISTRY; METALLURGY
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- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
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- C—CHEMISTRY; METALLURGY
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- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C07K—PEPTIDES
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- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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- C07K2317/622—Single chain antibody (scFv)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
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| PCT/EP2011/073496 WO2012085015A1 (en) | 2010-12-20 | 2011-12-20 | Anti-il-18 antibodies and their uses |
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| JP2014508511A true JP2014508511A (ja) | 2014-04-10 |
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| EP (1) | EP2655416A1 (enExample) |
| JP (1) | JP2014508511A (enExample) |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20170121199A (ko) * | 2015-03-05 | 2017-11-01 | 에이비2 바이오 에스에이 | 염증성 질환에서 il-18 결합 단백질(ｉｌ-18ｂｐ) 및 항체 |
| US10858426B2 (en) | 2013-09-05 | 2020-12-08 | Ab2 Bio Sa | IL-18 binding protein (IL-18BP) in inflammatory diseases |
| JP2023526853A (ja) * | 2020-05-19 | 2023-06-23 | バイオシリウス・リミテッド | ウイルス性呼吸器感染症の処置 |
| JP2023528455A (ja) * | 2020-06-01 | 2023-07-04 | アバロ・セラピューティクス・インコーポレーテッド | Ｉｌ－１８に対する抗体を伴う方法および処置 |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20200308A1 (ar) * | 2012-09-07 | 2017-06-16 | Novartis Ag | جزيئات إرتباط il-18 |
| US10570199B2 (en) * | 2012-11-21 | 2020-02-25 | Km Biologics Co., Ltd. | Human antibody against IL-18 |
| WO2015160795A1 (en) * | 2014-04-14 | 2015-10-22 | The Regents Of The University Of California | Compositions and methods for treating inflammation |
| ES3042097T3 (en) | 2017-03-09 | 2025-11-18 | Mab Discovery Gmbh | Antibodies specifically binding to human il-1r7 |
| WO2019213686A1 (en) * | 2018-05-10 | 2019-11-14 | The Council Of The Queensland Institute Of Medical Research | Therapeutic compositions and uses therefor |
| EP3892300A4 (en) | 2018-12-03 | 2022-12-14 | Mabprotein Co.,Ltd. | ANTIBODIES RECOGNIZING A NEO-EPITOPE OF ACTIVATED INTERLEUKIN-18 PROTEINS AND ASSOCIATED APPLICATION |
| CN109870570A (zh) * | 2018-12-29 | 2019-06-11 | 广东云天抗体生物科技有限公司 | 一种检测猴il-18的酶联免疫试剂盒 |
| CN112415191A (zh) * | 2020-11-06 | 2021-02-26 | 郑州人福博赛生物技术有限责任公司 | 一种白细胞三烯检测试剂盒 |
| JPWO2023286694A1 (enExample) | 2021-07-13 | 2023-01-19 | ||
| WO2023067348A1 (en) | 2021-10-21 | 2023-04-27 | Biosirius Ltd | Treatment for virally-induced pneumonia |
| WO2023121643A1 (en) * | 2021-12-20 | 2023-06-29 | Avalo Therapeutics, Inc. | Methods and treatment for adult-onset still's disease and systemic-onset juvenile idiopathic arthritis involving antibodies to il-18 |
| JP2025509832A (ja) | 2022-03-15 | 2025-04-11 | コンピュジェン リミテッド | Ｉｌ－１８ｂｐアンタゴニスト抗体、並びに癌の治療での単剤療法及び併用療法におけるそれらの使用 |
| CN116236560A (zh) * | 2022-12-13 | 2023-06-09 | 华中科技大学同济医学院附属同济医院 | 人白细胞介素-37b在制备治疗鼻息肉的药品中的应用 |
| WO2024261470A1 (en) | 2023-06-20 | 2024-12-26 | Apollo Ap43 Limited | Anti-il-18 antibody therapy for treating atopic dermatitis |
| TW202515608A (zh) | 2023-06-26 | 2025-04-16 | 以色列商坎布根有限公司 | Ｉｌ—１８ｂｐ拮抗抗體及其於癌症治療之單一療法及組合療法的用途 |
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- 2011-12-20 KR KR1020137018576A patent/KR20140003467A/ko not_active Withdrawn
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- 2011-12-20 BR BR112013015508-6A patent/BR112013015508B1/pt active IP Right Grant
- 2011-12-20 EP EP11799104.2A patent/EP2655416A1/en not_active Withdrawn
- 2011-12-20 JP JP2013545325A patent/JP2014508511A/ja active Pending
- 2011-12-20 CN CN2011800612426A patent/CN103339147A/zh active Pending
- 2011-12-20 RU RU2013133846/10A patent/RU2013133846A/ru not_active Application Discontinuation
- 2011-12-20 MX MX2013007067A patent/MX2013007067A/es not_active Application Discontinuation
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2017
- 2017-03-06 AU AU2017201512A patent/AU2017201512A1/en not_active Abandoned
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| JP2004500086A (ja) * | 2000-02-10 | 2004-01-08 | アボット・ラボラトリーズ | ヒトインターロイキン１８に結合する抗体とその調整方法および使用方法 |
| WO2009081201A2 (en) * | 2007-12-21 | 2009-07-02 | Medimmune Limited | BINDING MEMBERS FOR INTERLEUKIN-4 RECEPTOR ALPHA (IL-4Rα) - 173 |
| WO2009099545A1 (en) * | 2008-01-30 | 2009-08-13 | Abbott Laboratories | Compositions and methods for crystallizing antibody fragments |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10858426B2 (en) | 2013-09-05 | 2020-12-08 | Ab2 Bio Sa | IL-18 binding protein (IL-18BP) in inflammatory diseases |
| KR20170121199A (ko) * | 2015-03-05 | 2017-11-01 | 에이비2 바이오 에스에이 | 염증성 질환에서 il-18 결합 단백질(ｉｌ-18ｂｐ) 및 항체 |
| JP2018513116A (ja) * | 2015-03-05 | 2018-05-24 | エイビー２ バイオ ソシエテアノニム | 炎症性疾患におけるｉｌ−１８結合タンパク質（ｉｌ−１８ｂｐ）および抗体 |
| US10882905B2 (en) | 2015-03-05 | 2021-01-05 | Ab2 Bio Sa | IL-18 binding protein (IL-18BP) and antibodies in inflammatory diseases |
| JP2021176860A (ja) * | 2015-03-05 | 2021-11-11 | エイビー２ バイオ ソシエテアノニム | 炎症性疾患におけるｉｌ−１８結合タンパク質（ｉｌ−１８ｂｐ）および抗体 |
| KR102511343B1 (ko) * | 2015-03-05 | 2023-03-17 | 에이비2 바이오 에스에이 | 염증성 질환에서 il-18 결합 단백질(ｉｌ-18ｂｐ) 및 항체 |
| JP7274259B2 (ja) | 2015-03-05 | 2023-05-16 | エイビー２ バイオ ソシエテアノニム | 炎症性疾患におけるｉｌ－１８結合タンパク質（ｉｌ－１８ｂｐ）および抗体 |
| US11820817B2 (en) | 2015-03-05 | 2023-11-21 | Ab2 Bio Sa | IL-18 binding protein (IL-18BP) and antibodies in inflammatory diseases |
| US11926663B2 (en) | 2015-03-05 | 2024-03-12 | Ab2 Bio Sa | IL-18 binding protein (IL-18BP) and antibodies in inflammatory diseases |
| JP2023526853A (ja) * | 2020-05-19 | 2023-06-23 | バイオシリウス・リミテッド | ウイルス性呼吸器感染症の処置 |
| JP2023528455A (ja) * | 2020-06-01 | 2023-07-04 | アバロ・セラピューティクス・インコーポレーテッド | Ｉｌ－１８に対する抗体を伴う方法および処置 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2655416A1 (en) | 2013-10-30 |
| AU2017201512A1 (en) | 2017-03-23 |
| CA2822515A1 (en) | 2012-06-28 |
| RU2013133846A (ru) | 2015-01-27 |
| BR112013015508A2 (pt) | 2016-10-11 |
| CA2822515C (en) | 2023-04-25 |
| BR112013015508B1 (pt) | 2022-04-05 |
| WO2012085015A1 (en) | 2012-06-28 |
| US9255144B2 (en) | 2016-02-09 |
| WO2012085015A9 (en) | 2013-06-27 |
| CN103339147A (zh) | 2013-10-02 |
| MX2013007067A (es) | 2013-11-01 |
| AU2011347354A1 (en) | 2013-08-01 |
| US20140004128A1 (en) | 2014-01-02 |
| KR20140003467A (ko) | 2014-01-09 |
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