JP2014508300A5 - - Google Patents
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- JP2014508300A5 JP2014508300A5 JP2013556907A JP2013556907A JP2014508300A5 JP 2014508300 A5 JP2014508300 A5 JP 2014508300A5 JP 2013556907 A JP2013556907 A JP 2013556907A JP 2013556907 A JP2013556907 A JP 2013556907A JP 2014508300 A5 JP2014508300 A5 JP 2014508300A5
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- nanopipette
- nanopore
- binding molecule
- binding
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- 229920000642 polymer Polymers 0.000 claims description 6
- 150000002500 ions Chemical class 0.000 claims 7
- 239000011248 coating agent Substances 0.000 claims 4
- 238000000576 coating method Methods 0.000 claims 4
- 229920000768 polyamine Polymers 0.000 claims 4
- 239000012491 analyte Substances 0.000 claims 3
- 239000005518 polymer electrolyte Substances 0.000 claims 3
- 125000005620 boronic acid group Chemical group 0.000 claims 2
- 238000001514 detection method Methods 0.000 claims 2
- 150000004676 glycans Polymers 0.000 claims 2
- 229920000867 polyelectrolyte Polymers 0.000 claims 2
- 229920001282 polysaccharide Polymers 0.000 claims 2
- 239000005017 polysaccharide Substances 0.000 claims 2
- 150000004804 polysaccharides Polymers 0.000 claims 2
- 102000000584 Calmodulin Human genes 0.000 claims 1
- 108010041952 Calmodulin Proteins 0.000 claims 1
- 210000001736 Capillaries Anatomy 0.000 claims 1
- 229920001661 Chitosan Polymers 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- 206010012601 Diabetes mellitus Diseases 0.000 claims 1
- 230000000903 blocking Effects 0.000 claims 1
- 239000002738 chelating agent Substances 0.000 claims 1
- 230000001419 dependent Effects 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- 229920001184 polypeptide Polymers 0.000 claims 1
- 102000004169 proteins and genes Human genes 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 229910052904 quartz Inorganic materials 0.000 claims 1
- 239000010453 quartz Substances 0.000 claims 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 1
- 150000003384 small molecules Chemical class 0.000 claims 1
- YMWUJEATGCHHMB-UHFFFAOYSA-N methylene dichloride Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 2
- XKRFYHLGVUSROY-UHFFFAOYSA-N argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- OKKJLVBELUTLKV-UHFFFAOYSA-N methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 2
- 229920000075 poly(4-vinylpyridine) Polymers 0.000 description 2
- 238000003786 synthesis reaction Methods 0.000 description 2
- 230000002194 synthesizing Effects 0.000 description 2
- 238000005160 1H NMR spectroscopy Methods 0.000 description 1
- MYVJCOQGXCONPE-UHFFFAOYSA-N [2-(bromomethyl)phenyl]boronic acid Chemical compound OB(O)C1=CC=CC=C1CBr MYVJCOQGXCONPE-UHFFFAOYSA-N 0.000 description 1
- ATRFDLFMCLYROQ-UHFFFAOYSA-N [3-(bromomethyl)phenyl]boronic acid Chemical compound OB(O)C1=CC=CC(CBr)=C1 ATRFDLFMCLYROQ-UHFFFAOYSA-N 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 229910052786 argon Inorganic materials 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 238000003760 magnetic stirring Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Description
ポリマーPVP‐BAの合成:ポリ(4-ビニルピリジン)(MW 60,000)をSigma 社から購入し、そのまま用いた。o-ブロモメチルフェニルボロン酸の合成を、決められた手順を用いて実行した。磁気撹拌子を含む10mLの丸底フラスコに、ポリ(4-ビニルピリジン)(0.100g、0.00167ミリモル)及びm-ブロモメチルフェニルボロン酸(0.206g、0.954ミリモル)を加えた。次に、N,N‐ジメチルホルムアミド(2mL)及びメタノール(2mL)を加えて試薬を溶解させた。混合体を23時間撹拌させ、次にジクロロメタン(10mL)を入れた50mLのビーカーに液滴状に添加して生成物を沈殿させた。このビ−カーを氷の浴内に入れてこの生成物を完全に沈殿させた。次に、溶液を、上部が取り外し可能なツーピースフリットフィルタ内に注ぎ、アルゴンガスを用いて不活性状態の下で真空フィルタ処理した。この生成物をジクロロメタンの3×15mL部分で洗浄し、次いで真空デシケータ内に入れて一晩中乾燥させた。隔離された生成物は0.257g(90%の収率)であった。1H‐NMRはポリマーの82%アルキル化を呈した(データは示さない)。
Claims (21)
- 試料中の検体を検出する装置に用いるナノピペットであって、このナノピペットが、
(a)ナノポアに至るナノピペットの内部ボアを規定するキャピラリー部分
を具え、
(b)前記内部ボアは、その内部に電極と、前記ナノポアを通して外部溶液と連通する内部溶液とを含むように適合されており、
前記ナノピペットが更に、
(c)前記ナノポアの内側表面上の被膜であって、
(i)前記内側表面に直接結合された高分子電解質の層と、
(ii)前記高分子電解質に結合され、イオン又は200原子質量単位よりも少ない分子量を有する小分子より成る群から選択した検体を結合するのに特異的な結合分子と
を有する当該被膜
を具えているナノピペット。 - 請求項1に記載のナノピペットにおいて、前記結合分子をボロン酸としたナノピペット。
- 請求項2に記載のナノピペットにおいて、前記高分子電解質をポリカチオンとしたナノピペット。
- 請求項3に記載のナノピペットにおいて、前記ポリカチオンをポリアルキルピリジン又はポリアミンとしたナノピペット。
- 請求項2に記載のナノピペットにおいて、前記被膜が更に、前記ナノポア内に延在するとともにこのナノポアを部分的に封鎖する部分を有しているナノピペット。
- 請求項1に記載のナノピペットにおいて、前記結合分子をキレート剤としたナノピペット。
- 請求項6に記載のナノピペットにおいて、前記高分子電解質の層を、(a)ポリアクリルの層と、(b)ポリアミンの層と、(c)ポリアクリル及びポリアミンの交互に重なった層とより成る群から選択したナノピペット。
- 請求項7に記載のナノピペットにおいて、前記ポリアミンをポリアルキルピリジンとしたナノピペット。
- 請求項1に記載のナノピペットにおいて、前記結合分子を、多糖又はポリペプチドであるイオン結合ポリマーとしたナノピペット。
- 請求項9に記載のナノピペットにおいて、前記イオン結合ポリマーをキトサンとしたナノピペット。
- 請求項9に記載のナノピペットにおいて、前記イオン結合ポリマーをカルモジュリンとしたナノピペット。
- 試料中の糖検体を測定するナノピペット装置であって、このナノピペット装置が、
前記試料内に開口するナノポアを有する請求項1に記載のナノピペットと、
内部溶液と接触するように配置された、前記内部ボア内の電極、及び前記試料と接触するように配置された基準電極と、
を具え、
前記被膜は、糖を結合するのに特異的であり、この糖を結合させるのに有効な結合分子を有しており、
前記ナノピペット装置が更に、
電極間に電圧を発生させるとともに、前記試料、前記ナノポア及び前記内部溶液を通る正及び負のイオン電流を測定し、前記試料中の糖が、前記結合分子を有する前記被膜に結合された際に、負のイオン電流に濃度に依存する変化を生ぜしめるようにする電圧制御回路
を具えているナノピペット装置。 - 請求項12に記載のナノピペット装置において、前記結合分子をタンパク質としたナノピペット装置。
- 請求項12に記載のナノピペット装置において、前記結合分子をボロン酸としたナノピペット装置。
- 請求項12に記載のナノピペット装置において、前記ナノピペットを石英としたナノピペット装置。
- 請求項12に記載のナノピペット装置において、前記電圧制御回路が電圧クランプ増幅器を有しているナノピペット装置。
- 請求項12に記載のナノピペット装置において、前記被膜がポリカチオンを有しているナノピペット装置。
- 前記結合分子が検出用分子であり、そして、前記高分子電解質の層および前記検出用分子は、ナノポア内に延在してこのナノポアを部分的に遮断するようにナノポアに被着する、請求項1に記載のデバイス。
- 結合分子を、多糖であるイオン結合ポリマーとした請求項1に記載のデバイス。
- 糖尿病の危険性がある対象者が必要としうるためにグルコース検出に対し適合させた請求項1に記載のデバイス。
- 請求項1に記載されたナノピペット装置を用いて、試料中の検体を決定する方法。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161449379P | 2011-03-04 | 2011-03-04 | |
US61/449,379 | 2011-03-04 | ||
PCT/US2012/027531 WO2012122029A2 (en) | 2011-03-04 | 2012-03-02 | Nanopore device for reversible ion and molecule sensing or migration |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2014508300A JP2014508300A (ja) | 2014-04-03 |
JP2014508300A5 true JP2014508300A5 (ja) | 2016-06-30 |
JP6046058B2 JP6046058B2 (ja) | 2016-12-14 |
Family
ID=46752618
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013556907A Active JP6046058B2 (ja) | 2011-03-04 | 2012-03-02 | 可逆的なイオン及び分子検出又は移動用ナノポアデバイス |
Country Status (6)
Country | Link |
---|---|
US (4) | US8980073B2 (ja) |
EP (1) | EP2681542B1 (ja) |
JP (1) | JP6046058B2 (ja) |
KR (1) | KR101923241B1 (ja) |
CN (2) | CN105044170B (ja) |
WO (1) | WO2012122029A2 (ja) |
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