JP2014508131A - 薬物送達分散体及びそれから形成されるフィルム - Google Patents
薬物送達分散体及びそれから形成されるフィルム Download PDFInfo
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- JP2014508131A JP2014508131A JP2013547617A JP2013547617A JP2014508131A JP 2014508131 A JP2014508131 A JP 2014508131A JP 2013547617 A JP2013547617 A JP 2013547617A JP 2013547617 A JP2013547617 A JP 2013547617A JP 2014508131 A JP2014508131 A JP 2014508131A
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- organopolysiloxane
- sio
- film
- dispersion
- encapsulated particles
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- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 description 1
- ICUTUKXCWQYESQ-UHFFFAOYSA-N triclocarban Chemical compound C1=CC(Cl)=CC=C1NC(=O)NC1=CC=C(Cl)C(Cl)=C1 ICUTUKXCWQYESQ-UHFFFAOYSA-N 0.000 description 1
- 229960001325 triclocarban Drugs 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- MZHULIWXRDLGRR-UHFFFAOYSA-N tridecyl 3-(3-oxo-3-tridecoxypropyl)sulfanylpropanoate Chemical compound CCCCCCCCCCCCCOC(=O)CCSCCC(=O)OCCCCCCCCCCCCC MZHULIWXRDLGRR-UHFFFAOYSA-N 0.000 description 1
- WUUHFRRPHJEEKV-UHFFFAOYSA-N tripotassium borate Chemical compound [K+].[K+].[K+].[O-]B([O-])[O-] WUUHFRRPHJEEKV-UHFFFAOYSA-N 0.000 description 1
- WGKLOLBTFWFKOD-UHFFFAOYSA-N tris(2-nonylphenyl) phosphite Chemical compound CCCCCCCCCC1=CC=CC=C1OP(OC=1C(=CC=CC=1)CCCCCCCCC)OC1=CC=CC=C1CCCCCCCCC WGKLOLBTFWFKOD-UHFFFAOYSA-N 0.000 description 1
- ZQTYRTSKQFQYPQ-UHFFFAOYSA-N trisiloxane Chemical compound [SiH3]O[SiH2]O[SiH3] ZQTYRTSKQFQYPQ-UHFFFAOYSA-N 0.000 description 1
- 125000005387 trisiloxy group Chemical group 0.000 description 1
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 1
- BIKXLKXABVUSMH-UHFFFAOYSA-N trizinc;diborate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]B([O-])[O-].[O-]B([O-])[O-] BIKXLKXABVUSMH-UHFFFAOYSA-N 0.000 description 1
- 229940030300 trolamine salicylate Drugs 0.000 description 1
- 229940035936 ubiquinone Drugs 0.000 description 1
- 125000002948 undecyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 229930195735 unsaturated hydrocarbon Natural products 0.000 description 1
- 229960003824 ustekinumab Drugs 0.000 description 1
- 229940070710 valerate Drugs 0.000 description 1
- 239000004034 viscosity adjusting agent Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 230000004580 weight loss Effects 0.000 description 1
- 235000020681 well water Nutrition 0.000 description 1
- 239000002349 well water Substances 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000003871 white petrolatum Substances 0.000 description 1
- 229940118846 witch hazel Drugs 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 229960000314 zinc acetate Drugs 0.000 description 1
- 229940062776 zinc aspartate Drugs 0.000 description 1
- 239000011667 zinc carbonate Substances 0.000 description 1
- 235000004416 zinc carbonate Nutrition 0.000 description 1
- 229910000010 zinc carbonate Inorganic materials 0.000 description 1
- 239000011592 zinc chloride Substances 0.000 description 1
- 235000005074 zinc chloride Nutrition 0.000 description 1
- 239000011746 zinc citrate Substances 0.000 description 1
- 235000006076 zinc citrate Nutrition 0.000 description 1
- 229940068475 zinc citrate Drugs 0.000 description 1
- 239000011670 zinc gluconate Substances 0.000 description 1
- 235000011478 zinc gluconate Nutrition 0.000 description 1
- 229960000306 zinc gluconate Drugs 0.000 description 1
- 239000011576 zinc lactate Substances 0.000 description 1
- 235000000193 zinc lactate Nutrition 0.000 description 1
- 229940050168 zinc lactate Drugs 0.000 description 1
- 229960001296 zinc oxide Drugs 0.000 description 1
- 229940105296 zinc peroxide Drugs 0.000 description 1
- NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
- 229960001763 zinc sulfate Drugs 0.000 description 1
- 229910000368 zinc sulfate Inorganic materials 0.000 description 1
- POEVDIARYKIEGF-CEOVSRFSSA-L zinc;(2s)-2-aminobutanedioate;hydron Chemical compound [Zn+2].[O-]C(=O)[C@@H](N)CC(O)=O.[O-]C(=O)[C@@H](N)CC(O)=O POEVDIARYKIEGF-CEOVSRFSSA-L 0.000 description 1
- GAMIYQSIKAOVTG-UHFFFAOYSA-L zinc;2-aminopentanedioate Chemical compound [Zn+2].[O-]C(=O)C(N)CCC([O-])=O GAMIYQSIKAOVTG-UHFFFAOYSA-L 0.000 description 1
- CPYIZQLXMGRKSW-UHFFFAOYSA-N zinc;iron(3+);oxygen(2-) Chemical compound [O-2].[O-2].[O-2].[O-2].[Fe+3].[Fe+3].[Zn+2] CPYIZQLXMGRKSW-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7015—Drug-containing film-forming compositions, e.g. spray-on
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dispersion Chemistry (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP10306521 | 2010-12-27 | ||
| EP10306521.5 | 2010-12-27 | ||
| PCT/US2011/067400 WO2012092283A1 (en) | 2010-12-27 | 2011-12-27 | Drug delivery dispersion and film formed therefrom |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014508131A true JP2014508131A (ja) | 2014-04-03 |
| JP2014508131A5 JP2014508131A5 (enExample) | 2015-02-19 |
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| JP2013547617A Pending JP2014508131A (ja) | 2010-12-27 | 2011-12-27 | 薬物送達分散体及びそれから形成されるフィルム |
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| US (1) | US20130287856A1 (enExample) |
| EP (1) | EP2658524A1 (enExample) |
| JP (1) | JP2014508131A (enExample) |
| CN (1) | CN103347496A (enExample) |
| WO (1) | WO2012092283A1 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI445557B (zh) * | 2011-05-24 | 2014-07-21 | To induce new bone formation around the implant compositions | |
| US10130654B2 (en) * | 2011-05-24 | 2018-11-20 | Hangli Biosciences Co., Ltd. | Method of inducing osteogensis and promoting osseointegration around an implant |
| AR089765A1 (es) * | 2012-01-23 | 2014-09-17 | Bayer Oy | Un sistema para el suministro de un farmaco |
| EP2919903B1 (en) | 2012-11-14 | 2020-07-22 | W.R. Grace & CO. - CONN. | Compositions containing a biologically active material and a non-ordered inorganic oxide |
| GB2543417B (en) * | 2015-09-11 | 2017-10-18 | Guise Andrew | An oral particulate composition |
| US10787582B2 (en) * | 2015-12-25 | 2020-09-29 | 3M Innovative Properties Company | Composition, method of making composition, and article |
| WO2018144954A1 (en) * | 2017-02-03 | 2018-08-09 | City Of Hope | Silica nanoparticle with an insoluble drug |
| JP6699583B2 (ja) * | 2017-02-14 | 2020-05-27 | 信越化学工業株式会社 | 付加硬化型シリコーン組成物 |
| CN108786759B (zh) * | 2018-06-15 | 2020-10-16 | 山东交通学院 | 一种具有防污杀菌和染料吸附功能的油水分离材料及其制备方法 |
| CN112336688B (zh) * | 2020-08-14 | 2023-03-17 | 广东人人康药业有限公司 | 一种水包油型复方氢醌乳剂及其制备方法和其应用 |
| CN113149023B (zh) * | 2021-03-11 | 2023-05-02 | 昆明理工大学 | 一种介孔二氧化硅纳米颗粒经皮递送低共熔体系制备方法 |
| CN114847338B (zh) * | 2022-06-06 | 2023-10-24 | 河北天农农业科技有限公司 | 一种绿原酸保鲜膜的成膜方法及其在蛋品保鲜中的应用 |
| CN115876931B (zh) * | 2022-12-15 | 2025-01-21 | 武汉大学 | 一种高灵敏度定量检测rna中肌苷的方法 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005526025A (ja) * | 2002-02-07 | 2005-09-02 | ダウ・コ−ニング・コ−ポレ−ション | カプセル封入方法およびカプセル封入された組成物 |
| JP2008179616A (ja) * | 2006-12-20 | 2008-08-07 | L'oreal Sa | カプセル封入されたシリコーン化合物を含有する組成物 |
| JP2009542667A (ja) * | 2006-06-27 | 2009-12-03 | ダウ・コーニング・コーポレイション | テトラアルコキシシランの乳化重合からのマイクロカプセル |
| JP2010018614A (ja) * | 2008-07-10 | 2010-01-28 | L'oreal Sa | 日焼け保護キット |
| WO2011000902A2 (en) * | 2009-07-01 | 2011-01-06 | L'oréal | Cosmetic composition comprising encapsulated silicone compounds |
| WO2011002695A1 (en) * | 2009-07-01 | 2011-01-06 | Dow Corning Corporation | Microcapsules containing curable siloxanes |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1040124A (en) | 1912-02-24 | 1912-10-01 | Hydrocarbon Converter Company | Method of and apparatus for converting liquid hydrocarbons into gas or vapor. |
| BE553159A (enExample) | 1955-12-05 | |||
| US3220972A (en) | 1962-07-02 | 1965-11-30 | Gen Electric | Organosilicon process using a chloroplatinic acid reaction product as the catalyst |
| US3296291A (en) | 1962-07-02 | 1967-01-03 | Gen Electric | Reaction of silanes with unsaturated olefinic compounds |
| US3159601A (en) | 1962-07-02 | 1964-12-01 | Gen Electric | Platinum-olefin complex catalyzed addition of hydrogen- and alkenyl-substituted siloxanes |
| NL131800C (enExample) | 1965-05-17 | |||
| US3516946A (en) | 1967-09-29 | 1970-06-23 | Gen Electric | Platinum catalyst composition for hydrosilation reactions |
| US3814730A (en) | 1970-08-06 | 1974-06-04 | Gen Electric | Platinum complexes of unsaturated siloxanes and platinum containing organopolysiloxanes |
| US3715334A (en) | 1970-11-27 | 1973-02-06 | Gen Electric | Platinum-vinylsiloxanes |
| US3923705A (en) | 1974-10-30 | 1975-12-02 | Dow Corning | Method of preparing fire retardant siloxane foams and foams prepared therefrom |
| US3989668A (en) | 1975-07-14 | 1976-11-02 | Dow Corning Corporation | Method of making a silicone elastomer and the elastomer prepared thereby |
| US4784879A (en) | 1987-07-20 | 1988-11-15 | Dow Corning Corporation | Method for preparing a microencapsulated compound of a platinum group metal |
| JP2630993B2 (ja) | 1988-06-23 | 1997-07-16 | 東レ・ダウコーニング・シリコーン株式会社 | ヒドロシリル化反応用白金系触媒含有粒状物およびその製造方法 |
| JPH0768115B2 (ja) | 1989-05-17 | 1995-07-26 | 花王株式会社 | 洗浄剤組成物 |
| FR2653338B1 (fr) | 1989-10-23 | 1994-06-10 | Dow Corning Sa | Formulation pour des pansements a liberation prolongee de medicament et son utilisation. |
| US5036117A (en) | 1989-11-03 | 1991-07-30 | Dow Corning Corporation | Heat-curable silicone compositions having improved bath life |
| GB9103191D0 (en) | 1991-02-14 | 1991-04-03 | Dow Corning | Platinum complexes and use thereof |
| IL120022A (en) | 1997-01-16 | 2003-02-12 | Yissum Res Dev Co | Sunscreens for protection from sun radiation |
| AU5382599A (en) | 1998-08-13 | 2000-03-06 | Sol-Gel Technologies Ltd. | Method for the preparation of oxide microcapsules loaded with functional molecules and the products obtained thereof |
| US6238650B1 (en) | 1999-05-26 | 2001-05-29 | Sol-Gel Technologies Ltd. | Sunscreen composition containing sol-gel microcapsules |
| EA008771B1 (ru) | 2003-07-31 | 2007-08-31 | Сол-Джел Текнолоджиз Лтд. | Микрокапсулы, заполненные активными ингредиентами, и способ их приготовления |
-
2011
- 2011-12-27 US US13/976,312 patent/US20130287856A1/en not_active Abandoned
- 2011-12-27 WO PCT/US2011/067400 patent/WO2012092283A1/en not_active Ceased
- 2011-12-27 JP JP2013547617A patent/JP2014508131A/ja active Pending
- 2011-12-27 EP EP11811479.2A patent/EP2658524A1/en not_active Withdrawn
- 2011-12-27 CN CN2011800670898A patent/CN103347496A/zh active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2005526025A (ja) * | 2002-02-07 | 2005-09-02 | ダウ・コ−ニング・コ−ポレ−ション | カプセル封入方法およびカプセル封入された組成物 |
| JP2009542667A (ja) * | 2006-06-27 | 2009-12-03 | ダウ・コーニング・コーポレイション | テトラアルコキシシランの乳化重合からのマイクロカプセル |
| JP2008179616A (ja) * | 2006-12-20 | 2008-08-07 | L'oreal Sa | カプセル封入されたシリコーン化合物を含有する組成物 |
| JP2010018614A (ja) * | 2008-07-10 | 2010-01-28 | L'oreal Sa | 日焼け保護キット |
| WO2011000902A2 (en) * | 2009-07-01 | 2011-01-06 | L'oréal | Cosmetic composition comprising encapsulated silicone compounds |
| WO2011002695A1 (en) * | 2009-07-01 | 2011-01-06 | Dow Corning Corporation | Microcapsules containing curable siloxanes |
Also Published As
| Publication number | Publication date |
|---|---|
| US20130287856A1 (en) | 2013-10-31 |
| WO2012092283A1 (en) | 2012-07-05 |
| EP2658524A1 (en) | 2013-11-06 |
| CN103347496A (zh) | 2013-10-09 |
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