JP2014507474A5 - - Google Patents
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- Publication number
- JP2014507474A5 JP2014507474A5 JP2013557804A JP2013557804A JP2014507474A5 JP 2014507474 A5 JP2014507474 A5 JP 2014507474A5 JP 2013557804 A JP2013557804 A JP 2013557804A JP 2013557804 A JP2013557804 A JP 2013557804A JP 2014507474 A5 JP2014507474 A5 JP 2014507474A5
- Authority
- JP
- Japan
- Prior art keywords
- pirfenidone
- medicament
- medicament according
- food
- patient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 229960003073 pirfenidone Drugs 0.000 claims 23
- 239000003814 drug Substances 0.000 claims 16
- ISWRGOKTTBVCFA-UHFFFAOYSA-N pirfenidone Chemical compound C1=C(C)C=CC(=O)N1C1=CC=CC=C1 ISWRGOKTTBVCFA-UHFFFAOYSA-N 0.000 claims 7
- 235000013305 food Nutrition 0.000 claims 6
- 230000002411 adverse Effects 0.000 claims 3
- 206010028813 Nausea Diseases 0.000 claims 2
- 208000032140 Sleepiness Diseases 0.000 claims 2
- 206010041349 Somnolence Diseases 0.000 claims 2
- 208000002173 dizziness Diseases 0.000 claims 2
- 230000037406 food intake Effects 0.000 claims 2
- 235000012631 food intake Nutrition 0.000 claims 2
- 230000008693 nausea Effects 0.000 claims 2
- 208000010201 Exanthema Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 206010034972 Photosensitivity reaction Diseases 0.000 claims 1
- 206010000059 abdominal discomfort Diseases 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 201000005884 exanthem Diseases 0.000 claims 1
- 206010016256 fatigue Diseases 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 235000012054 meals Nutrition 0.000 claims 1
- 230000036211 photosensitivity Effects 0.000 claims 1
- 230000036470 plasma concentration Effects 0.000 claims 1
- 206010037844 rash Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161450489P | 2011-03-08 | 2011-03-08 | |
| US61/450,489 | 2011-03-08 | ||
| PCT/US2012/027872 WO2012122165A2 (en) | 2011-03-08 | 2012-03-06 | Substituted n-aryl pyridinones |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016244433A Division JP2017057220A (ja) | 2011-03-08 | 2016-12-16 | 置換ｎ−アリールピリジノン |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014507474A JP2014507474A (ja) | 2014-03-27 |
| JP2014507474A5 true JP2014507474A5 (enExample) | 2015-04-09 |
Family
ID=46798751
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013557804A Pending JP2014507474A (ja) | 2011-03-08 | 2012-03-06 | 置換ｎ−アリールピリジノン |
| JP2016244433A Pending JP2017057220A (ja) | 2011-03-08 | 2016-12-16 | 置換ｎ−アリールピリジノン |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016244433A Pending JP2017057220A (ja) | 2011-03-08 | 2016-12-16 | 置換ｎ−アリールピリジノン |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US9018232B2 (enExample) |
| EP (1) | EP2683379A4 (enExample) |
| JP (2) | JP2014507474A (enExample) |
| KR (1) | KR20140011355A (enExample) |
| CN (1) | CN103561741A (enExample) |
| AU (1) | AU2012225611B2 (enExample) |
| BR (1) | BR112013022766A2 (enExample) |
| CA (1) | CA2828895A1 (enExample) |
| WO (1) | WO2012122165A2 (enExample) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2691379C (en) | 2007-06-20 | 2015-06-09 | Auspex Pharmaceuticals, Inc. | Substituted n-aryl pyridinones |
| CN103561741A (zh) * | 2011-03-08 | 2014-02-05 | 奥斯拜客斯制药有限公司 | 取代的n-芳基吡啶酮 |
| AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
| US10233195B2 (en) | 2014-04-02 | 2019-03-19 | Intermune, Inc. | Anti-fibrotic pyridinones |
| CN105315198A (zh) * | 2015-11-02 | 2016-02-10 | 重庆康乐制药有限公司 | 一种吡非尼酮的晶型及其制备方法 |
| CN105330598B (zh) * | 2015-12-02 | 2017-11-14 | 新发药业有限公司 | 一种吡非尼酮的制备方法 |
| CA2937365C (en) | 2016-03-29 | 2018-09-18 | F. Hoffmann-La Roche Ag | Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same |
| CN106748984A (zh) * | 2016-11-22 | 2017-05-31 | 斯芬克司药物研发（天津）股份有限公司 | 6‑羟甲基‑1‑苯基吡啶‑2‑酮及其制备方法与应用 |
| WO2020003107A1 (en) * | 2018-06-29 | 2020-01-02 | Zenvision Pharma Llp | Low dose oral pharmaceutical composition of pirfenidone or salt thereof |
| CN121108041A (zh) | 2018-09-14 | 2025-12-12 | 纯技术莱特100股份有限公司 | 富含氘的吡非尼酮及其使用方法 |
| US20250114341A1 (en) | 2018-09-14 | 2025-04-10 | Puretech Lyt 100, Inc. | Methods of treating idiopathic pulmonary fibrosis with deupirfenidone |
| CA3171622A1 (en) | 2020-03-13 | 2021-09-16 | Puretech Lyt 100, Inc. | Methods of treating respiratory disease with deupirfenidone |
| JP2025511066A (ja) * | 2022-03-31 | 2025-04-15 | ピュアテック・エル・ワイ・ティ・１００・インコーポレイテッド | デューピルフェニドンにより間質性肺疾患ならびに他の線維化介在性肺疾患及び障害を治療する方法 |
Family Cites Families (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH02215719A (ja) | 1989-02-15 | 1990-08-28 | Yamauchi Akitomo | 線維化病変組織の修復並びに線維化病変の阻止剤 |
| US5310562A (en) | 1989-11-22 | 1994-05-10 | Margolin Solomon B | Composition and method for reparation and prevention of fibrotic lesions |
| CN1087725C (zh) | 1994-03-25 | 2002-07-17 | 同位素技术有限公司 | 用氘代方法增强药物效果 |
| US6221335B1 (en) | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| US5962478A (en) | 1995-09-19 | 1999-10-05 | Margolin; Solomon B. | Inhibition of tumor necrosis factor α |
| US6294350B1 (en) | 1997-06-05 | 2001-09-25 | Dalhousie University | Methods for treating fibroproliferative diseases |
| US6440710B1 (en) | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| DK1104760T3 (da) | 1999-12-03 | 2003-06-30 | Pfizer Prod Inc | Sulfamoylheteroarylpyrazolforbindelser som anti-inflammatoriske/analgetiske midler |
| EP1134290A3 (en) | 2000-03-14 | 2004-01-02 | Pfizer Products Inc. | Pharmacophore models for the identification of the CYP2D6 inhibitory potency of selective serotonin reuptake inhibitors |
| US20030194748A1 (en) | 2000-05-29 | 2003-10-16 | Tohru Nagasaki | Method for labeling with tritium |
| ES2334990T3 (es) | 2002-02-14 | 2010-03-18 | Pharmacia Corporation | Piridinonas sustituidas como moduladores de p38 map quinasa. |
| AU2003258305A1 (en) | 2002-08-28 | 2004-03-19 | Intermune, Inc. | Combination therapy for treatment of fibrotic disorders |
| TW200413273A (en) | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| US20070072181A1 (en) | 2003-02-28 | 2007-03-29 | Blatt Lawrence M | Combination therapy for treating alphavirus infection and liver fibrosis |
| WO2004105684A2 (en) | 2003-05-16 | 2004-12-09 | Intermune, Inc. | Combination therapy for proliferative disorders |
| WO2005038056A1 (en) | 2003-10-14 | 2005-04-28 | Intermune, Inc. | Combination therapy for the treatment of viral diseases |
| US7407973B2 (en) | 2003-10-24 | 2008-08-05 | Intermune, Inc. | Use of pirfenidone in therapeutic regimens |
| JP4072623B2 (ja) | 2004-03-09 | 2008-04-09 | 独立行政法人産業技術総合研究所 | ピリジン−ｎ−オキシド類の製造方法 |
| WO2005110478A2 (en) | 2004-04-13 | 2005-11-24 | Intermune, Inc. | Combination therapy for treating fibrotic disorders |
| MX2007014114A (es) | 2005-05-10 | 2008-03-14 | Intermune Inc | Derivados de piridona para modular el sistema de proteina cinasa activada por estres. |
| US20080033011A1 (en) | 2005-07-29 | 2008-02-07 | Concert Pharmaceuticals Inc. | Novel benzo[d][1,3]-dioxol derivatives |
| NZ591443A (en) | 2005-09-22 | 2013-04-26 | Intermune Inc | Granule formation of pirfenidone and pharmaceutically acceptable excipients |
| US20070203202A1 (en) * | 2005-12-02 | 2007-08-30 | Robinson Cynthia Y | Methods of reducing adverse events associated with pirfenidone therapy |
| US7750168B2 (en) | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| US20080103122A1 (en) | 2006-09-05 | 2008-05-01 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
| US20080287508A1 (en) * | 2007-05-18 | 2008-11-20 | Intermune, Inc. | Altering pharmacokinetics of pirfenidone therapy |
| CA2691379C (en) | 2007-06-20 | 2015-06-09 | Auspex Pharmaceuticals, Inc. | Substituted n-aryl pyridinones |
| WO2009035598A1 (en) | 2007-09-10 | 2009-03-19 | Concert Pharmaceuticals, Inc. | Deuterated pirfenidone |
| EP2389227A4 (en) | 2009-01-26 | 2012-08-08 | Intermune Inc | METHOD FOR THE TREATMENT OF ACUTE MYOCARDINE CARDS AND ASSOCIATED ILLNESSES THEREOF |
| CN103561741A (zh) * | 2011-03-08 | 2014-02-05 | 奥斯拜客斯制药有限公司 | 取代的n-芳基吡啶酮 |
| KR20140022048A (ko) * | 2011-05-25 | 2014-02-21 | 인터뮨, 인크. | 선택된 환자에서의 피르페니돈 및 항-섬유성 치료제 |
-
2012
- 2012-03-06 CN CN201280012472.8A patent/CN103561741A/zh active Pending
- 2012-03-06 JP JP2013557804A patent/JP2014507474A/ja active Pending
- 2012-03-06 KR KR20137025865A patent/KR20140011355A/ko not_active Withdrawn
- 2012-03-06 BR BR112013022766A patent/BR112013022766A2/pt not_active IP Right Cessation
- 2012-03-06 WO PCT/US2012/027872 patent/WO2012122165A2/en not_active Ceased
- 2012-03-06 AU AU2012225611A patent/AU2012225611B2/en not_active Ceased
- 2012-03-06 EP EP12755283.4A patent/EP2683379A4/en not_active Withdrawn
- 2012-03-06 CA CA 2828895 patent/CA2828895A1/en not_active Abandoned
- 2012-03-06 US US14/003,106 patent/US9018232B2/en not_active Expired - Fee Related
-
2015
- 2015-01-14 US US14/596,727 patent/US20150126562A1/en not_active Abandoned
-
2016
- 2016-12-16 JP JP2016244433A patent/JP2017057220A/ja active Pending
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