JP2014507446A5 - - Google Patents
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- Publication number
- JP2014507446A5 JP2014507446A5 JP2013555647A JP2013555647A JP2014507446A5 JP 2014507446 A5 JP2014507446 A5 JP 2014507446A5 JP 2013555647 A JP2013555647 A JP 2013555647A JP 2013555647 A JP2013555647 A JP 2013555647A JP 2014507446 A5 JP2014507446 A5 JP 2014507446A5
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- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- following
- compound
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 239000000546 pharmaceutic aid Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 0 CC(CCN1c(cnc(N2CC*(C)(COP(O)(O)=O)CC2)c2)c2-c2c(C)cccc2)(C1=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 Chemical compound CC(CCN1c(cnc(N2CC*(C)(COP(O)(O)=O)CC2)c2)c2-c2c(C)cccc2)(C1=O)c1cc(C(F)(F)F)cc(C(F)(F)F)c1 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161564537P | 2011-11-29 | 2011-11-29 | |
| US61/564,537 | 2011-11-29 | ||
| US13/478,361 US8426450B1 (en) | 2011-11-29 | 2012-05-23 | Substituted 4-phenyl pyridines having anti-emetic effect |
| US13/478,361 | 2012-11-23 | ||
| PCT/US2012/066778 WO2013082102A1 (en) | 2011-11-29 | 2012-11-28 | Substituted 4 - phenyl - pyridines for the treatment of nk-1 receptor related diseases |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014210716A Division JP6023146B2 (ja) | 2011-11-29 | 2014-10-15 | Ｎｋ−１レセプター関連疾患の治療のための置換４−フェニル−ピリジン |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014507446A JP2014507446A (ja) | 2014-03-27 |
| JP2014507446A5 true JP2014507446A5 (US07981874-20110719-C00313.png) | 2014-06-19 |
| JP5635708B2 JP5635708B2 (ja) | 2014-12-03 |
Family
ID=48094815
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013555647A Active JP5635708B2 (ja) | 2011-11-29 | 2012-11-28 | Ｎｋ−１レセプター関連疾患の治療のための置換４−フェニル−ピリジン |
| JP2014210716A Active JP6023146B2 (ja) | 2011-11-29 | 2014-10-15 | Ｎｋ−１レセプター関連疾患の治療のための置換４−フェニル−ピリジン |
| JP2016034427A Active JP6074083B2 (ja) | 2011-11-29 | 2016-02-25 | Ｎｋ−１レセプター関連疾患の治療のための置換４−フェニル−ピリジン |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014210716A Active JP6023146B2 (ja) | 2011-11-29 | 2014-10-15 | Ｎｋ−１レセプター関連疾患の治療のための置換４−フェニル−ピリジン |
| JP2016034427A Active JP6074083B2 (ja) | 2011-11-29 | 2016-02-25 | Ｎｋ−１レセプター関連疾患の治療のための置換４−フェニル−ピリジン |
Country Status (50)
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2705027T3 (es) | 2010-08-19 | 2019-03-21 | Buck Institute For Age Res | Métodos de tratamiento del deterioro cognitivo leve (DCL) y trastornos relacionados |
| CA2820626C (en) | 2010-12-07 | 2018-01-09 | Allison Transmission, Inc. | Energy storage system for hybrid electric vehicle |
| KR20150055094A (ko) | 2011-06-22 | 2015-05-20 | 퍼듀 퍼머 엘피 | 디히드록시 치환기를 포함하는 trpv1 길항제 및 그의 용도 |
| US8426450B1 (en) | 2011-11-29 | 2013-04-23 | Helsinn Healthcare Sa | Substituted 4-phenyl pyridines having anti-emetic effect |
| AU2014347644B2 (en) | 2013-11-08 | 2018-06-14 | Kissei Pharmaceutical Co., Ltd. | Carboxymethyl piperidine derivative |
| WO2015171489A1 (en) * | 2014-05-05 | 2015-11-12 | Apicore Us Llc | Methods of making netupitant and intermediates thereof |
| TWI649307B (zh) | 2014-05-07 | 2019-02-01 | 日商橘生藥品工業股份有限公司 | Cyclohexylpyridine derivative |
| TW201613888A (en) * | 2014-09-26 | 2016-04-16 | Helsinn Healthcare Sa | Crystalline forms of an NK-1 antagonist |
| EP3203840B1 (en) | 2014-10-06 | 2020-08-05 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| CN105061303A (zh) * | 2015-08-03 | 2015-11-18 | 成都欣捷高新技术开发有限公司 | 一种制备奈妥吡坦关键中间体n-甲基-4-(2-甲基苯基)-6-(4-甲基-1-哌嗪基)-3-吡啶胺的新方法 |
| US10005803B2 (en) | 2015-10-06 | 2018-06-26 | Helsinn Healthcare Sa | Crystalline forms of fosnetupitant |
| CN106892864A (zh) * | 2015-12-21 | 2017-06-27 | 上海科胜药物研发有限公司 | 一种奈妥皮坦游离碱的晶型a及其制备方法 |
| AU2017240685B2 (en) | 2016-03-31 | 2021-08-12 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator |
| UA122285C2 (uk) * | 2016-06-06 | 2020-10-12 | Хелсінн Хелскеа Са | Фізіологічно збалансовані склади для ін'єкцій, які включають фоснетупітант |
| CN109803962B (zh) | 2016-09-30 | 2022-04-29 | 弗特克斯药品有限公司 | 囊性纤维化跨膜传导调控蛋白的调节剂、以及药物组合物 |
| WO2018107100A1 (en) | 2016-12-09 | 2018-06-14 | Vertex Pharmaceuticals Incorporated | Modulator of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| CN108619525B (zh) * | 2017-03-15 | 2020-12-29 | 和龙 | 奈妥吡坦-mPEG-PLA纳米粒及其制备方法和用途 |
| BR112019025801A2 (pt) | 2017-06-08 | 2020-07-07 | Vertex Pharmaceuticals Incorporated | métodos de tratamento para fibrose cística |
| CA3104811C (en) | 2017-06-30 | 2024-05-28 | Chase Therapeutics Corporation | Composition comprising pramipexole and nk1-antagonists for treating depression |
| AU2018304168B2 (en) | 2017-07-17 | 2023-05-04 | Vertex Pharmaceuticals Incorporated | Methods of treatment for cystic fibrosis |
| KR102606188B1 (ko) | 2017-08-02 | 2023-11-23 | 버텍스 파마슈티칼스 인코포레이티드 | 피롤리딘 화합물을 제조하기 위한 공정 |
| CN107698500A (zh) * | 2017-10-17 | 2018-02-16 | 扬子江药业集团四川海蓉药业有限公司 | 一种奈妥匹坦的制备方法 |
| AU2018351533B2 (en) | 2017-10-19 | 2023-02-02 | Vertex Pharmaceuticals Incorporated | Crystalline forms and compositions of CFTR modulators |
| KR20200097293A (ko) | 2017-12-08 | 2020-08-18 | 버텍스 파마슈티칼스 인코포레이티드 | 낭포성 섬유증 막횡단 전도 조절자의 조정제의 제조 방법 |
| PL3737378T3 (pl) * | 2018-01-12 | 2023-07-31 | Orion Corporation | Krople do oczu z palonosetronem do leczenia nudności i wymiotów lub zapobiegania im |
| TWI810243B (zh) | 2018-02-05 | 2023-08-01 | 美商維泰克斯製藥公司 | 用於治療囊腫纖化症之醫藥組合物 |
| US11414439B2 (en) | 2018-04-13 | 2022-08-16 | Vertex Pharmaceuticals Incorporated | Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulator |
| JP7156154B2 (ja) * | 2019-04-18 | 2022-10-19 | 株式会社島津製作所 | 培地処理システム及び培地処理方法 |
| CN112174881B (zh) * | 2019-07-04 | 2022-06-21 | 上海森辉医药有限公司 | 一种奈妥匹坦的衍生物及其制备方法 |
| BR112022018876A2 (pt) | 2020-04-03 | 2022-11-22 | Nerre Therapeutics Ltd | Antagonista de receptor de nk-1 para tratar uma doença selecionada a partir de sepse, choque séptico, síndrome de desconforto respiratório agudo (ards) ou síndrome de disfunção múltipla dos órgãos |
| MX2022014901A (es) * | 2020-06-02 | 2023-01-18 | Nerre Therapeutics Ltd | Antagonistas del receptor de neuroquinina (nk)-1 para su uso en el tratamiento de condiciones de fibrosis pulmonar promovidas por lesion mecanica a los pulmones. |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1999033846A2 (en) * | 1997-12-31 | 1999-07-08 | The University Of Kansas | Water soluble prodrugs of secondary and tertiary amine containing drugs and methods of making thereof |
| SI1035115T1 (en) * | 1999-02-24 | 2005-02-28 | F. Hoffmann-La Roche Ag | 4-Phenylpyridine derivatives and their use as NK-1 receptor antagonists |
| US6303790B1 (en) | 1999-11-29 | 2001-10-16 | Hoffman-La Roche Inc. | Process for the preparation of pyridine derivatives |
| ES2208205T3 (es) * | 1999-11-29 | 2004-06-16 | F. Hoffmann-La Roche Ag | 2-(3,5-bis-trifluorometil-fenil)-n-metil-n-(6-morfolin-4-il-4-otolil-piridin-3-il)-isobutiramida. |
| US6362172B2 (en) * | 2000-01-20 | 2002-03-26 | Bristol-Myers Squibb Company | Water soluble prodrugs of azole compounds |
| PL205207B1 (pl) | 2000-07-14 | 2010-03-31 | Hoffmann La Roche | N-tlenki pochodnych 4-fenylopirydyny środek leczniczy, sposób wytwarzania tych N-tlenków i ich zastosowanie |
| TWI287003B (en) * | 2000-07-24 | 2007-09-21 | Hoffmann La Roche | 4-phenyl-pyridine derivatives |
| AU1608502A (en) | 2000-12-14 | 2002-06-24 | Hoffmann La Roche | Self emulsifying lipid matrix (selm) |
| US6531597B2 (en) | 2001-02-13 | 2003-03-11 | Hoffmann-La Roche Inc. | Process for preparation of 2-phenyl acetic acid derivatives |
| US7745625B2 (en) * | 2004-03-15 | 2010-06-29 | Bristol-Myers Squibb Company | Prodrugs of piperazine and substituted piperidine antiviral agents |
| US20060030600A1 (en) * | 2004-08-06 | 2006-02-09 | Patrick Schnider | Dual NK1/NK3 receptor antagonists for the treatment of schizophrenia |
| ATE425144T1 (de) * | 2005-03-23 | 2009-03-15 | Hoffmann La Roche | Metaboliten für nk-i-antagonisten zur emesis |
| JP4981673B2 (ja) * | 2005-09-13 | 2012-07-25 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 安定性が改善されたクロロメチルフォスフェイト誘導体を含む組成物およびその製造方法 |
| GB0808747D0 (en) | 2008-05-14 | 2008-06-18 | Glaxo Wellcome Mfg Pte Ltd | Novel compounds |
| UA108077C2 (xx) * | 2009-07-02 | 2015-03-25 | Синтез динатрієвої солі n4-(2,2-диметил-4-$(дигідрофосфонокси)метил]-3-оксо-5-піридо$1,4]оксазин-6-іл)-5-фтор-n2-(3,4,5-триметоксифеніл)-2,4-піримідиндіаміну | |
| CN106421793B (zh) * | 2009-11-18 | 2023-06-16 | 赫尔森保健股份公司 | 用于治疗中枢介导的恶心及呕吐的组合物及方法 |
| EP2521711B1 (en) * | 2010-01-07 | 2017-08-16 | Alkermes Pharma Ireland Limited | Quaternary ammonium salt prodrugs |
| PL2646035T3 (pl) * | 2010-12-02 | 2016-08-31 | Univ Kansas | Proleki 6-cykloheksylo-1-hydroksy-4-metylopirydyn-2(1h)-onu i ich pochodne |
| US8426450B1 (en) | 2011-11-29 | 2013-04-23 | Helsinn Healthcare Sa | Substituted 4-phenyl pyridines having anti-emetic effect |
| US9403772B2 (en) | 2011-11-29 | 2016-08-02 | Helsinn Healthcare Sa | 4-(5-(2-(3,5-bis(trifluoromethyl)phenyl)-N,2-dimethylpropanamido)-4-(o-tolyl)pyridin-2-yl)-1-methyl-1-((phosphonooxy)methyl)piperazin-1-ium as a neurokinin receptor modulator |
| TW201400446A (zh) | 2012-05-22 | 2014-01-01 | Genentech Inc | Ｎ－取代之苯甲醯胺及其使用方法 |
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2012
- 2012-05-23 US US13/478,361 patent/US8426450B1/en active Active
- 2012-11-19 JO JOP/2012/0348A patent/JO3202B1/ar active
- 2012-11-28 CN CN201710324776.2A patent/CN106986822B/zh active Active
- 2012-11-28 AU AU2012346133A patent/AU2012346133B2/en active Active
- 2012-11-28 LT LTEP12798549.7T patent/LT2785706T/lt unknown
- 2012-11-28 CA CA2850644A patent/CA2850644C/en active Active
- 2012-11-28 MD MDA20140059A patent/MD4539C1/ro active IP Right Grant
- 2012-11-28 BR BR112014012878-2A patent/BR112014012878B1/pt active IP Right Grant
- 2012-11-28 PT PT127985497T patent/PT2785706T/pt unknown
- 2012-11-28 EA EA201400624A patent/EA026553B1/ru unknown
- 2012-11-28 JP JP2013555647A patent/JP5635708B2/ja active Active
- 2012-11-28 WO PCT/US2012/066778 patent/WO2013082102A1/en active Application Filing
- 2012-11-28 MX MX2014006423A patent/MX2014006423A/es unknown
- 2012-11-28 UY UY0001034472A patent/UY34472A/es active IP Right Grant
- 2012-11-28 CN CN201610957278.7A patent/CN106518924B/zh active Active
- 2012-11-28 MY MYPI2014001505A patent/MY165514A/en unknown
- 2012-11-28 ES ES12798549.7T patent/ES2603958T3/es active Active
- 2012-11-28 SI SI201230810A patent/SI2785706T1/sl unknown
- 2012-11-28 EP EP12798549.7A patent/EP2785706B1/en active Active
- 2012-11-28 PL PL12798549T patent/PL2785706T3/pl unknown
- 2012-11-28 CN CN201280058800.8A patent/CN104053652A/zh active Pending
- 2012-11-28 DK DK12798549.7T patent/DK2785706T3/en active
- 2012-11-28 UA UAA201407175A patent/UA115136C2/uk unknown
- 2012-11-28 GE GEAP201213508A patent/GEP201706695B/en unknown
- 2012-11-28 SG SG11201402044XA patent/SG11201402044XA/en unknown
- 2012-11-28 HU HUE12798549A patent/HUE032288T2/hu unknown
- 2012-11-28 KR KR1020147017431A patent/KR101979050B1/ko active IP Right Grant
- 2012-11-28 CN CN202110222524.5A patent/CN112961104A/zh active Pending
- 2012-11-28 ME MEP-2016-283A patent/ME02561B/me unknown
- 2012-11-28 RS RS20161103A patent/RS55448B1/sr unknown
- 2012-11-28 CN CN202010607408.0A patent/CN111662330B/zh active Active
- 2012-11-28 IN IN4907CHN2014 patent/IN2014CN04907A/en unknown
- 2012-11-28 AP AP2014007729A patent/AP2014007729A0/xx unknown
- 2012-11-28 CN CN202110222556.5A patent/CN112979543A/zh active Pending
- 2012-11-28 PE PE2014000630A patent/PE20141421A1/es active IP Right Grant
- 2012-11-29 AR ARP120104473A patent/AR089019A1/es active IP Right Grant
- 2012-11-29 TW TW101144681A patent/TWI638806B/zh active
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2013
- 2013-04-17 US US13/864,381 patent/US8895586B2/en active Active
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2014
- 2014-04-18 TN TNP2014000165A patent/TN2014000165A1/en unknown
- 2014-05-13 NI NI201400043A patent/NI201400043A/es unknown
- 2014-05-15 CL CL2014001280A patent/CL2014001280A1/es unknown
- 2014-05-26 GT GT201400102A patent/GT201400102A/es unknown
- 2014-05-28 DO DO2014000115A patent/DOP2014000115A/es unknown
- 2014-05-28 IL IL232859A patent/IL232859B/en active IP Right Grant
- 2014-05-28 PH PH12014501199A patent/PH12014501199B1/en unknown
- 2014-06-05 EC ECIEPI20143642A patent/ECSP14003642A/es unknown
- 2014-06-20 CO CO14134660A patent/CO6990728A2/es unknown
- 2014-06-25 MA MA37152A patent/MA35836B1/fr unknown
- 2014-06-27 ZA ZA2014/04787A patent/ZA201404787B/en unknown
- 2014-06-27 CR CR20140312A patent/CR20140312A/es unknown
- 2014-10-15 JP JP2014210716A patent/JP6023146B2/ja active Active
- 2014-12-15 HK HK14112566.3A patent/HK1199030A1/zh unknown
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2016
- 2016-02-25 JP JP2016034427A patent/JP6074083B2/ja active Active
- 2016-06-28 US US15/194,984 patent/US9908907B2/en active Active
- 2016-12-09 CY CY20161101278T patent/CY1118416T1/el unknown
- 2016-12-13 HR HRP20161708TT patent/HRP20161708T1/hr unknown
- 2016-12-22 SM SM201600467T patent/SMT201600467B/it unknown
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2018
- 2018-01-18 US US15/874,325 patent/US10208073B2/en active Active
- 2018-12-21 US US16/228,835 patent/US10717721B2/en active Active
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2020
- 2020-06-08 US US16/896,135 patent/US11312698B2/en active Active
- 2020-06-16 LT LTPA2020510C patent/LTC2785706I2/lt unknown
- 2020-06-18 NL NL301047C patent/NL301047I2/nl unknown
- 2020-07-03 FR FR20C1029C patent/FR20C1029I2/fr active Active
- 2020-07-03 CY CY2020017C patent/CY2020017I2/el unknown
- 2020-08-18 HU HUS2000032C patent/HUS2000032I1/hu unknown
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2022
- 2022-03-21 US US17/699,522 patent/US20220401463A1/en active Pending
