JP2014505734A5 - - Google Patents

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Publication number
JP2014505734A5
JP2014505734A5 JP2013554588A JP2013554588A JP2014505734A5 JP 2014505734 A5 JP2014505734 A5 JP 2014505734A5 JP 2013554588 A JP2013554588 A JP 2013554588A JP 2013554588 A JP2013554588 A JP 2013554588A JP 2014505734 A5 JP2014505734 A5 JP 2014505734A5
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JP
Japan
Prior art keywords
alkylene
alkyl
compound according
halo
benzyl
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JP2013554588A
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English (en)
Japanese (ja)
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JP2014505734A (ja
JP5959066B2 (ja
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Priority claimed from PCT/US2012/025369 external-priority patent/WO2012154249A1/en
Publication of JP2014505734A publication Critical patent/JP2014505734A/ja
Publication of JP2014505734A5 publication Critical patent/JP2014505734A5/ja
Application granted granted Critical
Publication of JP5959066B2 publication Critical patent/JP5959066B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2013554588A 2011-02-17 2012-02-16 ネプリライシン阻害剤としての置換アミノ酪酸誘導体 Expired - Fee Related JP5959066B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161443828P 2011-02-17 2011-02-17
US61/443,828 2011-02-17
PCT/US2012/025369 WO2012154249A1 (en) 2011-02-17 2012-02-16 Substituted aminobutyric derivatives as neprilysin inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015246947A Division JP2016094453A (ja) 2011-02-17 2015-12-18 ネプリライシン阻害剤としての置換アミノ酪酸誘導体

Publications (3)

Publication Number Publication Date
JP2014505734A JP2014505734A (ja) 2014-03-06
JP2014505734A5 true JP2014505734A5 (cg-RX-API-DMAC7.html) 2015-04-02
JP5959066B2 JP5959066B2 (ja) 2016-08-02

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ID=45814662

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013554588A Expired - Fee Related JP5959066B2 (ja) 2011-02-17 2012-02-16 ネプリライシン阻害剤としての置換アミノ酪酸誘導体
JP2015246947A Withdrawn JP2016094453A (ja) 2011-02-17 2015-12-18 ネプリライシン阻害剤としての置換アミノ酪酸誘導体

Family Applications After (1)

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JP2015246947A Withdrawn JP2016094453A (ja) 2011-02-17 2015-12-18 ネプリライシン阻害剤としての置換アミノ酪酸誘導体

Country Status (5)

Country Link
US (5) US8449890B2 (cg-RX-API-DMAC7.html)
EP (1) EP2675792B1 (cg-RX-API-DMAC7.html)
JP (2) JP5959066B2 (cg-RX-API-DMAC7.html)
ES (1) ES2564275T3 (cg-RX-API-DMAC7.html)
WO (1) WO2012154249A1 (cg-RX-API-DMAC7.html)

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EP3048100A1 (en) 2009-05-28 2016-07-27 Novartis AG Substituted aminobutyric derivatives as neprilysin inhibitors
HRP20151115T1 (en) 2010-12-15 2015-11-20 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
BR112013014952A2 (pt) 2010-12-15 2017-05-30 Theravance Inc inibidores de neprilisina
WO2012154249A1 (en) 2011-02-17 2012-11-15 Theravance, Inc. Substituted aminobutyric derivatives as neprilysin inhibitors
EP2675795B1 (en) 2011-02-17 2016-04-20 Theravance Biopharma R&D IP, LLC Substituted aminobutyric derivatives as neprilysin inhibitors
JP5959074B2 (ja) 2011-05-31 2016-08-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤
EP2714660B1 (en) 2011-05-31 2018-09-26 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
CN104350052B (zh) 2012-05-31 2017-05-31 施万生物制药研发Ip有限责任公司 一氧化氮供体脑啡肽酶抑制剂
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RU2726623C2 (ru) 2015-02-11 2020-07-15 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи (2s,4r)-5-(5'-хлор-2'-фторбифенил-4-ил)-4-(этоксиоксалиламино)-2-гидроксиметил-2-метилпентановая кислота
RU2715241C2 (ru) 2015-02-19 2020-02-26 ТЕРЕВАНС БАЙОФАРМА Ар энд Ди АйПи, ЭлЭлСи (2r,4r)-5-(5′-хлор-2′-фторбифенил-4-ил)-2-гидрокси-4-[(5-метилоксазол-2-карбонил)амино]пентановая кислота
US10100021B2 (en) 2016-03-08 2018-10-16 Theravance Biopharma R&D Ip, Llc Crystalline(2S,4R)-5-(5′-chloro-2′-fluoro-[1,1′-biphenyl]-4-yl)-2-(ethoxymethyl)-4-(3-hydroxyisoxazole-5-carboxamido)-2-methylpentanoic acid and uses thereof
CN106905348B (zh) * 2017-02-13 2018-12-04 牡丹江医学院 一种预防和治疗急性肾损伤的药物及其制备方法和用途
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CN111630005A (zh) 2018-01-03 2020-09-04 埃科莱布美国股份有限公司 作为腐蚀抑制剂的苯并三唑衍生物
UY38072A (es) 2018-02-07 2019-10-01 Novartis Ag Compuestos derivados de éster butanoico sustituido con bisfenilo como inhibidores de nep, composiciones y combinaciones de los mismos

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EP3048100A1 (en) 2009-05-28 2016-07-27 Novartis AG Substituted aminobutyric derivatives as neprilysin inhibitors
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HRP20151115T1 (en) * 2010-12-15 2015-11-20 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
BR112013014952A2 (pt) * 2010-12-15 2017-05-30 Theravance Inc inibidores de neprilisina
WO2012154249A1 (en) 2011-02-17 2012-11-15 Theravance, Inc. Substituted aminobutyric derivatives as neprilysin inhibitors
EP2675795B1 (en) 2011-02-17 2016-04-20 Theravance Biopharma R&D IP, LLC Substituted aminobutyric derivatives as neprilysin inhibitors
EP2714660B1 (en) 2011-05-31 2018-09-26 Theravance Biopharma R&D IP, LLC Neprilysin inhibitors
JP5959074B2 (ja) 2011-05-31 2016-08-02 セラヴァンス バイオファーマ アール＆ディー アイピー， エルエルシー ネプリライシン阻害剤
CN103748070B (zh) 2011-05-31 2015-06-24 施万生物制药研发Ip有限责任公司 脑啡肽酶抑制剂
TWI560172B (en) 2011-11-02 2016-12-01 Theravance Biopharma R&D Ip Llc Neprilysin inhibitors
CN104350052B (zh) 2012-05-31 2017-05-31 施万生物制药研发Ip有限责任公司 一氧化氮供体脑啡肽酶抑制剂
RS55967B1 (sr) 2012-06-08 2017-09-29 Theravance Biopharma R&D Ip Llc Inhibitori neprilizina
CA2873328A1 (en) 2012-06-08 2013-12-12 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors
SMT201700134T1 (it) 2012-08-08 2017-05-08 Theravance Biopharma R&D Ip Llc Inibitori della neprilisina
WO2014138053A1 (en) 2013-03-05 2014-09-12 Theravance Biopharma R&D Ip, Llc Neprilysin inhibitors

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