JP2014505594A5 - - Google Patents

Download PDF

Info

Publication number
JP2014505594A5
JP2014505594A5 JP2013552712A JP2013552712A JP2014505594A5 JP 2014505594 A5 JP2014505594 A5 JP 2014505594A5 JP 2013552712 A JP2013552712 A JP 2013552712A JP 2013552712 A JP2013552712 A JP 2013552712A JP 2014505594 A5 JP2014505594 A5 JP 2014505594A5
Authority
JP
Japan
Prior art keywords
microfluidic channel
microfluidic
droplet
inlet
cross
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2013552712A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014505594A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2012/023961 external-priority patent/WO2012109138A1/en
Publication of JP2014505594A publication Critical patent/JP2014505594A/ja
Publication of JP2014505594A5 publication Critical patent/JP2014505594A5/ja
Pending legal-status Critical Current

Links

JP2013552712A 2011-02-07 2012-02-06 液滴を分裂させるためのシステムおよび方法 Pending JP2014505594A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161440198P 2011-02-07 2011-02-07
US61/440,198 2011-02-07
PCT/US2012/023961 WO2012109138A1 (en) 2011-02-07 2012-02-06 Systems and methods for splitting droplets

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016148580A Division JP2016224057A (ja) 2011-02-07 2016-07-28 液滴を分裂させるためのシステムおよび方法

Publications (2)

Publication Number Publication Date
JP2014505594A JP2014505594A (ja) 2014-03-06
JP2014505594A5 true JP2014505594A5 (https=) 2015-03-26

Family

ID=45774321

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2013552712A Pending JP2014505594A (ja) 2011-02-07 2012-02-06 液滴を分裂させるためのシステムおよび方法
JP2016148580A Pending JP2016224057A (ja) 2011-02-07 2016-07-28 液滴を分裂させるためのシステムおよび方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016148580A Pending JP2016224057A (ja) 2011-02-07 2016-07-28 液滴を分裂させるためのシステムおよび方法

Country Status (7)

Country Link
US (1) US20140026968A1 (https=)
EP (1) EP2673088A1 (https=)
JP (2) JP2014505594A (https=)
KR (1) KR20140063507A (https=)
CN (2) CN105689030A (https=)
BR (1) BR112013019880A2 (https=)
WO (1) WO2012109138A1 (https=)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL229042B1 (pl) * 2011-09-30 2018-06-29 Inst Chemii Fizycznej Polskiej Akademii Nauk Sposób dzielenia kropel w złączu mikroprzepływowym i układ do dzielenia kropel w złączu mikroprzepływowym
WO2013119753A1 (en) 2012-02-08 2013-08-15 President And Fellows Of Harvard College Droplet formation using fluid breakup
DE102012217487A1 (de) * 2012-09-26 2014-04-17 Agilent Technologies, Inc. - A Delaware Corporation - Fluidschnittstelle zwischen Fluidleitungen unterschiedlicher Querschnitte
CN108212237B (zh) * 2013-03-06 2020-12-08 哈佛学院院长及董事 形成相对单分散液滴的装置和方法
CN103285946A (zh) * 2013-05-27 2013-09-11 苏州扬清芯片科技有限公司 一种生物芯片及其操控方法
CN103285947A (zh) * 2013-05-27 2013-09-11 苏州扬清芯片科技有限公司 一种液滴微流控芯片及其操控方法
WO2015112985A1 (en) * 2014-01-24 2015-07-30 The Johns Hopkins University System and device for high throughput generation of combinatorial droplets and methods of use
CN105478177A (zh) * 2014-09-18 2016-04-13 苏州贝和医疗科技有限公司 一种用于数字pcr的液滴生成装置及方法
US10178027B2 (en) * 2016-01-27 2019-01-08 Oracle International Corporation System and method for supporting inter subnet partitions in a high performance computing environment
US10171353B2 (en) * 2016-03-04 2019-01-01 Oracle International Corporation System and method for supporting dual-port virtual router in a high performance computing environment
JP2019514002A (ja) * 2016-04-15 2019-05-30 プレジデント アンド フェローズ オブ ハーバード カレッジ 液滴および／または他の実体の収集のためのシステムおよび方法
US10143129B2 (en) * 2017-02-27 2018-12-04 Cnh Industrial Canada, Ltd. Flow splitter for distributing agricultural products and related system
US10408852B2 (en) * 2017-04-26 2019-09-10 Lawrence Livermore National Security, Llc Automated control of microfluidic devices based on machine learning
CN107323090B (zh) * 2017-07-27 2019-01-18 京东方科技集团股份有限公司 一种打印喷头、打印设备及打印方法
CN107754960B (zh) * 2017-10-26 2019-09-03 北京工业大学 基于附加流量实现双乳液滴非对称分裂的微流控芯片
DE102018203047A1 (de) * 2018-03-01 2019-09-05 Robert Bosch Gmbh Mikrofluidische Vorrichtung
CN112399882B (zh) 2018-04-16 2023-08-01 派特恩生物技术有限公司 用于形成二维微滴阵列的方法和设备
CN108956558B (zh) * 2018-05-24 2023-09-15 深圳市帝迈生物技术有限公司 一种微流控芯片和免疫荧光分析仪
US11703427B2 (en) * 2018-06-25 2023-07-18 10X Genomics, Inc. Methods and systems for cell and bead processing
US10486155B1 (en) * 2018-10-22 2019-11-26 Klaris Corporation Vacuum-loaded, droplet-generating microfluidic chips and related methods
CN109289951B (zh) * 2018-10-29 2021-01-05 深圳先进技术研究院 液滴分裂微流控芯片及应用
JP6761153B1 (ja) * 2019-03-20 2020-09-23 京セラ株式会社 粒子計測デバイスならびに粒子分離計測デバイスおよび粒子分離計測装置
CN111821927B (zh) * 2019-04-17 2021-12-07 北京大学 一种制备微/纳结构材料的方法及装置
CN112108192B (zh) * 2019-06-19 2022-03-22 中国科学院大连化学物理研究所 一种微流控芯片及其应用
EP3763438A1 (en) * 2019-07-12 2021-01-13 Curiosity Diagnostics sp. z o.o Microfluidic chip, production process and uses
CN110449195A (zh) * 2019-09-05 2019-11-15 北京工业大学 一种提高液滴在不对称通道分裂均匀度的装置
CN110643488A (zh) * 2019-09-27 2020-01-03 晶准生物医学（深圳）有限公司 微流控液滴操纵分割装置及其操纵分割方法
CN113811389B (zh) * 2020-02-28 2023-04-11 京东方科技集团股份有限公司 一种微流控芯片和微流控系统
CN111537398B (zh) * 2020-05-29 2021-10-15 河南农业大学 一种控制液滴撞击形态、接触时间及液滴可控分裂的方法
EP4208291B1 (en) * 2020-09-02 2025-11-05 10X Genomics, Inc. Devices, systems, and methods for high throughput droplet formation
EP4154972B1 (en) * 2021-09-24 2024-11-20 KIST-Europe Forschungsgesellschaft mbH Monodisperse microdroplet producing device and method of producing the same
EP4180123A1 (en) * 2021-11-12 2023-05-17 Ecole Polytechnique Fédérale de Lausanne (EPFL) EPFL-TTO Microfluidic device for sample encapsulation and method for operation thereof
CN114534811B (zh) * 2022-02-28 2024-10-18 上海天马微电子有限公司 微流控装置及其制作方法
CN115254217B (zh) * 2022-07-27 2023-12-01 领航基因科技（杭州）有限公司 液滴制备装置及方法
CN117205975A (zh) * 2022-10-20 2023-12-12 中国科学技术大学 一种基于约束圆的微流控芯片分叉结构及通用设计方法
CN118892767A (zh) * 2024-07-16 2024-11-05 四川大学 并行多级分裂倍增微流控装置及单分散双重乳液的高通量制备方法
CN119657247B (zh) * 2025-01-20 2025-10-10 中国工程物理研究院激光聚变研究中心 一种基于液滴分裂制备单固核固水油液滴的方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2422804A (en) 1946-01-26 1947-06-24 Walter H Schroeder Kite
US5862808A (en) 1997-08-26 1999-01-26 Cigar Savor Enterprises Llc Cigar punch
WO2001088525A1 (en) * 2000-05-12 2001-11-22 University Of Cincinnati Structurally programmable microfluidic systems
US7901939B2 (en) * 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
JP2006507921A (ja) * 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
US20060078893A1 (en) * 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
AU2004229440B2 (en) 2003-04-10 2010-08-12 President And Fellows Of Harvard College Formation and control of fluidic species
DE112004001376D2 (de) * 2003-05-19 2006-04-13 Knoell Hans Forschung Ev Vorrichtung und Verfahren zur Strukturierung von Flüssigkeiten und zum zudosieren von Reaktionsflüssigkeiten zu in Separationsmedium eingebetteten Flüssigkeitskompartimenten
WO2005021151A1 (en) * 2003-08-27 2005-03-10 President And Fellows Of Harvard College Electronic control of fluidic species
US20050221339A1 (en) * 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7655470B2 (en) * 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
US7968287B2 (en) * 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
WO2006096571A2 (en) 2005-03-04 2006-09-14 President And Fellows Of Harvard College Method and apparatus for forming multiple emulsions
FR2890578B3 (fr) * 2005-09-09 2007-11-30 Rhodia Chimie Sa Dispositif d'ecoulement microfluidique permettant de determiner des parametres d'une transformation physique et/ ou chimique, et son utilisation
US7915030B2 (en) * 2005-09-01 2011-03-29 Canon U.S. Life Sciences, Inc. Method and molecular diagnostic device for detection, analysis and identification of genomic DNA
TWI296711B (en) * 2005-10-11 2008-05-11 Ind Tech Res Inst Biochip with microchannels
EP1861914B1 (en) 2005-10-24 2008-12-03 Conergy AG Inverter
CN102102197B (zh) 2005-12-06 2014-04-16 荏原优莱特科技股份有限公司 钯配合物以及使用该配合物的催化剂赋予处理液
US7811603B2 (en) * 2006-05-09 2010-10-12 The Regents Of The University Of California Microfluidic device for forming monodisperse lipoplexes
EP2530167A1 (en) * 2006-05-11 2012-12-05 Raindance Technologies, Inc. Microfluidic Devices
WO2008063135A1 (en) * 2006-11-24 2008-05-29 Agency For Science, Technology And Research Apparatus for processing a sample in a liquid droplet and method of using the same
EP2136786B8 (en) 2007-03-28 2012-11-14 President and Fellows of Harvard College Apparatus for forming droplets
EP2183408A2 (en) 2007-08-07 2010-05-12 President And Fellows Of Harvard College Metal oxide coating on surfaces
JP2011515236A (ja) 2008-03-28 2011-05-19 プレジデント アンド フェローズ オブ ハーバード カレッジ 制御された濡れ特性を有するマイクロ流体チャネルを含む表面
CN102124259B (zh) 2008-05-16 2015-12-16 哈佛大学 在包含微流体系统的流体系统中的阀和其它流动控制
US8093501B2 (en) 2008-06-11 2012-01-10 Stansberry Jr David L Universal variable transmission line hanger
JP5553428B2 (ja) * 2008-08-27 2014-07-16 Ｎｓマテリアルズ株式会社 ペプチドポリマーの製造方法
EP2340435A1 (en) * 2008-10-08 2011-07-06 Université de Strasbourg Microfluidic devices for reliable on-chip incubation of droplets in delay lines
WO2010104604A1 (en) 2009-03-13 2010-09-16 President And Fellows Of Harvard College Method for the controlled creation of emulsions, including multiple emulsions
US9625454B2 (en) * 2009-09-04 2017-04-18 The Research Foundation For The State University Of New York Rapid and continuous analyte processing in droplet microfluidic devices
JP4973721B2 (ja) * 2009-12-07 2012-07-11 東ソー株式会社 微小粒子構造体およびそれを用いた微小粒子の製造方法
TWI499552B (zh) * 2012-12-07 2015-09-11 Univ Nat Cheng Kung 液滴產生方法及裝置
US20140161686A1 (en) * 2012-12-10 2014-06-12 Advanced Liquid Logic, Inc. System and method of dispensing liquids in a microfluidic device
US11141730B2 (en) * 2013-06-14 2021-10-12 President And Fellows Of Harvard College Coalescence of droplets
EP3039119A4 (en) * 2013-08-27 2017-04-05 GnuBIO, Inc. Microfluidic devices and methods of their use

Similar Documents

Publication Publication Date Title
JP2014505594A5 (https=)
Liu et al. Lattice Boltzmann phase-field modeling of thermocapillary flows in a confined microchannel
Jose et al. Droplet arrangement and coalescence in diverging/converging microchannels
JP2013503743A5 (https=)
Wu et al. Anti-synchronization control of a class of memristive recurrent neural networks
Erb et al. Predicting sizes of droplets made by microfluidic flow-induced dripping
BR112013019880A2 (pt) sistemas e métodos para dividir gotículas
JP2016515214A5 (https=)
JP2018502700A5 (https=)
JP2014039534A5 (https=)
CA2931582C (en) Microfluidic cartridge for molecular diagnosis, docking station using such a microfluidic cartridge, and process for analyzing a biological sample
WO2013160408A3 (en) Microfluidic device for performing operations on microdroplets
JP2010531730A5 (https=)
CN105170207B (zh) 一种基于支路结构的微液滴控制芯片
WO2012154688A3 (en) Methods and devices to control fluid volumes, reagent and particle concentration in arrays of microfluidic drops
CN104525286A (zh) 基于t型通道实现液滴同步融合的微流控芯片
WO2011119994A3 (en) Devices, systems, and methods for amplifying nucleic acids
JP2016509969A5 (https=)
WO2011028760A3 (en) Multiple emulsions created using junctions
WO2015047502A3 (en) Systems, apparatus, and methods for droplet-based microfluidics cell poration
WO2014159204A3 (en) Thrombectomy catheters, systems and methods
JP2014534353A5 (https=)
Kushnir et al. Inclined two-layered stratified channel flows: Long wave stability analysis of multiple solution regions
WO2015019336A3 (en) Fluid triggable valves
WO2014025973A3 (en) High definition nanomaterials