JP2014505594A5 - - Google Patents

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JP2014505594A5
JP2014505594A5 JP2013552712A JP2013552712A JP2014505594A5 JP 2014505594 A5 JP2014505594 A5 JP 2014505594A5 JP 2013552712 A JP2013552712 A JP 2013552712A JP 2013552712 A JP2013552712 A JP 2013552712A JP 2014505594 A5 JP2014505594 A5 JP 2014505594A5
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JP
Japan
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microfluidic channel
microfluidic
droplet
inlet
cross
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JP2013552712A
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English (en)
Japanese (ja)
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JP2014505594A (ja
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Priority claimed from PCT/US2012/023961 external-priority patent/WO2012109138A1/en
Publication of JP2014505594A publication Critical patent/JP2014505594A/ja
Publication of JP2014505594A5 publication Critical patent/JP2014505594A5/ja
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JP2013552712A 2011-02-07 2012-02-06 液滴を分裂させるためのシステムおよび方法 Pending JP2014505594A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161440198P 2011-02-07 2011-02-07
US61/440,198 2011-02-07
PCT/US2012/023961 WO2012109138A1 (en) 2011-02-07 2012-02-06 Systems and methods for splitting droplets

Related Child Applications (1)

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JP2016148580A Division JP2016224057A (ja) 2011-02-07 2016-07-28 液滴を分裂させるためのシステムおよび方法

Publications (2)

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JP2014505594A JP2014505594A (ja) 2014-03-06
JP2014505594A5 true JP2014505594A5 (cg-RX-API-DMAC7.html) 2015-03-26

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JP2013552712A Pending JP2014505594A (ja) 2011-02-07 2012-02-06 液滴を分裂させるためのシステムおよび方法
JP2016148580A Pending JP2016224057A (ja) 2011-02-07 2016-07-28 液滴を分裂させるためのシステムおよび方法

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JP2016148580A Pending JP2016224057A (ja) 2011-02-07 2016-07-28 液滴を分裂させるためのシステムおよび方法

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US (1) US20140026968A1 (cg-RX-API-DMAC7.html)
EP (1) EP2673088A1 (cg-RX-API-DMAC7.html)
JP (2) JP2014505594A (cg-RX-API-DMAC7.html)
KR (1) KR20140063507A (cg-RX-API-DMAC7.html)
CN (2) CN105689030A (cg-RX-API-DMAC7.html)
BR (1) BR112013019880A2 (cg-RX-API-DMAC7.html)
WO (1) WO2012109138A1 (cg-RX-API-DMAC7.html)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL229042B1 (pl) * 2011-09-30 2018-06-29 Inst Chemii Fizycznej Polskiej Akademii Nauk Sposób dzielenia kropel w złączu mikroprzepływowym i układ do dzielenia kropel w złączu mikroprzepływowym
JP2015513451A (ja) 2012-02-08 2015-05-14 プレジデント アンド フェローズ オブ ハーバード カレッジ 流体分割を用いる液滴形成
DE102012217487A1 (de) * 2012-09-26 2014-04-17 Agilent Technologies, Inc. - A Delaware Corporation - Fluidschnittstelle zwischen Fluidleitungen unterschiedlicher Querschnitte
EP2964390B1 (en) * 2013-03-06 2018-12-26 President and Fellows of Harvard College Use of devices for forming relatively monodisperse droplets
CN103285946A (zh) * 2013-05-27 2013-09-11 苏州扬清芯片科技有限公司 一种生物芯片及其操控方法
CN103285947A (zh) * 2013-05-27 2013-09-11 苏州扬清芯片科技有限公司 一种液滴微流控芯片及其操控方法
ES2876264T3 (es) * 2014-01-24 2021-11-12 Univ Johns Hopkins Sistema y dispositivo para la generación de gotitas combinatorias de alto rendimiento
CN105478177A (zh) * 2014-09-18 2016-04-13 苏州贝和医疗科技有限公司 一种用于数字pcr的液滴生成装置及方法
US10355992B2 (en) * 2016-01-27 2019-07-16 Oracle International Corporation System and method for supporting router SMA abstractions for SMP connectivity checks across virtual router ports in a high performance computing environment
US10171353B2 (en) * 2016-03-04 2019-01-01 Oracle International Corporation System and method for supporting dual-port virtual router in a high performance computing environment
CN109311010B (zh) * 2016-04-15 2022-05-17 哈佛学院院长及董事 用于收集液滴或其他实体的系统和方法
US10143129B2 (en) * 2017-02-27 2018-12-04 Cnh Industrial Canada, Ltd. Flow splitter for distributing agricultural products and related system
US10408852B2 (en) 2017-04-26 2019-09-10 Lawrence Livermore National Security, Llc Automated control of microfluidic devices based on machine learning
CN107323090B (zh) * 2017-07-27 2019-01-18 京东方科技集团股份有限公司 一种打印喷头、打印设备及打印方法
CN107754960B (zh) * 2017-10-26 2019-09-03 北京工业大学 基于附加流量实现双乳液滴非对称分裂的微流控芯片
DE102018203047A1 (de) * 2018-03-01 2019-09-05 Robert Bosch Gmbh Mikrofluidische Vorrichtung
WO2019204279A1 (en) 2018-04-16 2019-10-24 Klaris Corporation Methods and apparatus for forming 2-dimensional drop arrays
CN108956558B (zh) * 2018-05-24 2023-09-15 深圳市帝迈生物技术有限公司 一种微流控芯片和免疫荧光分析仪
US11703427B2 (en) * 2018-06-25 2023-07-18 10X Genomics, Inc. Methods and systems for cell and bead processing
US10486155B1 (en) * 2018-10-22 2019-11-26 Klaris Corporation Vacuum-loaded, droplet-generating microfluidic chips and related methods
CN109289951B (zh) * 2018-10-29 2021-01-05 深圳先进技术研究院 液滴分裂微流控芯片及应用
EP3943913A4 (en) * 2019-03-20 2022-12-21 Kyocera Corporation PARTICLE MEASURING DEVICE, PARTICLE SEPARATION AND MEASURING DEVICE AND PARTICLE SEPARATION AND MEASURING DEVICE
CN111821927B (zh) * 2019-04-17 2021-12-07 北京大学 一种制备微/纳结构材料的方法及装置
CN112108192B (zh) * 2019-06-19 2022-03-22 中国科学院大连化学物理研究所 一种微流控芯片及其应用
EP3763438A1 (en) * 2019-07-12 2021-01-13 Curiosity Diagnostics sp. z o.o Microfluidic chip, production process and uses
CN110449195A (zh) * 2019-09-05 2019-11-15 北京工业大学 一种提高液滴在不对称通道分裂均匀度的装置
CN110643488A (zh) * 2019-09-27 2020-01-03 晶准生物医学（深圳）有限公司 微流控液滴操纵分割装置及其操纵分割方法
WO2021168768A1 (zh) * 2020-02-28 2021-09-02 京东方科技集团股份有限公司 一种微流控芯片和微流控系统
CN111537398B (zh) * 2020-05-29 2021-10-15 河南农业大学 一种控制液滴撞击形态、接触时间及液滴可控分裂的方法
WO2022051529A1 (en) * 2020-09-02 2022-03-10 10X Genomics, Inc. Devices, systems, and methods for high throughput droplet formation
EP4180123A1 (en) * 2021-11-12 2023-05-17 Ecole Polytechnique Fédérale de Lausanne (EPFL) EPFL-TTO Microfluidic device for sample encapsulation and method for operation thereof
CN114534811B (zh) * 2022-02-28 2024-10-18 上海天马微电子有限公司 微流控装置及其制作方法
CN115254217B (zh) * 2022-07-27 2023-12-01 领航基因科技（杭州）有限公司 液滴制备装置及方法
CN117205975A (zh) * 2022-10-20 2023-12-12 中国科学技术大学 一种基于约束圆的微流控芯片分叉结构及通用设计方法
CN118892767A (zh) * 2024-07-16 2024-11-05 四川大学 并行多级分裂倍增微流控装置及单分散双重乳液的高通量制备方法
CN119657247B (zh) * 2025-01-20 2025-10-10 中国工程物理研究院激光聚变研究中心 一种基于液滴分裂制备单固核固水油液滴的方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2422804A (en) 1946-01-26 1947-06-24 Walter H Schroeder Kite
US5862808A (en) 1997-08-26 1999-01-26 Cigar Savor Enterprises Llc Cigar punch
AU2001261462A1 (en) * 2000-05-12 2001-11-26 University Of Cincinnati Structurally programmable microfluidic systems
US7901939B2 (en) * 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
JP2006507921A (ja) 2002-06-28 2006-03-09 プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ 流体分散のための方法および装置
US20060078893A1 (en) * 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
EP2127736A1 (en) * 2003-04-10 2009-12-02 The President and Fellows of Harvard College Formation and control of fluidic species
DE112004001376D2 (de) * 2003-05-19 2006-04-13 Knoell Hans Forschung Ev Vorrichtung und Verfahren zur Strukturierung von Flüssigkeiten und zum zudosieren von Reaktionsflüssigkeiten zu in Separationsmedium eingebetteten Flüssigkeitskompartimenten
JP4630870B2 (ja) * 2003-08-27 2011-02-09 プレジデント アンド フェロウズ オブ ハーバード カレッジ 流体種の電子的制御
US20050221339A1 (en) * 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
US7655470B2 (en) * 2004-10-29 2010-02-02 University Of Chicago Method for manipulating a plurality of plugs and performing reactions therein in microfluidic systems
US7968287B2 (en) * 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
WO2006096571A2 (en) 2005-03-04 2006-09-14 President And Fellows Of Harvard College Method and apparatus for forming multiple emulsions
FR2890578B3 (fr) * 2005-09-09 2007-11-30 Rhodia Chimie Sa Dispositif d'ecoulement microfluidique permettant de determiner des parametres d'une transformation physique et/ ou chimique, et son utilisation
US7915030B2 (en) * 2005-09-01 2011-03-29 Canon U.S. Life Sciences, Inc. Method and molecular diagnostic device for detection, analysis and identification of genomic DNA
TWI296711B (en) * 2005-10-11 2008-05-11 Ind Tech Res Inst Biochip with microchannels
DE602005011494D1 (de) 2005-10-24 2009-01-15 Conergy Ag Wechselrichter
WO2007066460A1 (ja) 2005-12-06 2007-06-14 Ebara-Udylite Co., Ltd. パラジウム錯体およびこれを利用する触媒付与処理液
US7811603B2 (en) * 2006-05-09 2010-10-12 The Regents Of The University Of California Microfluidic device for forming monodisperse lipoplexes
ATE540750T1 (de) * 2006-05-11 2012-01-15 Raindance Technologies Inc Mikrofluidische vorrichtung und verfahren
WO2008063135A1 (en) * 2006-11-24 2008-05-29 Agency For Science, Technology And Research Apparatus for processing a sample in a liquid droplet and method of using the same
CN102014871A (zh) 2007-03-28 2011-04-13 哈佛大学 乳液及其形成技术
US8883291B2 (en) 2007-08-07 2014-11-11 President And Fellows Of Harvard College Metal oxide coating on surfaces
JP2011515236A (ja) 2008-03-28 2011-05-19 プレジデント アンド フェローズ オブ ハーバード カレッジ 制御された濡れ特性を有するマイクロ流体チャネルを含む表面
CN105344389B (zh) 2008-05-16 2018-01-02 哈佛大学 微流体系统、方法和装置
US8093501B2 (en) 2008-06-11 2012-01-10 Stansberry Jr David L Universal variable transmission line hanger
JP5553428B2 (ja) * 2008-08-27 2014-07-16 Ｎｓマテリアルズ株式会社 ペプチドポリマーの製造方法
WO2010042744A1 (en) * 2008-10-08 2010-04-15 Universite De Strasbourg Microfluidic devices for reliable on-chip incubation of droplets in delay lines
WO2010104604A1 (en) 2009-03-13 2010-09-16 President And Fellows Of Harvard College Method for the controlled creation of emulsions, including multiple emulsions
US9625454B2 (en) * 2009-09-04 2017-04-18 The Research Foundation For The State University Of New York Rapid and continuous analyte processing in droplet microfluidic devices
JP4973721B2 (ja) * 2009-12-07 2012-07-11 東ソー株式会社 微小粒子構造体およびそれを用いた微小粒子の製造方法
TWI499552B (zh) * 2012-12-07 2015-09-11 Univ Nat Cheng Kung 液滴產生方法及裝置
US20140161686A1 (en) * 2012-12-10 2014-06-12 Advanced Liquid Logic, Inc. System and method of dispensing liquids in a microfluidic device
WO2014201196A2 (en) * 2013-06-14 2014-12-18 President And Fellows Of Harvard College Coalescence of droplets
WO2015031528A1 (en) * 2013-08-27 2015-03-05 Gnubio, Inc. Microfluidic devices and methods of their use

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