|
HUE033581T2
(hu)
|
2010-06-10 |
2017-12-28 |
Seragon Pharmaceuticals Inc |
Ösztrogén receptor modulátorok és alkalmazásaik
|
|
US8853423B2
(en)
|
2010-06-17 |
2014-10-07 |
Seragon Pharmaceuticals, Inc. |
Indane estrogen receptor modulators and uses thereof
|
|
SG11201403002RA
(en)
|
2011-12-14 |
2014-07-30 |
Seragon Pharmaceuticals Inc |
Fluorinated estrogen receptor modulators and uses thereof
|
|
HUE039052T2
(hu)
|
2013-02-19 |
2018-12-28 |
Novartis Ag |
Benzotiofénszármazékok és azok készítményei szelektív ösztrogén receptor lebontóként
|
|
CN117865872A
(zh)
|
2014-12-18 |
2024-04-12 |
豪夫迈·罗氏有限公司 |
四氢-吡啶并[3,4-b]吲哚雌激素受体调节剂及其用途
|
|
WO2016174551A1
(en)
*
|
2015-04-27 |
2016-11-03 |
Pfizer Inc. |
Anti-estrogenic compounds
|
|
DK3355884T3
(da)
|
2015-10-01 |
2021-08-02 |
Olema Pharmaceuticals Inc |
Tetrahydro-1h-pyrido[3,4-b]indol-antiøstrogenlægemidler
|
|
CN108349952A
(zh)
*
|
2015-11-09 |
2018-07-31 |
豪夫迈·罗氏有限公司 |
四氢萘雌激素受体调节剂及其用途
|
|
ES2935125T3
(es)
|
2015-12-09 |
2023-03-01 |
Univ Illinois |
Reguladores a la baja selectivos de los receptores de estrógenos con base en benzotiofeno
|
|
AU2017221083B2
(en)
*
|
2016-02-15 |
2021-06-24 |
Sanofi |
6,7-dihydro-5H-benzo[7]annulene derivatives as estrogen receptor modulators
|
|
US9969732B2
(en)
*
|
2016-04-08 |
2018-05-15 |
Genentech, Inc. |
Tetrahydroisoquinoline estrogen receptor modulators and uses thereof
|
|
EP3455219A4
(en)
|
2016-05-10 |
2019-12-18 |
C4 Therapeutics, Inc. |
AMINE-RELATED C3-GLUTARIMIDE DEGRONIMERS FOR TARGET PROTEIN REDUCTION
|
|
CN109641874A
(zh)
|
2016-05-10 |
2019-04-16 |
C4医药公司 |
用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
|
|
EP4483875A3
(en)
|
2016-05-10 |
2025-04-02 |
C4 Therapeutics, Inc. |
Spirocyclic degronimers for target protein degradation
|
|
CN109562107A
(zh)
|
2016-05-10 |
2019-04-02 |
C4医药公司 |
用于靶蛋白降解的杂环降解决定子体
|
|
BR112018077136A2
(pt)
|
2016-07-01 |
2019-04-30 |
G1 Therapeutics, Inc. |
composto, e, métodos para tratar um distúrbio associado com proliferação celular anormal e para reduzir o efeito de quimioterapia em células saudáveis.
|
|
WO2018081168A2
(en)
|
2016-10-24 |
2018-05-03 |
The Board Of Trustees Of The University Of Illinois |
Benzothiophene-based selective mixed estrogen receptor downregulators
|
|
JOP20190090B1
(ar)
*
|
2016-10-24 |
2023-03-28 |
Astrazeneca Ab |
مشتقات 9،8،7،6-رابع هيدرو-3h-بيرازولو [4،3-f]أيزوكينولين مفيدة في علاج السرطان
|
|
SG11201903908PA
(en)
|
2016-11-17 |
2019-05-30 |
Sanofi Sa |
Novel substituted n-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof
|
|
AR110728A1
(es)
|
2017-01-06 |
2019-04-24 |
G1 Therapeutics Inc |
Terapia combinada para el tratamiento del cáncer
|
|
WO2018138739A1
(en)
|
2017-01-27 |
2018-08-02 |
Sun Pharma Advanced Research Company Limited |
Novel antiestrogenic heterocyclic compounds
|
|
TW201835064A
(zh)
|
2017-02-10 |
2018-10-01 |
美商G1治療公司 |
苯并噻吩雌激素受體調節劑
|
|
GB201706806D0
(en)
|
2017-04-28 |
2017-06-14 |
Sentinel Oncology Ltd |
Pharmaceutical compounds
|
|
EP3641762B1
(en)
|
2017-06-20 |
2026-02-18 |
C4 Therapeutics, Inc. |
N/o-linked degrons and degronimers for protein degradation
|
|
CA3067873A1
(en)
|
2017-06-29 |
2019-01-03 |
G1 Therapeutics, Inc. |
Morphic forms of g1t38 and methods of manufacture thereof
|
|
EP3434272A1
(en)
|
2017-07-25 |
2019-01-30 |
Sanofi |
Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid
|
|
WO2019157020A1
(en)
|
2018-02-06 |
2019-08-15 |
The Board Of Trustees Of The University Of Illinois |
Substituted benzothiophene analogs as selective estrogen receptor degraders
|
|
TWI915239B
(zh)
|
2018-06-21 |
2026-02-11 |
瑞士商赫孚孟拉羅股份公司 |
3-((1r,3r)-1-(2,6-二氟-4-((1-(3-氟丙基)氮雜環丁-3-基)胺基)苯基)-3-甲基-1,3,4,9-四氫-2h-吡啶并[3,4-b]吲哚-2-基)-2,2-二氟丙-1-醇之固體形式及用於製備包含經取代苯基或吡啶基部分之稠合三環化合物之製程,包括其使用方法
|
|
ES2923412T3
(es)
|
2018-09-07 |
2022-09-27 |
Sanofi Sa |
Sales de 6-(2,4-diclorofenil)-5-[4-[(3S)-1-(3-fluoropropil)pirrolidin-3-il]oxifenil]-8,9-dihidro-7H-benzo[7]anuleno-2-carboxilato de metilo y proceso de preparación de las mismas
|
|
CN120698983A
(zh)
|
2018-12-20 |
2025-09-26 |
C4医药公司 |
靶向蛋白降解
|
|
CA3144791A1
(en)
|
2019-07-07 |
2021-01-14 |
Olema Pharmaceuticals, Inc. |
Regimens of estrogen receptor antagonists
|
|
JP7680438B2
(ja)
|
2019-10-01 |
2025-05-20 |
サノフイ |
新規の置換6,7-ジヒドロ-5h-ベンゾ[7]アンヌレン化合物、その製造方法およびその治療的使用
|
|
BR112022009705A2
(pt)
|
2019-12-09 |
2022-08-09 |
Sanofi Sa |
Forma cristalina anidra de um derivado de ácido 7h-benzo[7]anuleno-2-carboxílico, seus usos e processos de preparação, forma sólida, medicamento e composição farmacêutica
|
|
EP4681715A3
(en)
|
2019-12-20 |
2026-01-28 |
C4 Therapeutics, Inc. |
Isoindolinone and indazole compounds for the degradation of egfr
|
|
TW202146007A
(zh)
|
2020-02-27 |
2021-12-16 |
法商賽諾菲公司 |
包含阿培利司(alpelisib)與6-(2,4-二氯苯基)-5-[4-[(3s)-1-(3-氟丙基)吡咯啶-3-基]氧苯基]-8,9-二氫-7h-苯并[7]輪烯-2-羧酸之組合
|
|
IL295709A
(en)
|
2020-03-05 |
2022-10-01 |
C4 Therapeutics Inc |
Compounds for targeted degradation of brd9
|
|
MX2022010425A
(es)
|
2020-03-06 |
2022-09-07 |
Olema Pharmaceuticals Inc |
Metodos de tratamiento de enfermedades asociadas a los receptores de estrogenos.
|
|
EP4192458A4
(en)
|
2020-08-05 |
2024-09-04 |
C4 Therapeutics, Inc. |
COMPOUNDS FOR TARGETED DEGRADATION OF RET
|
|
US12595230B2
(en)
|
2020-10-19 |
2026-04-07 |
Sanofi |
Substituted 6,7-dihydro-5H-benzo[7]annulene compounds and their derivatives, processes for their preparation and therapeutic uses thereof
|
|
AU2021366223A1
(en)
|
2020-10-19 |
2023-06-22 |
Sanofi |
Substituted 6,7-dihydro-5h-benzo[7]annulene compounds and their derivatives, processes for their preparation and therapeutic uses thereof
|
|
CN113248455A
(zh)
*
|
2021-05-25 |
2021-08-13 |
湖北科技学院 |
一种3,5-二取代异噁唑类衍生物及其合成方法
|
|
JP2024523839A
(ja)
|
2021-06-08 |
2024-07-02 |
シーフォー セラピューティクス, インコーポレイテッド |
突然変異体brafを分解する療法薬
|
|
WO2023059714A1
(en)
*
|
2021-10-06 |
2023-04-13 |
Olema Pharmaceuticals, Inc. |
Methods of treating estrogen receptor-mediated disorders
|
|
KR20250055538A
(ko)
|
2022-08-03 |
2025-04-24 |
브리스톨-마이어스 스큅 컴퍼니 |
Ret 단백질을 조정하기 위한 화합물
|
|
CN117924262A
(zh)
*
|
2022-10-14 |
2024-04-26 |
中国科学院上海药物研究所 |
二氢苯并噻喃类衍生物及其制备方法和用途
|
|
JP2025540906A
(ja)
|
2022-11-04 |
2025-12-17 |
ブリストル-マイヤーズ スクイブ カンパニー |
Ret-lddタンパク質阻害剤
|
|
CN120569388A
(zh)
|
2022-11-04 |
2025-08-29 |
百时美施贵宝公司 |
Ret-ldd蛋白降解剂
|
|
CN116813603B
(zh)
*
|
2023-06-02 |
2024-10-22 |
成都市第三人民医院 |
一种选择性雌激素受体α降解化合物及其制备方法和应用
|
|
AU2024310341A1
(en)
|
2023-06-30 |
2026-02-12 |
Merck Patent Gmbh |
Heterobifunctional compounds for the degradation of kras protein
|