JP2014502272A5 - - Google Patents
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- Publication number
- JP2014502272A5 JP2014502272A5 JP2013541958A JP2013541958A JP2014502272A5 JP 2014502272 A5 JP2014502272 A5 JP 2014502272A5 JP 2013541958 A JP2013541958 A JP 2013541958A JP 2013541958 A JP2013541958 A JP 2013541958A JP 2014502272 A5 JP2014502272 A5 JP 2014502272A5
- Authority
- JP
- Japan
- Prior art keywords
- ligand
- amino acid
- protein
- immunoglobulin
- monomers
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000003446 ligand Substances 0.000 claims 21
- 229940024606 amino acid Drugs 0.000 claims 12
- 235000001014 amino acid Nutrition 0.000 claims 12
- 150000001413 amino acids Chemical class 0.000 claims 12
- 108060003951 Immunoglobulin Proteins 0.000 claims 9
- 102000018358 immunoglobulin Human genes 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- 239000000178 monomer Substances 0.000 claims 8
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims 6
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 claims 6
- 239000011159 matrix material Substances 0.000 claims 6
- 125000001500 prolyl group Chemical group [H]N1C([H])(C(=O)[*])C([H])([H])C([H])([H])C1([H])[H] 0.000 claims 6
- 235000018102 proteins Nutrition 0.000 claims 6
- 108090000623 proteins and genes Proteins 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 210000004899 c-terminal region Anatomy 0.000 claims 5
- 108010025221 plasma protein Z Proteins 0.000 claims 5
- 108010088160 Staphylococcal Protein A Proteins 0.000 claims 4
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 4
- 238000000926 separation method Methods 0.000 claims 3
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims 2
- 229960000310 isoleucine Drugs 0.000 claims 2
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 229920001817 Agar Polymers 0.000 claims 1
- 229920000936 Agarose Polymers 0.000 claims 1
- 239000008272 agar Substances 0.000 claims 1
- -1 agar or agarose Chemical class 0.000 claims 1
- 239000003513 alkali Substances 0.000 claims 1
- 239000003480 eluent Substances 0.000 claims 1
- 150000004676 glycans Chemical class 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
- 238000005406 washing Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41749410P | 2010-11-29 | 2010-11-29 | |
| US61/417,494 | 2010-11-29 | ||
| PCT/SE2011/051432 WO2012074463A1 (en) | 2010-11-29 | 2011-11-28 | Affinity chromatography matrix |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014502272A JP2014502272A (ja) | 2014-01-30 |
| JP2014502272A5 true JP2014502272A5 (OSRAM) | 2015-01-15 |
Family
ID=46172160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013541958A Pending JP2014502272A (ja) | 2010-11-29 | 2011-11-28 | アフィニティークロマトグラフィーマトリックス |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8859726B2 (OSRAM) |
| EP (1) | EP2646126A4 (OSRAM) |
| JP (1) | JP2014502272A (OSRAM) |
| CN (1) | CN103228328A (OSRAM) |
| WO (1) | WO2012074463A1 (OSRAM) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8592555B2 (en) | 2008-08-11 | 2013-11-26 | Emd Millipore Corporation | Immunoglobulin-binding proteins with improved specificity |
| SG195555A1 (en) | 2008-12-24 | 2013-12-30 | Emd Millipore Corp | Caustic stable chromatography ligands |
| JP5997176B2 (ja) * | 2010-12-21 | 2016-09-28 | ザ ユニバーシティ オブ ウエスタン オンタリオＴｈｅ Ｕｎｉｖｅｒｓｉｔｙ ｏｆ Ｗｅｓｔｅｒｎ Ｏｎｔａｒｉｏ | プロテインａの新規アルカリ抵抗性変異体及びアフィニティークロマトグラフィーにおけるその使用 |
| SG186552A1 (en) | 2011-06-08 | 2013-01-30 | Emd Millipore Corp | Chromatography matrices including novel staphylococcus aureus protein a based ligands |
| US9896486B2 (en) * | 2013-07-10 | 2018-02-20 | Ge Healthcare Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| JP7138411B2 (ja) * | 2013-08-28 | 2022-09-16 | アフィボディ・アーベー | 変異した骨格を有する結合ポリペプチド |
| CN104513309A (zh) * | 2013-09-26 | 2015-04-15 | 上海亨臻实业有限公司 | 一种蛋白功能结构域铰链肽及其用途 |
| US11566082B2 (en) | 2014-11-17 | 2023-01-31 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| GB201506868D0 (en) | 2015-04-22 | 2015-06-03 | Ucb Biopharma Sprl | Method for protein purification |
| US10513537B2 (en) | 2016-05-11 | 2019-12-24 | Ge Healthcare Bioprocess R&D Ab | Separation matrix |
| JP7106187B2 (ja) | 2016-05-11 | 2022-07-26 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックスを保存する方法 |
| US10703774B2 (en) | 2016-09-30 | 2020-07-07 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| US11753438B2 (en) | 2016-05-11 | 2023-09-12 | Cytiva Bioprocess R&D Ab | Method of cleaning and/or sanitizing a separation matrix |
| JP7031934B2 (ja) | 2016-05-11 | 2022-03-08 | サイティバ・バイオプロセス・アールアンドディ・アクチボラグ | 分離マトリックス |
| US10730908B2 (en) | 2016-05-11 | 2020-08-04 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| US10654887B2 (en) | 2016-05-11 | 2020-05-19 | Ge Healthcare Bio-Process R&D Ab | Separation matrix |
| US10889615B2 (en) | 2016-05-11 | 2021-01-12 | Cytiva Bioprocess R&D Ab | Mutated immunoglobulin-binding polypeptides |
| CN106117324A (zh) * | 2016-07-29 | 2016-11-16 | 湖北爱晟生物科技有限公司 | 重组蛋白a及其编码基因和应用 |
| US12448411B2 (en) | 2016-09-30 | 2025-10-21 | Cytiva Bioprocess R&D Ab | Separation method |
| GB201703116D0 (en) * | 2017-02-27 | 2017-04-12 | Ge Healthcare Bioprocess R&D Ab | A seperation matrix and a method of seperating antibodies |
| GB2569585A (en) * | 2017-12-20 | 2019-06-26 | Ge Healthcare Bio Sciences Ab | A method for preparation of a separation matrix |
| CN109721645A (zh) * | 2017-12-29 | 2019-05-07 | 兆生生物科技南京有限公司 | 一种基因突变的蛋白a及其应用 |
| EP3650465A1 (en) | 2018-11-12 | 2020-05-13 | Navigo Proteins Gmbh | Novel populations of polypeptides having a triple-helical structure |
| AU2020253470A1 (en) | 2019-04-02 | 2021-11-04 | Bondwell Technologies Lp | Functionalized Ubx protein materials for enhanced purification of antibodies |
| GB202113626D0 (en) | 2021-09-24 | 2021-11-10 | Cytiva Bioprocess R & D Ab | FC binding polypeptides |
| CN113999294B (zh) * | 2021-12-30 | 2022-03-29 | 苏州纳微科技股份有限公司 | 免疫球蛋白结合蛋白及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5362859A (en) | 1992-07-27 | 1994-11-08 | Sepracor, Inc. | High-capacity affinity supports and methods for the preparation and use of same |
| SE0104353D0 (sv) * | 2001-12-19 | 2001-12-19 | Amersham Biosciences Ab | Separation method |
| SE0200943D0 (sv) * | 2002-03-25 | 2002-03-25 | Amersham Biosciences Ab | Mutant protein |
| US7709209B2 (en) | 2002-03-25 | 2010-05-04 | Ge Healthcare Bio-Sciences Ab | Protein ligands |
| SE0400274D0 (sv) * | 2004-02-09 | 2004-02-09 | Affibody Ab | New polypeptide |
| AU2007300751B2 (en) | 2006-09-29 | 2012-01-19 | Cytiva Bioprocess R&D Ab | Chromatography ligand comprising Domain C from Staphyloccocus aureus protein A for antibody isolation |
| CN101224414A (zh) * | 2007-10-18 | 2008-07-23 | 西北大学 | 以四唑为功能基的多用途分离介质及其制备方法 |
| JP5229888B2 (ja) * | 2008-09-30 | 2013-07-03 | 独立行政法人産業技術総合研究所 | 弱酸性域での易解離性を向上したプロテインａ変異型タンパク質及び抗体捕捉剤 |
| JP2012515160A (ja) | 2009-01-12 | 2012-07-05 | ジーイー・ヘルスケア・バイオサイエンス・アクチボラグ | アフィニティークロマトグラフィーマトリックス |
-
2011
- 2011-11-28 JP JP2013541958A patent/JP2014502272A/ja active Pending
- 2011-11-28 EP EP11845161.6A patent/EP2646126A4/en not_active Withdrawn
- 2011-11-28 WO PCT/SE2011/051432 patent/WO2012074463A1/en not_active Ceased
- 2011-11-28 CN CN2011800565779A patent/CN103228328A/zh active Pending
- 2011-11-28 US US13/990,135 patent/US8859726B2/en active Active
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