JP2014501513A5 - - Google Patents

Info

Publication number

JP2014501513A5

JP2014501513A5 JP2013541012A JP2013541012A JP2014501513A5 JP 2014501513 A5 JP2014501513 A5 JP 2014501513A5 JP 2013541012 A JP2013541012 A JP 2013541012A JP 2013541012 A JP2013541012 A JP 2013541012A JP 2014501513 A5 JP2014501513 A5 JP 2014501513A5

Authority

JP

Japan

Prior art keywords

seq

amino acid

acid sequence

variable region

chain variable

Prior art date

2011-11-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 125000003275 alpha amino acid group Chemical group 0.000 claims 178
• 102100035360 Cerebellar degeneration-related antigen 1 Human genes 0.000 claims 45
• 101000737793 Homo sapiens Cerebellar degeneration-related antigen 1 Proteins 0.000 claims 42
• 229920001184 polypeptide Polymers 0.000 claims 11
• 102000004196 processed proteins & peptides Human genes 0.000 claims 11
• 108090000765 processed proteins & peptides Proteins 0.000 claims 11
• 238000001727 in vivo Methods 0.000 claims 8
• 102000039446 nucleic acids Human genes 0.000 claims 8
• 108020004707 nucleic acids Proteins 0.000 claims 8
• 150000007523 nucleic acids Chemical class 0.000 claims 8
• 102000040430 polynucleotide Human genes 0.000 claims 7
• 108091033319 polynucleotide Proteins 0.000 claims 7
• 239000002157 polynucleotide Substances 0.000 claims 7
• 239000008194 pharmaceutical composition Substances 0.000 claims 5
• 210000000988 bone and bone Anatomy 0.000 claims 4
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
• 150000001413 amino acids Chemical class 0.000 claims 3
• 230000001054 cortical effect Effects 0.000 claims 3
• 230000000694 effects Effects 0.000 claims 3
• 238000003556 assay Methods 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000035475 disorder Diseases 0.000 claims 2
• 210000002436 femur neck Anatomy 0.000 claims 2
• 238000000338 in vitro Methods 0.000 claims 2
• 230000011164 ossification Effects 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 241000700199 Cavia porcellus Species 0.000 claims 1
• 101000604110 Homo sapiens Palmitoleoyl-protein carboxylesterase NOTUM Proteins 0.000 claims 1
• 241000282567 Macaca fascicularis Species 0.000 claims 1
• 241000282560 Macaca mulatta Species 0.000 claims 1
• 101100187355 Mus musculus Notum gene Proteins 0.000 claims 1
• 208000001132 Osteoporosis Diseases 0.000 claims 1
• 102000013814 Wnt Human genes 0.000 claims 1
• YUCMRRWKCRHOKJ-UHFFFAOYSA-N [Na].[Na].[Na].CCCCCCCC(=O)Oc1cc(c2ccc3c(cc(c4ccc1c2c34)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O Chemical compound [Na].[Na].[Na].CCCCCCCC(=O)Oc1cc(c2ccc3c(cc(c4ccc1c2c34)S(O)(=O)=O)S(O)(=O)=O)S(O)(=O)=O YUCMRRWKCRHOKJ-UHFFFAOYSA-N 0.000 claims 1
• 239000002552 dosage form Substances 0.000 claims 1
• 210000000501 femur body Anatomy 0.000 claims 1
• 229910052500 inorganic mineral Inorganic materials 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000011707 mineral Substances 0.000 claims 1
• 230000002265 prevention Effects 0.000 claims 1
• 230000001737 promoting effect Effects 0.000 claims 1
• 210000002966 serum Anatomy 0.000 claims 1
• 230000011664 signaling Effects 0.000 claims 1