JP2014501490A5 - - Google Patents
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- Publication number
- JP2014501490A5 JP2014501490A5 JP2013530798A JP2013530798A JP2014501490A5 JP 2014501490 A5 JP2014501490 A5 JP 2014501490A5 JP 2013530798 A JP2013530798 A JP 2013530798A JP 2013530798 A JP2013530798 A JP 2013530798A JP 2014501490 A5 JP2014501490 A5 JP 2014501490A5
- Authority
- JP
- Japan
- Prior art keywords
- binding polypeptide
- antigen
- composition
- polypeptide according
- motomeko
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 51
- 229920001184 polypeptide Polymers 0.000 claims description 50
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 50
- 239000000427 antigen Substances 0.000 claims description 47
- 102000036639 antigens Human genes 0.000 claims description 47
- 108091007433 antigens Proteins 0.000 claims description 47
- 239000000126 substance Substances 0.000 claims description 19
- 238000000034 method Methods 0.000 claims description 16
- 210000005166 vasculature Anatomy 0.000 claims description 11
- 206010003246 arthritis Diseases 0.000 claims description 10
- 239000002122 magnetic nanoparticle Substances 0.000 claims description 9
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 8
- 230000001225 therapeutic effect Effects 0.000 claims description 7
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 6
- 150000007523 nucleic acids Chemical group 0.000 claims description 6
- 210000001258 synovial membrane Anatomy 0.000 claims description 6
- 102000004127 Cytokines Human genes 0.000 claims description 4
- 108090000695 Cytokines Proteins 0.000 claims description 4
- 239000004037 angiogenesis inhibitor Substances 0.000 claims description 4
- 239000003435 antirheumatic agent Substances 0.000 claims description 4
- 238000003384 imaging method Methods 0.000 claims description 4
- 239000000463 material Substances 0.000 claims description 4
- 201000008482 osteoarthritis Diseases 0.000 claims description 4
- 206010039073 rheumatoid arthritis Diseases 0.000 claims description 4
- 230000004913 activation Effects 0.000 claims description 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 2
- 230000000903 blocking effect Effects 0.000 claims description 2
- 210000004027 cell Anatomy 0.000 claims description 2
- 230000001268 conjugating effect Effects 0.000 claims description 2
- 230000006378 damage Effects 0.000 claims description 2
- 238000003745 diagnosis Methods 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 238000004393 prognosis Methods 0.000 claims description 2
- 230000001588 bifunctional effect Effects 0.000 claims 2
- 229960002964 adalimumab Drugs 0.000 claims 1
- 230000002917 arthritic effect Effects 0.000 claims 1
- 210000003668 pericyte Anatomy 0.000 claims 1
- 239000003814 drug Substances 0.000 description 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 description 1
- 238000009175 antibody therapy Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 210000004786 perivascular cell Anatomy 0.000 description 1
- 230000009257 reactivity Effects 0.000 description 1
- 210000005222 synovial tissue Anatomy 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 230000002792 vascular Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1016494.5A GB201016494D0 (en) | 2010-09-30 | 2010-09-30 | Polypeptide |
| GB1016494.5 | 2010-09-30 | ||
| PCT/GB2011/051854 WO2012042270A1 (en) | 2010-09-30 | 2011-09-30 | Antibody specifically binding synovial microvasculature of arthritis patients |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014501490A JP2014501490A (ja) | 2014-01-23 |
| JP2014501490A5 true JP2014501490A5 (https=) | 2014-11-13 |
| JP6134266B2 JP6134266B2 (ja) | 2017-05-24 |
Family
ID=43243319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013530798A Expired - Fee Related JP6134266B2 (ja) | 2010-09-30 | 2011-09-30 | 関節炎患者の滑膜の微小血管系に特異的に結合する抗体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US9416174B2 (https=) |
| EP (1) | EP2621948B1 (https=) |
| JP (1) | JP6134266B2 (https=) |
| CN (1) | CN103403028B (https=) |
| CA (1) | CA2849982A1 (https=) |
| ES (1) | ES2582041T3 (https=) |
| GB (1) | GB201016494D0 (https=) |
| WO (1) | WO2012042270A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014160336A1 (en) * | 2013-03-13 | 2014-10-02 | University Of Kentucky Research Foundation | METHODS OF ADMINISTERING IgG1 ANTIBODIES AND METHODS OF SUPPRESSING ANGIOGENESIS |
| GB201315788D0 (en) * | 2013-09-05 | 2013-10-23 | Univ London Queen Mary | Molecule |
| WO2015117088A2 (en) | 2014-01-31 | 2015-08-06 | Arizona Board Of Regents On Behalf Of Arizona State University | Antibody based reagents that specifically recognize neurodegenerative disease related forms of the protein tdp-43 |
| US10092891B2 (en) * | 2014-04-25 | 2018-10-09 | University Of Florida Research Foundation, Incorporated | Controlling the activity of growth factors, particularly TGF-β, in vivo |
| GB201418626D0 (en) | 2014-10-20 | 2014-12-03 | Univ London Queen Mary | Method |
| CN110957031B (zh) * | 2019-12-13 | 2023-09-22 | 重庆首厚智能科技研究院有限公司 | 一种疾病预防信息服务平台 |
| CN119125571A (zh) * | 2024-08-19 | 2024-12-13 | 安徽医科大学 | 用于类风湿关节炎诊断的生物标志物及其应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0368684B2 (en) | 1988-11-11 | 2004-09-29 | Medical Research Council | Cloning immunoglobulin variable domain sequences. |
| US5859205A (en) * | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| DK1399484T3 (da) | 2001-06-28 | 2010-11-08 | Domantis Ltd | Dobbelt-specifik ligand og anvendelse af denne |
| WO2005058352A2 (en) | 2003-12-17 | 2005-06-30 | Entelos, Inc. | Treatment of rheumatoid arthritis with galectin-3 antagonists |
| CA2575791A1 (en) * | 2004-08-03 | 2006-02-16 | Dyax Corp. | Hk1-binding proteins |
| US20090098536A1 (en) * | 2007-10-12 | 2009-04-16 | C-A-I-R- Biosciences Gmbh | Method for subgroup analysis in subjects having or being suspected of having inflammatory disease, use of anti-p38MAPK antibodies, kits and their use |
| US9079947B2 (en) | 2007-11-27 | 2015-07-14 | The University Of British Columbia | 14-3-3 eta antibodies and uses thereof for the diagnosis and treatment of arthritis |
-
2010
- 2010-09-30 GB GBGB1016494.5A patent/GB201016494D0/en not_active Ceased
-
2011
- 2011-09-30 ES ES11764844.4T patent/ES2582041T3/es active Active
- 2011-09-30 JP JP2013530798A patent/JP6134266B2/ja not_active Expired - Fee Related
- 2011-09-30 US US13/877,097 patent/US9416174B2/en not_active Expired - Fee Related
- 2011-09-30 CA CA2849982A patent/CA2849982A1/en not_active Abandoned
- 2011-09-30 WO PCT/GB2011/051854 patent/WO2012042270A1/en not_active Ceased
- 2011-09-30 CN CN201180057703.2A patent/CN103403028B/zh not_active Expired - Fee Related
- 2011-09-30 EP EP11764844.4A patent/EP2621948B1/en not_active Not-in-force
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