JP2014227403A - Skin anti-aging composition - Google Patents
Skin anti-aging composition Download PDFInfo
- Publication number
- JP2014227403A JP2014227403A JP2013110405A JP2013110405A JP2014227403A JP 2014227403 A JP2014227403 A JP 2014227403A JP 2013110405 A JP2013110405 A JP 2013110405A JP 2013110405 A JP2013110405 A JP 2013110405A JP 2014227403 A JP2014227403 A JP 2014227403A
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- JP
- Japan
- Prior art keywords
- extract
- acid
- oil
- adiponectin
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Abstract
Description
本発明は、新規な抗皮膚老化用組成物に関するものである。本発明は食品、医薬品、化粧料等に広く利用することができる。 The present invention relates to a novel anti-skin aging composition. The present invention can be widely used for foods, pharmaceuticals, cosmetics and the like.
アディポネクチンは脂肪細胞から産生されるアディポカインの一種で,メタボリックシンドロームの改善因子として,広く知られている。これまで,生活習慣病の改善を目的に内臓脂肪由来のアディポネクチンの研究が行われてきたが,近年皮下脂肪由来のアディポネクチンに関する研究が注目を集めつつある。アディポネクチンは真皮に存在する線維芽細胞に作用することで,ヒアルロン酸の産生を高めることが報告されている(Yamane TらAdiponectin promotes hyaluronan synthesis along with increases in
hyaluronan synthase 2 transcripts through an AMP-activated protein
kinase/peroxisome proliferator-activated receptor-α-dependent pathway in human
dermal fibroblasts. Biochem Biophys Res Commun. 2011,
415, 235-8.)。また同様の結果は,マウスの皮膚でも確認されている(Akazawa Y, らAdiponectin resides
in mouse skin and upregulates hyaluronan synthesis in dermal fibroblasts. Connect Tissue Res. 2011, 52, 322-8)。さらに,アディポネクチンは真皮のコラーゲン産生を高める(Ezure T, Amano S. Adiponectin and leptin up-regulate extracellular
matrix production by dermal
fibroblasts. Biofactors. 2007, 31, 229-36.)。以上の背景から,アディポネクチンは線維芽細胞に作用し,皮膚の弾力性や保湿に関与する細胞外マトリックス成分の産生を促進することが証明されている。
Adiponectin is a kind of adipokine produced from adipocytes, and is widely known as an improvement factor of metabolic syndrome. So far, studies on adiponectin derived from visceral fat have been conducted for the purpose of improving lifestyle-related diseases. Recently, research on adiponectin derived from subcutaneous fat is attracting attention. Adiponectin has been reported to increase hyaluronic acid production by acting on fibroblasts in the dermis (Yamane T et al. Adiponectin promotes hyaluronan synthesis along with increases in
hyaluronan synthase 2 transcripts through an AMP-activated protein
kinase / peroxisome proliferator-activated receptor-α-dependent pathway in human
dermal fibroblasts. Biochem Biophys Res Commun. 2011,
415, 235-8.). Similar results have also been confirmed in mouse skin (Akazawa Y, et al. Adiponectin resides
in mouse skin and upregulates hyaluronan synthesis in dermal fibroblasts. Connect Tissue Res. 2011, 52, 322-8). In addition, adiponectin increases dermal collagen production (Ezure T, Amano S. Adiponectin and leptin up-regulate extracellular).
matrix production by dermal
fibroblasts. Biofactors. 2007, 31, 229-36.). From the above background, it has been proved that adiponectin acts on fibroblasts and promotes the production of extracellular matrix components involved in skin elasticity and moisture retention.
このような、背景の下、本発明者は、ジュンサイ抽出物及びその含有成分とアディポネクチンとを配合することにより相乗的に優れたヒアルロン酸およびコラーゲンの産生を促進する作用を有することを見出し、本発明を完成させた。
本発明は、優れたヒアルロン酸およびコラーゲンの産生を促進する作用を有する組成物を提供することを目的とする。
Under such circumstances, the present inventor has found that synergistically promoting the production of hyaluronic acid and collagen by combining Junsai extract and its components and adiponectin, Completed the invention.
An object of this invention is to provide the composition which has the effect | action which accelerates | stimulates the production | generation of the outstanding hyaluronic acid and collagen.
上記課題を解決するための本発明の特徴は以下の通りである。
1.ジュンサイ抽出物及びアディポネクチン及び/またはアディポネクチン産生促進剤を有効成分とするヒアルロン酸産生促進用組成物。
2.ジュンサイ抽出物及びアディポネクチン/またはアディポネクチン産生促進剤を有効成分とするコラーゲン産生促進用組成物。
3.上記1.または2.の組成物を有効成分とする抗皮膚老化用組成物。
The features of the present invention for solving the above-described problems are as follows.
1. A hyaluronic acid production promoting composition comprising Junsai extract and adiponectin and / or an adiponectin production promoter as active ingredients.
2. A composition for promoting collagen production comprising Junsai extract and adiponectin / or adiponectin production promoter as active ingredients.
3. Above 1. Or 2. The composition for anti-skin aging which uses the composition of 1 as an active ingredient.
以下、本発明を詳細に説明する。
また、本発明は、ジュンサイ(Brasenia schreberi)抽出物を有効成分とすることを特徴とする。
ジュンサイ(Brasenia schreberi)は,秋田県三種町が一大産地の食材である。じゅんさい沼に大きなたらいを浮かべ若芽を摘む姿は初夏の風物詩になっている。ジュンサイは多糖類に富むゲル状粘液質に覆われていることから食感が良く,高級料亭の食材としても珍重されている。またカロリーが低いことから,ヘルシー食材としても認知が進みつつある。
ジュンサイ抽出物の抽出溶媒としては、例えば、メタノール、エタノール、プロパノール、ブタノール等のアルコール類;1,3−ブチレングリコール、グリセリン、プロピレングリコール等のグリコール類;酢酸エチル、酢酸ブチル等のエステル類;エチルエーテル、プロピルエーテル、イソプロピルエーテル、テトラヒドロフラン、ジオキサン等のエーテル類;ジクロロメタン、クロロホルム等のハロゲン化炭化水素;アセトン、メチルエチルケトン、ジエチルケトン、シクロヘキサノン等のケトン類;ヘキサン、シクロヘキサン、石油エーテル、水等を用いることができる。これらの中で、エタノール、1,3−ブチレングリコール、水、アセトン、メタノール、ジクロロメタン等が好ましく用いられる。これらの溶媒は、単独で又は2種以上を混合して用いることができる。溶媒を混合して用いる場合、各溶媒の混合比は、溶媒の種類に応じて適宜調整すればよい。
Hereinafter, the present invention will be described in detail.
In addition, the present invention is characterized by using Junsei (Brasenia schreberi) extract as an active ingredient.
Junsai (Brasenia schreberi) is a major ingredient in Sanse-cho, Akita Prefecture. The figure of picking up young shoots with a big tub in Junsai Marsh is an early summer feature. Junsai has a good texture because it is covered with a gel-like mucus that is rich in polysaccharides. In addition, since it is low in calories, it is also gaining recognition as a healthy food.
Examples of the extraction solvent for Junsai extract include alcohols such as methanol, ethanol, propanol and butanol; glycols such as 1,3-butylene glycol, glycerin and propylene glycol; esters such as ethyl acetate and butyl acetate; Ethers such as ether, propyl ether, isopropyl ether, tetrahydrofuran and dioxane; halogenated hydrocarbons such as dichloromethane and chloroform; ketones such as acetone, methyl ethyl ketone, diethyl ketone and cyclohexanone; hexane, cyclohexane, petroleum ether, water, etc. be able to. Of these, ethanol, 1,3-butylene glycol, water, acetone, methanol, dichloromethane and the like are preferably used. These solvents can be used alone or in admixture of two or more. When mixing and using a solvent, what is necessary is just to adjust the mixing ratio of each solvent suitably according to the kind of solvent.
抽出方法については、特に限定されるものではなくジュンサイに溶媒(例えば、エタノール)を加えた後、抽出物に含まれる活性成分の活性を失活させない程度に加温加熱する加熱抽出法や、超臨界抽出法等を適宜適用できる。また、一定量の溶媒にジュンサイを浸漬してバッチ処理する浸漬抽出法や連続的に溶媒を送り続ける連続抽出法等、公知の種々の抽出法を適用できる。 The extraction method is not particularly limited, and after adding a solvent (for example, ethanol) to Junsai, it is heated and heated to an extent that does not deactivate the activity of the active ingredient contained in the extract, A critical extraction method or the like can be applied as appropriate. Further, various known extraction methods such as an immersion extraction method in which Junsai is immersed in a certain amount of solvent and batch-treated, and a continuous extraction method in which the solvent is continuously fed can be applied.
具体的な抽出方法の一例を挙げると、例えば、ジュンサイに対して、その乾燥重量の5〜50重量倍程度、好ましくは、10〜40重量倍程度の抽出溶媒を加えて浸漬して加温(25〜100℃)し、1〜6時間程度溶媒を攪拌させることにより、活性成分を抽出することができる。勿論、溶媒の種類、溶媒量や加熱温度、加熱時間等については、活性成分を効率的に抽出できるように適宜調整すればよい。 An example of a specific extraction method is, for example, about 5 to 50 times the dry weight of Junsai, preferably about 10 to 40 times the extraction solvent, and dipped and heated (for example) The active ingredient can be extracted by stirring the solvent for about 1 to 6 hours. Of course, the type of solvent, the amount of solvent, the heating temperature, the heating time, etc. may be appropriately adjusted so that the active ingredient can be extracted efficiently.
また、上記ジュンサイ抽出物は、ethyl gallate,caffeoyl glucose,methoxy caffeic (ferulic)acid,hypoletin 7-O-glucoside,quercetin 3-O-(6"-galloyl)-glucoside,Quercetin 3-O-glucoside,kaempferol 3-O-(6"-galloyl)-glucoside,gossypetin,junsainoside A,quercetinおよびkaempferolを含有することが好ましい。
更には、ethyl gallate、 gossypetin、,junsainoside Aを含有することがより好ましい。より優れた抗皮膚老化作用を有するからである。尚、これらは1種のみ含有されていても良いし、2種以上含有されていてもよい。尚、上記化合物は下記化学式(1)に示されるものである。
In addition, the above-mentioned Junsai extract is ethyl gallate, caffeoyl glucose, methoxy caffeic (ferulic) acid, hypoletin 7-O-glucoside, quercetin 3-O- (6 "-galloyl) -glucoside, Quercetin 3-O-glucoside, kaempferol It preferably contains 3-O- (6 "-galloyl) -glucoside, gossypetin, junsainoside A, quercetin and kaempferol.
Furthermore, it is more preferable to contain ethyl gallate, gossypetin, and junsainoside A. This is because it has a better anti-skin aging action. In addition, these may be contained only 1 type and may be contained 2 or more types. In addition, the said compound is shown by following Chemical formula (1).
更に本発明は、アディポネクチンを含有することを特徴とする。
アディポネクチンはヒトを含む動物の脂肪組織で産生され、血中にも多量存在するタンパク質である。ヒト・アディポネクチンについては、これをコードするcDNAから遺伝子組換え法により高純度に精製されたものが得られている。このヒト・アディポネクチンのcDNAのヌクレオチド配列はGenBankにアクセッション番号D45371で登録されている。
Furthermore, the present invention is characterized by containing adiponectin.
Adiponectin is a protein that is produced in adipose tissue of animals including humans and is also present in large amounts in blood. As for human adiponectin, a product purified from a cDNA encoding the same with a gene recombination method has been obtained. The nucleotide sequence of this human adiponectin cDNA is registered with GenBank under the accession number D45371.
また、マウス3T3−F442A細胞からクローニングされたACRP30と呼ばれる物質(Scherer. P E, et al. J. Biol. Chem. 270:26746〜26749(1995))が、アディポネクチンと同一物質と考えられている。この物質も、組み替え遺伝子の手技により高純度のものが得られており、前者と同様に使用できる。そして、アディポネクチンのアミノ酸配列において、1若しくは数個のアミノ酸が欠失、置換若しくは付加されたアミノ酸配列からなり、かつ、抗腫瘍活性を有するタンパク質も本発明におけるアディポネクチンに含まれる。
また、本発明のアディポネクチンは上記したものに限定されず、例えば、市販品を使用することもできる。
In addition, a substance called ACRP30 (Scherer. PE, et al. J. Biol. Chem. 270: 26746-26749 (1995)) cloned from mouse 3T3-F442A cells is considered to be the same substance as adiponectin. This substance has also been obtained in high purity by the recombinant gene technique and can be used in the same manner as the former. Adiponectin also includes a protein having an amino acid sequence in which one or several amino acids are deleted, substituted or added in the amino acid sequence of adiponectin and having antitumor activity.
Moreover, the adiponectin of this invention is not limited to what was mentioned above, For example, a commercial item can also be used.
本発明は、アディポネクチンの代わりに体内にてアディポネクチンの産生を促進する成分(アディポネクチン産生促進剤)を配合しても良い。アディポネクチン産生促進剤を配合することにより、体内でアディポネクチンが増加するため、アディポネクチンを配合したときと同様の効果を有するからである。
アディポネクチン産生促進剤は特に限定されず、公知のものを用いることができ、例えば、イチゴ種子エキス、あか生姜エキス、カレープラントエキス、白甘藷由来のアラビノガラクタンプロテイン、サケ白子抽出物、ビール酵母抽出物、チェストツリー抽出物、タイワンニンジンボク抽出物、ハマゴウ抽出物、シメジ抽出物、発芽玄米由来のステロール配糖体、アイブライト抽出物、明日葉抽出物、ビンチョウ鮪油、キハダ鮪油、西洋梨抽出物、ケツメイシ抽出物、黒酢、フコイダン、ルテイン、パプリカ抽出物、メロン抽出物、クランベリー抽出物、大豆蛋白加水分解物、サラシア・オブロンガ抽出物、サラシア・レチキュラータ抽出物、サラシア・プリノイデス抽出物、カボチャ種子抽出物、ブナシメジ抽出物、温州みかん抽出物、デビルスクロー抽出物、葛花抽出物、紅花種子抽出物、柿の抽出物、プロポリス抽出物、茶、茶の花抽出物、シナモン抽出物、ユーカリ抽出物、イチジク抽出物、オリーブ葉抽出物、オオズキンカブリタケ抽出物、ムキタケ抽出物、エルゴステロール、イソロイシン、ロイシン、バリン、アスタキサンチン、フコキサンチン、9−シス−β−カロテン、β−クリプトキサンチン、ビオラキサンチン、クロセチン、カプサンチン、ネオキサンチン、グルコサミン類、カテキン類、レスベラトロール、レスベラトロール誘導体、チリロサイド、ヘリピロンA、カスチシン、セリシン、リコピン、水溶性β−1,3−1,4−グルカン、ジンゲロール及びその誘導体、カルノシン、アンセリン、キサントアンゲロール、4−ヒドロキシデリシン、1,5−D−アンヒドロフルクトース、1,5−D−アンヒドログルシトール、ナリンゲニンカルコン又はその誘導体等が挙げられるが、これらに限定されない。尚、これらの成分は1種のみ含んでも良いし、2種以上併用しても良い。
In the present invention, instead of adiponectin, a component that promotes adiponectin production in the body (adiponectin production promoter) may be blended. This is because by adding an adiponectin production promoter, adiponectin is increased in the body, and thus has the same effect as when adiponectin is added.
The adiponectin production promoter is not particularly limited, and known ones can be used. For example, strawberry seed extract, red ginger extract, curry plant extract, arabinogalactan protein derived from white sweet potato, salmon white extract, brewer's yeast extract , Chest tree extract, Thai carrot extract, Clam extract, Shimeji extract, Germ brown rice-derived sterol glycoside, Ibright extract, Tomorrow leaf extract, Butterfly camellia oil, Yellowfin camellia oil, Western pear Extract, Ketsumeishi extract, black vinegar, fucoidan, lutein, paprika extract, melon extract, cranberry extract, soy protein hydrolysate, Salacia oblonga extract, Salacia reticulata extract, Salacia prinoides extract, Pumpkin seed extract, beech shimeji extract, Wenzhou mandarin orange extract, dessert Rusclaw extract, kuzuhana extract, safflower seed extract, persimmon extract, propolis extract, tea, tea flower extract, cinnamon extract, eucalyptus extract, fig extract, olive leaf extract, oozukin Kabritake extract, Mukitake extract, ergosterol, isoleucine, leucine, valine, astaxanthin, fucoxanthin, 9-cis-β-carotene, β-cryptoxanthin, violaxanthin, crocetin, capsanthin, neoxanthine, glucosamines, catechin , Resveratrol, resveratrol derivatives, tiliroside, helipyrone A, castisin, sericin, lycopene, water-soluble β-1,3-1,4-glucan, gingerol and its derivatives, carnosine, anserine, xanthoangelol, 4-hydroxyderricin, 1,5-D -Anhydrofructose, 1,5-D-anhydroglucitol, naringenin chalcone or a derivative thereof may be mentioned, but is not limited thereto. These components may be included alone or in combination of two or more.
本発明の抗皮膚老化用組成物は、その形状も特に制限されない。例えば、粉末状、顆粒状、錠剤状、丸剤状、乳剤状、液状、懸濁液状、濃縮エキス、乾燥エキス等を例示することができる。 The shape of the anti-skin aging composition of the present invention is not particularly limited. Examples thereof include powder, granule, tablet, pill, emulsion, liquid, suspension, concentrated extract, and dry extract.
本発明の抗皮膚老化用組成物は、前述の効果を目的として、様々な用途に適用することができる。用途として、医薬品、試薬(研究用、テストキット用)、化粧料、経口並びに、摂取用美肌用組成物(たとえば、食品、健康食品、機能性食品、サプリメント、特定用途食品、特定健康用食品、ペットフード、及びペット用サプリメント等の食品組成物等)が挙げられる。 The anti-skin aging composition of the present invention can be applied to various uses for the purpose of the above-mentioned effects. Applications include pharmaceuticals, reagents (for research, test kits), cosmetics, oral, and skin beautifying compositions (for example, foods, health foods, functional foods, supplements, special-purpose foods, specific health foods, And food compositions such as pet food and pet supplements).
本発明の抗皮膚老化用組成物を含む医薬組成物は、賦形剤、担体又は添加剤を含んでいてもよい。賦形剤、担体及び添加剤としては、通常使用され、かつ薬学的に許容されるものであれば特に限定されず、その種類及び組成は、適宜変更が可能である。 The pharmaceutical composition containing the anti-skin aging composition of the present invention may contain an excipient, carrier or additive. The excipient, carrier and additive are not particularly limited as long as they are usually used and pharmaceutically acceptable, and the type and composition thereof can be appropriately changed.
賦形剤としては、塩化ナトリウム、クエン酸ナトリウム等が挙げられ、担体としては、滅菌水、生理食塩水、及び各種緩衝液等が挙げられる。添加剤としては、粘ちょう剤、緩衝材、保存剤、防腐剤等が挙げられる。 Examples of the excipient include sodium chloride and sodium citrate, and examples of the carrier include sterilized water, physiological saline, and various buffers. Examples of additives include thickeners, buffer materials, preservatives, preservatives, and the like.
医薬用組成物の剤型としては特に制限されるものではなく、必要に応じて適宜選択すればよいが、例えば、錠剤、カプセル剤、顆粒剤、細粒剤、散剤等の経口剤;注射剤、坐剤、塗布剤等の非経口剤が挙げられる。 The dosage form of the pharmaceutical composition is not particularly limited and may be appropriately selected as necessary. For example, oral preparations such as tablets, capsules, granules, fine granules, powders; injections And parenterals such as suppositories and coating agents.
錠剤、カプセル剤、顆粒剤、細粒剤、散剤等の経口剤は、例えば、デンプン、乳糖、白糖、トレハロース、マンニット、カルボキシメチルセルロース、コーンスターチ、無機塩類等を用いて常法に従って製造される、これらの製剤中の本発明の配合量は特に限定されるものではなく、適宜設定することができる。この種の製剤には、結合剤、崩壊剤、界面活性剤、滑沢剤、流動性促進剤、矯味剤、着色剤、香料等を適宜使用することができる。 Oral preparations such as tablets, capsules, granules, fine granules, powders and the like are produced according to a conventional method using, for example, starch, lactose, sucrose, trehalose, mannitol, carboxymethylcellulose, corn starch, inorganic salts, The compounding amount of the present invention in these preparations is not particularly limited and can be set as appropriate. In this type of preparation, binders, disintegrants, surfactants, lubricants, fluidity promoters, corrigents, colorants, fragrances and the like can be used as appropriate.
非経口剤の場合、患者の年齢、体重、疾患の程度等に応じて用量を調節し、例えば、静注、点滴静注、皮下注射、筋肉注射等によって投与する。この非経口剤は常法に従って製造され、希釈剤として一般に注射用蒸留水、生理食塩水等を用いることができる。さらに必要に応じて、殺菌剤、防腐剤、安定剤等を加えてもよい。また、この非経口剤は安定性の点から、バイアル等に充填後冷凍し、通常の凍結乾燥処理により水分を除き、使用直前に凍結乾燥物から液剤を再調製することもできる。さらに必要に応じて、等張化剤、安定剤、防腐剤、無痛化剤等を加えてもよい。その他の非経口剤の例として、外用液剤、軟膏等の塗布剤、直腸内投与のための坐剤等が挙げられ、これらも常法に従って製造される。 In the case of a parenteral preparation, the dose is adjusted according to the age, weight, disease level, etc. of the patient, and for example, intravenous administration, intravenous infusion, subcutaneous injection, intramuscular injection or the like is used. This parenteral preparation is produced according to a conventional method, and distilled water for injection, physiological saline and the like can be generally used as a diluent. Furthermore, you may add a bactericidal agent, antiseptic | preservative, a stabilizer, etc. as needed. In addition, from the viewpoint of stability, this parenteral preparation can be frozen after filling into a vial or the like, the water can be removed by ordinary freeze-drying treatment, and the liquid preparation can be re-prepared from the freeze-dried product immediately before use. Furthermore, an isotonic agent, stabilizer, preservative, soothing agent and the like may be added as necessary. Examples of other parenteral agents include liquid preparations for external use, coating agents such as ointments, suppositories for rectal administration, etc., and these are also produced according to conventional methods.
本発明は抗皮膚老化用組成物を化粧料(化粧料組成物)に用いる場合、抗皮膚老化用組成物を、化粧料成分として一般に使用されている成分、例えば、界面活性剤、油分、保湿剤、皮膜形成剤、色素、香料等と任意に組み合わせて配合することにより調製することができる。その形態は特に制限されず、例えば、化粧水、クリーム、乳液、ゲル剤、エアゾール、エッセンス、パック、洗浄剤、ファンデーション、打粉、各種メーク剤(口紅、チーク等)とすることができる。 In the present invention, when an anti-skin aging composition is used in a cosmetic (cosmetic composition), the anti-skin aging composition is generally used as a cosmetic ingredient, for example, a surfactant, oil, moisturizing agent. It can be prepared by mixing in any combination with an agent, a film forming agent, a pigment, a fragrance and the like. The form in particular is not restrict | limited, For example, it can be set as a lotion, a cream, a milky lotion, a gel agent, an aerosol, an essence, a pack, a washing | cleaning agent, a foundation, powdering, various makeup agents (lipstick, teak etc.).
化粧料に配合される抗皮膚老化用組成物の配合割合は、抗皮膚老化作用が期待される効果が得られるのであれば特に制限されないが、通常、0.0001〜10重量%程度である。抽出物を用いる場合には、その中抗皮膚老化用組成物が上記割合となるような量を設定すればよい。 The blending ratio of the anti-skin aging composition to be blended in the cosmetic is not particularly limited as long as the anti-skin aging effect is expected, but is usually about 0.0001 to 10% by weight. In the case of using the extract, the amount of the anti-skin aging composition may be set to the above ratio.
上記化粧料には、本発明の抗皮膚老化用組成物の他に、その抗皮膚老化作用を損なわない範囲で化粧品に配合される成分、油分、高級アルコール、脂肪酸、紫外線吸収剤、粉体、顔料、界面活性剤、多価アルコール・糖、高分子、生理活性成分、溶媒、酸化防止剤、香料、防腐剤等を配合することができる。
例を以下に羅列するが、本発明はこれらの例に限定されるものではない。
In addition to the anti-skin aging composition of the present invention, the above cosmetics include ingredients, oils, higher alcohols, fatty acids, UV absorbers, powders, and other ingredients that are blended in cosmetics as long as the anti-skin aging effect is not impaired. Pigments, surfactants, polyhydric alcohols / sugars, polymers, physiologically active ingredients, solvents, antioxidants, fragrances, preservatives, and the like can be blended.
Examples are listed below, but the present invention is not limited to these examples.
(1)油分の例
エステル系の油相成分:トリ2-エチルヘキサン酸グリセリル、2-エチルヘキサン酸セチル、ミリスチン酸イソプロピル、ミリスチン酸ブチル、パルミチン酸イソプロピル、ステアリン酸エチル、パルミチン酸オクチル、イソステアリン酸イソセチル、ステアリン酸ブチル、ミリスチン酸ブチル、リノール酸エチル、リノール酸イソプロピル、オレイン酸エチル、ミリスチン酸イソセチル、ミリスチン酸イソステアリル、パルミチン酸イソステアリル、ミリスチン酸オクチルドデシル、イソステアリン酸イソセチル、セバシン酸ジエチル、アジピン酸ジイソプロピル、ネオペンタン酸イソアラキル、トリ(カプリル・カプリン酸)グリセリル、トリ2-エチルヘキサン酸トリメチロールプロパン、トリイソステアリン酸トリメチロールプロパン、テトラ2-エチルヘキサン酸ペンタエリスリトール、カプリル酸セチル、ラウリン酸デシル、ラウリン酸ヘキシル、ミリスチン酸デシル、ミリスチン酸ミリスチル、ミリスチン酸セチル、ステアリン酸ステアリル、オレイン酸デシル、リシノレイン酸セチル、ラウリン酸イソステアリル、ミリスチン酸イソトリデシル、ミリスチン酸イソセチル、ミリスチン酸イソステアリル、パルミチン酸イソセチル、パルミチン酸イソステアリル、ステアリン酸オクチル、ステアリン酸イソセチル、オレイン酸イソデシル、オレイン酸オクチルドデシル、リノール酸オクチルドデシル、イソステアリン酸イソプロピル、2-エチルヘキサン酸セトステアリル、2-エチルヘキサン酸ステアリル、イソステアリン酸ヘキシル、ジオクタン酸エチレングリコール、ジオレイン酸エチレングリコール、ジカプリン酸プロピレングリコール、ジ(カプリル・カプリン酸)プロピレングリコール、ジカプリル酸プロピレングリコール、ジカプリン酸ネオペンチルグリコール、ジオクタン酸ネオペンチルグリコール、トリカプリル酸グリセリル、トリウンデシル酸グリセリル、トリイソパルミチン酸グリセリル、トリイソステアリン酸グリセリル、ネオペンタン酸オクチルドデシル、オクタン酸イソステアリル、イソノナン酸オクチル、ネオデカン酸ヘキシルデシル、ネオデカン酸オクチルドデシル、イソステアリン酸イソセチル、イソステアリン酸イソステアリル、イソステアリン酸オクチルデシル、ポリグリセリンオレイン酸エステル、ポリグリセリンイソステアリン酸エステル、炭酸ジプロピル、炭酸ジアルキル(C12-18)、クエン酸トリイソセチル、クエン酸トリイソアラキル、クエン酸トリイソオクチル、乳酸ラウリル、乳酸ミリスチル、乳酸セチル、乳酸オクチルデシル、クエン酸トリエチル、クエン酸アセチルトリエチル、クエン酸アセチルトリブチル、クエン酸トリオクチル、リンゴ酸ジイソステアリル、ヒドロキシステアリン酸2-エチルヘキシル、コハク酸ジ2-エチルヘキシル、アジピン酸ジイソブチル、セバシン酸ジイソプロピル、セバシン酸ジオクチル、ステアリン酸コレステリル、イソステアリン酸コレステリル、ヒドロキシステアリン酸コレステリル、オレイン酸コレステリル、オレイン酸ジヒドロコレステリル、イソステアリン酸フィトステリル、オレイン酸フィトステリル、12-ステアロイルヒドロキシステアリン酸イソセチル、12-ステアロイルヒドロキシステアリン酸ステアリル、12-ステアロイルヒドロキシステアリン酸イソステアリル等が挙げられる。
炭化水素系の油相成分:スクワラン、流動パラフィン、α-オレフィンオリゴマー、イソパラフィン、セレシン、パラフィン、流動イソパラフィン、ポリブテン、マイクロクリスタリンワックス、ワセリン等が挙げられる。
動植物油とその硬化油、および天然由来のロウ:牛脂、硬化牛脂、豚脂、硬化豚脂、馬油、硬化馬油、ミンク油、オレンジラフィー油、魚油、硬化魚油、卵黄油等の動物油およびその硬化油、アボカド油、アルモンド油、オリーブ油、カカオ脂、杏仁油、ククイナッツ油、ゴマ油、小麦胚芽油、コメ胚芽油、コメヌカ油、サフラワー油、シアバター、大豆油、月見草油、シソ油、茶実油、ツバキ油、トウモロコシ油、ナタネ油、硬化ナタネ油、パーム核油、硬化パーム核油、パーム油、硬化パーム油、ピーナッツ油、硬化ピーナッツ油、ヒマシ油、硬化ヒマシ油、ヒマワリ油、ブドウ種子油、ホホバ油、硬化ホホバ油、マカデミアナッツ油、メドホーム油、綿実油、硬化綿実油、ヤシ油、硬化ヤシ油等の植物油およびその硬化油、ミツロウ、高酸価ミツロウ、ラノリン、還元ラノリン、硬化ラノリン、液状ラノリン、カルナバロウ、モンタンロウ等のロウ等が挙げられる。
シリコーン系の油相成分:ジメチルポリシロキサン、メチルフェニルポリシロキサン、メチルシクロポリシロキサン、オクタメチルポリシロキサン、デカメチルポリシロキサン、ドデカメチルシクロシロキサン、メチルハイドロジェンポリシロキサン、ポリエーテル変性オルガノポリシロキサン、ジメチルシロキサン・メチルセチルオキシシロキサン共重合体、ジメチルシロキサン・メチルステアロキシシロキサン共重合体、アルキル変性オルガノポリシロキサン、末端変性オルガノポリシロキサン、アミノ変性シリコーン油、アミノ変性オルガノポリシロキサン、ジメチコノール、シリコーンゲル、アクリルシリコーン、トリメチルシロキシケイ酸、シリコーンRTVゴム等が挙げられる。
フッ素系の油相成分:パーフルオロポリエーテル、フッ素変性オルガノポリシロキサン、フッ化ピッチ、フルオロカーボン、フルオロアルコール、フルオロアルキル・ポリオキシアルキレン共変性オルガノポリシロキサン等が挙げられる。
(1) Examples of oil components Ester-based oil phase components: glyceryl tri-2-ethylhexanoate, cetyl 2-ethylhexanoate, isopropyl myristate, butyl myristate, isopropyl palmitate, ethyl stearate, octyl palmitate, isostearic acid Isocetyl, butyl stearate, butyl myristate, ethyl linoleate, isopropyl linoleate, ethyl oleate, isocetyl myristate, isostearyl myristate, isostearyl palmitate, octyldodecyl myristate, isocetyl isostearate, diethyl sebacate, adipine Diisopropyl acid, isoaralkyl neopentanoate, glyceryl tri (capryl / caprate), trimethylolpropane tri-2-ethylhexanoate, trimethylol triisostearate Propane, pentaerythritol tetra-2-ethylhexanoate, cetyl caprylate, decyl laurate, hexyl laurate, decyl myristate, myristyl myristate, cetyl myristate, stearyl stearate, decyl oleate, cetyl ricinoleate, isolaurate Stearyl, isotridecyl myristate, isocetyl myristate, isostearyl myristate, isocetyl palmitate, isostearyl palmitate, octyl stearate, isocetyl stearate, isodecyl oleate, octyldodecyl linoleate, octyldodecyl isoleate, isopropyl isostearate Cetostearyl 2-ethylhexanoate, stearyl 2-ethylhexanoate, hexyl isostearate, ethyleneglycol dioctanoate , Ethylene glycol dioleate, propylene glycol dicaprate, propylene glycol di (capryl / capric acid), propylene glycol dicaprylate, neopentyl glycol dicaprate, neopentyl glycol dioctanoate, glyceryl tricaprylate, glyceryl triundecylate, triisopalmitine Glyceryl acid, glyceryl triisostearate, octyldodecyl neopentanoate, isostearyl octanoate, octyl isononanoate, hexyl decyl neodecanoate, octyldodecyl neodecanoate, isocetyl isostearate, isostearyl isostearate, octyldecyl isostearate, polyglycerin oleic acid Ester, polyglycerol isostearate, dipropyl carbonate, charcoal Dialkyl (C12-18), triisocetyl citrate, triisoaralkyl citrate, triisooctyl citrate, lauryl lactate, myristyl lactate, cetyl lactate, octyl decyl lactate, triethyl citrate, acetyl triethyl citrate, acetyl tributyl citrate, Trioctyl citrate, diisostearyl malate, 2-ethylhexyl hydroxystearate, di-2-ethylhexyl succinate, diisobutyl adipate, diisopropyl sebacate, dioctyl sebacate, cholesteryl stearate, cholesteryl isostearate, cholesteryl hydroxystearate, olein Cholesteryl acid, dihydrocholesteryl oleate, phytosteryl isostearate, phytosteryl oleate, 12-stearoyl hydroxystearate Cetyl, 12-stearoyl-hydroxystearic acid stearyl 12-stearoyl-hydroxystearic acid isostearate, and the like.
Hydrocarbon oil phase components: squalane, liquid paraffin, α-olefin oligomer, isoparaffin, ceresin, paraffin, liquid isoparaffin, polybutene, microcrystalline wax, petrolatum and the like.
Animal and vegetable oils and their hydrogenated oils, and naturally occurring waxes: beef tallow, hydrogenated beef tallow, lard, hydrogenated tallow, horse oil, hydrogenated horse oil, mink oil, orange luffy oil, fish oil, hydrogenated fish oil, egg yolk oil Its hardened oil, avocado oil, almond oil, olive oil, cacao butter, apricot oil, kukui nut oil, sesame oil, wheat germ oil, rice germ oil, rice bran oil, safflower oil, shea butter, soybean oil, evening primrose oil, perilla oil, Tea seed oil, camellia oil, corn oil, rapeseed oil, hardened rapeseed oil, palm kernel oil, hardened palm kernel oil, palm oil, hardened palm oil, peanut oil, hardened peanut oil, castor oil, hardened castor oil, sunflower oil, Vegetable oil such as grape seed oil, jojoba oil, hardened jojoba oil, macadamia nut oil, medhome oil, cottonseed oil, hardened cottonseed oil, coconut oil, hardened coconut oil and its hardened oil, beeswax, Acid number beeswax, lanolin, reduced lanolin, hydrogenated lanolin, liquid lanolin, carnauba wax and montan wax.
Silicone oil phase components: dimethylpolysiloxane, methylphenylpolysiloxane, methylcyclopolysiloxane, octamethylpolysiloxane, decamethylpolysiloxane, dodecamethylcyclosiloxane, methylhydrogenpolysiloxane, polyether-modified organopolysiloxane, dimethyl Siloxane / methylcetyloxysiloxane copolymer, dimethylsiloxane / methylstearoxysiloxane copolymer, alkyl-modified organopolysiloxane, terminal-modified organopolysiloxane, amino-modified silicone oil, amino-modified organopolysiloxane, dimethiconol, silicone gel, acrylic Examples include silicone, trimethylsiloxysilicic acid, and silicone RTV rubber.
Fluorine oil phase components: perfluoropolyether, fluorine-modified organopolysiloxane, fluorinated pitch, fluorocarbon, fluoroalcohol, fluoroalkyl / polyoxyalkylene co-modified organopolysiloxane, and the like.
(2)高級アルコールの例
ラウリルアルコール、ミリスチルアルコール、セチルアルコール、ステアリルアルコール、イソステアリルアルコール、オレイルアルコール、ベヘニルアルコール、2-エチルヘキサノール、ヘキサデシルアルコール、オクチルドデカノール等が挙げられる。
(2) Examples of higher alcohols Lauryl alcohol, myristyl alcohol, cetyl alcohol, stearyl alcohol, isostearyl alcohol, oleyl alcohol, behenyl alcohol, 2-ethylhexanol, hexadecyl alcohol, octyldodecanol and the like can be mentioned.
(3)脂肪酸の例
カプリル酸、カプリン酸、ウンデシレン酸、ラウリン酸、ミリスチン酸、パルミチン酸、パルミトレイン酸、ステアリン酸、イソステアリン酸、オレイン酸、リノール酸、リノレン酸、アラキン酸、アラキドン酸、ベヘン酸、エルカ酸、2-エチルヘキサン酸等が挙げられる。
(3) Examples of fatty acids Caprylic acid, capric acid, undecylenic acid, lauric acid, myristic acid, palmitic acid, palmitoleic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, linolenic acid, arachidic acid, arachidonic acid, behenic acid , Erucic acid, 2-ethylhexanoic acid and the like.
(4)紫外線吸収剤の例
パラアミノ安息香酸、パラアミノ安息香酸アミル、パラアミノ安息香酸エチルジヒドロキシプロピル、パラアミノ安息香酸グリセリル、パラアミノ安息香酸エチル、パラアミノ安息香酸オクチル、パラアミノ安息香酸オクチルジメチル、サリチル酸エチレングリコール、サリチル酸オクチル、サリチル酸トリエタノールアミン、サリチル酸フェニル、サリチル酸ブチルフェニル、サリチル酸ベンジル、サリチル酸ホモメンチル、ケイ皮酸ベンジル、パラメトキシケイ皮酸オクチル、パラメトキシケイ皮酸2-エチルヘキシル、ジパラメトキシケイ皮酸モノ2-エチルヘキサン酸グリセリル、パラメトキシケイ皮酸イソプロピル、パラメトキシヒドロケイ皮酸ジエタノールアミン塩、ジイソプロピル・ジイソプロピルケイ皮酸エステル混合物、ウロカニン酸、ウロカニン酸エチル、ヒドロキシメトキシベンゾフェノン、ヒドロキシメトキシベンゾフェノンスルホン酸及びその塩、ジヒドロキシメトキシベンゾフェノン、ジヒドロキシメトキシベンゾフェノンジスルホン酸ナトリウム、ジヒドロキシベンゾフェノン、ジヒドロキシジメトキシベンゾフェノン、ヒドロキシオクトキシベンゾフェノン、テトラヒドロキシベンゾフェノン、ブチルメトキシジベンゾイルメタン、2、4、6-トリアニリノ-p-(カルボ-2-エチルヘキシル-1-オキシ)-1、3、5-トリアジン、2-(2-ヒドロキシ-5-メチルフェニル)ベンゾトリアゾール、メチル-O-アミノベンゾエート、2-エチルヘキシル-2-シアノ-3、3-ジフェニルアクリレート、フェニルベンゾイミダゾール硫酸、3-(4-メチルベンジリデン)カンフル、イソプロピルジベンゾイルメタン、4-(3、4-ジメトキシフェニルメチレン)-2、5-ジオキソ-1-イミダゾリジンプロピオン酸2-エチルヘキシル等、およびこれらの高分子誘導体やシラン誘導体等が挙げられる。
(4) Examples of UV absorbers Paraaminobenzoic acid, amyl paraaminobenzoate, ethyldihydroxypropyl paraaminobenzoate, glyceryl paraaminobenzoate, ethyl paraaminobenzoate, octyl paraaminobenzoate, octyldimethyl paraaminobenzoate, ethylene glycol salicylate, salicylic acid Octyl, triethanolamine salicylate, phenyl salicylate, butylphenyl salicylate, benzyl salicylate, homomenthyl salicylate, benzyl cinnamate, octyl paramethoxycinnamate, 2-ethylhexyl paramethoxycinnamate, mono-2-diparamethoxycinnamate Glyceryl ethylhexanoate, isopropyl paramethoxycinnamate, diethanolamine salt of paramethoxyhydrocinnamic acid, diisopropyl diisopropylcinnamic acid Stealth mixture, urocanic acid, ethyl urocanate, hydroxymethoxybenzophenone, hydroxymethoxybenzophenone sulfonic acid and its salts, dihydroxymethoxybenzophenone, dihydroxymethoxybenzophenone sodium disulfonate, dihydroxybenzophenone, dihydroxydimethoxybenzophenone, hydroxyoctoxybenzophenone, tetrahydroxybenzophenone, Butylmethoxydibenzoylmethane, 2,4,6-trianilino-p- (carbo-2-ethylhexyl-1-oxy) -1,3,5-triazine, 2- (2-hydroxy-5-methylphenyl) benzotriazole , Methyl-O-aminobenzoate, 2-ethylhexyl-2-cyano-3, 3-diphenyl acrylate, phenylbenzimidazole sulfate, 3- (4-methylbenzylidene) can Examples include full, isopropyldibenzoylmethane, 4- (3,4-dimethoxyphenylmethylene) -2, 5-dioxo-1-imidazolidinepropionate 2-ethylhexyl, and the like, polymer derivatives, silane derivatives, and the like.
(5)粉体・顔料の例
赤色104号、赤色201号、黄色4号、青色1号、黒色401号等の色素、黄色4号ALレーキ、黄色203号BAレーキ等のレーキ色素、ナイロンパウダー、シルクパウダー、ウレタンパウダー、テフロン(登録商標)パウダー、シリコーンパウダー、ポリメタクリル酸メチルパウダー、セルロースパウダー、デンプン、シリコーンエラストマー球状粉体、ポリエチレン末等の高分子、黄酸化鉄、赤色酸化鉄、黒酸化鉄、酸化クロム、カーボンブラック、群青、紺青等の有色顔料、酸化亜鉛、酸化チタン、酸化セリウム等の白色顔料、タルク、マイカ、セリサイト、カオリン、板状硫酸バリウム等の体質顔料、雲母チタン等のパール顔料、硫酸バリウム、炭酸カルシウム、炭酸マグネシウム、珪酸アルミニウム、珪酸マグネシウム等の金属塩、シリカ、アルミナ等の無機粉体、ステアリン酸アルミニウム、ステアリン酸マグネシウム、パルミチン酸亜鉛、ミリスチン酸亜鉛、ミリスチン酸マグネシウム、ラウリン酸亜鉛、ウンデシレン酸亜鉛等の金属セッケン、ベントナイト、スメクタイト、窒化ホウ素等が挙げられる。これらの粉体の形状(球状、棒状、針状、板状、不定形状、燐片状、紡錘状等)および粒子径に特に制限はない。なおこれらの粉体は、従来公知の表面処理、例えばフッ素化合物処理、シリコーン処理、シリコーン樹脂処理、ペンダント処理、シランカップリング剤処理、チタンカップリング剤処理、油剤処理、N-アシル化リジン処理、ポリアクリル酸処理、金属セッケン処理、アミノ酸処理、レシチン処理、無機化合物処理、プラズマ処理、メカノケミカル処理等によって事前に表面処理されていてもいなくても構わない。
(5) Examples of powders and pigments Red 104, Red 201, Yellow 4, Blue 1, Black 401 and other dyes, Yellow 4 AL lake, Yellow 203 BA lake and other lake dyes, nylon powder , Silk powder, urethane powder, Teflon (registered trademark) powder, silicone powder, polymethyl methacrylate powder, cellulose powder, starch, silicone elastomer spherical powder, polyethylene powder, yellow iron oxide, red iron oxide, black Colored pigments such as iron oxide, chromium oxide, carbon black, ultramarine and bitumen, white pigments such as zinc oxide, titanium oxide and cerium oxide, extender pigments such as talc, mica, sericite, kaolin and barium sulfate plate, titanium mica Pearl pigments such as barium sulfate, calcium carbonate, magnesium carbonate, aluminum silicate, metal salts such as magnesium silicate, Inorganic powders such as Rica and alumina, metal soaps such as aluminum stearate, magnesium stearate, zinc palmitate, zinc myristate, magnesium myristate, zinc laurate, zinc undecylenate, bentonite, smectite, boron nitride, etc. It is done. There are no particular restrictions on the shape of these powders (spherical, rod-like, needle-like, plate-like, irregular shape, flake-like, spindle-like, etc.) and particle diameter. These powders are conventionally known surface treatments such as fluorine compound treatment, silicone treatment, silicone resin treatment, pendant treatment, silane coupling agent treatment, titanium coupling agent treatment, oil agent treatment, N-acylated lysine treatment, The surface treatment may or may not be performed in advance by polyacrylic acid treatment, metal soap treatment, amino acid treatment, lecithin treatment, inorganic compound treatment, plasma treatment, mechanochemical treatment or the like.
(6)界面活性剤の例
アニオン性界面活性剤:脂肪酸セッケン、α-アシルスルホン酸塩、アルキルスルホン酸塩、アルキルアリルスルホン酸塩、アルキルナフタレンスルホン酸塩、アルキル硫酸塩、POEアルキルエーテル硫酸塩、アルキルアミド硫酸塩、アルキルリン酸塩、POEアルキルリン酸塩、アルキルアミドリン酸塩、アルキロイルアルキルタウリン塩、N-アシルアミノ酸塩、POEアルキルエーテルカルボン酸塩、アルキルスルホコハク酸塩、アルキルスルホ酢酸ナトリウム、アシル化加水分解コラーゲンペプチド塩、パーフルオロアルキルリン酸エステル等が挙げられる。
カチオン性界面活性剤:塩化アルキルトリメチルアンモニウム、塩化ステアリルトリメチルアンモニウム、臭化ステアリルトリメチルアンモニウム、塩化セトステアリルトリメチルアンモニウム、塩化ジステアリルジメチルアンモニウム、塩化ステアリルジメチルベンジルアンモニウム、臭化ベヘニルトリメチルアンモニウム、塩化ベンザルコニウム、塩化ベヘニン酸アミドプロピルジメチルヒドロキシプロピルアンモニウム、ステアリン酸ジエチルアミノエチルアミド、ステアリン酸ジメチルアミノプロピルアミド、ラノリン誘導体第四級アンモニウム塩等が挙げられる。
両性界面活性剤:カルボキシベタイン型、アミドベタイン型、スルホベタイン型、ヒドロキシスルホベタイン型、アミドスルホベタイン型、ホスホベタイン型、アミノカルボン酸塩型、イミダゾリン誘導体型、アミドアミン型等が挙げられる。
ノニオン性界面活性剤:プロピレングリコール脂肪酸エステル、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ソルビタン脂肪酸エステル、POEソルビタン脂肪酸エステル、POEソルビット脂肪酸エステル、POEグリセリン脂肪酸エステル、POEアルキルエーテル、POE脂肪酸エステル、POE硬化ヒマシ油、POEヒマシ油、POE・POP共重合体、POE・POPアルキルエーテル、ポリエーテル変性シリコーンラウリン酸アルカノールアミド、アルキルアミンオキシド、水素添加大豆リン脂質等が挙げられる。
天然系界面活性剤:レシチン、サポニン、糖系界面活性剤等が挙げられる。
(6) Examples of surfactants Anionic surfactants: fatty acid soap, α-acyl sulfonate, alkyl sulfonate, alkyl allyl sulfonate, alkyl naphthalene sulfonate, alkyl sulfate, POE alkyl ether sulfate , Alkylamide sulfate, alkyl phosphate, POE alkyl phosphate, alkylamide phosphate, alkyloylalkyl taurine salt, N-acyl amino acid salt, POE alkyl ether carboxylate, alkyl sulfosuccinate, alkyl sulfoacetic acid Sodium, acylated hydrolyzed collagen peptide salt, perfluoroalkyl phosphate, etc. are mentioned.
Cationic surfactant: alkyltrimethylammonium chloride, stearyltrimethylammonium chloride, stearyltrimethylammonium bromide, cetostearyltrimethylammonium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, behenyltrimethylammonium bromide, benzalkonium chloride , Behenic acid amidopropyldimethylhydroxypropylammonium chloride, stearic acid diethylaminoethylamide, stearic acid dimethylaminopropylamide, lanolin derivative quaternary ammonium salts, and the like.
Amphoteric surfactants: carboxybetaine type, amide betaine type, sulfobetaine type, hydroxysulfobetaine type, amide sulfobetaine type, phosphobetaine type, aminocarboxylate type, imidazoline derivative type, amidoamine type and the like.
Nonionic surfactant: propylene glycol fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, sorbitan fatty acid ester, POE sorbitan fatty acid ester, POE sorbitol fatty acid ester, POE glycerin fatty acid ester, POE alkyl ether, POE fatty acid ester, POE cured castor Oil, POE castor oil, POE / POP copolymer, POE / POP alkyl ether, polyether-modified silicone lauric acid alkanolamide, alkylamine oxide, hydrogenated soybean phospholipid, and the like.
Natural surfactant: lecithin, saponin, sugar surfactant and the like.
(7)多価アルコール、糖の例
エチレングリコール、ジエチレングリコール、ポリエチレングリコール、プロピレングリコール、ジプロピレングリコール、ポリプロピレングリコール、グリセリン、ジグリセリン、ポリグリセリン、3-メチル-1、3-ブタンジオール、1、3-ブチレングリコール、ソルビトール、マンニトール、ラフィノース、エリスリトール、グルコース、ショ糖、果糖、キシリトール、ラクトース、マルトース、マルチトール、トレハロース、アルキル化トレハロース、混合異性化糖、硫酸化トレハロース、プルラン等が挙げられる。またこれらの化学修飾体等も使用可能である。
(7) Examples of polyhydric alcohols and sugars Ethylene glycol, diethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, glycerin, diglycerin, polyglycerin, 3-methyl-1,3-butanediol, 1, 3 -Butylene glycol, sorbitol, mannitol, raffinose, erythritol, glucose, sucrose, fructose, xylitol, lactose, maltose, maltitol, trehalose, alkylated trehalose, mixed isomerized sugar, sulfated trehalose, pullulan and the like. These chemically modified compounds can also be used.
(8)高分子の例
アクリル酸エステル/メタクリル酸エステル共重合体(プラスサイズ、互応化学社製)、酢酸ビニル/クロトン酸共重合体(レジン28-1310、NSC社製)、酢酸ビニル/クロトン酸/ビニルネオデカネート共重合体(28-2930、NSC社製)、メチルビニルエーテルマレイン酸ハーフエステル(ガントレッツES、ISP社製)、T-ブチルアクリレート/アクリル酸エチル/メタクリル酸共重合体(ルビマー、BASF社製)、ビニルピロリドン/ビニルアセテート/ビニルプロピオネート共重合体(ルビスコールVAP、BASF社製)、ビニルアセテート/クロトン酸共重合体(ルビセットCA、BASF社製)、ビニルアセテート/クロトン酸/ビニルピロリドン共重合体(ルビセットCAP、BASF社製)、ビニルピロリドン/アクリレート共重合体(ルビフレックス、BASF社製)、アクリレート/アクリルアミド共重合体(ウルトラホールド、BASF社製)、ビニルアセテート/ブチルマレエート/イソボルニルアクリラート共重合体(アドバンテージ、ISP社製)、カルボキシビニルポリマー(カーボポール、BFGoodrich社製)、アクリル酸・メタクリル酸アルキル共重合体(ペミュレン、BF Goodrich社製)等のアニオン性高分子化合物や、ジアルキルアミノエチルメタクリレート重合体の酢酸両性化物(ユカフォーマー、三菱化学社製)、アクリル酸オクチルアクリルアミド/アクリル酸ヒドロキシプロピル/メタクリル酸ブチルアミノエチル共重合体(AMPHOMER、NSC社製)等の両性高分子化合物、ビニルピロリドン/ジメチルアミノエチルメタクリレートの4級化物(GAFQUAT、ISP社製)、メチルビニルイミダゾリウムクロリド/ビニルピロリドン共重合体(ルビコート、BASF社製)等のカチオン性高分子化合物、ポリビニルピロリドン(ルビスコールK、BASF社製)、ビニルピロリドン/酢酸ビニル共重合体(ルビスコールVA、BASF社製)、ビニルピロリドン/ジメチルアミノエチルメタクリレート共重合体(コポリマー937、ISP社製)、ビニルカプロラクタム/ビニルピロリドン/ジメチルアミノエチルメタクリレート共重合体(コポリマーVC713、ISP社製)等のノニオン性高分子化合物等がある。また、セルロースまたはその誘導体、ケラチン及びコラーゲンまたはその誘導体、アルギン酸カルシウム、プルラン、寒天、ゼラチン、タマリンド種子多糖類、キサンタンガム、カラギーナン、ハイメトキシルペクチン、ローメトキシルペクチン、グアーガム、アラビアゴム、結晶セルロース、アラビノガラクタン、カラヤガム、トラガカントガム、アルギン酸、アルブミン、カゼイン、カードラン、ジェランガム、デキストラン等の天然由来高分子化合物も好適に用いることができる。
(8) Examples of polymers Acrylic ester / methacrylic acid ester copolymer (plus size, manufactured by Kyoyo Chemical), vinyl acetate / crotonic acid copolymer (resin 28-1310, manufactured by NSC), vinyl acetate / croton Acid / vinyl neodecanate copolymer (28-2930, manufactured by NSC), methyl vinyl ether maleic acid half ester (Gantrez ES, manufactured by ISP), T-butyl acrylate / ethyl acrylate / methacrylic acid copolymer (rubymer) , BASF), vinyl pyrrolidone / vinyl acetate / vinyl propionate copolymer (Rubicol VAP, BASF), vinyl acetate / crotonic acid copolymer (Rubiset CA, BASF), vinyl acetate / croton Acid / vinyl pyrrolidone copolymer (Rubiset CAP, manufactured by BASF), vinyl pyrrolidone / acrylate copolymer (Rubiflex, BA SF), acrylate / acrylamide copolymer (Ultrahold, BASF), vinyl acetate / butyl maleate / isobornyl acrylate copolymer (Advantage, ISP), carboxy vinyl polymer (Carbopol, BF Goodrich), anionic polymer compounds such as acrylic acid / alkyl methacrylate copolymer (Pemulene, BF Goodrich), and acetic acid amphoteric products of dialkylaminoethyl methacrylate polymers (Yukaformer, Mitsubishi Chemical) Amphoteric polymer compounds such as octyl acrylate acrylate / hydroxypropyl acrylate / butylaminoethyl methacrylate copolymer (AMPHOMER, NSC), quaternized vinylpyrrolidone / dimethylaminoethyl methacrylate (GAFQUAT, ISP) , Methyl vinyl imidazolium chloride Cationic polymer compounds such as vinyl / vinylpyrrolidone copolymer (rubicoat, manufactured by BASF), polyvinylpyrrolidone (rubiscol K, manufactured by BASF), vinylpyrrolidone / vinyl acetate copolymer (rubiscol VA, manufactured by BASF) ), Nonionic polymer compounds such as vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer (copolymer 937, manufactured by ISP), vinylcaprolactam / vinylpyrrolidone / dimethylaminoethyl methacrylate copolymer (copolymer VC713, manufactured by ISP), etc. There is. Cellulose or derivatives thereof, keratin and collagen or derivatives thereof, calcium alginate, pullulan, agar, gelatin, tamarind seed polysaccharide, xanthan gum, carrageenan, high methoxyl pectin, low methoxyl pectin, guar gum, gum arabic, crystalline cellulose, arabino Naturally derived polymer compounds such as galactan, gum karaya, gum tragacanth, alginic acid, albumin, casein, curdlan, gellan gum and dextran can also be suitably used.
(9)生理活性成分の例
生理活性成分としては、皮膚に塗布した場合に皮膚に何らかの生理活性を与える物質が挙げられる。例えば、美白成分、抗炎症剤、老化防止剤、紫外線防御剤、スリミング剤、ひきしめ剤、抗酸化剤、発毛剤、育毛剤、保湿剤、血行促進剤、抗菌剤、殺菌剤、乾燥剤、冷感剤、温感剤、ビタミン類、アミノ酸、創傷治癒促進剤、刺激緩和剤、鎮痛剤、細胞賦活剤、酵素成分等が挙げられる。これらの好適な配合成分の例としては、例えばアシタバエキス、アボカドエキス、アマチャエキス、アルテアエキス、アルニカエキス、アロエエキス、アンズエキス、アンズ核エキス、イチョウエキス、ウイキョウエキス、ウコンエキス、ウーロン茶エキス、エイジツエキス、エチナシ葉エキス、オウゴンエキス、オウバクエキス、オウレンエキス、オオムギエキス、オトギリソウエキス、オドリコソウエキス、オランダカラシエキス、オレンジエキス、海水乾燥物、海藻エキス、加水分解エラスチン、加水分解コムギ末、加水分解シルク、カモミラエキス、カロットエキス、カワラヨモギエキス、甘草エキス、カルカデエキス、カキョクエキス、キナエキス、キューカンバ-エキス、グアノシン、クチナシエキス、クマザサエキス、クララエキス、クルミエキス、グレープフルーツエキス、クレマティスエキス、クロレラエキス、クワエキス、ゲンチアナエキス、紅茶エキス、酵母エキス、ゴボウエキス、コメヌカ発酵エキス、コメ胚芽油、コンフリーエキス、コラーゲン、コケモモエキス、サイシンエキス、サイコエキス、サイタイ抽出液、サルビアエキス、サボンソウエキス、ササエキス、サンザシエキス、サンショウエキス、シイタケエキス、ジオウエキス、シコンエキス、シソエキス、シナノキエキス、シモツケソウエキス、シャクヤクエキス、ショウブ根エキス、シラカバエキス、スギナエキス、セイヨウキズタエキス、セイヨウサンザシエキス、セイヨウニワトコエキス、セイヨウノコギリソウエキス、セイヨウハッカエキス、セ-ジエキス、ゼニアオイエキス、センキュウエキス、センブリエキス、ダイズエキス、タイソウエキス、タイムエキス、茶エキス、チョウジエキス、チガヤエキス、チンピエキス、トウキエキス、トウキンセンカエキス、トウニンエキス、トウヒエキス、ドクダミエキス、トマトエキス、納豆エキス、ニンジンエキス、ニンニクエキス、ノバラエキス、ハイビスカスエキス、バクモンドウエキス、パセリエキス、蜂蜜、ハマメリスエキス、パリエタリアエキス、ヒキオコシエキス、ビサボロール、ビワエキス、フキタンポポエキス、フキノトウエキス、ブクリョウエキス、ブッチャーブルームエキス、ブドウエキス、プロポリス、ヘチマエキス、ベニバナエキス、ペパーミントエキス、ボダイジュエキス、ボタンエキス、ホップエキス、マツエキス、マロニエエキス、ミズバショウエキス、ムクロジエキス、メリッサエキス、モモエキス、ヤグルマギクエキス、ユーカリエキス、ユキノシタエキス、ヨクイニンエキス、ヨモギエキス、ラベンダーエキス、リンゴエキス、レタスエキス、レモンエキス、レンゲソウエキス、ローズエキス、ローズマリーエキス、ローマカミツレエキス、ローヤルゼリーエキス等を挙げることができる。
また、デオキシリボ核酸、ムコ多糖類、ヒアルロン酸ナトリウム、コンドロイチン硫酸ナトリウム、コラーゲン、エラスチン、キチン、キトサン、加水分解卵殻膜などの生体高分子、アミノ酸、加水分解ペプチド、乳酸ナトリウム、尿素、ピロリドンカルボン酸ナトリウム、ベタイン、ホエイ、トリメチルグリシンなどの保湿成分、スフィンゴ脂質、セラミド、フィトスフィンゴシン、コレステロール、コレステロール誘導体、リン脂質などの油性成分、ε-アミノカプロン酸、グリチルリチン酸、β-グリチルレチン酸、塩化リゾチーム、グアイアズレン、ヒドロコールチゾン等の抗炎症剤、ビタミンA、ビタミンB2、ビタミンB6、ビタミンC、ビタミンD、ビタミンE、パントテン酸カルシウム、ビオチン、ニコチン酸アミド、ビタミンCエステル等のビタミン類、アラントイン、ジイソプロピルアミンジクロロアセテート、4-アミノメチルシクロヘキサンカルボン酸等の活性成分、トコフェロール、カロチノイド、フラボノイド、タンニン、リグナン、サポニン等の抗酸化剤、α-ヒドロキシ酸、β-ヒドロキシ酸などの細胞賦活剤、γ-オリザノール、ビタミンE誘導体などの血行促進剤、レチノール、レチノール誘導体等の創傷治癒剤、アルブチン、コウジ酸、プラセンタエキス、イオウ、エラグ酸、リノール酸、トラネキサム酸、グルタチオン等の美白剤、セファランチン、カンゾウ抽出物、トウガラシチンキ、ヒノキチオール、ヨウ化ニンニクエキス、塩酸ピリドキシン、DL-α-トコフェロール、酢酸DL-α-トコフェロール、ニコチン酸、ニコチン酸誘導体、パントテン酸カルシウム、D-パントテニルアルコール、アセチルパントテニルエチルエーテル、ビオチン、アラントイン、イソプロピルメチルフェノール、エストラジオール、エチニルエストラジオール、塩化カプロニウム、塩化ベンザルコニウム、塩酸ジフェンヒドラミン、タカナール、カンフル、サリチル酸、ノニル酸バニリルアミド、ノナン酸バニリルアミド、ピロクトンオラミン、ペンタデカン酸グリセリル、L-メントール、モノニトログアヤコール、レゾルシン、γ-アミノ酪酸、塩化ベンゼトニウム、塩酸メキシレチン、オーキシン、女性ホルモン、カンタリスチンキ、シクロスポリン、ジンクピリチオン、ヒドロコールチゾン、ミノキシジル、モノステアリン酸ポリオキシエチレンソルビタン、ハッカ油、ササニシキエキス等の育毛剤などが挙げられる。
(9) Examples of physiologically active ingredients Examples of physiologically active ingredients include substances that impart some physiological activity to the skin when applied to the skin. For example, whitening ingredients, anti-inflammatory agents, anti-aging agents, UV protection agents, slimming agents, tanning agents, antioxidants, hair growth agents, hair restorers, moisturizers, blood circulation promoters, antibacterial agents, bactericides, desiccants, A cooling sensation agent, a warming sensation agent, vitamins, an amino acid, a wound healing promoter, an irritation relaxation agent, an analgesic agent, a cell activator, an enzyme component, etc. are mentioned. Examples of these suitable ingredients include, for example, ashitaba extract, avocado extract, amateur extract, altea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo biloba extract, fennel extract, turmeric extract, oolong tea extract, ages Extract, Echinacea leaf extract, Ogon extract, Oat extract, Oen extract, Barley extract, Hypericum extract, Oyster extract, Dutch mustard extract, Orange extract, Seawater dried product, Seaweed extract, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk , Chamomile extract, Carrot extract, Kawara mugwort extract, Licorice extract, Calcade extract, Oyster extract, Kina extract, Cucumber extract, Guanosine, Gardenia extract, Kumazasa extract, Clarae Kiss, walnut extract, grapefruit extract, clematis extract, chlorella extract, mulberry extract, gentian extract, tea extract, yeast extract, burdock extract, fermented rice bran extract, rice germ oil, comfrey extract, collagen, bilberry extract, saicin extract, psycho extract Extract Kizuta extract, hawthorn extract, elderberry extract, yarrow extract, mint extract, sage extract, mallow extract, senki Sue extract, assembly extract, soybean extract, tiso extract, thyme extract, tea extract, clove extract, chigaya extract, chimpi extract, touki extract, toshinsen extract, tonin extract, spruce extract, dokudami extract, tomato extract, natto extract, carrot extract, garlic extract, Novara extract, hibiscus extract, bacmond extract, parsley extract, honey, hamamelis extract, parietalia extract, toad extract, bisabolol, loquat extract, dandelion extract, burdock extract, bukuro extract, butcher bloom extract, grape extract, propolis, loofah extract, Safflower extract, peppermint extract, bodaige extract, button extract, hop extract, pine extract, marronnier extract, mizubasho Kiss, Mukuroji extract, Melissa extract, Peach extract, Cornflower extract, Eucalyptus extract, Yukinoshita extract, Yokuinin extract, Artemisia extract, Lavender extract, Apple extract, Lettuce extract, Lemon extract, Lotus root extract, Rose extract, Rosemary extract, Roman chamomile extract And royal jelly extract.
Biopolymers such as deoxyribonucleic acid, mucopolysaccharide, sodium hyaluronate, sodium chondroitin sulfate, collagen, elastin, chitin, chitosan, hydrolyzed eggshell membranes, amino acids, hydrolyzed peptides, sodium lactate, urea, sodium pyrrolidonecarboxylate , Moisturizing ingredients such as betaine, whey, trimethylglycine, oily ingredients such as sphingolipid, ceramide, phytosphingosine, cholesterol, cholesterol derivatives, phospholipids, ε-aminocaproic acid, glycyrrhizic acid, β-glycyrrhetinic acid, lysozyme chloride, guaiazulene, Anti-inflammatory agents such as hydrocortisone, vitamin A, vitamin B2, vitamin B6, vitamin C, vitamin D, vitamin E, calcium pantothenate, biotin, nicotinamide, vitamin C ester, etc. Active ingredients such as vitamins, allantoin, diisopropylamine dichloroacetate, 4-aminomethylcyclohexanecarboxylic acid, antioxidants such as tocopherol, carotenoid, flavonoid, tannin, lignan, saponin, α-hydroxy acid, β-hydroxy acid, etc. Cell activators, blood circulation promoters such as γ-oryzanol and vitamin E derivatives, wound healing agents such as retinol and retinol derivatives, whitening such as arbutin, kojic acid, placenta extract, sulfur, ellagic acid, linoleic acid, tranexamic acid and glutathione Agent, cephalanthin, licorice extract, capsicum tincture, hinokitiol, garlic iodide extract, pyridoxine hydrochloride, DL-α-tocopherol, DL-α-tocopherol acetate, nicotinic acid, nicotinic acid derivative, calcium pantothenate, D-pant Tenenyl alcohol, acetyl pantothenyl ethyl ether, biotin, allantoin, isopropylmethylphenol, estradiol, ethinyl estradiol, capronium chloride, benzalkonium chloride, diphenhydramine hydrochloride, takanal, camphor, salicylic acid, nonylic acid vanillylamide, nonanoic acid vanillylamide, piroctone ola Mines, glyceryl pentadecanoate, L-menthol, mononitroguaiacol, resorcin, γ-aminobutyric acid, benzethonium chloride, mexiletine hydrochloride, auxin, female hormone, cantalis tincture, cyclosporine, zinc pyrithione, hydrocortisone, minoxidil, polymonostearate Examples include hair restorers such as oxyethylene sorbitan, mint oil, and Sasanishiki extract.
(10)酸化防止剤の例
亜硫酸水素ナトリウム、亜硫酸ナトリウム、エリソルビン酸、エリソルビン酸ナトリウム、チオジプロピオン酸ジラウリル、トコフェロール、トリルビグアナイド、ノルジヒドログアヤレチン酸、パラヒドロキシアニソール、ブチルヒドロキシアニソール、ジブチルヒドロキシトルエン、ステアリン酸アスコルビル、パルミチン酸アスコルビル、没食子酸オクチル、没食子酸プロピル、カロチノイド、フラボノイド、タンニン、リグナン、サポニン、リンゴエキスやチョウジエキスなどの酸化防止効果の認められる植物エキス等が挙げられる。
(10) Examples of antioxidants Sodium bisulfite, sodium sulfite, erythorbic acid, sodium erythorbate, dilauryl thiodipropionate, tocopherol, tolyl biguanide, nordihydroguaiaretic acid, parahydroxyanisole, butylhydroxyanisole, dibutylhydroxy Examples include plant extracts having an antioxidant effect such as toluene, ascorbyl stearate, ascorbyl palmitate, octyl gallate, propyl gallate, carotenoid, flavonoid, tannin, lignan, saponin, apple extract and clove extract.
(11)溶媒の例
精製水、エタノール、低級アルコール、エーテル類、LPG、フルオロカーボン、N-メチルピロリドン、フルオロアルコール、揮発性直鎖状シリコーン、次世代フロン等が挙げられる。
(11) Examples of solvents Purified water, ethanol, lower alcohol, ethers, LPG, fluorocarbon, N-methylpyrrolidone, fluoroalcohol, volatile linear silicone, next-generation chlorofluorocarbon and the like.
本発明を食品組成物に用いる場合、各種飲料や各種加工製品の原材料として本発明を飲食品に添加したり、必要に応じてデキストリン、乳糖、デンプン等の賦形剤や香料、色素等とともにペレット、錠剤、顆粒等に加工したり、またゼラチン等で被覆してカプセルに成形加工して健康食品、保健食品等の食品組成物を製造することができる。 When the present invention is used in food compositions, the present invention can be added to foods and drinks as raw materials for various beverages and various processed products, or pellets with excipients such as dextrin, lactose, starch, flavorings, pigments, etc. It can be processed into tablets, granules, etc., or coated with gelatin and molded into capsules to produce food compositions such as health foods and health foods.
食品組成物に配合される本発明の抗皮膚老化用組成物の配合割合は、抗皮膚老化用組成物の期待される効果が得られるのであれば特に制限されないが、通常、1回あたりの摂取量が0.0001〜20mg程度である。 The blending ratio of the anti-skin aging composition of the present invention blended in the food composition is not particularly limited as long as the expected effect of the anti-skin aging composition can be obtained. The amount is about 0.0001 to 20 mg.
これらの食品組成物には、その種類に応じて種々の成分を配合することができ、例えば、ブドウ糖、果糖、ショ糖、マルトース、ソルビトール、ステビオサイド、コーンシロップ、乳糖、クエン酸、酒石酸、リンゴ酸、コハク酸、乳酸、L−アスコルビン酸、dl−α−トコフェロール、エリソルビン酸ナトリウム、グリセリン、プロピレングリコール、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ショ糖脂肪酸エステル、ソルビタン脂肪酸エステル、プロピレングリコール脂肪酸エステル、アラビアガム、カラギーナン、カゼイン、ゼラチン、ペクチン、寒天、ビタミンB類、ニコチン酸アミド、パントテン酸カルシウム、アミノ酸類、カルシウム塩類、色素、香料、保存剤等の食品素材を使用することができる。さらに、健康維持機能をもった本美肌用組成物には、他の抗酸化物質や健康食品素材などの配剤、例えば、抗酸化物質(還元型アスコルビン酸(ビタミンC)、ビタミンE、還元型グルタチン、トコトリエノール、ビタミンA誘導体、リコピン、ルテイン、アスタキサンチン、ゼアキサンチン、フコキサンチン、尿酸、ユビキノン、コエンザイムQ10、葉酸、ニンニクエキス、アリシン、セサミン、リグナン類、カテキン、イソフラボン、カルコン、タンニン類、フラボノイド類、クマリン、イソクマリン類、ブルーベリーエキス)、健康食品素材(V.(ビタミン)A、V.B1、V.B2、V.B6、V.B12、V.C、V.D、V.E、V.P、コリン、ナイアシン、パントテン酸、葉酸カルシウム、EPA、オリゴ糖、食物繊維、スクアレン、大豆レシチン、タウリン、ドナリエラ、プロテイン、オクタコサノール、DHA、卵黄レシチン、リノール酸、ラクトフェリン、マグネシウム、亜鉛、クロム、セレン
、カリウム、ヘム鉄、カキ肉エキス、キトサン、キチンオリゴ糖、コラーゲン、コンドロイチン、ウコン、カンゾウ、クコシ、ケイヒ、サンザシ、生姜、霊芝、シジミエキス、スッポン、カンゾウ、クコシ、ケイヒ、サンザシ、生姜、霊芝、オオバコ、カミツレ、カモミール、セイヨウタンポポ、ハイビスカス、ハチミツ、ボーレン、ローヤルゼリー、ライム、ラベンダー、ローズヒップ
、ローズマリー、セージ、ビフィズス菌、フェーカリス菌、ラクリス、小麦胚芽油、ゴマ油、シソ油、大豆油、中鎖脂肪酸、アガリクス、イチョウ葉エキス、ウコン、コンドロイチン、玄米胚芽エキス、レイシ、タマネギ、DHA、 EPA、 DPA、 甜茶、冬虫夏草、ニンニク、蜂の子、パパイヤ、プーアル、プロポリス、メグスリの木、ヤブシタケ、ロイヤルゼリー、ノコギリヤシ、ヒアルロン酸、コラーゲン、ギャバ、ハープシールオイル、サメ軟骨、グルコサミン、レシチン、ホスファチジルセリン、田七ニンジン、桑葉、大豆抽出物、エキナセア、エゾウコギ、大麦抽出物、オリーブ葉、オリーブ実、ギムネマ、バナバ、サラシア、ガルシニア、キトサン、セントジョーンズワート、ナツメ、ニンジン、パッションフラワー、ブロッコリー、プラセンタ、ハトムギ、ブドウ種子、ピーナッツ種皮、ビルベリー、ブラックコホシュ、マリアアザミ、月桂樹、セージ、ローズマリー、ラフマ、黒酢、ゴーヤー、マカ、紅花、亜麻、ウーロン茶、花棘、カフェイン、カプサイシン、キシロオリゴ糖、グルコサミン、ソバ、シトラス、食物繊維、プロテイン、プルーン、スピルリナ、大麦若葉、核酸、酵母、椎茸、梅肉、アミノ酸、深海鮫抽出物、ノニ、カキ肉、スッポン、シャンピニオン、オオバコ、アセロラ、パイナップル、バナナ、モモ、アンズ、メロン、イチゴ、ラズベリー、オレンジ、フコイダン、メシマコブ、クランベリー、コンドロイチン硫酸、亜鉛、鉄、セラミド、シルクペプチド、グリシン、ナイアシン、チェストツリー、L-システイン、赤ワイン葉、ミレット、ホーステール、ビオチン、センテラアジアティカ、ハスカップ、ピクノジェノール、フキ、ルバーブ、クローブ、ローズマリー、カテキン、プーアル、クエン酸、ビール酵母、メリロート、ブラックジンガー、ショウガ、ガジュツ、ナットウキナーゼ、ベニコウジ、トコトリエノール、ラクトフェリン、シナモン、韃靼ソバ、ココア、ユズ種子エキス、シソの実エキス、ライチ種子エキス、月見草エキス、黒米エキス、α−リポ酸、生コーヒー豆エキス)なども配合することができる。
These food compositions can be blended with various components depending on the type, for example, glucose, fructose, sucrose, maltose, sorbitol, stevioside, corn syrup, lactose, citric acid, tartaric acid, malic acid. Succinic acid, lactic acid, L-ascorbic acid, dl-α-tocopherol, sodium erythorbate, glycerin, propylene glycol, glycerin fatty acid ester, polyglycerin fatty acid ester, sucrose fatty acid ester, sorbitan fatty acid ester, propylene glycol fatty acid ester, Arabia Food materials such as gum, carrageenan, casein, gelatin, pectin, agar, vitamin Bs, nicotinic acid amide, calcium pantothenate, amino acids, calcium salts, pigments, fragrances and preservatives can be used. In addition, this skin-beautifying composition having a health maintenance function includes other antioxidants and health food ingredients such as antioxidants (reduced ascorbic acid (vitamin C), vitamin E, reduced glutatin). , Tocotrienol, vitamin A derivatives, lycopene, lutein, astaxanthin, zeaxanthin, fucoxanthin, uric acid, ubiquinone, coenzyme Q10, folic acid, garlic extract, allicin, sesamin, lignans, catechin, isoflavone, chalcone, tannins, flavonoids, coumarin , Isocoumarins, blueberry extract), health food ingredients (V. (vitamin) A, V.B1, V.B2, V.B6, V.B12, VC, VD, VE, VP, choline, niacin, pantothenic acid, Calcium folate, EPA, oligosaccharide, dietary fiber, squalene, soybean lecithin, taurine, donariella, pro Thein, octacosanol, DHA, egg yolk lecithin, linoleic acid, lactoferrin, magnesium, zinc, chromium, selenium, potassium, heme iron, oyster meat extract, chitosan, chitin oligosaccharides, collagen, chondroitin, turmeric, licorice, kokushi, keihi, hawthorn , Ginger, ganoderma, swordfish extract, suppon, licorice, kokushi, keihi, hawthorn, ginger, ganoderma, plantain, chamomile, chamomile, dandelion, hibiscus, honey, boren, royal jelly, lime, lavender, rosehip, rosemary, Sage, bifidobacteria, faecalis, lacris, wheat germ oil, sesame oil, perilla oil, soybean oil, medium chain fatty acid, agaricus, ginkgo biloba extract, turmeric, chondroitin, brown rice germ extract, litchi, onion, DHA, EPA, DPA甜 Tea, Cordyceps, Garlic, Bee, Papaya, Puaru, Propolis, Meguri Tree, Yabushitake, Royal Jelly, Saw Palmetto, Hyaluronic Acid, Collagen, Gabba, Harpseal Oil, Shark Cartilage, Glucosamine, Lecithin, Phosphatidylserine, Tabashi Carrot, mulberry leaf, soy extract, echinacea, sorghum, barley extract, olive leaf, olive fruit, gymnema, banaba, salacia, garcinia, chitosan, st jones wort, jujube, carrot, passion flower, broccoli, placenta, pearl barley, grape Seeds, peanut seed coat, bilberry, black cohosh, maria thistle, laurel, sage, rosemary, raffma, black vinegar, bitter gourd, maca, safflower, flax, oolong tea, flower spine, caffeine, capsaicin, xy Oligosaccharide, Glucosamine, Buckwheat, Citrus, Dietary fiber, Protein, Prunes, Spirulina, Barley young leaves, Nucleic acid, Yeast, Shiitake, Plum meat, Amino acid, Deep sea potato extract, Noni, Oyster meat, Suppon, Champignon, Psyllium, Acerola, Pineapple, banana, peach, apricot, melon, strawberry, raspberry, orange, fucoidan, mesimacob, cranberry, chondroitin sulfate, zinc, iron, ceramide, silk peptide, glycine, niacin, chesttree, L-cysteine, red wine leaf, millet, Horsetail, Biotin, Centella Asiatica, Lotus Cup, Pycnogenol, Japanese cypress, Rhubarb, Clove, Rosemary, Catechin, Pual, Citric Acid, Beer Yeast, Merirot, Black Zinger, Ginger, Gajutsu, Nattokina , Benikouji, Tocotrienol, Lactoferrin, Cinnamon, Persimmon Buckwheat, Cocoa, Yuzu Seed Extract, Perilla Seed Extract, Lychee Seed Extract, Evening Primrose Extract, Black Rice Extract, α-Lipoic Acid, Raw Coffee Bean Extract) .
以下、本発明の実施例を説明する。
実施例
ジュンサイ抽出物の調製
乾燥ジュンサイ(200 g)に30w/w%のエタノール(6 kg)を加えて50℃で2時間撹拌抽出後,濾過を行った。濾液を減圧濃縮・乾燥してジュンサイ抽出物(44.3 g,収率22.1%)を得た。
Examples of the present invention will be described below.
Example Preparation of Junsai extract 30 wt / w% ethanol (6 kg) was added to dried Junsai (200 g), followed by stirring and extraction at 50 ° C. for 2 hours, followed by filtration. The filtrate was concentrated under reduced pressure and dried to obtain Junsai extract (44.3 g, yield 22.1%).
試験例:線維芽細胞からのヒアルロン酸およびコラーゲン産生に対する作用の評価
試験方法
線維芽細胞(TIG-108)を10%ウシ胎児血清(FCS)含有D-MEM培地に2×104
cells/mLになるようにサスペンドし,6穴プレートに500 μLずつ播種した。48時間培養後,培地を0.5%FCS含有D-MEM培地に交換し,24時間培養した。ここにジュンサイ抽出物を1または10 μg/mLになるように添加し,アディポネクチン(1 μg/mL)存在下または非存在下で72時間培養した。培地を除去したのちRIPAバッファー(200 μg/mL)を加えて細胞を回収した。得られた細胞懸濁液を500 μg/mLのタンパク濃度になるように希釈し,サンプルバッファーで2倍希釈したものを95度で5分間熱処理した。この溶液(15 μL)を10%ポリアクリルアミドゲル上で電気泳動したのち,PVDFメンブレンに転写した。転写後のメンブレンに,抗ヒアルロン酸合成酵素2(HAS2)抗体,抗I型コラーゲン抗体,抗ヒアルロン酸結合タンパク2(HABP2)抗体または抗β-アクチン抗体を反応させた。それぞれの抗体の動物種に反応する二次抗体(ペルオキシダーゼ標識)を作用させた後,化学発光法によりHAS2,HABP2,I型コラーゲンおよびβ-アクチンの発現量を調べた。
Test example: Evaluation method for effects on production of hyaluronic acid and collagen from fibroblasts Test method Fibroblasts (TIG-108) in D-MEM medium containing 10% fetal calf serum (FCS) 2 × 10 4
Suspends to cells / mL and seeds 500 μL each in a 6-well plate. After culturing for 48 hours, the medium was replaced with 0.5% FCS-containing D-MEM medium and cultured for 24 hours. Junsai extract was added to 1 or 10 μg / mL and cultured for 72 hours in the presence or absence of adiponectin (1 μg / mL). After removing the medium, RIPA buffer (200 μg / mL) was added to recover the cells. The obtained cell suspension was diluted to a protein concentration of 500 μg / mL, and diluted twice with sample buffer, and heat-treated at 95 ° C. for 5 minutes. This solution (15 μL) was electrophoresed on a 10% polyacrylamide gel and then transferred to a PVDF membrane. The membrane after transfer was reacted with anti-hyaluronic acid synthase 2 (HAS2) antibody, anti-type I collagen antibody, anti-hyaluronic acid binding protein 2 (HABP2) antibody or anti-β-actin antibody. After reacting each antibody species with a secondary antibody (peroxidase label), the expression levels of HAS2, HABP2, type I collagen and β-actin were examined by chemiluminescence.
結果及び実施例の効果
図1にはアディポネクチン非存在下でのHAS2,HABP2,I型コラーゲンおよびβ-アクチンの発現量を示した。マーカータンパクのβ-アクチンの発現はジュンサイ抽出物(WSE)の有り無しにかかわらず一定であった。またHAS2,I型コラーゲンおよびHABP2の発現はWSEの添加により増加しなかった。
図2にはアディポネクチン(1 μg/mL)存在下での各タンパクの発現量を示した。β-アクチンの発現は,アディポネクチンやWSEの有り無しにかかわらず一定であった。HAS2,HABP2およびI型コラーゲンの発現量はアディポネクチン(1 μg/mL)の添加により,若干増加した。これに対し,アディポネクチン(1 μg/mL)とWSE(10 μg/mL)を共存させた時,HAS2,HABP2およびI型コラーゲンの発現量は劇的に増加した。
以上の結果より,WSEはアディポネクチンと10:1の割合の濃度で共存する時,劇的に細胞外マトリックス構成成分であるコラーゲンやヒアルロン酸の産生を高めることが示された。
以上により、ジュンサイ抽出物とアディポネクチンとを配合することにより相乗的にヒアルロン酸及びコラーゲンの産生を促進するため、より優れた抗皮膚老化用組成物を得ることができることが確認された。
Results and Effects of Examples FIG. 1 shows the expression levels of HAS2, HABP2, type I collagen and β-actin in the absence of adiponectin. Expression of the marker protein β-actin was constant regardless of the presence or absence of Junsai extract (WSE). The expression of HAS2, type I collagen and HABP2 did not increase with the addition of WSE.
FIG. 2 shows the expression level of each protein in the presence of adiponectin (1 μg / mL). β-actin expression was constant with or without adiponectin or WSE. The expression levels of HAS2, HABP2 and type I collagen increased slightly with the addition of adiponectin (1 μg / mL). In contrast, the expression levels of HAS2, HABP2 and type I collagen increased dramatically when adiponectin (1 μg / mL) and WSE (10 μg / mL) coexisted.
The above results indicate that WSE dramatically increases the production of extracellular matrix components such as collagen and hyaluronic acid when coexisting with adiponectin at a concentration of 10: 1.
From the above, it was confirmed that a superior anti-aging composition for skin aging can be obtained because the production of hyaluronic acid and collagen is synergistically promoted by combining Junsai extract and adiponectin.
本発明の抗皮膚老化用組成物(ジュンサイ抽出物及びアディポネクチンまたはアディポネクチン産生促進剤)の配合例を示す。尚、以下の配合例は本発明を限定するものではない。
配合例1:化粧クリーム
スクワラン 20.0wt%
ミツロウ 5.0
精製ホホバ油 5.0
グリセリン 5.0
グリセリンモノステアレート 2.0
ポリオキシエチレン(20)ソルビタン-
モノステアレート 2.0
抗皮膚老化用組成物 2.0
防腐剤 適量
香料 適量
精製水 残余
100.0wt%
The compounding example of the composition for anti-skin aging (Junsai extract and adiponectin or adiponectin production promoter) of the present invention is shown. In addition, the following compounding examples do not limit the present invention.
Formulation Example 1: Cosmetic cream
Squalane 20.0wt%
Beeswax 5.0
Refined jojoba oil 5.0
Glycerin 5.0
Glycerol monostearate 2.0
Polyoxyethylene (20) sorbitan-
Monostearate 2.0
Anti-skin aging composition 2.0
Preservative appropriate amount
Perfume
Purified water residue
100.0wt%
配合例2:化粧水
エタノール 5.0wt%
グリセリン 2.0
1,3−ブチレングリコール 2.0
ポリエチレンオレイルエーテル 0.5
クエン酸ナトリウム 0.1
クエン酸 0.1
抗皮膚老化用組成物 0.1
精製水 残余
100.0wt%
Formulation Example 2: Lotion
Ethanol 5.0wt%
Glycerin 2.0
1,3-butylene glycol 2.0
Polyethylene oleyl ether 0.5
Sodium citrate 0.1
Citric acid 0.1
Anti-skin aging composition 0.1
Purified water residue
100.0wt%
配合例3:ボディージェル
マカデミアナッツ油 2.0wt%
ミリスチン酸オクチルドデシル 10.0
メチルフェニルポリシロキサン 5.0
ベヘニルアルコール 3.0
ステアリン酸 3.0
バチルアルコール 1.0
モノステアリン酸グリセリル 1.0
テトラオレイン酸ポリオキシエチレンソルビット 2.0
水素添加大豆リン脂質 1.0
セラミド 0.1
パルミチン酸レチノール 0.1
防腐剤 適量
ツボクサ抽出物 1.0
抗皮膚老化用組成物 1.0
1、3−ブチレングリコール 5.0
精製水 残余
100.0wt%
Formulation Example 3: Body Gel
Macadamia nut oil 2.0wt%
Octyldodecyl myristate 10.0
Methylphenylpolysiloxane 5.0
Behenyl alcohol 3.0
Stearic acid 3.0
Batyl alcohol 1.0
Glyceryl monostearate 1.0
Tetraoleic acid polyoxyethylene sorbit 2.0
Hydrogenated soybean phospholipid 1.0
Ceramide 0.1
Retinol palmitate 0.1
Preservative appropriate amount
Centella extract 1.0
Anti-skin aging composition 1.0
1,3-butylene glycol 5.0
Purified water residue
100.0wt%
配合例4:乳液
スクワラン 4.0wt%
ワセリン 2.5
セタノール 2.0
グリセリン 2.0
親油型モノステアリン酸グリセリン 1.0
ステアリン酸 1.0
L−アルギニン 1.0
抗皮膚老化用組成物 0.5
水酸化カリウム 0.1
香料 微量
精製水 残余
100.0wt%
Formulation Example 4: Latex
Squalane 4.0wt%
Vaseline 2.5
Cetanol 2.0
Glycerin 2.0
Lipophilic glyceryl monostearate 1.0
Stearic acid 1.0
L-Arginine 1.0
Anti-skin aging composition 0.5
Potassium hydroxide 0.1
Perfume
Purified water residue
100.0wt%
配合例5:浴用剤(液状)
プロピレングリコール 50.0wt%
エタノール 20.0
硫酸ナトリウム 5.0
抗皮膚老化用組成物 0.5
ラノリン 0.5
アボガド油 0.5
色素 1.5
香料 22.0
100.0wt%
配合例6:シャンプー
ポリオキシエチレンアルキルエーテル硫酸ナトリウム
(E.O2モル) 15.0
ヤシ油脂肪族ジエタノールアミド 5.0
グリセリン 3.0
抗皮膚老化用組成物 0.4
エタノール 5.0
香料及び防腐剤 適量
イオン交換水 残余
全体 100wt%
Formulation Example 5: Bath agent (liquid)
Propylene glycol 50.0wt%
Ethanol 20.0
Sodium sulfate 5.0
Anti-skin aging composition 0.5
Lanolin 0.5
Avocado oil 0.5
Dye 1.5
Fragrance 22.0
100.0wt%
Formulation Example 6: Shampoo Polyoxyethylene alkyl ether sodium sulfate
(E.O2 mol) 15.0
Palm oil aliphatic diethanolamide 5.0
Glycerin 3.0
Anti-skin aging composition 0.4
Ethanol 5.0
Perfume and preservatives
Ion exchange water
Total 100wt%
配合例7:ヘヤークリーム
流動パラフィン 20.0wt%
固形パラフィン 3.0
ポリオキシエチレンセチル エーテル
(E.O15モル) 2.0
ソルビタンセスキオレート 1.0
抗皮膚老化用組成物 0.2
エタノール 10.0
水酸化カリウム 0.1
グリセリン 3.0
香料及び防腐剤 適量
全体 100wt%
Formulation Example 7: Hair Cream
Liquid paraffin 20.0wt%
Solid paraffin 3.0
Polyoxyethylene cetyl ether
(E.O15 mol) 2.0
Sorbitan sesquioleate 1.0
Anti-skin aging composition 0.2
Ethanol 10.0
Potassium hydroxide 0.1
Glycerin 3.0
Perfume and preservatives
Total 100wt%
配合例8:軟膏剤
サラシミツロウ 5.0wt%
精製ラノリン 5.0
抗皮膚老化用組成物 1.0
香料 0.1
ワセリン 残余
全体 100wt%
Formulation Example 8: Ointment
White beeswax 5.0wt%
Purified lanolin 5.0
Anti-skin aging composition 1.0
Fragrance 0.1
Vaseline residue
Total 100wt%
配合例9:チューインガム
砂糖 53.0wt%
ガムベース 20.0
グルコース 10.0
水飴 16.0
香料 0.5
抗皮膚老化用組成物 0.5
100.0wt%
Formulation Example 9: Chewing gum
53.0wt% sugar
Gum base 20.0
Glucose 10.0
Minamata 16.0
Fragrance 0.5
Anti-skin aging composition 0.5
100.0wt%
配合例10:グミ
還元水飴 40.0wt%
グラニュー糖 20.0
ブトウ糖 20.0
ゼラチン 4.7
水 9.68
ユズ果汁 4.0
ユズフレーバー 0.6
色素 0.02
抗皮膚老化用組成物 1.0
100.0wt%
Formulation Example 10: Gummy
Reduced water tank 40.0wt%
Granulated sugar 20.0
Buto sugar 20.0
Gelatin 4.7
Water 9.68
Yuzu fruit juice 4.0
Yuzu Flavor 0.6
Dye 0.02
Anti-skin aging composition 1.0
100.0wt%
配合例11:キャンディー
砂糖 50.0wt%
水飴 33.0
水 14.4
有機酸 2.0
香料 0.2
抗皮膚老化用組成物 0.4
100.0wt%
Formulation Example 11: Candy
50.0 wt% sugar
Minamata 33.0
Water 14.4
Organic acid 2.0
Fragrance 0.2
Anti-skin aging composition 0.4
100.0wt%
配合例12:ヨーグルト(ハード・ソフト)
牛乳 41.5wt%
脱脂粉乳 5.8
砂糖 8.0
寒天 0.15
ゼラチン 0.1
乳酸菌 0.005
抗皮膚老化用組成物 0.4
香料 微量
水 残余
100.0wt%
Formulation Example 12: Yogurt (hard / soft)
Milk 41.5wt%
Nonfat dry milk 5.8
Sugar 8.0
Agar 0.15
Gelatin 0.1
Lactic acid bacteria 0.005
Anti-skin aging composition 0.4
Perfume
Water residue
100.0wt%
配合例13:清涼飲料
果糖ブドウ糖液糖 30.0wt%
乳化剤 0.5
抗皮膚老化用組成物 0.3
香料 適量
精製水 残余
100.0wt%
Formulation Example 13: Soft drink
Fructose glucose liquid sugar 30.0wt%
Emulsifier 0.5
Anti-skin aging composition 0.3
Perfume
Purified water residue
100.0wt%
配合例14:錠菓
砂糖 76.4wt%
グルコース 19.0
ショ糖脂肪酸エステル 0.2
抗皮膚老化用組成物 0.5
精製水 3.9
100.0wt%
Formulation Example 14: Tablet
76.4 wt% sugar
Glucose 19.0
Sucrose fatty acid ester 0.2
Anti-skin aging composition 0.5
Purified water 3.9
100.0wt%
配合例15:ソフトカプセル
玄米胚芽油 47.0wt%
ユズ種子油 40.0
乳化剤 12.0
抗皮膚老化用組成物 1.0
100.0wt%
Formulation Example 15: Soft capsule
Brown rice germ oil 47.0wt%
Yuzu seed oil 40.0
Emulsifier 12.0
Anti-skin aging composition 1.0
100.0wt%
配合例16:錠剤
乳糖 54.0wt%
結晶セルロース 30.0
澱粉分解物 10.0
グリセリン脂肪酸エステル 5.0
抗皮膚老化用組成物 1.0
100.0wt%
Formulation Example 16: Tablet
Lactose 54.0wt%
Crystalline cellulose 30.0
Starch degradation product 10.0
Glycerin fatty acid ester 5.0
Anti-skin aging composition 1.0
100.0wt%
以上により、本発明は、抗皮膚老化用組成物として有用であり、医薬品、化粧料、食品組成物等に利用することができる。 As described above, the present invention is useful as an anti-skin aging composition and can be used for pharmaceuticals, cosmetics, food compositions and the like.
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Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
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CN104958203A (en) * | 2015-06-17 | 2015-10-07 | 石柱土家族自治县潘婆婆莼菜科技发展有限公司 | Water shield mask lotion |
CN104958205A (en) * | 2015-06-17 | 2015-10-07 | 石柱土家族自治县潘婆婆莼菜科技发展有限公司 | Water shield essential lotion |
JP2017128550A (en) * | 2016-01-22 | 2017-07-27 | 国立大学法人 鹿児島大学 | Cellular aging inhibitor |
KR101774408B1 (en) | 2017-05-10 | 2017-09-04 | 최완 | Cosmetic Composition for Silver Generation for Improving Skin Winkles and MaskPack Sheet using the same |
CN112022772A (en) * | 2020-09-25 | 2020-12-04 | 福建省春秋刺明珠葡萄酒庄园有限公司 | Vitis davidii willd plant essence rich in veratryl alcohol and preparation method thereof |
CN114344226A (en) * | 2022-02-25 | 2022-04-15 | 河南科技大学 | Traditional Chinese medicine preservative, preparation method and application |
CN115708789A (en) * | 2022-10-25 | 2023-02-24 | 南京赫亿斯生物科技有限公司 | Application of skin external composition containing cordycepin in preparation of anti-aging cosmetics |
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CN104958203A (en) * | 2015-06-17 | 2015-10-07 | 石柱土家族自治县潘婆婆莼菜科技发展有限公司 | Water shield mask lotion |
CN104958205A (en) * | 2015-06-17 | 2015-10-07 | 石柱土家族自治县潘婆婆莼菜科技发展有限公司 | Water shield essential lotion |
CN104958203B (en) * | 2015-06-17 | 2017-10-17 | 石柱土家族自治县潘婆婆莼菜科技发展有限公司 | Water shield facial mask liquid |
JP2017128550A (en) * | 2016-01-22 | 2017-07-27 | 国立大学法人 鹿児島大学 | Cellular aging inhibitor |
KR101774408B1 (en) | 2017-05-10 | 2017-09-04 | 최완 | Cosmetic Composition for Silver Generation for Improving Skin Winkles and MaskPack Sheet using the same |
CN112022772A (en) * | 2020-09-25 | 2020-12-04 | 福建省春秋刺明珠葡萄酒庄园有限公司 | Vitis davidii willd plant essence rich in veratryl alcohol and preparation method thereof |
CN112022772B (en) * | 2020-09-25 | 2022-09-16 | 福建省春秋刺明珠葡萄酒庄园有限公司 | Vitis davidii willd plant essence rich in resveratrol and preparation method thereof |
CN114344226A (en) * | 2022-02-25 | 2022-04-15 | 河南科技大学 | Traditional Chinese medicine preservative, preparation method and application |
CN115708789A (en) * | 2022-10-25 | 2023-02-24 | 南京赫亿斯生物科技有限公司 | Application of skin external composition containing cordycepin in preparation of anti-aging cosmetics |
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