JP2014221801A5 - - Google Patents
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- Publication number
- JP2014221801A5 JP2014221801A5 JP2014142904A JP2014142904A JP2014221801A5 JP 2014221801 A5 JP2014221801 A5 JP 2014221801A5 JP 2014142904 A JP2014142904 A JP 2014142904A JP 2014142904 A JP2014142904 A JP 2014142904A JP 2014221801 A5 JP2014221801 A5 JP 2014221801A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- helix
- enhanced
- modified
- helix polypeptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 55
- 229920001184 polypeptide Polymers 0.000 claims 54
- 102000004196 processed proteins & peptides Human genes 0.000 claims 54
- 238000000034 method Methods 0.000 claims 41
- 150000001413 amino acids Chemical class 0.000 claims 16
- 239000003431 cross linking reagent Substances 0.000 claims 13
- 210000004027 cell Anatomy 0.000 claims 5
- 210000000170 cell membrane Anatomy 0.000 claims 5
- 230000002378 acidificating effect Effects 0.000 claims 4
- 230000002209 hydrophobic effect Effects 0.000 claims 4
- 102000004506 Blood Proteins Human genes 0.000 claims 3
- 108010017384 Blood Proteins Proteins 0.000 claims 3
- 210000004369 blood Anatomy 0.000 claims 3
- 239000008280 blood Substances 0.000 claims 3
- 230000001419 dependent effect Effects 0.000 claims 3
- 238000000338 in vitro Methods 0.000 claims 3
- 230000003834 intracellular effect Effects 0.000 claims 3
- 210000002966 serum Anatomy 0.000 claims 3
- 238000003556 assay Methods 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 230000003463 hyperproliferative effect Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000007935 neutral effect Effects 0.000 claims 2
- 101100455978 Arabidopsis thaliana MAM1 gene Proteins 0.000 claims 1
- 102000051485 Bcl-2 family Human genes 0.000 claims 1
- 108700038897 Bcl-2 family Proteins 0.000 claims 1
- 102100031633 Chorionic somatomammotropin hormone-like 1 Human genes 0.000 claims 1
- 108010016626 Dipeptides Proteins 0.000 claims 1
- 101000940558 Homo sapiens Chorionic somatomammotropin hormone-like 1 Proteins 0.000 claims 1
- 102000005650 Notch Receptors Human genes 0.000 claims 1
- 108010070047 Notch Receptors Proteins 0.000 claims 1
- 230000001594 aberrant effect Effects 0.000 claims 1
- 239000007801 affinity label Substances 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 230000001413 cellular effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 229910052736 halogen Inorganic materials 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000012466 permeate Substances 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US9906308P | 2008-09-22 | 2008-09-22 | |
| US61/099,063 | 2008-09-22 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011528084A Division JP5711128B2 (ja) | 2008-09-22 | 2009-09-22 | ペプチド模倣大環状分子 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016159624A Division JP2016190882A (ja) | 2008-09-22 | 2016-08-16 | ペプチド模倣大環状分子 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014221801A JP2014221801A (ja) | 2014-11-27 |
| JP2014221801A5 true JP2014221801A5 (OSRAM) | 2015-09-10 |
| JP6067626B2 JP6067626B2 (ja) | 2017-01-25 |
Family
ID=41611441
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011528084A Expired - Fee Related JP5711128B2 (ja) | 2008-09-22 | 2009-09-22 | ペプチド模倣大環状分子 |
| JP2014142904A Expired - Fee Related JP6067626B2 (ja) | 2008-09-22 | 2014-07-11 | ペプチド模倣大環状分子 |
| JP2016159624A Pending JP2016190882A (ja) | 2008-09-22 | 2016-08-16 | ペプチド模倣大環状分子 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011528084A Expired - Fee Related JP5711128B2 (ja) | 2008-09-22 | 2009-09-22 | ペプチド模倣大環状分子 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016159624A Pending JP2016190882A (ja) | 2008-09-22 | 2016-08-16 | ペプチド模倣大環状分子 |
Country Status (10)
| Country | Link |
|---|---|
| US (5) | US8524653B2 (OSRAM) |
| EP (1) | EP2342222B1 (OSRAM) |
| JP (3) | JP5711128B2 (OSRAM) |
| CN (1) | CN102482336B (OSRAM) |
| AU (1) | AU2009294877C1 (OSRAM) |
| BR (1) | BRPI0918948A2 (OSRAM) |
| CA (1) | CA2737922A1 (OSRAM) |
| ES (1) | ES2666458T3 (OSRAM) |
| IL (1) | IL211836A0 (OSRAM) |
| WO (1) | WO2010034034A1 (OSRAM) |
Families Citing this family (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| PT2332968T (pt) * | 2003-11-05 | 2016-08-17 | Harvard College | Péptidos alfa-helicoidais adequados para a activação ou inibição da morte celular |
| WO2005118620A2 (en) | 2004-05-27 | 2005-12-15 | New York University | Methods for preparing internally constraied peptides and peptidomimetics |
| US7981998B2 (en) * | 2006-12-14 | 2011-07-19 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| BRPI0720306A2 (pt) * | 2006-12-14 | 2014-02-04 | Aileron Therapeutics Inc | Sistemas de macrociclização da bis-sufidrila |
| EP2118123B1 (en) | 2007-01-31 | 2015-10-14 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| CN104086641A (zh) * | 2007-02-23 | 2014-10-08 | 爱勒让治疗公司 | 三唑大环系统 |
| EP3159352B1 (en) | 2007-03-28 | 2023-08-02 | President and Fellows of Harvard College | Stitched polypeptides |
| EP2247298B1 (en) * | 2007-12-31 | 2016-08-31 | New York University | Control of viral-host membrane fusion with hydrogen bond surrogate-based artificial helices |
| WO2009099677A2 (en) | 2008-02-08 | 2009-08-13 | Aileron Therapeutics, Inc. | Therapeutic peptidomimetic macrocycles |
| US20110144303A1 (en) * | 2008-04-08 | 2011-06-16 | Aileron Therapeutics, Inc. | Biologically Active Peptidomimetic Macrocycles |
| WO2010011313A2 (en) | 2008-07-23 | 2010-01-28 | President And Fellows Of Harvard College | Ligation of stapled polypeptides |
| CN102203126A (zh) | 2008-09-22 | 2011-09-28 | 爱勒让治疗公司 | 用于制备纯化的多肽组合物的方法 |
| AU2009294877C1 (en) | 2008-09-22 | 2015-05-07 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| EP2352507A4 (en) | 2008-11-24 | 2012-04-25 | Aileron Therapeutics Inc | PEPTIDOMIMETIC MACROCYCLES WITH IMPROVED PROPERTIES |
| JP2012515172A (ja) | 2009-01-14 | 2012-07-05 | エルロン・セラピューティクス・インコーポレイテッド | ペプチド模倣大環状分子 |
| WO2011008260A2 (en) | 2009-07-13 | 2011-01-20 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
| AU2010298338A1 (en) | 2009-09-22 | 2012-04-12 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| WO2011047215A1 (en) * | 2009-10-14 | 2011-04-21 | Aileron Therapeutics, Inc. | Improved peptidomimetic macrocycles |
| KR102104762B1 (ko) * | 2010-08-13 | 2020-04-24 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| WO2012040459A2 (en) | 2010-09-22 | 2012-03-29 | President And Fellows Of Harvard College | Beta-catenin targeting peptides and uses thereof |
| EP2627662B1 (en) | 2010-10-13 | 2015-09-16 | Bristol-Myers Squibb Company | Methods for preparing macrocycles and macrocycle stabilized peptides |
| JP2014502152A (ja) | 2010-11-12 | 2014-01-30 | ダナ ファーバー キャンサー インスティテュート，インコーポレイテッド | 癌の治療及び診断 |
| US9029332B2 (en) | 2010-12-15 | 2015-05-12 | The Research Foundation For The State University Of New York | Cross-linked peptides and proteins, methods of making same, and uses thereof |
| JP2014520120A (ja) * | 2011-06-17 | 2014-08-21 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 安定化した変異型ｍａｍｌペプチドおよびその使用 |
| WO2012174423A1 (en) | 2011-06-17 | 2012-12-20 | President And Fellows Of Harvard College | Stabilized polypeptides as regulators of rab gtpase function |
| AU2012301605A1 (en) * | 2011-08-31 | 2014-04-17 | New York University | Thioether-,ether-, and alkylamine-linked hydrogen bond surrogate pertidomimentics |
| TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
| CA2864120A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| NZ627528A (en) | 2012-02-15 | 2016-05-27 | Aileron Therapeutics Inc | Peptidomimetic macrocycles |
| EP2920197B1 (en) | 2012-09-26 | 2021-03-17 | President and Fellows of Harvard College | Proline-locked stapled peptides and uses thereof |
| BR112015009470A2 (pt) | 2012-11-01 | 2019-12-17 | Aileron Therapeutics Inc | aminoácidos dissubstituídos e seus métodos de preparação e uso |
| US20140205681A1 (en) * | 2013-01-19 | 2014-07-24 | New York University | HYDROGEN-BOND SURROGATE PEPTIDES AND PEPTIDOMIMETICS FOR p53 REACTIVATION |
| EP2991665A4 (en) | 2013-03-13 | 2016-11-09 | Harvard College | STACKED AND GRAFTED POLYPEPTIDES AND USES THEREOF |
| KR20160019547A (ko) | 2013-06-14 | 2016-02-19 | 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 | 안정화된 폴리펩티드 인슐린 수용체 조절제 |
| CN105792851B (zh) | 2013-09-13 | 2023-10-10 | 斯克利普斯研究所 | 修饰的治疗剂及其组合物 |
| AU2014364589B2 (en) | 2013-12-18 | 2020-02-27 | The California Institute For Biomedical Research | Modified therapeutic agents, stapled peptide lipid conjugates, and compositions thereof |
| CN111620940A (zh) | 2014-05-21 | 2020-09-04 | 哈佛大学的校长及成员们 | Ras抑制肽和其用途 |
| KR20170058424A (ko) | 2014-09-24 | 2017-05-26 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드모방 거대고리 및 이의 용도 |
| MX389354B (es) | 2014-09-24 | 2025-03-20 | Aileron Therapeutics Inc | Macrociclos peptidomimeticos y formulaciones de los mismos. |
| SG11201707750YA (en) | 2015-03-20 | 2017-10-30 | Aileron Therapeutics Inc | Peptidomimetic macrocycles and uses thereof |
| CN107709508B (zh) * | 2015-06-25 | 2020-03-20 | Agc 株式会社 | 拒水剂组合物、拒水剂组合物的制造方法及物品 |
| WO2017004548A1 (en) | 2015-07-01 | 2017-01-05 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| US10023613B2 (en) | 2015-09-10 | 2018-07-17 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles as modulators of MCL-1 |
| US11957148B2 (en) | 2015-12-15 | 2024-04-16 | Societe Des Produits Nestle S.A. | Mixture of human milk oligosaccharides(HMOs) |
| KR20180128022A (ko) * | 2016-03-21 | 2018-11-30 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티드 모방 거대고리에 대한 동반 진단 도구 |
| WO2018085208A1 (en) | 2016-11-02 | 2018-05-11 | The Research Foundation For The State University Of New York | Methods of inhibiting viruses using compositions targeting tsg101-ubiquitin interaction |
| KR20200064075A (ko) | 2017-09-07 | 2020-06-05 | 포그 파마슈티컬스 인코포레이티드 | 베타-카테닌 기능을 조절하는 제제 및 이의 방법 |
| CA3078682A1 (en) | 2017-12-15 | 2019-06-20 | Dana-Farber Cancer Institute, Inc. | Stabilized peptide-mediated targeted protein degradation |
| EP3749678A1 (en) | 2018-02-07 | 2020-12-16 | Dana Farber Cancer Institute, Inc. | Cell-permeable stapled peptide modules for cellular delivery |
| WO2020023502A1 (en) | 2018-07-23 | 2020-01-30 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
| WO2022081827A1 (en) | 2020-10-14 | 2022-04-21 | Dana-Farber Cancer Institute, Inc. | Chimeric conjugates for degradation of viral and host proteins and methods of use |
| CA3209603A1 (en) * | 2021-01-28 | 2022-08-04 | Institute For Cancer Research D/B/A/ The Research Institute Of Fox Chase Cancer Center | Treatment of integrin-related disorders with stapled peptides |
| AU2022289610A1 (en) | 2021-06-09 | 2024-01-25 | The Scripps Research Institute | Long-acting dual gip/glp-1 peptide conjugates and methods of use |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5811515A (en) | 1995-06-12 | 1998-09-22 | California Institute Of Technology | Synthesis of conformationally restricted amino acids, peptides, and peptidomimetics by catalytic ring closing metathesis |
| AU777363B2 (en) | 1999-03-01 | 2004-10-14 | Nuvelo, Inc. | Methods for targeting RNA molecules |
| US7192713B1 (en) | 1999-05-18 | 2007-03-20 | President And Fellows Of Harvard College | Stabilized compounds having secondary structure motifs |
| ZA200509229B (en) * | 2003-05-01 | 2007-03-28 | Cornell Res Foundation Inc | Method and carrier complexes for delivering molecules to cells |
| PT2332968T (pt) | 2003-11-05 | 2016-08-17 | Harvard College | Péptidos alfa-helicoidais adequados para a activação ou inibição da morte celular |
| GB2427550B (en) | 2004-03-17 | 2007-05-30 | 7Tm Pharma As | Y2/Y4 selective receptor agonists for therapeutic interventions |
| EP1737884B1 (en) | 2004-03-19 | 2016-10-19 | The University Of Queensland | Alpha helical mimics, their uses and methods for their production |
| WO2005118620A2 (en) | 2004-05-27 | 2005-12-15 | New York University | Methods for preparing internally constraied peptides and peptidomimetics |
| US7084248B2 (en) * | 2004-07-14 | 2006-08-01 | Gene Tools, Llc | Peptide composition and method for delivering substances into the cytosol of cells |
| WO2006103666A2 (en) | 2005-03-28 | 2006-10-05 | Yeda Research And Development Co. Ltd. | Isolated bid polypeptides, polynucleotides encoding same and antibodies directed thereagainst and methods of using same for inducing cell cycle arrest or apoptosis |
| EP2091552A4 (en) | 2006-11-15 | 2010-01-06 | Dana Farber Cancer Inst Inc | STABILIZED MAML-PEPTIDES AND ITS USES |
| US7981998B2 (en) | 2006-12-14 | 2011-07-19 | Aileron Therapeutics, Inc. | Bis-sulfhydryl macrocyclization systems |
| BRPI0720306A2 (pt) | 2006-12-14 | 2014-02-04 | Aileron Therapeutics Inc | Sistemas de macrociclização da bis-sufidrila |
| EP2118123B1 (en) | 2007-01-31 | 2015-10-14 | Dana-Farber Cancer Institute, Inc. | Stabilized p53 peptides and uses thereof |
| CN104086641A (zh) | 2007-02-23 | 2014-10-08 | 爱勒让治疗公司 | 三唑大环系统 |
| EP3159352B1 (en) | 2007-03-28 | 2023-08-02 | President and Fellows of Harvard College | Stitched polypeptides |
| EP2152294B1 (en) | 2007-05-02 | 2017-07-26 | Dana-Farber Cancer Institute, Inc. | A bad bh3 domain peptide for use in treating or delaying the onset of diabetes. |
| EP2247298B1 (en) | 2007-12-31 | 2016-08-31 | New York University | Control of viral-host membrane fusion with hydrogen bond surrogate-based artificial helices |
| EP2247606B1 (en) | 2008-01-23 | 2019-08-21 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for the treatment of viral infections |
| WO2009099677A2 (en) * | 2008-02-08 | 2009-08-13 | Aileron Therapeutics, Inc. | Therapeutic peptidomimetic macrocycles |
| US20110144303A1 (en) | 2008-04-08 | 2011-06-16 | Aileron Therapeutics, Inc. | Biologically Active Peptidomimetic Macrocycles |
| EP2310407A4 (en) | 2008-04-08 | 2011-09-14 | Aileron Therapeutics Inc | BIOLOGICALLY ACTIVE PEPTIDOMIMETIC MACROCYCLES |
| EP2285970A4 (en) | 2008-06-03 | 2011-10-12 | Aileron Therapeutics Inc | COMPOSITIONS AND METHODS FOR REINFORCING THE CELL TRANSPORT OF BIOMOLECULES |
| WO2010011313A2 (en) | 2008-07-23 | 2010-01-28 | President And Fellows Of Harvard College | Ligation of stapled polypeptides |
| JP2012503013A (ja) | 2008-09-18 | 2012-02-02 | ニューヨーク ユニバーシティ | ＨＩＦ−１αと水素結合代替ヘリックスを有するｐ３００／ＣＢＰの間の相互作用の阻害 |
| WO2010034026A1 (en) | 2008-09-22 | 2010-03-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| AU2009294874A1 (en) | 2008-09-22 | 2010-03-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| CN102197046A (zh) | 2008-09-22 | 2011-09-21 | 爱勒让治疗公司 | 拟肽大环化合物 |
| CN102203126A (zh) | 2008-09-22 | 2011-09-28 | 爱勒让治疗公司 | 用于制备纯化的多肽组合物的方法 |
| AU2009294872A1 (en) | 2008-09-22 | 2010-03-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| AU2009294877C1 (en) | 2008-09-22 | 2015-05-07 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| EP2352507A4 (en) | 2008-11-24 | 2012-04-25 | Aileron Therapeutics Inc | PEPTIDOMIMETIC MACROCYCLES WITH IMPROVED PROPERTIES |
| JP2012515172A (ja) | 2009-01-14 | 2012-07-05 | エルロン・セラピューティクス・インコーポレイテッド | ペプチド模倣大環状分子 |
| WO2011008260A2 (en) | 2009-07-13 | 2011-01-20 | President And Fellows Of Harvard College | Bifunctional stapled polypeptides and uses thereof |
| AU2010298338A1 (en) | 2009-09-22 | 2012-04-12 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| WO2011047215A1 (en) | 2009-10-14 | 2011-04-21 | Aileron Therapeutics, Inc. | Improved peptidomimetic macrocycles |
| KR102104762B1 (ko) | 2010-08-13 | 2020-04-24 | 에일러론 테라퓨틱스 인코포레이티드 | 펩티도미메틱 거대고리 |
| EP2681235B1 (en) | 2011-03-04 | 2016-05-04 | New York University | Hydrogen bond surrogate macrocycles as modulators of ras |
| WO2012173846A2 (en) | 2011-06-06 | 2012-12-20 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| AU2012301605A1 (en) | 2011-08-31 | 2014-04-17 | New York University | Thioether-,ether-, and alkylamine-linked hydrogen bond surrogate pertidomimentics |
| WO2013059530A2 (en) | 2011-10-18 | 2013-04-25 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
| TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
| NZ627528A (en) | 2012-02-15 | 2016-05-27 | Aileron Therapeutics Inc | Peptidomimetic macrocycles |
| CA2864120A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
| BR112015009470A2 (pt) | 2012-11-01 | 2019-12-17 | Aileron Therapeutics Inc | aminoácidos dissubstituídos e seus métodos de preparação e uso |
| WO2014138429A2 (en) | 2013-03-06 | 2014-09-12 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and use thereof in regulating hif1alpha |
-
2009
- 2009-09-22 AU AU2009294877A patent/AU2009294877C1/en not_active Ceased
- 2009-09-22 CA CA2737922A patent/CA2737922A1/en not_active Abandoned
- 2009-09-22 ES ES09736335.2T patent/ES2666458T3/es active Active
- 2009-09-22 CN CN200980142223.9A patent/CN102482336B/zh not_active Expired - Fee Related
- 2009-09-22 BR BRPI0918948A patent/BRPI0918948A2/pt not_active Application Discontinuation
- 2009-09-22 JP JP2011528084A patent/JP5711128B2/ja not_active Expired - Fee Related
- 2009-09-22 WO PCT/US2009/057934 patent/WO2010034034A1/en not_active Ceased
- 2009-09-22 EP EP09736335.2A patent/EP2342222B1/en not_active Not-in-force
- 2009-09-22 US US12/564,910 patent/US8524653B2/en not_active Expired - Fee Related
-
2011
- 2011-03-21 IL IL211836A patent/IL211836A0/en active IP Right Grant
-
2012
- 2012-02-03 US US13/366,113 patent/US8399405B2/en not_active Expired - Fee Related
-
2013
- 2013-08-02 US US13/957,667 patent/US9175045B2/en not_active Expired - Fee Related
-
2014
- 2014-07-11 JP JP2014142904A patent/JP6067626B2/ja not_active Expired - Fee Related
-
2015
- 2015-09-25 US US14/866,445 patent/US20160096873A1/en not_active Abandoned
-
2016
- 2016-08-16 JP JP2016159624A patent/JP2016190882A/ja active Pending
- 2016-09-06 US US15/257,807 patent/US20170299576A1/en not_active Abandoned
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