JP2014166186A5 - - Google Patents
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- Publication number
- JP2014166186A5 JP2014166186A5 JP2014095688A JP2014095688A JP2014166186A5 JP 2014166186 A5 JP2014166186 A5 JP 2014166186A5 JP 2014095688 A JP2014095688 A JP 2014095688A JP 2014095688 A JP2014095688 A JP 2014095688A JP 2014166186 A5 JP2014166186 A5 JP 2014166186A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- tumor
- compound
- carcinoma
- binder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 150000001875 compounds Chemical class 0.000 claims 13
- 206010028980 Neoplasm Diseases 0.000 claims 12
- 239000011230 binding agent Substances 0.000 claims 7
- 239000012636 effector Substances 0.000 claims 5
- 206010006187 Breast cancer Diseases 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 4
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 4
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 4
- 206010060862 Prostate cancer Diseases 0.000 claims 4
- 102000011652 Formyl peptide receptors Human genes 0.000 claims 3
- 108010076288 Formyl peptide receptors Proteins 0.000 claims 3
- PRQROPMIIGLWRP-BZSNNMDCSA-N chemotactic peptide Chemical compound CSCC[C@H](NC=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(O)=O)CC1=CC=CC=C1 PRQROPMIIGLWRP-BZSNNMDCSA-N 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 206010005003 Bladder cancer Diseases 0.000 claims 2
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 2
- 208000004463 Follicular Adenocarcinoma Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 206010029260 Neuroblastoma Diseases 0.000 claims 2
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 208000024770 Thyroid neoplasm Diseases 0.000 claims 2
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 claims 2
- 210000004204 blood vessel Anatomy 0.000 claims 2
- 208000019065 cervical carcinoma Diseases 0.000 claims 2
- 239000013043 chemical agent Substances 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 208000029742 colonic neoplasm Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000004927 fusion Effects 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 2
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 2
- 239000003446 ligand Substances 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 102000007863 pattern recognition receptors Human genes 0.000 claims 2
- 108010089193 pattern recognition receptors Proteins 0.000 claims 2
- 201000001514 prostate carcinoma Diseases 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 201000002510 thyroid cancer Diseases 0.000 claims 2
- 208000030901 thyroid gland follicular carcinoma Diseases 0.000 claims 2
- 208000019179 thyroid gland undifferentiated (anaplastic) carcinoma Diseases 0.000 claims 2
- 201000005112 urinary bladder cancer Diseases 0.000 claims 2
- NVHPXYIRNJFKTE-HAGHYFMRSA-N 2-[(2s,5r,8s,11s)-8-(4-aminobutyl)-5-benzyl-11-[3-(diaminomethylideneamino)propyl]-3,6,9,12,15-pentaoxo-1,4,7,10,13-pentazacyclopentadec-2-yl]acetic acid Chemical compound N1C(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@H]1CC1=CC=CC=C1 NVHPXYIRNJFKTE-HAGHYFMRSA-N 0.000 claims 1
- SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims 1
- 229930182818 D-methionine Natural products 0.000 claims 1
- 125000000296 D-methionine group Chemical group [H]N([H])[C@@]([H])(C(=O)[*])C([H])([H])C([H])([H])SC([H])([H])[H] 0.000 claims 1
- 108010033584 FROP-1 peptide Proteins 0.000 claims 1
- PNNNRSAQSRJVSB-SLPGGIOYSA-N Fucose Natural products C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C=O PNNNRSAQSRJVSB-SLPGGIOYSA-N 0.000 claims 1
- SHZGCJCMOBCMKK-DHVFOXMCSA-N L-fucopyranose Chemical compound C[C@@H]1OC(O)[C@@H](O)[C@H](O)[C@@H]1O SHZGCJCMOBCMKK-DHVFOXMCSA-N 0.000 claims 1
- OVRNDRQMDRJTHS-CBQIKETKSA-N N-Acetyl-D-Galactosamine Chemical compound CC(=O)N[C@H]1[C@@H](O)O[C@H](CO)[C@H](O)[C@@H]1O OVRNDRQMDRJTHS-CBQIKETKSA-N 0.000 claims 1
- MBLBDJOUHNCFQT-UHFFFAOYSA-N N-acetyl-D-galactosamine Natural products CC(=O)NC(C=O)C(O)C(O)C(O)CO MBLBDJOUHNCFQT-UHFFFAOYSA-N 0.000 claims 1
- PYUSHNKNPOHWEZ-YFKPBYRVSA-N N-formyl-L-methionine Chemical compound CSCC[C@@H](C(O)=O)NC=O PYUSHNKNPOHWEZ-YFKPBYRVSA-N 0.000 claims 1
- 108010038807 Oligopeptides Proteins 0.000 claims 1
- 102000015636 Oligopeptides Human genes 0.000 claims 1
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 108010039918 Polylysine Proteins 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 210000004899 c-terminal region Anatomy 0.000 claims 1
- 239000002771 cell marker Substances 0.000 claims 1
- 108010008021 cysteinyl-seryl-aspartyl-seryl-tryptophyl-histidyl-tyrosyl-tryptophyl-cysteine Proteins 0.000 claims 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 1
- 108010046019 histidyl-glutamyl-tryptophyl-seryl-tyrosyl-leucyl-alanyl-prolyl-tyrosyl-prolyl-tryptophyl-phenylalanine Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 239000000816 peptidomimetic Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 229920000656 polylysine Polymers 0.000 claims 1
- 108010091705 seryl-tryptophyl-lysyl-leucyl-prolyl-prolyl-serine Proteins 0.000 claims 1
- 229920001059 synthetic polymer Polymers 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 229940126585 therapeutic drug Drugs 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US80629806P | 2006-06-30 | 2006-06-30 | |
| EP06013640.5 | 2006-06-30 | ||
| EP06013641.3 | 2006-06-30 | ||
| EP06013640 | 2006-06-30 | ||
| EP06013641 | 2006-06-30 | ||
| US60/806,298 | 2006-06-30 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009517014A Division JP2009541398A (ja) | 2006-06-30 | 2007-07-02 | 医薬目的のための新規な多官能性化合物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016114025A Division JP2017002039A (ja) | 2006-06-30 | 2016-06-08 | 医薬目的のための新規な多官能性化合物 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014166186A JP2014166186A (ja) | 2014-09-11 |
| JP2014166186A5 true JP2014166186A5 (enExample) | 2015-05-07 |
Family
ID=38353353
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009517014A Pending JP2009541398A (ja) | 2006-06-30 | 2007-07-02 | 医薬目的のための新規な多官能性化合物 |
| JP2014095688A Withdrawn JP2014166186A (ja) | 2006-06-30 | 2014-05-07 | 医薬目的のための新規な多官能性化合物 |
| JP2016114025A Pending JP2017002039A (ja) | 2006-06-30 | 2016-06-08 | 医薬目的のための新規な多官能性化合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009517014A Pending JP2009541398A (ja) | 2006-06-30 | 2007-07-02 | 医薬目的のための新規な多官能性化合物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016114025A Pending JP2017002039A (ja) | 2006-06-30 | 2016-06-08 | 医薬目的のための新規な多官能性化合物 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US8470963B2 (enExample) |
| EP (3) | EP3669894A3 (enExample) |
| JP (3) | JP2009541398A (enExample) |
| CN (1) | CN101528263B (enExample) |
| WO (1) | WO2008000517A2 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8815804B2 (en) * | 2006-02-06 | 2014-08-26 | Sanford-Burnham Medical Research Institute | Methods and compositions related to targeting tumors and wounds |
| CA2682580A1 (en) | 2007-03-30 | 2008-10-09 | Duke University | A method of modulating the activity of a nucleic acid molecule |
| US20120010153A1 (en) | 2009-01-14 | 2012-01-12 | Andre Koltermann | Novel tumor-targeting compounds |
| IN2012DN02345A (enExample) * | 2009-09-16 | 2015-08-21 | Univ Duke | |
| JP2015513358A (ja) * | 2012-03-22 | 2015-05-11 | ザ キュレイターズ オブ ザ ユニバーシティ オブ ミズーリ | 金結合性及びｅｇｆｒ受容体親和性を有するペプチド、並びに金ナノ構造に結合したペプチド |
| US10066323B2 (en) | 2014-04-16 | 2018-09-04 | Duke University | Electrospun cationic nanofibers and methods of making and using the same |
| US12514872B2 (en) | 2015-11-04 | 2026-01-06 | Duke University | Polycationic polymers for use in treating and detecting cancer |
| GB201609083D0 (en) * | 2016-05-24 | 2016-07-06 | Syntab Therapeutics Gmbh | Synthetic compound |
| WO2018119422A1 (en) | 2016-12-22 | 2018-06-28 | Duke University | Polycationic microfibers and methods of using the same |
| US20200155702A1 (en) * | 2017-06-16 | 2020-05-21 | Eli Lilly And Company | Engineered Antibody Compounds and Conjuates Thereof |
| CN112672747B (zh) | 2018-07-19 | 2025-02-18 | 加利福尼亚大学董事会 | 用于激活骨祖细胞中细胞信号传导的肽 |
| CN109055476B (zh) * | 2018-08-07 | 2021-07-09 | 河南大学 | 一种生物活性肽p11在治疗甲状腺癌的药物中效果分析方法 |
| CN109679981A (zh) * | 2019-02-21 | 2019-04-26 | 武汉大学 | 一种甲酰基肽定向进化噬菌体及其制备方法与应用 |
| CN111474370B (zh) * | 2020-04-22 | 2021-04-06 | 天津医科大学总医院 | 检测甲酰肽或甲酰肽受体-1配体含量的方法及应用 |
| WO2022189361A1 (en) * | 2021-03-08 | 2022-09-15 | Universiteit Gent | Conjugates including multiple saccharidic chains on a linear protein and uses in mammals feed |
| CN115448980A (zh) * | 2021-06-08 | 2022-12-09 | 戴德森医疗财团法人嘉义基督教医院 | 表面链结标靶多肽的类病毒颗粒及其用途 |
| WO2025262329A1 (en) | 2024-06-21 | 2025-12-26 | Syntab Therapeutics Gmbh | Synthetic molecules comprising tlr2 ligands |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1055932A (en) | 1975-10-22 | 1979-06-05 | Hematech Inc. | Blood substitute based on hemoglobin |
| US4427660A (en) * | 1982-03-03 | 1984-01-24 | Research Corporation | Formyl-methionyl chemotatic peptide antibiotic conjugates useful in treating infections |
| IT1164225B (it) | 1983-05-13 | 1987-04-08 | Anic Spa | Analoghi retro-invertiti del pentapeptide potenziante la bradichina bpp5a e metodi per la loro preparazione |
| WO1993022343A1 (en) * | 1992-05-01 | 1993-11-11 | The Rockfeller University | Multiple antigen peptide system having adjuvant properties and vaccines prepared therefrom |
| US5767078A (en) | 1995-06-07 | 1998-06-16 | Johnson; Dana L. | Agonist peptide dimers |
| KR100459984B1 (ko) | 1995-06-07 | 2005-06-20 | 아피맥스 테크놀로지스, 엔.브이. | 에리트로포이에틴수용체(epo-r)에결합하는화합물및펩티드 |
| DE19853778C1 (de) | 1998-11-21 | 2000-09-21 | Basf Ag | DNA-Sequenzen kodierend einen Glutamat/Malat-Translokator, Plasmide Bakterien, Hefen und Pflanzen enthaltend diesen Transporter |
| AU2030000A (en) | 1998-11-25 | 2000-06-13 | Cadus Pharmaceutical Corporation | Methods and compositions for identifying receptor effectors |
| US6017537A (en) * | 1998-12-18 | 2000-01-25 | Connaught Laboratories, Inc. | Formyl methionyl peptide vaccine adjuvant |
| US20030099629A1 (en) * | 1999-03-11 | 2003-05-29 | Immunomedics, Inc. | Recombinant onconase and chemical conjugates and fusion proteins of recombinant onconase |
| US6703480B1 (en) | 1999-11-24 | 2004-03-09 | Palani Balu | Peptide dimers as agonists of the erythropoientin (EPO) receptor, and associated methods of synthesis and use |
| AU7490401A (en) | 2000-05-26 | 2001-12-11 | Ortho Mcneil Pharm Inc | Neuroprotective peptides |
| IL156942A0 (en) | 2001-01-16 | 2004-02-08 | Univ Ramot | Compounds, pharmaceutical compositions and methods for treatment of bacteremia and/or septicemia |
| US7265084B2 (en) * | 2001-10-10 | 2007-09-04 | Neose Technologies, Inc. | Glycopegylation methods and proteins/peptides produced by the methods |
| EP1532159A4 (en) * | 2002-06-20 | 2009-10-21 | Univ Maryland Biotech Inst | MALEIMIDES CLUSTERS ON SCAFFOLDING FOR PLURIVALENT PEPTIDE ASSEMBLIES |
| WO2004024761A1 (en) | 2002-09-11 | 2004-03-25 | Fresenius Kabi Deutschland Gmbh | Hasylated polypeptides, especially hasylated erythropoietin |
| CN1820024B (zh) | 2003-05-12 | 2011-06-22 | 阿费麦克斯公司 | 新的聚(乙二醇)修饰的化合物及其用途 |
| EP1629007B1 (en) | 2003-05-12 | 2009-04-15 | Affymax, Inc. | Novel peptides that bind to the erythropoietin receptor |
| KR101227666B1 (ko) | 2003-05-12 | 2013-01-31 | 아피맥스, 인크. | 에리스로포이에틴 수용체에 결합하는 펩티드 |
| EP2204193A3 (en) | 2003-05-12 | 2010-08-18 | Affymax, Inc. | Novel spacer moiety for poly(ethylene glycol)-modified peptide-based compounds |
| EP1538164A1 (en) * | 2003-12-04 | 2005-06-08 | Vectron Therapeutics AG | RGD targeting moiety its production and use |
-
2007
- 2007-07-02 EP EP20150389.3A patent/EP3669894A3/en not_active Withdrawn
- 2007-07-02 CN CN200780024865XA patent/CN101528263B/zh active Active
- 2007-07-02 EP EP10011976A patent/EP2275142A3/en not_active Withdrawn
- 2007-07-02 US US12/305,898 patent/US8470963B2/en active Active
- 2007-07-02 EP EP07764993.7A patent/EP2035041B1/en active Active
- 2007-07-02 WO PCT/EP2007/005836 patent/WO2008000517A2/en not_active Ceased
- 2007-07-02 JP JP2009517014A patent/JP2009541398A/ja active Pending
-
2014
- 2014-05-07 JP JP2014095688A patent/JP2014166186A/ja not_active Withdrawn
-
2016
- 2016-06-08 JP JP2016114025A patent/JP2017002039A/ja active Pending
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