JP2014162787A - Kinesin inhibitor - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a novel and useful kinesin inhibitor, and to provide a composition useful for alleviating, preventing and improving various hemochromatosis such as stains and freckles.SOLUTION: The invention relates to a kinesin inhibitor which contains a specific plant extract (Aspalathus linearis extract, Hypericum erectum extract, lemon grass extract) as an active ingredient, and a pigmentation inhibitor based on a kinesin inhibition. Furthermore, it relates to various compositions (pharmaceutical compositions, food compositions, cosmetic compositions) containing the kinesin inhibitor.

Description

  The present invention is a kinesin inhibitor useful for the promotion of melanin pigment production and pigmentation caused by various causes including ultraviolet rays, and the prevention and improvement of symptoms associated with physiological aging and photoaging of the skin, And various compositions containing a kinesin inhibitor.

    Spindles formed during cell division, and the main structures of cilia and flagella are made up of bundles of microtubules, which are responsible for movements such as chromosome movement and flagellar striking. Dynein and kinesin are known as motor proteins using microtubules as scaffolds. These are also involved in the intracellular localization of molecules such as proteins and mRNAs, but in this case, the transport from the-end to the + end is antegrade and the transport from the + end to the-end is reversed. Differentiated by sex, both transports are caused by the interaction of the microtubule system with a group of motor proteins present in the cytoplasm. Kinesin is said to play an important role in antegrade transport and dynein in retrograde transport.

  Kinesin is a group of proteins that are contained in the cytoplasm of eukaryotes and are widely present from yeast to rats and humans. Kinesin mainly has the property of moving along microtubules while hydrolyzing ATP, and plays an important role in intracellular substance transport such as cell division and nerve axon transport.

  In particular, kinesin is regarded as important in melanocytes, which synthesize melanin pigments that determine skin color. Melanin is produced in vesicles called melanosomes, and kinesin is involved in transporting these melanosomes to keratinocytes. It has been reported that by suppressing the action of kinesin, pigmentation due to ultraviolet rays is suppressed (Hara et al., 2000), suggesting the development of a new whitening agent. (See Non-Patent Document 1, etc.)

  Therefore, we investigated substances, extracts, etc. that suppress the action of kinesin, but did not find any.

Hara et al: J Invest Dermatol 114 (3): 438-43,2000

  Accordingly, an object of the present invention is to provide a novel and useful kinesin inhibitor and a composition useful for alleviating, preventing and improving various pigmentation symptoms including stains and buckwheat.

  Based on the above findings, the present inventor investigated various plant extracts and repeated diligent studies with natural plants having excellent transdermal absorbability, stability and safety as the theme of development. .

  As a result, the present inventors have found that specific plant extracts (asparasslinealis extract, hypericum extract, lemongrass extract) have an excellent kinesin inhibitory action. And it contains the kinesin inhibitor which uses a specific plant extract (Asparasas cinereas extract, Hypericum perforatum extract, lemongrass extract) as an active ingredient, a pigmentation inhibitor based on a kinesin inhibitory action, and a kinesin inhibitor The present invention has been completed by providing various compositions (pharmaceutical composition, food composition, cosmetic composition).

The figure which shows the kinesin inhibitory action of the other plant extracts (sencuo extract, safflower extract) used as the sample for a comparison, and the kinesin inhibitory action of the asparagus linen alice extract of this invention, a hypericum extract, and a lemongrass extract It is.

  The “Asparathus linealis” used in the present invention includes the leaves, stems, and whole grasses of the plant of the family Legaceae (Fabaceae) and the genus Aspalathus (Aspalathus linealis).

  In addition, the term “hypericum” used in the present invention refers to the plants of the family Hypericum (Guttiferae) and Hypericum (Hypericum): flowers, flower spikes, pericarps, fruits, stems, leaves, branches, leaves and stems of Hypericum erectum. Use bark, rhizome, root bark, roots, seeds or whole grass.

  In addition, the “lemongrass” used in the preparation of the present invention uses Gramineae, Cymbopogon plant: Lemongrass “Cymbopogon citratu (= Cymbopogon Schoenanthus)” leaves, stems, and whole plants. .

  In addition, asparassine linealis extract, hypericum extract, and lemongrass extract used in the present invention are obtained by extracting various used parts of each plant as they are or after pulverization. Alternatively, it is extracted as it is or after pulverization with a solvent.

  As an extraction solvent for obtaining an extract of each plant used in the present invention, water, lower alcohol such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isobutanol or the like, hydrous lower alcohol, propylene glycol, 1,3- Butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,3,5 -Polyhydric alcohol or hydrous polyhydric alcohol such as pentanetriol, glycerin, polyethylene glycol (molecular weight 100 to 100,000), acetone, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene, chloroform, Carbon tetrachloride, phenol, toluene Selected from various organic solvents, acids (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, etc.) prepared as appropriate 1 type, or 2 or more types of mixed liquids are mentioned, It is preferable to select 1 type, or 2 or more types especially chosen from water, ethanol, and 1, 3- butylene glycol. However, if it is not preferable to use a solvent depending on the application, use only water, or perform extraction with a highly volatile solvent that can be easily removed after extraction, and dissolve in water after removing the solvent. Such a method is also possible.

  Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used. Although it can set arbitrarily as the temperature of a solvent in the range of -4 degreeC to 100 degreeC, 10-40 degreeC vicinity is preferable from the stability point of the component contained in a raw material. Also, the weight ratio of the solvent to the raw material can be arbitrarily set, for example, in the range of the raw material: solvent 4: 1 to 1: 100, and the weight ratio of 1: 1 to 1:20 is particularly preferable.

  Each plant extract used in the present invention can be further subjected to a refining operation after solvent extraction. The refining operation includes an acid (hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, organic acid, etc.) or an alkali ( Decomposition by adding sodium hydroxide, calcium hydroxide, ammonia, etc., fermentation or metabolic conversion by microorganisms, component adsorption by ion exchange resin, activated carbon, diatomaceous earth, etc., various separation modes (ion exchange, hydrophilic adsorption, hydrophobicity) Fractionation using chromatography with adsorption, size exclusion, ligand exchange, affinity, etc.), filtration using filter paper or membrane filter, ultrafiltration membrane, etc., pressurization or decompression, heating or cooling, drying, Examples include pH adjustment, deodorization, decolorization, and long-term storage, and these can be arbitrarily selected and combined.

  In producing the various compositions of the present invention, the shape of each plant extract used in the present invention may be any form such as liquid, solid, powder, paste, etc., and the present invention is carried out. The optimum shape can be arbitrarily selected.

  The content of each plant extract used in the present invention in the various compositions of the present invention is not particularly limited as long as it can be confirmed that kinesin can be suppressed, but generally 0.01 mg / g to It is set in the range of 200 mg / g (the denominator indicates the weight of the preparation). Preferably it is the range of 0.1 mg / g-20 mg / g, Most preferably, it is 200 microgram / g-10 mg / g.

 As an application method as a pharmaceutical composition, either oral administration or parenteral administration can be adopted. In administration, the active ingredient can be mixed with a solid or liquid nontoxic pharmaceutical carrier suitable for administration methods such as oral administration, rectal administration and injection, and administered in the form of a conventional pharmaceutical preparation. Examples of such preparations include solid preparations such as tablets, granules, powders and capsules, liquid preparations such as solutions, suspensions and emulsions, freeze-dried preparations, and the like. It can be prepared by conventional means. Examples of the non-toxic pharmaceutical carrier include glucose, lactose, sucrose, starch, mannitol, dextrin, fatty acid glyceride, polyethylene glycol, hydroxyethyl starch, ethylene glycol, polyoxyethylene sorbitan fatty acid ester, amino acid, gelatin, Examples include albumin, water, and physiological saline. If necessary, conventional additives such as a stabilizer, a wetting agent, an emulsifier, a binder, and a tonicity agent may be added as appropriate.

  Moreover, as a food composition, various nutritional components are added as it is or added to foods and drinks, and eaten as health foods or health foods, supplements, and food materials. For example, after adding the above-mentioned appropriate auxiliaries, it may be used for edible by using conventional means, and forming into an edible form, for example, granular, granular, tablet, capsule, paste, etc. In addition, various foods such as processed marine products such as kamaboko and chikuwa, livestock products such as sausage and ham, Western confectionery, Japanese confectionery, raw noodles, Chinese noodles, boiled noodles, buckwheat noodles, sauce, soy sauce, sauce, Seasonings such as sugar, honey, powdered candy, syrup, etc., spices such as curry powder, mustard powder, pepper powder, jam, marmalade, chocolate spread, pickles, red vegetables, sprinkles, canned and bottled vegetables and fruits Processed vegetables and fruits, dairy products such as cheese, butter, yogurt, miso soup, soup, fruit juice, vegetable juice, whey beverage, soft drink, alcoholic beverages, liquid food, etc. Addition to can be used, also, pet food, can also be used for animals and plants for feed and the like.

  As a cosmetic composition, for example, it can be used in various external preparations (including preparations used for animals) in general, specifically, ampoules, capsules, pills, tablets, powders, granules, solids, liquids 1) Pharmaceuticals, 2) Quasi-drugs, 3) Topical or systemic skin cosmetics (eg lotion) , Basic cosmetics such as emulsion, cream, ointment, lotion, oil, pack, facial cleanser and skin cleanser, massage agent, cleansing agent, hair remover, hair remover, shaving treatment, after shave lotion, pre-shave Makeup cosmetics such as lotion, shaving cream, foundation, lipstick, blusher, eye shadow, eyeliner, mascara, perfume, beauty nail preparation, beauty nail enamel, beauty Enamel removers, poultices, plasters, tapes, sheets, patches, aerosols, etc.), 4) medicinal and / or cosmetic preparations applied to the scalp and hair (eg shampoos, rinses, Hair treatment agent, pre-hair treatment agent, permanent liquid, hair dye, hair styling agent, hair styling agent, hair growth / hair restoration agent, poultice agent, plaster agent, tape agent, sheet agent, patch, aerosol agent, etc.), 5) bath Bathing agent used in hot water, 6) Other anti-smell and deodorants, deodorants, antiperspirants, hygiene products, sanitary cotton, wet tissue, toothpaste, mouth freshener, gargle, dishwashing It can also be used for agents.

  In addition, the components and additives exemplified below are arbitrarily added to the kinesin inhibitor and various compositions of the present invention within a range that does not impair the effects of the invention of the extract of each plant of the present invention that is an essential active ingredient. They can be selected and used together, and can be added with various functions. The content in the preparation is not particularly limited, but a concentration range of usually 0.0001 to 50% is preferable.

Pigmentation inhibitor A pigmentation inhibitor can be added to the present invention. Specific examples of pigmentation inhibitors include p-aminobenzoic acid derivatives, salicylic acid derivatives, benzenesulfonamide derivatives, imidazole derivatives, naphthalene derivatives, hydroxyanthranilic acid or salts thereof, and derivatives thereof, anthranilic acid derivatives, coumarin derivatives, amino acids Derivatives (2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid, 2-amino-3- [1-carboxyl-2- (1H-imidazole) -4-yl) ethyl] aminobutanoic acid hydrochloride, 2-amino-3- [1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid sodium salt, 2-amino-3- [ 1-carboxyl-2- (1H-imidazol-4-yl) ethyl] aminobutanoic acid potassium salt, etc.), benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimidine derivatives, dioxane derivatives Body, camphor derivative, furan derivative, pyrone derivative, nucleic acid derivative, allantoin derivative, nicotinic acid derivative, ascorbic acid or its salt and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbine) Hydroxyprophosphate phosphate, 5-o-α-D-glucopyranosyl-L-ascorbic acid, L-ascorbate phosphate sodium salt, L-ascorbate phosphate potassium salt, L-ascorbate phosphate magnesium Salt, L-ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt L-ascorbic acid sulfate calcium salt, L-ascorbic acid sulfate aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid Aluminum salt, 6-o-α-D-galactopyranosyl-L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L -Ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbine Acid phosphate ester isopropanolamine salt, 3-o-isopropyl-L-ascorbic acid, 6-o-alkyl ascorb Phosphoric acid ester potassium salt, 6-o-alkylascorbic acid phosphate calcium salt, 6-o-alkylascorbic acid phosphate barium salt, 6-o-alkylascorbic acid phosphate ammonium salt, 6-o -Alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl ascorbic acid phosphate diethanolamine salt, 6-o-alkyl ascorbic acid phosphate triethanolamine salt, 6-o-alkyl ascorbic acid phosphate ester Monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o- β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid Cholesterol acid ester, palmitic acid-L-ascorbyl, isopalmitic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl , Distearic acid-L-ascorbyl, diisostearic acid-L-ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethyl Hexanoic acid-L-ascorbyl, di-2-ethylhexanoic acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D- Maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L -Ascor Binic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitate, L-ascorbic acid tetralaurate, L-ascorbic acid tetra-2-ethylhexanoic acid Esters, L-ascorbic acid tetraoleate, 5,6-isopropylidene-L-ascorbic acid, L-ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbine Acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2 -o-ascorbyl caffeate, 2-o-ascorbyl cinnamate, 2-o- [6-palmitoyl ascorbyl] -4'-acetoxyfe Lurate, DL-α-tocopherol-2-L-ascorbic acid diester, ascorbic acid inositol-conjugated derivative, ascorbic acid phosphoramide derivative, ascorbyl arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic acid derivative Etc.), tocopherol or a salt thereof and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, toco Ferryl phosphate ester, tocopherol acetate, tocopherol nicotinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-to Ferryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ- Tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ -Tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L- β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1 -(Sulfoe Ruamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol, 1- (carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride , S- [3- (α-Tocopheryl-6-Iroxy) -2-hydroxypropyl] cysteine, S- [3- (α-Tocopheryl-6-Iroxy) -2-hydroxypropyl] -γ- Glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxy Propyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol, γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, Cotrienol linoleate, tocotrienol orotate, etc.), tranexamic acid amide or a salt thereof, and derivatives thereof (trans-4-aminomethylcyclohexanecarbonamide, trans-4-aminomethylcyclohexanecarbonamide hydrochloride, Nn-hexyl-trans) -4-aminomethylcyclohexanecarbonamide, Nn-hexyl hydrochloride-trans-4-aminomethylcyclohexanecarbonamide, Nn-heptyl-trans-4-aminomethylcyclohexanecarbonamide, Nn-heptyl-trans hydrochloride -4-aminomethylcyclohexanecarbonamide, Nn-butyl-trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid Nn-butyl-trans-4-aminomethylcyclohexane Namide, Nn-propyl-trans-4-aminomethylcyclohexanecarbonamide, N-cyclohexyl-trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N-cyclohexyl-trans-4-aminomethylcyclohexanecarbonamide, N, N -Dicyclohexyl-trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N, N-dicyclohexyl-trans-4-aminomethylcyclohexanecarbonamide, N, N-diethyl-trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N, N -Diethyl-trans-4-aminomethylcyclohexanecarbonamide, N-benzyl-trans-4-aminomethylcyclohexanecarbonamide, N-benzyl-trans-4-a hydrochloride Nomethylcyclohexanecarbonamide, N- (4'-methoxyphenyl) -trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N- (4'-methoxyphenyl) -trans-4-aminomethylcyclohexanecarbonamide, N- ( 4'-ethoxyphenyl) -trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N- (4'-ethoxyphenyl) -trans-4-aminomethylcyclohexanecarbonamide, N- (2'-methylphenyl) -trans- 4-aminomethylcyclohexanecarbonamide, hydrochloric acid N- (2'-methylphenyl) -trans-4-aminomethylcyclohexanecarbonamide, N- (3'-methylphenyl) -trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N -(3'-methylphenyl) -trans-4-aminomethylcyclohexanecarbonamide, N- (4'-chlorophenyl) -trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N- (4'-chlorophenyl) -trans- 4-aminomethylcyclohexanecarbonamide etc.), kojic acid or derivatives thereof (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2- Benzoluyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-cinnamoyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4 -On, kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate, kojic acid monopalmitate, kojic acid monostearate , Kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, kojic acid dioleate, etc.), oxybenzone, benzophenone, guaiazulene, shikonin, baicalin or salts thereof and derivatives thereof, baicalein Or salts thereof and derivatives thereof, berberine or salts thereof and derivatives thereof, chrysin or salts thereof and derivatives thereof, apigenin or salts thereof and derivatives thereof, luteolin or salts thereof and derivatives thereof, acacetin or salts thereof and the like Derivatives, diosmethine or a salt thereof and derivatives thereof, kaempferol or a salt thereof and derivatives thereof, triphorin or a salt thereof and derivatives thereof, astragalin or a salt thereof and These derivatives, quercetin or a salt thereof and derivatives thereof, quercitrin or a salt thereof and derivatives thereof, isoquercitrin or a salt thereof and derivatives thereof, rutin or a salt thereof and derivatives thereof, morin or a salt thereof and them Derivatives, myricetin or salts thereof and derivatives thereof, myristitrin or salts thereof and derivatives thereof, datiscetin or salts thereof and derivatives thereof, quercetagetin or salts thereof and derivatives thereof, isorhamnetin or salts thereof and derivatives thereof, pinocembrin Or salts thereof and derivatives thereof, naringenin or salts thereof and derivatives thereof, hesperetin or salts thereof and derivatives thereof, eriodictyol or salts thereof and derivatives thereof, pinobankin or salts thereof And derivatives thereof, aromadendrine or a salt thereof and derivatives thereof, engelitin or a salt thereof and derivatives thereof, taxofolin or a salt thereof and derivatives thereof, astilbine or a salt thereof and derivatives thereof, amperopsin or a salt thereof and a derivative thereof Derivatives, spiraeosides, kaempferol-7-neohesperidoside, glutathione or salts thereof and derivatives thereof, isoflavone glycosides (6-o-apiosyl puerarin-4'-o-glucoside, 6-o-glucosyl puerarin, 3'-hydroxypuerarin-4'-o-glucoside, 6-o-apiosyl-3'-hydroxypuerarin), γ-pyrone glycoside (maltol-3-o- (6'-o-apiosyl) -glucoside , Maltol-3-o- (6′-o-apiosyl) -glucoside, etc.), isononyl ferrate, ellagic acid or a salt thereof, and their Conductors (5,4-dimethylellagic acid, 3,3'-dimethylellagic acid, 3,3 ', 4-trimethylellagic acid, 3,3', 4,4'-tetramethyl-5-methoxyellagic acid, 3 -Ethyl-4-methyl-5-hydroxyellagic acid, amritoside, etc.), lucinol, ondisaponin, bacmond saponin, ruscogenin, sericoside, asiaticoside, hederin, senegin, benzoic acid anilides (4-hydroxy-N- ( 2-hydroxyphenyl) benzoic acid amide, 4-hydroxy-N- (3-hydroxyphenyl) benzamide, 4-hydroxy-N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy -N- (4-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N- (3-hydroxyphenyl) benzamide, 3,5-di-t-butyl-4-hydroxy-N -(2-hydroxyphenyl) benzamide, etc.), diphenyl Larin, cyproheptadine, triprolidine, dimethindene, ozagrel, isothipentyl, iproheptin, homochlorcyclidine, alimemazine, bucillamine, oxytosamide, vidarabine, xanthotoxol, phenylmercury hexachlorophene, mercuric oxide, mercuric chloride, hydrogen peroxide Water, zinc peroxide, placenta (bovine origin, porcine origin, horse origin, sheep origin, etc.) extract, almond extract, amaranth extract, octopus extract, lobster extract, querca extract, kofuyou extract, unca Rear extract, gaija extract, gypsophila extract, licorice extract, gardenia extract, cranigean extract, clara extract, koganebana extract, wheat (wheat) extract, rice (rice) extract, cori Aria extract, Sidwaya extract, Sankyu extract, Sanvitro extract, Sunpens extract, Silane (Biacyu) extract, Senkyu (river cucumber) extract, Senna extract, Senpukuka extract, Senktsusai extract, Surigatin extract, Nodake (maehu) Extract, pearl barley (Yokuinin) extract, hamago extract, honey beetle extract, hamamelis extract, palm extract, parietalia extract, safflower (safflower) extract, mugwa (mulberry bark) extract, malvanojadine (bitter) extract , Purple squirrel extract, white squirrels extract, mugwort extract, yashajitsu extract, hongkong extract, bituminous (soil) extract, quail extract, sorghum extract, millipede extract and the like.

Tyrosinase activity inhibitor A tyrosinase activity inhibitor can be added to this invention. Specific examples of tyrosinase activity inhibitors include ascorbic acid or a salt thereof and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, hydroxyprophosphate phosphate ascorbate, 5-o-α -D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid Sulfuric acid Stell aluminum salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyrano Sil-L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate Ester sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl- L-ascorbic acid, 6-o-alkylascorbic acid phosphate potassium salt, 6-o-alkylascorbic acid phosphoric acid Steal calcium salt, 6-o-alkyl ascorbic acid phosphate barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o-alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl Ascorbic acid phosphate diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanol Amine salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, phosphorus ascorbate Acid cholesterol ester, palmitic acid-L-ascorbyl, iso Lumic acid-L-ascorbyl, dipalmitic acid-L-ascorbyl, diisopalmitic acid-L-ascorbyl, stearic acid-L-ascorbyl, isostearic acid-L-ascorbyl, distearic acid-L-ascorbyl, diisostearic acid-L- Ascorbyl, myristic acid-L-ascorbyl, isomyristic acid-L-ascorbyl, dimyristic acid-L-ascorbyl, diisomyristic acid-L-ascorbyl, 2-ethylhexanoic acid-L-ascorbyl, di-2-ethylhexane Acid-L-ascorbyl, oleic acid-L-ascorbic acid, 2-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α- D-maltotriosyl-L-ascorbic acid, 3-o-α-D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-malto Triosyl-L-ascorbic acid, L-ascorbine Tetraisopalmitate, L-ascorbyl tetralaurate, L-ascorbate tetra-2-ethylhexanoate, L-ascorbate tetraoleate, 5,6-isopropylidene-L-ascorbate, L -Ascorbic acid retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate , L-ascorbyl triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl ] -4'-acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid phosphoric acid diester, Ascorbic acid inositol binding derivative, ascorbic acid phosphoramide derivative, ascorbic acid arbutin conjugate, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivative, ascorbic acid sialic acid derivative, etc.), hydroquinone or its salt and derivatives thereof (hydroquinone α-D-glucose) , Hydroquinone β-D-glucose, hydroquinone α-L-glucose, hydroquinone β-L-glucose, hydroquinone α-D-galactose, hydroquinone β-D-galactose, hydroquinone α-L-galactose, hydroquinone β-L-galactose, etc. Hexoses, hydroquinone α-D-ribose, hydroquinone β-D-ribose, hydroquinone α-L-ribose, hydroquinone β-L-ribose, hydroquinone α-D-arabinose, hydroquinone β Five-carbon sugar glycosides such as -D-arabinose, hydroquinone α-L-arabinose, hydroquinone β-L-arabinose, hydroquinone α-D-glucosamine, hydroquinone β-D-glucosamine, hydroquinone α-L-glucosamine, hydroquinone β -Amino sugar glycosides such as L-glucosamine, hydroquinone α-D-galactosamine, hydroquinone β-D-galactosamine, hydroquinone α-L-galactosamine, hydroquinone β-L-galactosamine, hydroquinone α-D-glucuronic acid, hydroquinone β -D-glucuronic acid, hydroquinone α-L-glucuronic acid, hydroquinone β-L-glucuronic acid, hydroquinone α-D-galacturonic acid, hydroquinone β-D-galacturonic acid, hydroquinone α-L-galacturonic acid, hydroquinone β-L -Hydroquinone coordination such as uronic acid glycosides such as galacturonic acid Body, hydroquinone benzyl ether, 4-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) butane, 5-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) pentane, 6-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) hexane, 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propane, 2-β-D- Hydroquinone hydroxyalkyl ether glycosides such as glucopyranosyloxy-1- (4-hydroxyphenoxy) butane and 2-β-D-glucopyranosyloxy-1- (4-hydroxyphenoxy) propan-3-ol ), Kojic acid or a salt thereof and derivatives thereof (2-methoxymethyl-hydroxy-4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4-one, 2-benzoluyloxy Methyl-5-hydroxy-4H-pyran-4-one, 2-cin Moyloxymethyl-5-hydroxy-4H-pyran-4-one, 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one, kojic acid glycoside, geranylgeranylacetone, kojic acid monobutyrate, kojic acid monocaprate , Kojic acid monopalmitate, kojic acid monostearate, kojic acid monocinnamate, kojic acid monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, kojic acid distearate, kojic acid dioleate, etc.), tocopherol or salts thereof and Derivatives (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, Coferol nicotinate, tocopherol succinate, tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocopheryl glucoside, DL-β-tocopheryl maltoside DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α-tocopheryl glucoside, D-α-tocopheryl maltoside Sid, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ-tocopheryl glucoside, D-δ-tocopheryl Maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L-γ-to Ferryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, L- (sulfoethylamino) -3- (α-tocopheryl-6-iroxy) Propan-2-ol, 1- (carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) ) -2-Hydroxypropyl] cysteine, S- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl) -6-Iroxy) -2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α -Tocotrienol, β-Tocotrienol, γ-Tocotrieno , Δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate, etc.), N-acetyltyrosine or salts thereof and derivatives thereof, glutathione or salts thereof and derivatives thereof, ellagic acid Or a salt thereof and a derivative thereof (3,4-dimethylellagic acid, 3,3′-dimethylellagic acid, 3,3 ′, 4-trimethylellagic acid, 3,3 ′, 4,4′-tetramethyl-5 -Methoxyellagic acid, 3-ethyl-4-methyl-5-hydroxyellagic acid, amritoside, etc.), isonitrine A, isonitrine B, isonitrine C, isonitrine D, isonitrinic acid E, isonitrinic acid F, dermadein, tricobylidein, etc. Isonitrile antibiotics, orselinic acid derivatives (orceric acid, orthoselic acid ethyl Ester orcinol, p-geranyl orthoselic acid, p-geranyl orthoselic acid ethyl ester geranyl orcinol, p-farnesyl orthoselic acid, p-farnesyl orthoselic acid ethyl ester farnesyl orcinol, p-dodecanyl orthoseric acid, p-dodecanylorceric acid ethyl ester dodecanylorcinol, p-tetradecanylorceric acid, p-tetradecanylorceric acid ethylester tetradecanylorcinol, p-hexadecanylorceric acid, p- Hexadecanylorceric acid ethyl ester Hexadecanylorcinol, p-undecanylorceric acid, p-undecanylorceric acid ethyl ester undecanylorcinol, p-tridecanylorceric acid, p-tri Decanylorceric acid ethyl ester undecanylorcinol, p- Pentadecanylorceric acid, p-pentadecanylorceric acid ethyl ester pentadecanylorcinol, ethylhexylorceric acid, p-ethylhexylorceric acid ethylester ethylhexylorcinol, p-cyclohexylmethylorceric acid, p- Cyclohexylmethylorceric acid ethyl ester cyclohexylmethylorcinol, p-hydroxyethylhexylorceric acid methyl ester, p-hydroxyethylhexylorceric acid hydroxyethylhexylorcinol, etc.), umbelic acid, brefeldin, oxydesveratrol, resorcinol derivatives (4-cyclohexylresorcinol), 3-hydroxyketone compounds (1,5-bis (p-hydroxyphenyl) -2-hydroxypentan-4-one, 1,5-bis (o, p-dihydroxypheny) ) -2-hydroxypentan-4-one, 1,5-bis (p-hydroxyphenyl-m-methoxyphenyl) -2-hydroxypentan-4-one, etc.), 1,3-diketone compound (1,5- Bis (p-hydroxyphenyl) -2,4-pentanedione, 1,5-bis (o, p-dihydroxyphenyl) -2,4-pentanedione, 1,5-bis (p-hydroxyphenyl-m-methoxy) Phenyl) -2,4-pentanedione), bishydroxybenzyl amides, γ-aminobutyric acid or its derivatives (N-methyl-γ-aminobutyric acid, N-dimethyl-γ-aminobutyric acid, γ-aminobutyric acid oleyl ester) Etc.), Hydrogen peroxide, Zinc peroxide, Placenta extract, Lucinol, Silk extract, Acacia extract, Acerola extract, Ichibi (winter position) extract, Inula racemosa extract, Weeping birch extract, Quercus extract, Chestnut extract , Kamehiba kokoshi extract Black-bellied toad extract, senshinren (Pinced lotus) extract, seri extract, buckwheat extract, dabilia extract, nazuna extract, Fujibaka extract (Orchid grass) extract, chamomile extract, mulberry extract, gardenia extract, red snapper extract, bitumen extract, clara extract, mugwort extract, honeysuckle extract, yellowfin Extract, Bokudami extract, Matsuhodo extract, pearl barley extract, nettle extract, hop extract, hawthorn extract, eucalyptus extract, yarrow extract, altea extract, cinnamon extract, bay extract, hamameris extract, yamagwa extract, bellflower extract, toshishi extract Extract, sprayed extract, maize extract, senkyu extract, dokkatsu extract, psycho extract, boufu extract, kingfish extract, oxon extract, peony Examples include peel extract, peony extract, geno shoko extract, kudzu root extract, licorice extract, pentaploid extract, aloe extract, shouma extract, safflower extract, green tea extract, black tea extract, and asen drug extract.

Melanocyte Melanin Production Inhibitor A melanocyte melanin production inhibitor can be added to the present invention. Specific examples of melanocyte melanin production inhibitors include lobeline or lobeline derivatives, liquiritin derivatives (such as liquiritin-α-glucoside, liquiritin-α-maltoside), phenylchroman derivatives, chromone derivatives (2-butylchromone, 2-pentylchromone, 2 -Heptylchromone, 2-nonylchromone, 2-hexadecylchromone, 2- (1-ethylpentyl) chromone, 2-butyl-7-methoxychromone, 2-pentyl-7-methoxychromone, 2-heptyl-7-methoxychromone , 2-nonyl-7-methoxychromone, 2-pentadecyl-7-methoxychromone, 2- (1-ethylpentyl) -7-methoxychromone, 7-hydroxy-2-methylchromone, 7-hydroxy-2-butylchromone 7-hydroxy-2-pentylchromone, 7-hydroxy-2-heptylchromone, 7-hydroxy-2-nonylchromone, 7-hydroxy -2-pentadecylchromone, 7-hydroxy-2- (1-ethylpentyl) chromone), azelaic acid derivatives (eg azelaic acid monoalkyl ester, azelaic acid dialkyl ester), phosphatidylglucosamine, lysophosphatidylglucosamine, phenylhydroquinone, 3-β-D-glucopyranosyl manur, 3-β-D-maltopyranosyl manur, substituted amino acid derivatives (DL-N-formyl-3- (1-naphthyl) alanine, DL-N-acetyl-3 -(1-naphthyl) alanine, DL-N-propionyl-3- (1-naphthyl) alanine, DL-N-butyryl-3- (1-naphthyl) alanine, DL-N-isobutyryl-3- (1-naphthyl) ) Alanine, DL-N-valeryl-3- (1-naphthyl) alanine, DL-N-isovaleryl-3- (1-naphthyl) alanine, DL-N- (2-methylvaleryl) -3- (1-naphthyl) Alanine, DL-N- (3-Methylvaleryl) -3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine, DL-N-t-butylacetyl-3- (1-naphthyl) alanine, DL-N-pivaloyl- 3- (1-naphthyl) alanine, DL-N-caproyl-3- (1-naphthyl) alanine, DL-N- (2-ethylhexanoyl) -3- (1-naphthyl) alanine, DL-N- ( 2-methylhexanoyl) -3- (1-naphthyl) alanine, DL-N-heptanoyl-3- (1-naphthyl) alanine, DL-N-octanoyl-3- (1-naphthyl) alanine, DL-N- (2-propylpentanoyl) -3- (1-naphthyl) alanine, DL-N-nonanoyl-3- (1-naphthyl) alanine, DL-N-decanoyl-3- (1-naphthyl) alanine, DL-N -Undecanoyl-3- (1-naphthyl) alanine, DL-N-dodecanoyl-3- (1-naphthyl) alanine, DL-N-tridecanoyl-3- (1-naphthyl) alanine, DL-N-tetradecanoyl- 3- (1-Naph ) Alanine, DL-N-pentadecanoyl-3- (1-naphthyl) alanine, DL-N-hexadecanoyl-3- (1-naphthyl) alanine, DL-N-heptadecanoyl-3- (1-naphthyl) ) Alanine, DL-N-octadecanoyl-3- (1-naphthyl) alanine, DL-N-nonadecanoyl-DL-3- (1-naphthyl) alanine, DL-N-icosanoyl-3- (1-naphthyl) Alanine, DL-N-Acroyl-3- (1-naphthyl) alanine, DL-N-crotoniloyl-3- (1-naphthyl) alanine, DL-N-methacryloyl-3- (1-naphthyl) alanine, DL-N -Vinylacetyl-3- (1-naphthyl) alanine, DL-N-cyclopropanoyl-3- (1-naphthyl) alanine, DL-N- (2-pentenoyl) -3- (1-naphthyl) alanine, DL -N- (4-pentenoyl) -3- (1-naphthyl) alanine, DL-N- (2-hexenoyl) -3- (1-naphthyl) alanine, DL-N- (3-hexenoyl) -3- ( 1-naphthyl) Lanin, DL-N- (2-Methyl-3-pentenoyl) -3- (1-naphthyl) alanine, DL-N-cyclohexenoyl-3- (1-naphthyl) alanine, DL-N- (10 -Undecenoyl) -3- (1-naphthyl) alanine, DL-N-linoleyl-3- (1-naphthyl) alanine, DL-N-hydroxyacetyl-3- (1-naphthyl) alanine, DL-N- (6 -Hydroxycaproyl) -3- (1-naphthyl) alanine, DL-N- (8-hydroxyoctanoyl) -3- (1-naphthyl) alanine, DL-N- (9-hydroxynonanoyl) -3- (1-naphthyl) alanine, DL-N- (10-hydroxydecanoyl) -3- (1-naphthyl) alanine, DL-N- (11-hydroxyundecanoyl) -3- (1-naphthyl) alanine, DL-N- (12-hydroxydecanoyl) -3- (1-naphthyl) alanine, DL-N-benzoyl-3- (1-naphthyl) alanine, DL-N- (2-hydroxybenzoyl) -3- ( 1-naphthyl) arani DL-N- (3-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (4-hydroxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (o-toluyl) ) -3- (1-naphthyl) alanine, DL-N- (m-toluyl) -3- (1-naphthyl) alanine, DL-N- (p-toluyl) -3- (1-naphthyl) alanine, DL -N- (1-naphthoyl) -3- (1-naphthyl) alanine, DL-N- (2-naphthoyl) -3- (1-naphthyl) alanine, DL-N- (2-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (3-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N- (4-carboxybenzoyl) -3- (1-naphthyl) alanine, DL-N -(2-Picoloroyl) -3- (1-naphthyl) alanine, DL-N- (3-Picoloroyl) -3- (1-naphthyl) alanine, DL-N- (4-Picoloroyl) -3- (1- Naphthyl) alanine, DL-N-phenylacetyl-3- (1-naphthyl) arani DL-N- (2-phenylpropanoyl) -3- (1-naphthyl) alanine, DL-N- (3-phenylbutyryl) -3- (1-naphthyl) alanine, DL-N- (4 -Methylvaleryl) -3- (1-naphthyl) alanine, DL-N-valeryl-3- (1-naphthyl) alanine, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanineamide, DL- N- (4-methylvaleryl) -3- (1-naphthyl) alanine methyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine ethyl ester, DL-N- (4-methylvaleryl)- 3- (1-naphthyl) alanine propyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine-N-butyl ester, DL-N- (4-methylvaleryl) -3- (1- Naphthyl) alanine pentyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine isopropyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) ) Alanine isobutyl ester, DL-N- (4-methylvaleryl) -3- (1-naphthyl) alanine-t-butyl ester, etc.), benzolactam derivatives, indolactam derivatives, cedrol, guaioles, 1- (4-hydroxypheny Thio) -2-propanol, β-lactoglobulin, 2-methoxy-5-methylphenol, 5-ethyl-2-methoxyphenol, 5-N-propyl-2-methoxyphenol, 5-N-butyl-2-methoxy Phenol, 5-N-hexyl-2-methoxyphenol, 5-N-heptyl-2-methoxyphenol, 5-N-decyl-2-methoxyphenol, 5- (1,1-dimethylpropyl) -2-methoxyphenol , 5- (1,1-dimethylbutyl) -2-methoxyphenol, 5- (1,1-dimethylethyl) -2-methoxyphenol, 2-methoxy-5- (1-methylpentyl) phenol, 2-methoxy -5- (1-Methylhexyl) pheno 2-methoxy-5- (3-methylhexyl) phenol, 2-methoxy-5- (6-methylheptyl) phenol, 5- (1,3-dimethylheptyl) -2-methoxyphenol, malvelin, ferruginol, Sugiol, cryptojaponol, 1,5-bis [p-hydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [o-hydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [2,4-dihydroxyphenyl] -1,4-pentadien-3-one, 1,5-bis [3-methoxy-4-hydroxyphenyl] -1,4-pentadien-3-one , Haginin, agrimophor, agrimol, hydrangenol or derivatives thereof, alkylresorcinol or derivatives thereof (such as 4-N-butylresorcinol), aristrone, caramenenes (caramenene, 7-hydroxycaramenene, 5-hydroxycaramenene, 7-methoxycaramenene ), Trans-umberic acid, N-α-benzoyl-L-arginine, N-α-benzoyl-L-arginine ethyl ester or N-α-benzoyl-L-arginine ethyl ester, 5-methyl-2 (3H)- Furanone, 2-butene-4-olide, 2-hydroxymethylfuran, 2,5-dimethyl-4-hydroxy-3 (2H) -furanone, 2-formylfuran, 3-formylfuran, methyl α-furyl ketone, furfuryl Acetate, 2-hydroxy-3-methyl-2-cyclopenten-1-one, 2-hydroxy-3,5-dimethyl-2-cyclopenten-1-one, 2,5-dimethyl-4-hydroxy-3 (2H) -Thiophenone, 2-hydroxy-3-ethyl-2-cyclopenten-1-one, tetronic acid, pentanedione, iminodibenzyls (2,2'-iminodibenzyl, imipramine, imipramine hydrochloride, desipramine, desipramine hydrochloride , Chlorimipramine, trimipura Min), dibenzocycloheptadiene (amitriptyline, amitriptyline hydrochloride, nortriptyline, noxypetitin, etc.), tetrahydrocopalol glycoside (ketotifen fumarate, labda-8 (17), 13-dien-15-ol, tetrahydroma Nour, tetrahydrocoparol, tetrahydrocoparol glucoside, tetrahydrocoparol galactoside, tetrahydrocoparol maltoside, tetrahydrocoparol cellobioside, tetrahydrocoparol maltotrioside, etc.), spiroether compound, piochelin, phenothiazine compound, promethazine, alimemazine , Alimemazine tartrate, triflupromazine, levomepromazine, chlorpromazine, cyclandrate, 4-carboxymethyloxybenzoic acid, 4-carboxymethyloxy 2-hydroxybenzoic acid, 3- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) benzoic acid, 4- (3-carboxypropyl-1 -Oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-methoxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1-oxy) -2 -Hydroxybenzoic acid, 4- (10-carbamoyldecane-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl-1-oxy) benzoic acid, 4- (4-hydroxybutyl-1-oxy) ) -2-Hydroxybenzoic acid, 4- (4-acetoxybutyl-1-oxy) benzoic acid, 4- (4-acetoxybutyl-1-oxy) -2 -Hydroxybenzoic acid, 4- (3-ethoxycarbonylpropyl-1-oxy) -2-hydroxybenzoic acid, 3- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (4 -Methoxybutyl-1-oxy) -2-hydroxybenzoic acid, 4- (2,3-dihydroxypropyl-1-oxy) -2-hydroxybenzoic acid, 4-carboxymethyloxy-2-hydroxybenzoic acid, 3- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 5- (3-carboxypropyl-1-oxy) -2 -Hydroxybenzoic acid, 6- (3-carboxypropyl-1-oxy) -2-hydroxybenzoic acid, 4- (5-carboxypentyl-1-oxy) -2-hydroxybenzoic acid, 4- (4-hydroxybutyl) -1-oxy) -2-hydroxybenzoic acid, 4- (10-carboxydecane-1-oxy) -2-hydroxybenzoic acid Benzoic acid, hydroxytrimethylcyclohexanes (2-hydroxy-4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane)- 1-butene, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2-butene, 4- (2,2,6-trimethyl-1-yl-cyclohexane) butane, 3-methyl-3 -Hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3 -Methyl-5- (2,2,6-trimethyl-1-yl-cyclohexane) pentane, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -3- Pentene, 3-methyl-3-hydroxy-5- (2,2,6-trimethyl-1-yl-cyclohexane) -1-pentene, 3-methyl-1-hydroxy-5- (2,2,6-trimethyl 1-yl-cyclohexa ) -2-pentene, 2-hydroxy-4- (2,2,6-trimethyl-1-yl-cyclohexane) butane and other monosaccharides, disaccharides or trisaccharide glycosides), escinol, parahydroxycinnamic acid -4- (2,2,6-trimethyl-yl-cyclohexane) -2-butyl ester monosaccharide, disaccharide or trisaccharide glycoside, ondisaponin, bacmond saponin, ruscogenin, sericoside, asiaticoside, hederin , Senegin, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2-keto-butane, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2-keto -Butane, 4- (2,2,6-trimethyl-1-yl-cyclohexane) -2-keto-3-butene, 4- (2,2,6-trimethyl-1-yl-6-cyclohexene) -2 -Keto-3-butene (β-ionone), Lp-hydroxyphenylglycine, Dp-hydroxyphenylglycine, N-benzyloxycarbonyl-Lp-hydroxy Phenylglycine, N-benzyloxycarbonyl-Dp-hydroxyphenylglycine, N-benzoyl-Lp-hydroxyphenylglycine, N-benzoyl-Dp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-methoxybenzoyl) -Dp-hydroxyphenylglycine, N- (p-hydroxybenzoyl) -Lp-hydroxyphenylglycine, N- (p-hydroxybenzoyl) -Dp-hydroxyphenylglycine, N-acetyl-Lp -Hydroxyphenylglycine, N-acetyl-Dp-hydroxyphenylglycine, N-acetyl-Lp-hydroxyphenylglycine ethyl ester, N-acetyl-Dp-hydroxyphenylglycine ethyl ester, N-acetyl-Lp-hydroxyphenylglycinamide, N-acetyl-Dp-hydroxyphenylglycinamide, Lp- Toxiphenylglycine, Dp-methoxyphenylglycine, Lp-methoxyphenylglycine hydrochloride, Dp-methoxyphenylglycine hydrochloride, 4-hydroxy-3-methoxy-L-phenylglycine, 4-hydroxy-3-methoxy-D-phenyl Glycine, Lp-hydroxyphenylglycine ethylamide, Dp-hydroxyphenylglycine ethylamide, N-tert-butoxycarbonyl-Lp-hydroxyphenylglycine, N-tert-butoxycarbonyl-Dp-hydroxyphenylglycine, N-tert-butoxycarbonyl -Lp-methoxyphenylglycine, N-tert-butoxycarbonyl-Dp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Lp-methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-Dp- Methoxyphenylglycine, N-9-fluorenylmethyloxycarbonyl-L p-methoxyphenylglycine benzyl ester hydrochloride, N-9-fluorenylmethyloxycarbonyl-Dp-methoxyphenylglycine benzyl ester hydrochloride, Lp-hydroxyphenylglycinamide, Dp-hydroxyphenylglycinamide, Lp-hydroxyphenylglycine Allyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine allyl ester p-toluenesulfonate, Lp-hydroxyphenylglycine benzyl ester p-toluenesulfonate, Dp-hydroxyphenylglycine benzyl ester p-toluenesulfonate Lp-hydroxyphenylglycine ethyl ester, Dp-hydroxyphenylglycine ethyl ester, Lp-hydroxyphenylglycine ethyl ester hydrochloride, Dp-hydroxyphenylglycine ethyl ester hydrochloride, Lp- Loxyphenylglycine methyl ester, Dp-hydroxyphenylglycine methyl ester, etc., 1,3-diallylindane-2-carboxylic acids, stachybosines, pheophorbide derivatives, eleucerin, isoeleucerine or 4-β-hydroxyisoereucerine, eleucerinol, Spiroketal derivatives (2- (2,4-hexadinylidene) -1,6-dioxaspiro [4.5] dec-3-ene, 2- (2-hexynylidene) -1,6-dioxaspiro [4.4] non-3-ene 2-((4-methylphenyl) methylidene) -6,6-dioxaspiro [4.4] non-3-ene, 2- (2-hexenylidene) -6,6-dioxaspiro [4.5] dec-3-ene, 2 -(2-hexenylidene) -1,6-dioxaspiro [4.4] non-3-ene, 2-hexyl-1,6-dioxaspiro [4.4] nonane, 2- (2-hexenyl) -1,6-dioxaspiro [4.4 ] Nonane, 2- (2-hexynyl) -1,6-dioxaspir [4] nonane, 2-pentyl-1,6-dioxaspiro [4.4] nonane, 1,6-dioxaspiro [4.4] nonane, 1,6-dioxaspiro [4.5] decane, 1,7-dioxaspiro [5.5] undecane, 2,3-benzo-4,4-dimethyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-pentyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2- Hexyl-1,6-dioxaspiro [4.4] nonane, 3,4-benzo-2-octyl-1,6-dioxaspiro [4.4] nonane, 2-hexyl-9,9-dimethyl-1,6-dioxaspiro [4.4] Nonane, 2- (2,4-hexadiniylidene) -1,6-dioxaspiro [4.4] non-3-ene, etc.), malvalic acid, phosphonic acid derivative or salt thereof, aspergillomarasmine, aminophosphonic acid derivative or Its salt, diphenhydramine or its salt, pregnenolone or its derivative, lutein, farnesyl isopropanol derivative, hexahydrophal Silacetone, 4-benzoylamino-2-hydroxybenzoic acid, 5-benzoylamino-2-hydroxybenzoic acid, 4-benzoylaminobenzoic acid, 4- (1-naphthoylamino) -2-hydroxybenzoic acid, 5- ( 1-naphthoylamino) -2-hydroxybenzoic acid, 4- (2-naphthoylamino) -2-hydroxybenzoic acid, 5- (2-naphthoylamino) -2-hydroxybenzoic acid, 4- (1- Naphthoylamino) benzoic acid, 4- (2-naphthoylamino) benzoic acid, 4-phenylaminocarbonylbenzoic acid, 4-phenylaminocarbonyl-2-hydroxybenzoic acid, 5-phenylaminocarbonyl-2-hydroxybenzoic acid 4- (1-naphthylaminocarbonyl) benzoic acid, 4- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (1-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 4- (2- Naphtylaminocarbo E) Benzoic acid, 4- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, 5- (2-naphthylaminocarbonyl) -2-hydroxybenzoic acid, hexahydrofarnesyl isopropanol derivative, borneol-p-hydroxycinnamic Acid ester glucoside, borneol-p-hydroxycinnamic acid maltoside, borneol-p-hydroxycinnamic acid maltotrioside, cinnamic acid-4- (2,2,6-trimethyl-yl-cyclohexane) -2- Butyl ester derivatives, 2,4-dihydroxybenzophenone, 1- (2,4-dihydroxyphenyl) -ethanone (2 ', 4'-dihydroxyacetophenone), 1- (2,4-dihydroxyphenyl) -1-propanone (2 ', 4'-dihydroxypropiophenone), 1- (2,4-dihydroxyphenyl) -1-butanone, 1- (2,4-dihydroxyphenyl) -1-pentanone, 1- ( 2,4-dihydroxyphenyl) -1-hexanone, 1- (2,4-dihydroxyphenyl) -1-heptanone, 1- (2,4-dihydroxyphenyl) -1-octanone, 1- (2,4-dihydroxy Phenyl) -1-nonanone, 1- (2,4-dihydroxyphenyl) -1-decanone, 1- (2,4-dihydroxyphenyl) -1-undecanone, 1- (2,4-dihydroxyphenyl) -1- Dodecanone, 1- (2,4-dihydroxyphenyl) -1-tetradecanone, 1- (2,4-dihydroxyphenyl) -1-hexadecanone, 1- (2,4-dihydroxyphenyl) -1-octadecanone, 1- ( 2-hydroxy-4-methoxyphenyl) -ethanone (2'-hydroxy-4'-methoxyacetophenone), 1- (2-hydroxy-4-methoxyphenyl) -1-propanone (2'-hydroxy-4'-methoxy) Propiophenone), 1- (2-hydroxy-4-methoxyphenyl) -1-butanone, 1- (2-hydroxy-4) -Methoxyphenyl) -1-pentanone, 1- (2-hydroxy-4-methoxyphenyl) -1-hexanone, 1- (2-hydroxy-4-methoxyphenyl) -1-heptanone, 1- (2-hydroxy- 4-methoxyphenyl) -1-octanone, 1- (2-hydroxy-4-methoxyphenyl) -1-nonanone, 1- (2-hydroxy-4-methoxyphenyl) -1-decanone, 1- (2-hydroxy -4-methoxyphenyl) -1-undecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-dodecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-tetradecanone, 1- (2- Hydroxy-4-methoxyphenyl) -1-hexadecanone, 1- (2-hydroxy-4-methoxyphenyl) -1-octadecanone, 1- (4-hydroxy-2-methoxyphenyl) -ethanone (4′-hydroxy-2 '-Methoxyacetophenone), 1- (4-hydroxy-2-methoxyphenyl) -1-propanone (4'- Droxy-2'-methoxypropiophenone), 1- (2,4-dimethoxyphenyl) -ethanone (2 ', 4'-dimethoxyacetophenone), 1- (2,4-dimethoxyphenyl) -1-propanone (2 ', 4'-dimethoxypropiophenone), lactone derivatives (1,6-dioxaspiro [4.4] nonane-2,7-dione, 1,6-dioxaspiro [4.5] decane-2,7-dione, 4-tridecanolide, 4-dodecanolide, 4-undecanolide, 4-decanolide, 4-nonanolide, 4-octanolide, 4-heptanolide, 5-dodecanolide, 5-undecanolide, 5-decanolide, 5-nonanolide, 5-octanolide, 2-undecen-4- Orido, 2-Decene-4-Olide, 2-Nonene-4-Olide, 2-Heptene-4-Olide, 2-Undecen-5-Olide, 2-Decene-5-Olide, 2-Nonene-5-Olide, 2-octene-5-olide, 4-methyl-4-dodecanolide, 4-methyl-4-undecanolide, 4-methyl-4-de Nolide, 4-methyl-4-nonanolide, 4-methyl-4-heptanolide, 5-methyl-5-dodecanolide, 5-methyl-5-undecanolide, 5-methyl-5-decanolide, 5-methyl-5-nonanolide, 5-methyl-5-octanolide, 2-methoxycarbonyl-4-dodecanolide, 2-methoxycarbonyl-4-undecanolide, 2-methoxycarbonyl-4-decanolide, 2-methoxycarbonyl-4-nonanolide, 2-methoxycarbonyl-4 -Heptanolide, 2-methoxycarbonyl-5-undecanolide, 2-methoxycarbonyl-5-decanolide, 2-methoxycarbonyl-5-nonanolide, 2-methoxycarbonyl-5-octanolide, 2-allyl-4-undecanolide, 2-allyl -5-decanolide, 2-allyl-4-nonanolide, 2-pentyl-4-undecanolide, 2-pentyl-4-nonanolide, 2-methyl-4-undecanolide, 2-methyl-4-nonanolide, 2- (4- Hydroxybuty ) -4-undecanolide, 2- (4-hydroxybutyl) -4-nonanolide, 2- (4-hydroxybutyl) -5-decanolide, 5-propyloxy-4-pentanolide, 5-allyloxy-4-pentanolide, 5- (2-hydroxyethoxy) -4-pentanolide, 8-hydroxy-4-octanolide, 6-propyloxy-5-hexanolide, 6-allyloxy-5-hexanolide, 6- (2-hydroxyethoxy) -5-hexanolide , 9-hydroxy-5-nonanolide, etc.), ethinomycin, iriflorental, iriparidal, 2'-8-C-glucosyl-7-methylaloesol coumaroyl ester, 2'-8-C-glucosyl-7-methyl Aloesol cinnamoyl ester, chloropyramine, anise extract, aloe extract, Japanese knotweed extract, seaweed extract, shrimp extract, Ketsumeishi extract, ogi Kisses, yellow-tailed sea urchin extract, red-crowned cucumber (calocon) extract, red fir tree extract, white-faced yam extract (Tempa) extract, oyster extract, red-footed duck extract, yak extract, pumpkin extract, gamma (yellow) extract, kansui extract , Kimihiki (Sentsukakusa) extract, Black-bellied extract, Black-spotted extract, Sisal (Sisal Asa) extract, Saxima button leopard extract, Chinese peony extract, Chinese pear extract (Wei Sensen) extract, Oshima cherry extract, Oyama cherry extract, Bean cherry extract, Takane cherry Extract, Kohigan extract, Sato cherry extract, Zion (purple cocoon) extract, palm extract, white squirrels extract, ginseng (large persimmon) extract, corn shiba (hot pepper) extract, daimon ginseng extract, tsukimisoue , Toshishi extract, bean pod extract, pear extract, sagebrush extract, yarrow extract, cassava extract, dill extract, honey beetle extract, terrestris extract, human camellia extract, stag beetle extract, beetle extract, floral Blanka extract, Hermula extract, Syringa extract, Convolvulaceae extract, Sandalwood extract, Mannentake (Ganoderma biloba) extract, Mejijiki (benuse) extract, Chinese willow extract, Japanese red willow extract, Japanese willow extract, Japanese willow extract, Japanese willow extract, Unryu willow extract Extract, Miyama willow extract, Willow willow extract, Great willow willow extract, Tirikkinu willow extract, Fox willow extract, Dronoki extract, Yam Plum skin) extract, agave extract, aolan agave extract, fuchrin agave extract, mitsumata extract, aonori extract, usba aonori extract, sugiaonori extract, hiraaonori extract, bouaoonori extract, hosoeda aonori extract, kombu extract, silicon extract , Hosomomebu extract, Mitsushi Kombu extract, Wakame extract, Hirome extract, Aowakame extract, Hijiki extract, Hibamata extract, Umichiwa extract, Usubamichichiwa extract, Kirebano miwiwa extract, Akabami michiwa extract, Kona miwiwa extract, Okinawachiwa extract Extracts, Etsumiumichiwa Extract, Spikeling Rhinoceros Extract, Amakusa Rhinoceros Extract, Giraffe Rhinoceros Extract, Sandalwood Giraffe Kiss, Tsunomata Extract, Ibottsu no Mata Extract, Marubat Nomata Extract, Hirakotoji Extract, Sugi nori Extract, Shikinori Extract, Kainori Extract, Yakuzusa Extract, Urabo Shiyahaz Extract, Sea Urchin Extract, Ishimozuku Extract, Misjikonbu Extract, Atsuba Misikobu Extract, Isomok Extract Nagashima Moku Extract, Shida Moku Extract, Nesamoku Extract, Narasamo Extract, Mametawala Extract, Tatsukuri Extract, Yatsuma Tamoku Extract, Umitorano Extract, Oba Moku Extract, Fusiform Moku Extract, Haha Moku Extract, Yoremo Moku Extract, Saw Memox Extract, Obanoko Kiri Mokuri Mokura , Cronouraxa extract, Parrot caenade extract, Pine tree extract, Paragonori extract, Sponge extract, Fu Tuna extract, Japanese puffer tree extract, Hiroha Fushitsugi extract, Kurosozo extract, Kobuzozo extract, Shirozozo extract, Sozonohana extract, Sake mushroom extract, Thira extract, Camote de afuran extract, Hamica extract, Polo verde extract, Nabonegro extract, Korean sengo Misi extract, Matsubusa extract, Binankazura extract and the like.

Melanin production promoter A melanin production promoter can be added to the present invention. Specific examples of the melanin production promoter include salicylic acid or a salt thereof and derivatives thereof (salicylic acid glucoside, salicylic acid fatty acid ester, salicylic acid alcohol ether, salicylic acid amides, etc.), salicyl alcohol or a salt thereof and derivatives thereof, apigenin, and amentoflavone. , Salamander Extract, Udo Extract, Shishido Extract, Nilin Sou Extract, Oak Extract, Beef Taxi Extract, Cuckoo Thistle Extract, Gypsophila Extract, Gymnema Sylvestre Extract, Karo Oyster Extract, Ginkgo Kinca Extract, Konronka Extract, Sabin Ryo Extract, Jasmine (pine licorice) extract, hollyhock extract, scallop extract, Arabidopsis extract, lily of the valley extract, sawnose extract, deco extract, tochu , Nagii Kada (Butcher Bloom) extract, Teppo cucumber extract, Tokiwa Mansaku extract, Nankin goat extract, Elderflower extract, Nadeshiko extract, Michiyanagi extract, Japanese willow extract, Morohaya extract Tamazaki wisteria extract, Ryokaou extract, Amijigusa extract, shellfish extract (cockle extract, green mussel extract, oyster extract, European oyster extract, scallop extract, clam extract, clam extract, bakagai extract, isoyster mussel extract, red oyster extract, abalone extract , Sazae extract, bi-extract, etc.).

Humectant A humectant can be added to the present invention. Specific examples of moisturizers include gum arabic, benzoin rubber, danmar gum, guaiac oil, Irish moss, karaya gum, tragacanth gum, carob gum, quince seed, agar or its derivatives, casein, glucose, galactose, mannose, xylose, fructose, maltose, iso Maltose, cellobiose, gentiobiose, trehalose, cordierbiose, laminaribiose, nigerose, sambubiose, neohesperidose, apiose, hammamellose, streptose, hydroxystreptose, dihydrostreptose, 2-methylerythrose or derivatives thereof, 2-methylerythrono Lactone, micalose, cladinose, accessose, alkanose, olivomai course, chromose, ebamise, vinerose , Sugars such as nogarose, bilenose, nobiose, moenuronic acid, galosamine, cybirosamine, N-acylcansosamine, vancosamine, evanitrose, rubranitrose, tetronitrose, pyralose, α-octose, trioxacalcinose, aldgarose, blastminosin 1,3-butylene glycol, glycerin, propylene glycol, polyethylene glycol, dipropylene glycol, 1,2-pentanediol, 1,5-pentanediol, 1,2-hexanediol, 1,6-hexanediol, mannitol and Sorbitol, ethanediol, diethylene glycol, triethylene glycol, 2-amino-2-methyl-1,3-propanediol, 1,2-propanediol, 1,3-propanediol, polypropylene glycol, 1,2-butyl Diol, 1,3-butanediol, 1,4-butanediol, isopentanediol, pentylene glycol, hexylene glycol, 1,3-pentanediol, 1,4-pentanediol, 1,2,3-pentanetriol, 2,3,4-pentanetriol, 1,3,4-pentanetriol, 1,3,5-pentanetriol, 1,3-hexanediol, 1,4-hexanediol, 1,5-hexanediol, 1, 2,3-hexanetriol, 1,3,4-hexanetriol, 1,3,5-hexanetriol, 1,4,6-hexanetriol, erythritol, pentaerythritol, dipentaerythritol, threitol, arabitol, xylitol, Ribitol, galactitol, lactitol, maltitol, inositol, panthenol, laminitol, valienamine, validamine, validatitol, trehalose Is a derivative thereof, D-mannosamine and a derivative thereof, isomaltoligosaccharide (panose), primeverose or a derivative thereof, dextrin, gelatin, pectin, starch, carrageenan, carboxymethyl chitin or chitosan, alkylene (C2 to C4) oxide such as ethylene oxide Hydroxyalkyl (C2-C4) chitin or chitosan to which is added, low molecular chitin or chitosan, chitosan salt, sulfated chitin or chitosan, phosphorylated chitin or chitosan, alginic acid or salt thereof, hyaluronic acid or salt thereof, chondroitin sulfate or Its salts, β-1,3-glucan, β-1,4-glucan, β-1,6-glucan, heparin, ethylcellulose, methylcellulose, carboxymethylcellulose, carboxyethylcellulose, sodium carboxyethylcellulose, Roxyethyl cellulose, hydroxypropyl cellulose, nitrocellulose, crystalline cellulose, hydroxypropyl methylcellulose, polyvinyl alcohol, polyvinyl methyl ether, polyvinyl pyrrolidone, polyvinyl methacrylate, polyacrylate, polyalkylene oxide such as polyethylene oxide and polypropylene oxide, or cross-linking polymerization thereof Water-soluble polymers such as carboxyvinyl polymer, polyethyleneimine, dermatan sulfate, keratan sulfate, glycerin fatty acid pyrrolidone carboxylic acid ester, glycerin fatty acid acetyl amino acid ester, pyrrolidone carboxylic acid or salt thereof, polyaspartic acid or salt thereof Polyglutamic acid or a salt thereof, polylysine or a salt thereof, sodium lactate, hydantoin and Its derivatives, Np-vinylbenzyl-D-cellobionamide, Np-vinylbenzyl-D-lactone amide, Np-vinylbenzyl-D-maltonamide, Np-vinylbenzyl-D-gluconamide, glucosyloxyethyl methacrylate, galactosyl Oxypropyl acrylate, mannosyloxyethyl methacrylate, glutamyl lysine, glutaurine, 1,2,4-butanetriol, caran-3,4-diol, azoxaponin (3-o- [β-D-glucopyranosyl-β-D-glu Chronopyranosyl] -sophoradiol, 3-o- [β-D-glucopyranosyl-3-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D -Glucuronopyranosyl] -azuxapogenol, 3-o- [β-D-glucopyranosyl] -28-o- [β-D-glucopyranosyl-β-D-glucopyranosyl] -dipsogenic acid, 3-o- [α-L-Rhamnopyranosyl-β-D-G Lucopyranosyl-β-D-glucuronopyranosyl] -soyasapogenol B, 3-o- [β-D-glucopyranosyl-β-D-glucuronopyranosyl] -29-o- [β-D- Glucopyranosyl-β-D-glucopyranosyl] -azuxapogenol, etc.), Aoki (Aoki) extract, Aogiri extract, Kenashia Ogiri (Akatsuki) extract, Red clover extract, Red clover extract, Akikara pine extract, Aguahe (Omitenga palm) extract , Maruba morning glory extract, morning glory extract, athira (shokuyo kanna) extract, oilseed rape extract, amachazul extract, amana extract, sunfish extract, hagateto extract, scallop extract, garlic extract, sugimorige Ito extract, Hosoa Otome extract, Aogateto extract, Haribiyu extract, Aozuzuran extract, Amaranthus hippochondriax extract, Aristolomeria (Yurizuisen) extract, Alcana (alcanna) extract, Argarobo (cabbage) extract, Aloe vera extract, Rabbit extract (Yellow grass) extract, Yew (first place) extract, Strawberry extract, Carob extract, Inazuna (Tailexi) extract, rice extract, dog mint extract, sardine tobacco (Iwatsuki) extract, sardine hiba extract, sardine pine (roll mushroom) extract, wheat (chibusanoki) extract, duckweed (float) extract, euglena extract Uncaria extract, Enokitake mushroom extract, Eringi extract, Pre-lotus eringi extract, Ogata Hakken extract, Oguruma (civil engineering incense) extract, Oohushigusa (cereal essence) extract, Okaeki , Okazeri (snake bed) extract, Okra extract, Onidokoro extract, Tokoro extract, Nagadokoro (hikai) extract, Ononis extract, Yuuko extract, Oyster extract, Ginseng extract, Gaku hydrangea extract, Cascara sagrada extract, Gypsophila extract , Panax ginseng extract, cane extract, carnation extract, gerbera extract, camcam (camo duck) extract, color extract, oats extract, karin extract, kawara psycho (compulsed rye, extract), kawajisha extract, kawaranadeshiko (stone bamboo) extract , Ezokawaranadeshiko (buckwheat noodles, buckwheat) extract, Kantara Asa extract, Kikutanigiku extract, Quinua (quinoa) extract, cabbage extract, kiwi extract, cucumber extract, gyory (Nishikawa willow) ) Extract, Kiranso (Kinza hay) extract, guayule extract, Kusugi katsura (Tenmon winter) extract, Kudzu (Kazunori) extract, xanthus carp (yellow flower bud) extract, Kupuas extract, Gumbanazuna (Sekimei, Sekimeishi) extract, Kemponashi (Kigushi) Extract, Geckavidin (Beautiful Beauty) Extract, Koolen (Huo Ren) Extract, Coconut Extract, Cosmos Extract, Coconut Peel Extract, Rice Oil Extract, Konjac Extract, Saffron (Bansai Flower, West Red Flower) Extract, Sapodilla Extract, Sangre Degrad ( Croton extract, sancitin ginseng (37 ginseng) extract, shea (carite) extract, cyanoki extract, shiitake extract (shiitake) extract, shimeji mushroom extract, hinoki shimeji mushroom extract, shaka shimeji mushroom extract, hatake shimeji mushroom extract, oscillating shimeji mushroom extract, beech shimeji mushroom extract Kiss, Honjimeshi Extract, White-winged Mushroom Extract, Shimokuren Extract, Saishin Extract, Cactus Extract, Janohige (Bakumon Winter) Extract, Shukukonkasamisu Extract, Ganzan Hydrangea (Tsukuyama) Extract, Shirochochou Extract, White Azuki Bean (Chicken Bone) Grass) extract, Zinchoge (Mizuka, Mizuka flower, Shencho flower) extract, Watermelon (Seijo) extract, Suzu-Psycho (Xucho) extract, Surihiyu (Horse tooth extract, Horse tooth soap) extract, Sekkok extract, Sakura Sekkoku extract, Koki Sekkoku extract , Obanasekkokku extract, Okinawakekkukku extract, Honsekokukoku extract, moth-knotukukoku extract, deer-kokukokukoku extract, kibanano-sekkok extract, cedron extract, mallow extract, celery extract, senshinren Extract, Japanese radish extract, Takasaburo extract, Tachidokoro (hikai) extract, Dahlia (Tenjiku button) extract, Talwei extract, Senganshi extract, Sojitsu extract, Chankapiedora extract, Tulip extract, Chorogi extract, Tsukuritake (mushroom) extract, camellia extract, clover (lacquered licorice) extract, Tounabena (river cut) extract, corn extract, corn hair (Southern cocoon hair) extract, Toxa (wood bandage) extract, ash (skin) extract, Turkish Kyary Extract, Solid Bean Extract, Vertical Haki Extract (Sword Bean) Extract, Jujube (Daisatsu) Extract, Navena (Continued) Extract, Nameko Extract, Namban Karamushi (Cannabis) Extract, Niooi Sumire Extract, Nikuzu Extract, Nemunoki Extract, Nebu Kiss, Nebi extract, Nemuri extract, Digokubana extract, Nogateito extract, Hylindough extract, Hauchiwa extract, Hauchi bean extract, Papaya extract, Pahalobobo extract, Barata rubber extract, Agaric extract, White-faced agaric extract, Usukimorinokasa extract, Haran extract, Parisurus (Prunus edulis) extract, balsamina (crane licorice, bitter gourd) extract, harlindough extract, handdai kai (sea bream sea) extract, hygurum dahlia extract, beet extract, hiba extract, sunflower extract, bell pepper extract, himeuzu (tendon) extract, himematsutake (kawariharatake) , Hiromatsutake) extract, Euphorbiaceae extract, Brazilian daylily extract, hazelnut extract, loofah extract, crassulaceae Extract, nettle extract, scallop extract, sardine extract, nendo extract, scallop extract, ground scallop extract, spinach (aden, acute chick, pellucid) extract, scallop extract, sorghum 7) Extract, jojoba extract, Borage extract, Bordeaux extract, Hononiku (meat jujube, Daiki) extract, Honsekkok (iron crust stone, sparrow mountain stone agate) extract, maca extract, macadamia nut extract, margaret (mokushungiku) extract , Tamanosen Hallen extract, Kyukonkinrenka extract, Matatabi (wooden cocoon) extract, Matsukasa extract, Matsuhodo (potato) extract, Matico (cordon sillo) extract, Quince extract, Malene (Biloud mud squid) extract, Manzanya (Andesca chamomile) Extracts, Psyllium extract, Papilion extract, Green mint extract, Wheat straw extract, Munya extract, Purple extract, Purple purple extract, Purple nectar wisteria extract, Moge extract , Cinnamon extract, cornflower extract, yacon extract, palm extract, yabu tobacco (crane candy, Tenmeisei) extract, malonie extract, mokka extract, lily extract, ligan extract, lime extract, rye extract, rakkyo extract, shallot (white) ) Extract, apple extract, gentian extract, litchi (piper, edible nucleus) extract, forsythia extract, yokuinin extract, minisasaniki extract, chlorella vulgaris extract, chlorella pyrenoid extract, chlorella e Pseudiaia extract, Macrocystis pirifera extract, Yuikiri extract, Tosakanori extract, Cyprinus extract, Amakusanori extract, Aoumidro extract, Kawanori extract, Marimo extract, Motsukikitoe extract, Ezoyahaz extract, Habanori extract, Habanori extract, Watamo extract, Amame extract , Sujime extract, trochokonbu extract, antokume extract, pickled arame extract, black squirrel extract, cat corn extract, Ainu turtle extract, tigaiso extract, squirrel extract, yabanemoku extract, trumpet extract, uganomok extract, jolomok extract, hyamok extract, tamanashi moku extract, honda Extract Sanori Extract, Hosobanamino Hana Extract, Hanafnori Extract, Itofonori Extract, Kaginori Extract, Mirin Extract, Hosobamilin Extract, Kikutosaka Extract, Ezonameshi Extract, Ibaranori Extract, Kagyi Baranori Extract, Saidaibara Extract, Tatyibara Extract, Ogonori Extract, Examples include tsurushiramo extract, honey beetle extract, red clover extract, red ginseng extract, natto fungus culture metabolite, natto extract, loofah water, birch (white birch) or red pine sap.

Cell activating agent / metabolic activator A cell activating agent / metabolic activator can be added to the present invention. Specific examples of cell activators and metabolic activators include vitamin A group: retinol or its salts and derivatives thereof (retinyl unsaturated fatty acid esters such as retinyl linoleate, retinyl linolenate, retinyl oleate, retinyl arachidonic acid, etc.) ), Retinal or a salt thereof and derivatives thereof, dehydroretinal or a salt thereof and derivatives thereof, retinoic acid or a salt thereof and derivatives thereof, retinoic acid analogs (4-[[[8- (3,5-dimethylphenyl ) -2-Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3-methylphenyl) -2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[[8- (4-methylphenyl) ) -2-Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (3,4- Dimethylfe Nyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2,4-dimethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2 -Isopropylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-ethylphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2 -Fluorophenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[8- (2-methoxyphenyl) -2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(8-benzyl- 2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[(E) -2- (8-phenyl-2-naphthalenyl) propenyl] benzoic acid), retinoic acid derivative (4-hydroxyphenylretinamide), retinoid analogues (4-[[(5,6-dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[(5, 6-dihydro-5,5,8-trimethyl-2-naphthalenyl) amino] carbonyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) amino] Carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-ethyl-2-naphthalenyl) carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5, 5,8-Trimethyl-2-naphthalenyl) -carbonyl] amino] benzoic acid, 4- (E)-[2- (5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) -1 -Propenyl] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) oxy] carbonyl] benzoic acid, 4-[[(5,6-dihydro-5 , 5-Dimethyl-8-phenyl-2- (naphthalenyl) carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl-2- (naphthalenyl) carbonyl) oxy ] Benzoic acid, 4-[[5,6-dihydro-5,5-dimethyl-8- (2-fluoro Enyl) -naphthalenyl] carbonyl] amino] benzoic acid, 4-[[((5,6-dihydro-5,5,6-trimethyl) -8-phenyl-2- (naphthalenyl) carbonyl] amino] benzoic acid, 4- [[(5,6-dihydro-5,5,7-trimethyl-8-phenyl-2-naphthalenyl) carbonyl] benzoic acid, 4-[[((E)-(5,6-dihydro-5,5-dimethyl -8-phenyl) -2-naphthalenyl] vinyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] sulfamyl] benzoic acid, 4 -[[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl] sulfamyl] carbonyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8 -Phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] thiocarbonyl] amino] benzoic acid, 4- [[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalene Ru] carbonyl] methyl] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] oxy] benzoic acid, 4-[[[((5 , 6-Dihydro-5,5-dimethyl-8-phenyl) -2-naphthenyl] oxy] methyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8- (2, 4-Dimethylphenyl)]-2-naphthalenyl] carbonyl] amino] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8- (4-methylphenyl)]-2-naphthalenyl] Carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] ethyl] benzoic acid, 4-[[[(5,6-dihydro- 5,5-dimethyl-8-phenyl) -2-naphthalenyl] sulfamyl] methyl] benzoic acid, 4-[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] Amino] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] amino] thioca Bonyl] benzoic acid, 4-[[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] methyl] sulfamyl] benzoic acid, 4-[[[(5,6-dihydro -5,5-dimethyl-8-phenyl-2-naphthalenyl] amino] methyl] benzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl ] Amino] -2-hydroxybenzoic acid, 4-[[[((5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-nitrobenzoic acid, 4- [[[(5,6-dihydro-5,5-dimethyl-8-phenyl) -2-naphthalenyl] carbonyl] amino] -2-fluorobenzoic acid, 4-[[[((5,6-dihydro-5, 5-Dimethyl-8-phenyl-2-naphthalenyl] carbonyl] amino] -2-methoxybenzoic acid, 4-[[[[(5,6-dihydro-5,5-dimethyl-8- (2-naphthalene)]- 2-Naphthalenyl] carbonyl] amino] benzoic acid, 4-[[(5,6-dihydro-8-phenyl-2-naphthalenyl) ) Carbonyl] aminobenzoic acid, 4-[[(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) carbonyl] amino] -3-fluorobenzoic acid, 4-[[((5, 6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl) carbonyl] amino] -3-methylbenzoic acid, 4-[[(5,8,10,10a-tetrahydro-10,10-dimethyl- 9-phenyl-2-anthracenyl) carbonyl] amino] benzoic acid, 4-[[((1,1-dimethyl-3-phenyl-1H1-inden-5-yl) amino] carbonyl] benzoic acid, 4-[(1 , 1-Dimethyl-3-phenyl-1H-inden-5-yl-oxymethyl) benzoic acid, 4- [2- (1,1-dimethyl-3-phenyl-1H-inden-5-yl) vinyl] benzoic acid Acid, 4-[(1,1-dimethyl-3-phenyl-1H-indene-5-carbonyl) amino] benzoic acid), carotene or a salt thereof and derivatives thereof (α-carotene, β-carotene, γ-carotene, lycopene, Cryptoxanthi , Lutein, zeaxanthin, isozeaxanthin, rhodoxanthine, capsanthin, crocetin and other carotenoids), lycopene or salts thereof and derivatives thereof, vitamin B group: thiamine or salts thereof and derivatives thereof (thiamine hydrochloride, thiamine disulfide, bisbench Amines, bis-butyamines, thiamine monophosphate disulfides, benfotiamines, chicotiamines, octothiamines, dicetiamines, fursultiamines, prosultiamines, astaxanthinthiamine phosphate diesters), thiamine sulfates, riboflavins or their salts and their Derivatives (flavin adenine dinucleotide, flavin mononucleotide, riboflavin phosphate diester, 1-β-D-ribofuranosylnicotinamide pyrophosphate diester, 1-β-D- Bofuranosylnicotinic acid, etc.), pyridoxine or a salt thereof and derivatives thereof (pyridoxine 3,4-dipalmitate, pyridoxine 3,4-dicaprylate, pyridoxine sulfate diester, etc.), pyridoxal or a salt thereof and derivatives thereof, pyridoxamine Or salts thereof and derivatives thereof, cyanocobalamin or salts thereof and derivatives thereof, cobalamines (methylcobalamin, adenosylcobalamin, hydroxocobalamin, aquacobalamin etc.), folic acid or salts thereof and derivatives thereof, nicotinic acid or salts thereof and Derivatives thereof, pantothenic acid or a salt thereof and derivatives thereof, biotin or a salt thereof and derivatives thereof, choline or a salt thereof and derivatives thereof, inositol or a salt thereof and derivatives thereof, vitamin C group: ascor Binic acid or its salts and derivatives thereof, vitamin D group: Ergocalciferol or its salts and their derivatives, cholecalciferol and its salts and their derivatives (1α-hydroxy-22-[(1-hydroxy-1- Methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1R, 4R] -1α-hydroxy-22-[(1-hydroxy-1- Methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, [1R, 4S] -1α-hydroxy-22-[(1-hydroxy-1- Methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorcorecalciferol, [1S, 4R] -1α-hydroxy-22-[(1-hydroxy-1- Methyl) -2-cyclopenten-4-yl-oxy] -23,24,25,26,27-pentanorcorecalciferol, [1S, 4S] -1α-hydroxy-22-[(1-hydroxy-1- Methyl) -2-si Clopenten-4-yl-oxy] -23,24,25,26,27-pentanorolecalciferol, etc.), dihydrotaxosterol or a salt thereof and derivatives thereof, vitamin E group: tocopherol or a salt thereof and derivatives thereof , Tocotrienol or a salt thereof and derivatives thereof, ubiquinone or a salt thereof and derivatives thereof, vitamin K group: phytonadione or a salt thereof and derivatives thereof, menaquinone or a salt thereof and derivatives thereof, menadione or a salt thereof and derivatives thereof, Menadiol or a salt thereof and derivatives thereof, vitamin F group: linoleic acid or a salt thereof and derivatives thereof, linolenic acid or a salt thereof and derivatives thereof, carnitine or a salt thereof, and the like Derivatives, ferulic acid or salts thereof And derivatives thereof, γ-oryzanol or salts thereof and derivatives thereof, orotic acid or salts thereof and derivatives thereof, vitamin P group: rutin or salts thereof and derivatives thereof, eriocitrin or salts thereof and derivatives thereof, hesperidin Or salts thereof and derivatives thereof, vitamin L group: anthranilic acid or salt thereof and derivatives thereof, adenylthiomethylpentose or salt thereof and derivatives thereof, vitamin U group: methylmethionine sulfonium chloride or derivative thereof, valine, leucine , Isoleucine, threonine, methionine, phenylalanine, tryptophan, lysine, glycine, alanine, asparagine, glutamine, serine, cysteine, cystine, tyrosine, proline, hydroxyproline, aspartic acid, glu Minic acid, hydroxylysine, arginine, ornithine, histidine or derivatives thereof (N-octyloxycarbonyl-β-alanyl-L-histidine, N-dodecyloxycarbonyl-β-alanyl-L-histidine, N- (12-amino- 1-oxododecyl) -L-histidine, N-2-ethylhexyloxycarbonyl-β-alanyl-L-histidine hydrochloride, N-hexadecyloxycarbonyl-β-alanyl-L-histidine, N-octylaminocarbonyl-β -Alanyl-L-histidine, N-dodecylaminocarbonyl-β-alanyl-L-histidine, N-dodecylsulfonyl-β-alanyl-L-histidine, N-dodecylamino-oxalyl-β-alanyl-L-histidine, etc.) Amino acids such as sulfates, phosphates, nitrates, citrates or amino acid derivatives such as pyrrolidone carboxylic acid, glycolic acid, Α-hydroxy acids such as acid, malic acid, tartaric acid, lactic acid, succinic acid, 2-hydroxycarboxylic acids (methyl lactic acid, 2-hydroxybutanoic acid, 2-hydroxypentanoic acid, 2-hydroxyhexanoic acid, 2-hydroxyheptane Acid, 2-hydroxyoctanoic acid, 2-hydroxynonanoic acid, 2-hydroxydecanoic acid, 2-hydroxyundecanoic acid, α-hydroxylauric acid, α-hydroxymyristic acid, α-hydroxypalmitic acid, α-hydroxystearic acid, α-Hydroxyarachidonic acid, cerebronic acid, α-hydroxynervonic acid, mandelic acid, benzylic acid, phenyllactic acid, atrolactic acid, 2- (4'-hydroxyphenyl) -2-hydroxyethanoic acid, 2- (4'-chlorophenyl) ) -2-Hydroxyethanoic acid, 2- (3'-hydroxy-4'-methoxyphenyl) -2-hydroxyethanoic acid, 2- (4'-hydroxy-3'-me Xylphenyl) -2-hydroxyethanoic acid, 3- (2'-hydroxyphenyl) -2-hydroxypropanoic acid, 3- (4'-hydroxyphenyl) -2-hydroxypropanoic acid, 2- (3 ', 4'- Dihydroxyphenyl) -2-hydroxyethanoic acid, glyceric acid, erythronic acid, ribbon acid, arabinonic acid, xylonic acid, lyxonic acid, arolic acid, altronic acid, gluconic acid, mannonic acid, gulonic acid, idonic acid, galactonic acid, talon Acid, glucoheptonic acid, galactoheptonic acid, tartronic acid, mucinic acid, etc.), polyhydroxycarboxylic acid or hydroxypolycarboxylic acid (gluconolactone, galactonolactone, glucuronolactone, galacturonolactone, gulonolactone, ribonolactone, sugar lactone) , Pantoyl lactone, glucoheptonolactone, mannonolactone, Lactofeptonolactone, etc.), 2-keto acids (glyoxylic acid, methyl 2-ketoethanoate, benzoylformic acid, methyl benzoylformate, ethyl benzoylformate, phenylpyruvic acid, methyl phenylpyruvate, ethyl phenylpyruvate, 2-ketobutanoic acid 2-ketopentanoic acid, 2-ketohexanoic acid, 2-ketoheptanoic acid, 2-ketooctanoic acid, 2-ketododecanoic acid, methyl 2-ketooctanoate), quinic acid, isocitric acid, tropic acid, tretocanic acid, 3-chlorolactic acid , Cerebronic acid, citramalic acid, agaricinic acid, aleuricinic acid, pantoic acid, lactobionic acid, hexrosonic acid, photosensitizer 301, hinokitiol, pantothenic acid or derivatives thereof, allantoin, pentadecanoic acid glyceride, linolenic acid or derivatives thereof, eicosapentaenoic acid Or a derivative thereof, Sahexaenoic acid or its derivatives, estradiol, etenyl estradiol, antialol or its glycoside, lionilesinol or its glycoside, rhododendrol or its glycoside, platyphyronol or its glycoside, lactone compound (D- Glucurono-6,3-lactone, α-D-glucoheptonic-γ-lactone, δ-glucuronolactone, α, β-glucooctonic-γ-lactone, L-glonic-γ-lactone, γ-D- Galactonolactone, D-saccharide-1,4-lactone, D-saccharide-3,6-lactone, D-ribonic-γ-lactone, α-butyrolactone, γ-butyrolactone, α-octanoic lactone, γ-octa Neutic lactone, Nonanoic lactone, γ-valerolactone, D-manninoic-δ-lactone, D-xyleuic-δ-lactone, D-arabinoic-δ-lac , Stearoyl-δ-gluconolactone, DL-pantolactone, palmitoyl-DL-pantolactone, etc.), 3-hydroxy-3,4-dicarboxy-1,4-butanolide or its derivatives, 6-benzylaminopurine or Its derivatives, 1,4-diazadicyclooctane, 2,5-dimethylfuran, 2-methylfuran, 2,5-diphenylfuran, 1,3-diphenylisobenzofuran, rutin, tectrigenin 7-xylosylglucoside, captopril , Alasepril, lisinopril, enalapril, delapril, benazepril, cilazapril, imidapril, quinapril, trandelapril, perindopril, temocapril, losartan, endothelin, galactomannan saccharide polymer, mucin, trimethylglycine, proteoglycan, lactic acid bacteria extract, lactic acid bacteria extract, lactic acid bacteria extract, lactic acid bacteria extract fermentation Milk extract, bifidobacteria extract, bifidobacteria culture solution extract, bifidobacteria fermented milk extract, placenta extract, ganoderma extract, spleen extract, thymus extract, yeast extract, yeast culture extract, yeast fermentation extract, filamentous fungus extract, filamentous fungus Culture fluid extract, basidiomycete extract, basidiomycete culture fluid extract, bacterial cell disruption extract, bacterial culture fluid extract, cultured human dermal cell disruption extract, red ginger (ground yellow) extract, fennel (cage) extract, Ezokogi ) Extract, barley (barley) extract, oakuri higotai (Zhengzhou leakage) extract, Dutch jellied extract, Dutch honey beet extract, caliper extract, Roman chamomile extract, garcinia extract, kawaran ginseng (blue potato) extract, oyster extract, Quillaja extract, quince extract, ginkgo biloba extract, quince Extract, Sakaneran (Ezosakaneran) extract, Sasabaginran extract, Sawaguru (Yamatomo) extract, Shimotsumeso extract, Shajin extract, Plum extract, Prunus extract, Horsetail extract, Pineapple extract, Chinese plover extract, Giant oysters , Beech extract, physalis (Torone) extract, maitake (maiko) extract, misohagi (senju-na) extract, mugwort (mushroom) extract, mukuroji (long-lived skin) extract, bean sprout, eucalyptus extract, saxifrage (tiger ear grass) Extract, Suabisimus extract, Lettuce (Chisha) extract, Aloe extract, Ogon extract, Tonka bean extract, Gentian extract, Burdock extract, Shikon extract, Carrot extract, Hamamelis extract, Hop extract, Yokuinin extract, Odo Kiso extract, assembly extract, touki extract, tokisenka extract, achacha extract, cucumber extract, papaver extract, rosemary extract, parsley extract, sanda rush extract, fukurin amiji extract, guts comb extract, oyster comb extract, onikonbu extract , Gohei comb extract, Nagacomb extract, pea comb extract, Japanese corn comb extract, Rattle extract, Hiratara extract, Beni Mozuku extract, Hoso Beni Mozuku extract, Kagekinori extract, Ezotosaka extract, Silamo extract, Birch extract and the like.

Antioxidant An antioxidant can be added to the present invention. Specific examples of antioxidants include ascorbic acid or a salt thereof and derivatives thereof (phosphoric acid-magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmitate, ascorbyl hydroxyprophosphate, 5-o-α -D-glucopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate sodium salt, L-ascorbic acid phosphate potassium salt, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate calcium salt, L-ascorbic acid phosphate aluminum salt, L-ascorbic acid sulfate sodium salt, L-ascorbic acid sulfate potassium salt, L-ascorbic acid sulfate magnesium salt, L-ascorbic acid sulfate calcium salt, L-ascorbic acid Sulfate ester Nium salt, L-ascorbic acid sodium salt, L-ascorbic acid potassium salt, L-ascorbic acid magnesium salt, L-ascorbic acid calcium salt, L-ascorbic acid aluminum salt, 6-o-α-D-galactopyranosyl -L-ascorbic acid, 2-o-β-D-galactopyranosyl-L-ascorbic acid, L-ascorbic acid phosphate magnesium salt, L-ascorbic acid phosphate sodium salt, L-ascorbic acid sulfate Sodium salt, 6-o-acyl ascorbic acid phosphate sodium salt, 6-o-acyl ascorbic acid phosphate ammonium salt, 6-o-acyl ascorbic acid phosphate isopropanolamine salt, 3-o-isopropyl-L -Ascorbic acid, 6-o-alkylascorbic acid phosphate potassium salt, 6-o-alkylascorbic acid phosphate cal Um salt, 6-o-alkyl ascorbic acid phosphate barium salt, 6-o-alkyl ascorbic acid phosphate ammonium salt, 6-o-alkyl ascorbic acid phosphate monoethanolamine salt, 6-o-alkyl ascorbine Acid phosphate ester diethanolamine salt, 6-o-alkylascorbic acid phosphate triethanolamine salt, 6-o-alkylascorbic acid phosphate monoisopropanolamine salt, 6-o-alkylascorbic acid phosphate diisopropanolamine Salt, 6-o-alkylascorbic acid phosphate triisopropanolamine salt, 3-o-glycosyl-L-ascorbic acid, 6-o-β-D-galactopyranosyl-L-ascorbic acid, ascorbic acid phosphate Cholesterol ester, palmitate L-ascorbyl, isopalmitate L- Scorbyl, L-ascorbyl dipalmitate, L-ascorbyl diisopalmitate, L-ascorbyl stearate, L-ascorbyl isostearate, L-ascorbyl distearate, L-ascorbyl diisostearate, L-ascorbyl myristate, isomyristic acid L-ascorbyl, dimyristic acid L-ascorbyl, diisomyristic acid L-ascorbyl, 2-ethylhexanoic acid L-ascorbyl, di-2-ethylhexanoic acid L-ascorbyl, oleic acid L-ascorbic acid, 2-o-α -D-glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, 3-o-α-D- Glucosyl-L-ascorbic acid, 2-o-α-D-maltosyl-L-ascorbic acid, 2-o-α-D-maltotriosyl-L-ascorbic acid, L-ascorbic acid tetraisopalmitin Acid ester, L-ascorbic acid tetralauric acid ester, L-ascorbic acid tetra-2-ethylhexanoic acid ester, L-ascorbic acid tetraoleic acid ester, 5,6-isopropylidene-L-ascorbic acid, L-ascorbic acid Retinol ester, L-ascorbic acid-DL-tocopherol phosphate ester, L-3-o-ethylascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid tripalmitate, L-ascorbic acid trioleate, L- Ascorbyl triphosphate, 2-o-ascorbyl cinnamate, 2-o-ascorbyl ferrate, 2-o-ascorbyl caffeate, 2-o-ascorbyl synapate, 2-o- [6-palmitoyl ascorbyl] -4 '-Acetoxyferrate, DL-α-tocopherol-2-L-ascorbic acid diester, ascorbic acid ino Toll-binding derivatives, ascorbic acid phosphoramide derivatives, ascorbic acid arbutin conjugates, ascorbyl phosphoryl cholesterol, chromanyl ascorbic acid derivatives, ascorbic acid sialic acid derivatives, etc.), stearates, tocopherols or salts thereof and derivatives thereof (α-tocopherol, β-tocopherol, γ-tocopherol, δ-tocopherol, ε-tocopherol, α-tocopheryl retinoate, aminomethylated tocopherol, hydroxymethylated tocopherol, tocopheryl phosphate, tocopherol acetate, tocopherol nicotinate, tocopherol succinate, Tocopherol linoleate, tocopherol orotate, DL-α-tocopheryl glucoside, DL-α-tocopheryl maltoside, DL-β-tocophere Lyl glucoside, DL-β-tocopheryl maltoside, DL-γ-tocopheryl glucoside, DL-γ-tocopheryl maltoside, DL-δ-tocopheryl glucoside, DL-δ-tocopheryl maltoside, D-α- Tocopheryl glucoside, D-α-tocopheryl maltoside, D-β-tocopheryl glucoside, D-β-tocopheryl maltoside, D-γ-tocopheryl glucoside, D-γ-tocopheryl maltoside, D-δ -Tocopheryl glucoside, D-δ-tocopheryl maltoside, L-α-tocopheryl glucoside, L-α-tocopheryl maltoside, L-β-tocopheryl glucoside, L-β-tocopheryl maltoside, L- γ-tocopheryl glucoside, L-γ-tocopheryl maltoside, L-δ-tocopheryl glucoside, L-δ-tocopheryl maltoside, 1- (sulfoethylamino) -3- (α-tocopheryl-6 -Iroxy) propan-2-ol, 1- (carboxypropylamino) -3- (α-tocopheryl-6-iroxy) propan-2-ol hydrochloride, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl ] Cysteine, S- [3- (α-tocopheryl-6-iroxy) -2-hydroxypropyl] -γ-glutamylcystenylglycine, N- [3- (α-tocopheryl-6-iroxy)- 2-hydroxypropyl] aspartic acid, N- [3- (α-tocopheryl-6-yloxy) -2-hydroxypropyl] glutamic acid, etc.), tocotrienol or a salt thereof and derivatives thereof (α-tocotrienol, β-tocotrienol) , Γ-tocotrienol, δ-tocotrienol, tocotrienol acetate, tocotrienol nicotinate, tocotrienol succinate, tocotrienol linoleate, tocotrienol orotate), di Dropyridine derivatives (methyl-3-phenyl-2-propenyl 1,4-dihydro-2,6-dimethyl-4- (3-nitrophenyl) pyridine-3,5-dicarboxylate and its salts), benzochroman derivatives, nor Dihydroguaselectenic acid, butylhydroxytoluene (BHT), butylhydroxyanisole (BHA), hydroxytyrosol, parahydroxyanisole, coenzyme Qn (n = 7-10), pyrroloquinoline quinone, propyl gallate, sesamol, sesamorin, Gossypol, maritimane, sulfretin, xanthene-2,7-diols, caffeoylquinic acids, propolis, carotenoids (α-carotene, β-carotene, γ-carotene, lycopene, lutein, violaxanthin, spiroloxanthine, spheroidene, Astaxanthin), fluorotannin, akebi (wood) ) Extract, Achacha (Amacha) extract, Oolongcha extract, Dutch biloba extract, kanran extract, kumquat extract, gobishi extract, geno shochu (old lady's grass) extract, sesame extract, sesame culture cell extract, sesame extract, rice bran extract, pomegranate extract , Salamander extract, Pear extract, Daio extract, Tomato extract, Nanten extract, Noahami extract, Neubara extract, Paprika extract, Pistachio extract, Biwa extract, Betel wax (Large garment, coconut) extract, Japanese cypress extract, bokeh (wooden) extract, Hosoba-Oguruma extract, Mao (mao) extract, mimosa extract, Japanese cypress extract, Japanese black willow extract, willow deer extract, cotton-fat deer Kurami Domonas extract, red snow extract, red clover extract, red clover extract, clam extract, clove extract, melissa extract, birch extract, birch extract, salvia extract, rosemary extract, southern berry extract, ginkgo biloba extract, green tea extract, clove extract, etc. Is mentioned.

Active oxygen scavenger / radical scavenger An active oxygen scavenger / radical scavenger can be added to the present invention. Specific examples of active oxygen scavengers and radical scavengers include superoxide dismutase, catalase, glutathione peroxidase, bilirubin, quercetin, quercitrin, catechin, catechin derivatives, rutin or derivatives thereof, gallic acid or salts thereof, and derivatives thereof, curcumin Or salts thereof and derivatives thereof, transferrin, ceruloplasmin, coenzyme Qn (n = 7 to 10), uric acid, bilirubin, metallothionein, stilbengaloyl glycoside (3,5,4′-trihydroxystilbene 4′-o -β-D- (6 "galloyl) glucopyranoside, 3,5,4'-trihydroxystilbene 4'-o-β-D- (2" galloyl) glucopyranoside, etc.), chlorogenic acid phospholipid ester, chlorogenic acid sphingosine ester And derivatives thereof, chlorogenic acid glycolipid ester, black Rogenic acid sugar ester, chlorogenic acid sterol ester, thiazole derivative or salt thereof (2- (3,4-diethoxyphenyl) -4- (3-carboxy-4-hydroxyphenyl) thiazole, 2- (3,4-di Ethoxyphenyl) -4- [3-carboxy-4-hydroxy-5- (2-methyl-2-propenyl) phenyl] thiazole and 2- (3,4-diethoxyphenyl) -4- (3-carboxy-4 -Hydroxy-5-methylphenyl) thiazole, 2- (3,4-diethoxyphenyl) -4- (3-carboxy-5-methoxyphenyl) thiazole), hydroxymatylesinol, allohydroxymatylesinol, hydantoin derivatives , Akaminoki (logwood) extract, Akamegashiwa (red buds) extract, Akamino Akane extract, Acacia akane extract, Akane (Hakusai) extract, Hydrangea (hydrangea) extract, Abemaki extract, Chijiku extract, Ginkgo biloba extract, Asparagus extract, Japanese apricot extract, Vulcania serrata extract, Japanese walnut extract, Estragon extract, Enju (Safflower, Satsuma rice) extract, Kashiwa (Shinoki, Kashiwa) extract , Genus extract, birch extract, birch extract, cucumber extract Extract, Sasa (butterfly) extract, Perilla extract, Ajizo extract, Chimmento extract, Katamen diso extract, Peonies extract, Quercus extract, Mizunara extract, Crape myrtle extract, Zicopi extract, Shirakashi extract, White clover Clover) extract, horseradish extract, black tea extract, green tea extract, camellia extract, tencha (boiled tea) extract, tendaiu yak extract, nani waibara (gold cherry) extract, peanut (peanut) extract, kei extract, nikkei extract, ceylon nikkei extract, yavnikkei ( Cinnamon (bark) extract, cinnamon (Keishi branch) extract, nozenkazura (Ryoen flower) extract, lotus (extract), Chinese cabbage extract, hadakamugi extract, hanasuge (my mother) extract, hermanus (maikai flower) extract, rose (rose) extract, barbus Co-extract, Spinach extract, Beech extract, American beech extract, Inu beech extract, European beech extract, Convolvulus extract, Hosobaokera (蒼朮) extract, Button (peony) extract, Mayoram (Butterfly) extract, Melon extract, Examples include evening primrose extract, snow willow extract, orchid extract, rakanka extract, naminohana extract, eucalyptus extract, scallop extract, azusa extract, basil extract, mokko (woody incense) extract, and himefuuro extract.

Fat Metabolism Promoter A fat metabolism promoter can be added to the present invention. Specific examples of fat metabolism promoters include phthalazine derivatives (4-ethyl-1- (β-hydroxyethylamino) phthalazine, 4-N-propyl-1- (β-hydroxyethylamino) phthalazine, 4-N-butyl- 1- (β-hydroxyethylamino) phthalazine, 4-N-butyl-1- (β-hydroxypropylamino) phthalazine, etc.), xanthine derivatives (caffeine, theophylline, theobromine, xanthine, aminophylline, choline theophylline, diprofylline, proxy) Phyllin, oxtriphilin, etc.), Aotsuki-rafuji (wooden candy) extract, thistle extract, aletia thistle extract, mite thistle extract, scrub thistle extract, noel thistle extract, blue thistle extract, cacao extract, elcampuri extract, otsu-rafuji (preventive self) Extract, banquet extract, Karaku salmon man Kiss, Kyoukyo (Kikkyo, Kikyo Root) Extract, Ivy Extract, Pepper (Pepper) Extract, Cola Acuminata Extract, Sagiomodaka (Sawamata) Extract, Pomelo Extract, Sanshuyu (Yamatake) Extract, Tsutsu Rafu Extract, Otsu Samurai Extract, Chorei Maitake (猪苓) Extracts, Cranella extract, Proboscis extract, Ginseng extract, Korean ginseng extract (Ryu gall) extract, Naginata kouju extract, Banana extract, Puer tea (common ear tea) extract, Plum extract, Buufu (windproof) extract, etc. It is done.

UV protection agent / UV absorption promoter An UV protection agent / UV absorption promoter can be added to the present invention. Specific examples of UV protective agents and UV absorption accelerators include benzophenone derivatives (2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonic acid, 2-hydroxy-4-methoxybenzophenone-5- Sodium sulfonate, dihydroxydimethoxybenzophenone, dihydroxydimethoxybenzophenone sodium sulfonate, 2,4-dihydroxybenzophenone, tetrahydroxybenzophenone, etc.), 1,2-dihydroxy-4- (2-hydroxyethyl) benzene derivatives (1- (2- (4- (3,4-Dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) -3- Rhamnosyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (2-acetyl-4- (3,4-dihydride) Xycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (2-acetyl-6- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3, 4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (6- (4-hydroxy -3-methoxycinnamoyl) -3-rhamnosyl) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1- Methoxyethyl-3,4-dihydroxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) -3-rhamnosyl) glucosyl) -1-hydroxyethyl-3,4-dihydroxybenzene, 1- ( 2- (6- (3,4-Dihydroxycinnamoyl) -3-xylosyl) glucosyl) eth Ru-3,4-dihydroxybenzene, 1- (2- (3-allosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3,4-dihydroxybenzene, 1- (2- ( 3-glucosyl-6- (3-hydroxy-4-methoxycinnamoyl)) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (3-arosyl-6- (3-hydroxy-4-) Methoxycinnamoyl) glucosyl) ethyl-3-hydroxy-4-methoxybenzene, 1- (2- (4- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2 -(3- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydroxybenzene, 1- (2- (2- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4 -Dihydroxybenzene, 1- (2- (6- (3,4-dihydroxycinnamoyl) glucosyl) ethyl) -3,4-dihydride Xylbenzene, etc.), paraaminobenzoic acid derivatives (paraaminobenzoic acid, ethyl paraaminobenzoate, glyceryl paraaminobenzoate, amyl paradimethylaminobenzoate, octyl paradimethylaminobenzoate, etc.), methoxycinnamate derivatives (ethyl paramethoxycinnamate, paramethoxy, etc.) Isopropyl cinnamate, octyl paramethoxycinnamate, 2-ethoxyethyl paramethoxycinnamate, sodium paramethoxycinnamate, potassium paramethoxycinnamate, glyceryl di-2-methoxycinnamate mono-2-ethylhexanoate), anthranilic acid derivatives (such as methyl anthranilate) , Urocanic acid derivatives (urocanic acid, ethyl urocanate, etc.), coumarin derivatives, amino acid compounds, benzotriazole derivatives, tetrazole derivatives, imidazoline derivatives, pyrimi Derivatives, dioxane derivatives, camphor derivatives, furan derivatives, pyrone derivatives, nucleic acid derivatives, allantoin derivatives, nicotinic acid derivatives, pyridoxine derivatives, pyridoxal derivatives, pyridoxamine derivatives, amethoflavone, neosacranine, 6-dehydrocaine, triazine derivatives (4,4 '4 "-(1,3,5-triazine-2,4,6-triyltriimino) trisbenzoic acid tris-2-ethylhexyl, etc.), phosphatidylchromanol derivatives (1,2-dilaurolylglycero-3- Phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-dimyristoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6'-hydroxychroman, 1,2-dipalmitoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl -6'-hydroxychroman, 1,2- Stearoyl glycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1,2-dialachidonylglycero-3-phospho-2'- Hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-myristoyl-2-palmitoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7 ', 8'-Tetramethyl-6'-hydroxychroman, 1-myristoyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7', 8'-tetramethyl-6 ' -Hydroxychroman, 1-palmitoyl-2-myristoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-palmitoyl-2- Stearoylglycero-3-phospho-2'-hydroxymethyl-2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-stearoyl-2-myristoylglycero-3-phospho-2'- Hydroxyme 2 ', 5', 7 ', 8'-tetramethyl-6'-hydroxychroman, 1-stearoyl-2-palmitoylglycero-3-phospho-2'-hydroxymethyl-2', 5 ', 7' , 8'-tetramethyl-6'-hydroxychroman, etc.), L-carnosine zinc complex, umbelliferone, esculin, benzyl cinnamate, cinoxalate, oxybenzone, dioxybenzone, octabenzone, soribenzone, benzoresorcinol, arbutin, guaiazulene, Shikonin, baicalin, baicalein, berberine, neoheliopan, chlorophylls, xanthophylls, escalol, zinc oxide, talc, kaolin, anthracite extract, hub extract, giant rush extract, cassava extract, kawatake extract, islet jellyfish extract , Hassai extract, Spirulina extract , Aiacacio extract, Funori no Ushike extract, Himetengususa extract, Hytengususa extract, Oobusa extract, Chinomori extract and the like.

Astringents Astringents can be added to the present invention. Specific examples of astringents include succinic acid, allantoin, zinc chloride, zinc sulfate, zinc oxide, calamine, zinc p-phenolsulfonate, potassium aluminum sulfate, resorcin, ferric chloride, tannins (tannic acid, hammelitannin Acer tannin, tetragalloyl glucose, pentagalloyl glucose, hexagalloyl glucose, heptagalloyl glucose, octagalloyl glucose, nonagaroyl glucose, decagalloyl glucose, undecagalloyl glucose, dodecagalloyl glucose, etc. Gallotannins, telimaglandin I, telimaglandin II, casarictin, peduncraggin, geraniin, isoturkevin, granatin A, granatin B, ketulinic acid, keblagic acid, casuarinin, nuphalin, procyanidin B-2 Ellagitannins such as thiacinensin A and thiacinensin B), red grape grape extract, azuki bean (red bean) extract, altea extract, nettle extract, cascarilla extract, kapoch extract, guarana extract, ezo strawberry extract, Dutch strawberry extract, shrimp strawberry extract , Japanese White Strawberry Extract, Maple Strawberry Extract, European Raspberry Extract, Kidachi Aloe Extract, Hawthorn Extract, Coustella Hakka Extract, Cowberry (Etsutachibana) Extract, Cola Vera Extract, Sugarcane Extract, Chinese Red Flower Extract, Honeysuckle Extract Q) Extract, Japanese larch extract, Elder extract, Dandelion extract, Centarium extract, Shirobana dandelion extract, Mouko dandelion extract, Tsurua Woodpecker extract, Tsurutsuchiakebi extract, Teuchigurumi extract, Tormentilla extract, Novara extract, Tokiwyo Ryu extract, Hagoromogusa extract, Castor extract, Grape extract, Prune extract, Veronica extract, Bisnaga extract, Bilberry extract, Mansugulumi extract, Mitsuga wrinkle extract, Myrrh extract, Examples include melissa extract, witch hazel extract, black willow extract, latania (chlamelia) extract, lemon extract, and dairy extract.

Anti-inflammatory agent / interleukin production inhibitor / histamine release inhibitor An anti-inflammatory agent / interleukin production inhibitor / histamine release inhibitor can be added to the present invention. Specific examples of anti-inflammatory agents, interleukin production inhibitors and histamine release inhibitors include quinolinone derivatives, dibenzooxepin derivatives, thiotroposin, phthalimide derivatives, flurbiprofen, felbinac, bufexamac, suprofen, 1,4-diphenylpropyl Piperazine derivatives, carxin compounds, chromanol glycosides (2- (α-D-glucopyranosyl) methyl-2,5,7,8-tetramethylchroman-6-ol), ictamol, indomethacin, kaolin, diphenhydramine hydrochloride, d- Camphor, DL-camphor, salicylic acid, sodium salicylate, methyl salicylate, acetylsalicylic acid, hydrocortisone, guaiazulene, camazulene, chlorpheniramine maleate, diphenhydramine hydrochloride, clemastine fumarate, cyproheptadine hydrochloride, Promethazine hydrochloride, piperazine derivatives, α-D-phenylglycoside derivatives, glycyrrhizic acid or salts thereof and derivatives thereof (α-glycyrrhizic acid, β-glycyrrhizic acid, α-glycyrrhizic acid methyl ester, β-glycyrrhizic acid methyl ester, α- Trisodium glycyrrhizinate, monopotassium α-glycyrrhizinate, dipotassium α-glycyrrhizinate, monoammonium α-glycyrrhizinate, trisodium β-glycyrrhizinate, monopotassium β-glycyrrhizinate, dipotassium β-glycyrrhizinate, β-glycyrrhizic acid mono Ammonium), glycyrrhetinic acid or a salt thereof and derivatives thereof (α-glycyrrhetinic acid, β-glycyrrhetinic acid, stearyl α-glycyrrhetinic acid, stearyl β-glycyrrhetinic acid, pyridoxyl α-glycyrrhetinic acid , Β-glycyrrhetinic acid pyridoxine, α-glycyrrhetinic acid glycerin, β-glycyrrhetinic acid glycerin, 3-succinyloxyglycyrrhetinic acid disodium, etc.), mefenamic acid, phenylbutazone, ibuprofen, ketoprofen, allantoin, calcium pantothenate, pantothenylethyl Panthenol such as ether or salts thereof and derivatives thereof, ε-aminocaproic acid, diclofenac sodium, tranexamic acid or derivatives thereof (trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-nitrobenzyloxycarbonyl Aminomethylcyclohexanecarboxylic acid, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-bromobenzyloxycarbo Ruaminomethylcyclohexanecarboxylic acid, trans-4-m-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4-p-methylbenzyloxycarbonylamino Methylcyclohexanecarboxylic acid, sodium trans-4-benzyloxycarbonylaminomethylcyclohexanecarboxylate, ammonium trans-4-p-nitrobenzyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4-p-chlorobenzyloxycarbonylaminomethylcyclohexanecarboxylic acid Potassium acid, potassium trans-4-p-bromobenzyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4-m-chlorobenzyloxycarbo Calcium nylaminomethylcyclohexanecarboxylate, magnesium trans-4-p-methoxybenzyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4-p-methylbenzyloxycarbonylaminomethylcyclohexanecarboxylic acid monoethanolamine, trans-4-t- Butyloxycarbonylaminomethylcyclohexanecarboxylic acid, trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-biphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- ( 3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) Cyclohexanecarboxylic acid, sodium trans-4-t-butyloxycarbonylaminomethylcyclohexanecarboxylate, potassium trans-4- (2-phenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylate, trans-4- (p-biphenylisopropyloxycarbonyl) Aminomethyl) calcium cyclohexanecarboxylate, trans-4- (3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl) magnesium cyclohexanecarboxylate, trans-4- (p-methylphenylisopropyloxycarbonylaminomethyl) cyclohexanecarboxylic acid monoethanolo- Lumine, trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4-methylsulfonylethyloxycarbo Ruaminomethylcyclohexanecarboxylic acid, trans-4- (9-fluorenylmethyloxycarbonylaminomethyl) sodium cyclohexanecarboxylate, potassium trans-4-methylsulfonylethyloxycarbonylaminomethylcyclohexanecarboxylate, trans-4- (pyridine -4'-methyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexanecarboxylic acid, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexane Potassium carboxylate, trans-4- (pyridine-4′-methyloxycarbonylaminomethyl) cyclohexanecarboxylate sodium, trans-4- (2,2,2-trichloroethyloxycarbonylaminomethyl) cyclohexane Potassium sancarboxylate, trans-4- (2-trimethylsilylethoxycarbonylaminomethyl) cyclohexanecarboxylate, etc.), tranexamic acid amide or a salt thereof, and derivatives thereof (trans-4-aminomethylcyclohexanecarbonamide, trans-4 hydrochloride) Aminomethylcyclohexanecarbonamide, Nn-hexyl-trans-4-aminomethylcyclohexanecarbonamide, Nn-hexyl-trans-4-aminomethylcyclohexanecarbonamide hydrochloride, Nn-heptyl-trans-4- Aminomethylcyclohexanecarbonamide, Nn-heptyl-trans-4-aminomethylcyclohexanecarbonamide hydrochloride, Nn-butyl-trans-4-aminomethylcyclohexanecarbonamide N-butyl-trans-4-aminomethylcyclohexanecarbonamide, Nn-propyl-trans-4-aminomethylcyclohexanecarbonamide, N-cyclohexyl-trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N -Cyclohexyl-trans-4-aminomethylcyclohexanecarbonamide, N, N-dicyclohexyl-trans-4-aminomethylcyclohexanecarbonamide, N, N-dicyclohexyl-trans-4-aminomethylcyclohexanecarbonamide hydrochloride, N, N- Diethyl-trans-4-aminomethylcyclohexanecarbonamide, N, N-diethyl-trans-4-aminomethylcyclohexanecarbonamide hydrochloride, N-benzyl-trans-4-aminomethyl Cyclohexanecarbonamide, N-benzyl-trans-4-aminomethylcyclohexanecarbonamide hydrochloride, N- (4'-methoxyphenyl) -trans-4-aminomethylcyclohexanecarbonamide, N- (4'-methoxyphenyl) hydrochloride -Trans-4-aminomethylcyclohexanecarbonamide, N- (4'-ethoxyphenyl) -trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N- (4'-ethoxyphenyl) -trans-4-aminomethylcyclohexanecarboxylic acid Amide, N- (2'-methylphenyl) -trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N- (2'-methylphenyl) -trans-4-aminomethylcyclohexanecarbonamide, N- (3'-methylpheny ) -Trans-4-aminomethylcyclohexanecarbonamide, hydrochloric acid N- (3'-methylphenyl) -trans-4-aminomethylcyclohexanecarbonamide, N- (4'-chlorophenyl) -trans-4-aminomethylcyclohexanecarboxylic acid Amide, hydrochloric acid N- (4′-chlorophenyl) -trans-4-aminomethylcyclohexanecarbonamide, etc.), sulfatide, astaxanthin fatty acid diester (astaxanthin dilaurate, astaxanthin dimyristate, astaxanthin dipentadecanoate, astaxanthin diester) Palmitic acid ester, Astaxanthin dipalmitooleic acid ester, Astaxanthin diheptadecanoic acid ester, Astaxanthin dieraidic acid ester Astaxanthin diricinoleate, astaxanthin petrolinate, astaxanthin vacsenate, astaxanthin eleostearate, astaxanthin punicinate, astaxanthin licanoate, astaxanthin parinalate, astaxanthin gadorate, astaxanthin 5- Eicosenoic acid ester, astaxanthin 5-docosenic acid ester, astaxanthin cetolic acid ester, astaxanthin erucic acid ester, astaxanthin 5,13-docosadienoic acid ester, astaxanthin ceracholic acid ester, astaxanthin desenic acid ester, astaxanthin steric acid ester, astaxanthin dodecenoic acid Esther, Astaxanthin Diolei Acid esters, astaxanthin distearic acid esters, astaxanthin dieicosapentaenoic acid esters, astaxanthin didocosahexaenoic acid esters, astaxanthin dilinolenic acid esters, astaxanthin dilinolenic acid esters, astaxanthin diarachidonic acid esters, etc.), astaxanthin diglycerophosphates (astaxanthin diesters) Glycerophosphate, Astaxanthing lyserophosphate palmitic acid, Astaxanthing lyserophosphatidylcholine palmitic acid, Astaxanthing lyserophosphatidylcholine DHA, Astaxanthing lyserophosphatidylinositol palmitic acid, Astaxanthing lyserophosphatidylinositol DHA, Astaxanthin Luinositol linoleic acid, astaxanthin lyserophosphatidylcholine linoleic acid, etc., steviol glycosides, benzimidazole derivatives (1- (2-ethoxyethyl) -2- [1- (2- (4- (1- (4 , 4-Dimethyl-2-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- (4- (1- ( 2-Ethoxyethyl) benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoic acid, ethyl 2- [4- (2- (4- (1- (2-ethoxyethyl)) Benzimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanate, 1- (2-ethoxyethyl) -2- [1- (2- (4- (1,1-dimethyl) -2-hydroxyethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 1- (2-hydroxyethyl) -2- [1- (2- (4- (1- (4,4-Dimethyl-oxazolin-2-yl) -1-methylethyl) phenyl) ethyl) piperidin-4-yl] -1H-benzimidazole, 2- [4- (2- ( 4- (1- (2-hydroxyethyl) benzoimidazol-2-yl) piperidin-1-yl) ethyl) phenyl] -2-methylpropanoic acid), alanine derivatives or salts thereof (N- [3-isopentyl- 4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carbonyl] -L-alanine, N- [3-isopentyl-4-methyl-2- [4- (3-Trifluoromethylbenzamide) benzoylimino] -3H-thiazoline-5-carbonyl] -2-methylalanine, N- [3-isopentyl-4-methyl-2- [4- (3-trifluoromethylbenzamide) Benzoylimino] -3H-thiazoline-5-carbonyl] -N-methyl-L-alanine), thiazoline derivatives or salts thereof (3-isopenes) Ru-4-methyl-2- [4- (3-trifluoromethylbenzamido) benzoylimino] -3H-thiazoline-5-carboxylic acid, 4-isobutyl-3-methyl-2- [4- (3-trifluoro Methylbenzamide) benzoylimino] -3H-thiazoline-5-carboxylic acid, etc.), chlorpheniramine maleate, diphenhydramine hydrochloride, diphenylpyraline hydrochloride, carbinoxamine maleate, hydrocortisone butyrate, sulfated acidic mucopolysaccharides or salts thereof, sulfated Dextran or its salt, Fluoromethylhistidine or its hydrochloride, Histidine methyl ester or its hydrochloride, Licorice extract, Shikon extract, Ages extract, Propolis, Eye (Aiba) extract, Asenyaku (Asenyaku) extract, Avocado extract, Amadokoro Bamboo) extract, Amiga lily extract, Baimo (shellfish mother) extract, Igakouzo Na extract, Ibukitorano extract, Turmeric extract, Echinashi pear extract, Oren extract, Oguruma extract, Oniguri extract, Orange extract, Cassia extract, Kamiyatsude ) Extract, Kawamidori Extract, Kawara Mugwort Extract (Cotton Chin) Extract, Watercress Extract, Kenashi Sartorii Rose (Tsumago, Yamakage) Extract, Gentiana Extract, Koki Sekko Extract, Kouhon (Kakimoto, Karatsumoto) Extract, Kouryokyo (Koryo Kaki) Extract , Gosho Strawberry extract, Sai-Hairan extract, Cherries extract, Salvia (Sage) extract, Dikitaris extract, Linden extract, Salamander extract, Indobodai extract, Shukushamitsu (Sanjin, Shredded sand) extract, Juzudama Extract, white mint extract, licorice extract, licorice extract, yarrow extract (milfoil) extract, broadleaf sega extract, takasago rurigo tai extract, takaharabi extract, licorice extract Japanese persimmon mushroom rafuji extract, Tounin extract, Chigaya extract, Toga (winter coconut) extract, Dokudami (ten-drug) extract, Parsley (Netherlands jellied) extract, Japanese sea bream (Sutoshiri, Shishitsuri) extract, Hamasuge (Katsukishi) extract, Japanese persimmon (Hishimi) extract , Bellows oyster extract, sweet pod extract (southern rattan) extract, bundo (mung bean) extract, sandalwood extract, butcher bloom extract, pansy extract, hosoba aragiku extract, myrtle tennan show , Pheasant extract, miracle fruit extract, mulberry extract, peach (peach) extract, cornflower extract, willow willow extract, mistletoe (willow parasite) extract, yabukouji (purple gold beef) extract, sagebrush extract, mugwort (bamboo leaf) extract, Rosemary extract , Belladonna extract, cypress extract, harimille (crustacean, cinnamon bark, cocoon leaf) extract, Aozulan extract, sacanelan extract, sasabagin orchid extract, Chinese cabbage extract (including varieties and origin species), kanokosoueki , Evening primrose extract, Sen Ryukyu extract, apricot kernel extract, honeysuckle extract, angelica extract, fennel extract, peppermint extract, and the like.

Anti-seborrheic agent An anti-seborrheic agent can be added to the present invention. Specific examples of the antiseborrheic agent include chroman derivatives, pyridoxine or salts thereof and derivatives thereof, pyridoxal or salts thereof and derivatives thereof, pyridoxamine or salts thereof and derivatives thereof, sulfur, Asa extract, (Continuous) extract, Dutch mustard (watercress) extract, valerian extract (valerian root) extract, clematis extract, bear sebacekis, savonso extract, rosewood extract, horse chestnut extract, soybean (soybean) extract, milkflower extract (marigold) extract, Chinese yam Examples include extracts, yam extract, nosenhalen extract, dandelion poppy (sect winter flower, winter winter leaf) extract, japonica extract, giant kelp extract, hijirimen extract, primrose extract, haius banori extract and the like.

Antibacterial Agent An antibacterial agent can be added to the present invention. Specific examples of antibacterial agents include acrinol, sulfur, calcium gluconate, chlorhexidine gluconate, sulfamine, mercurochrome, lactoferrin or hydrolyzate thereof, alkyldiaminoethylglycine chloride solution, triclosan, sodium hypochlorite, chloramine T, salashi powder , Iodine compounds, iodoform, 1-alkylcarbapenem compounds, N-substituted azepane derivatives or salts thereof, sorbic acid or salts thereof, propionic acid or salts thereof, salicylic acid or salts thereof, dehydroacetic acid, parahydroxybenzoic acid esters, 2 -Keto-3-deoxyoctanoic acid fatty acid esters, inositol deoxy derivatives (such as quercitol), inositol unsaturated derivatives (such as chonditol), inositol dimethyl ether, methyl inositol, inositol Ether, inosamine, deoxyinosadiamine, shikimic acid, quinic acid, undecylenic acid, thiamine lauryl sulfate, thiamine lauryl nitrate, phenol, cresol, p-chlorophenol, p-chloro-m-xylenol, p-chloro-m-cresol , Thymol, phenethyl alcohol, o-phenylphenol, irgasan CH3565, halocarban, hexachlorophene, chlorohexidine, ethanol, methanol, isopropyl alcohol, benzyl alcohol, propylene glycol, 2-phenoxyethanol, 1,2-pentanediol, zinc pyridione, Chlorobutanol, isopropylmethylphenol, elemol, vetiverol, patchouli alcohol, nonionic surfactant (polyoxyethylene lauryl ether, polyoxyethylene nonyl) Phenyl ether, polyoxyethylene octyl phenyl ether, etc.), amphoteric surfactant, anionic surfactant (sodium lauryl sulfate, lauroyl sarcosine potassium, etc.), cationic surfactant (cetyltrimethylammonium bromide, benzalkonium chloride, benzethonium chloride) , Methylrosaniline chloride), formaldehyde, hexamine, brilliant green, malachite green, crystal violet, germal, photosensitive element 101, photosensitive element 201, photosensitive element 401, N-long chain acyl basic amino acid derivative and acid addition salt thereof, Zinc oxide, hinokitiol, propolis, cucumber extract, agi extract, asunaro extract, alpinia extract, katsudai (suzukuku) extract, Inubiyu extract, Aogate Extract, Haribiyu extract, Ayuyu extract, Hagatetou extract, Hosonagabiyu extract, Enmeiso extract, Warbler extract, Usubasaicin extract, Oshusaishin extract, Halibut extract, Ominaeshi (losing soy sauce) extract, Kajikazura鈎) Extract, Kahoku Salamander (蜀椒) Extract, Chamomile Extract, Kinakiki Extract, Red linden Extract, Yellow Spider Extract, Caraway Extract, Betel Extract, Kumazasa Extract, Cranberry Extract, Grapefruit Extract, Celosia (Chick Crown Flower, Chicken Crown) ) Extract, bay bay laurel extract, cinnabar rose (moon flower) extract, copaiba balsam extract, wild cherry extract, ed pear extract, Miyaza cherry extract, Yoshino cherry extract, Kazumi cherry extract, kanzaku La extract, sugar beet extract, white pepper extract, cicada extract, birch extract, cinnamon extract, sorrel extract Extract, Sowka (grass) extract, onion extract, chicory extract, Korean senile (蕪 夷) extract, tsuruna (apricot) extract, tokon (root) extract, leek (yuzu) extract, leek extract, leek extract, patchouli Extract, Japanese anemone extract (Ishibuchi, Bujushahua) extract, Japanese cypress extract, Pimenta extract, White-bellied clover (Bald eagle) extract, Blackberry extract, Hop extract, Makuri (Seaman grass) extract, Magnolia sprengeri extract, Mizokakushi ( Hanbe extract), Honey bee , Murasaki (purple root) extract, Moso bamboo extract, pokeweed (commercial land) extract, Yucca extract, Eurasian rush extract, lavender extract, Forsythia extract, Sylar Forsythia extract, Obatsunomata extract, Tochaka (Yahazutsu no Mata) extract, Akamominori Extract, Anaaasa Extract, Human Rabbit Extract, Hirohanohito Exa Extract, Ushito Rabbit Extract, Iroro Extract, Ishige Extract, Arame Extract, Tamai Taki Extract, Tambanori Extract, Kata Nori Extract, Sakuranori Extract, Fuji Matsumo Extract, Kawamokuzuku Extract, Akakawa Mozuku Extract And Yakuchi extract.

Blood flow promoter / vascular stimulator A blood flow promoter / vascular stimulator can be added to the present invention. Specific examples of blood flow promoters and vascular stimulants include tocopherol or salts thereof and derivatives thereof, tocotrienol or salts thereof and derivatives thereof, cephalanthin, carpronium chloride, eugenol derivatives (acetyl eugenol, methyl eugenol, methyl isoeugenol, ethyl Eugenol, ethylisoeugenol, eugenol salicylate, etc.), minoxidil, chili pepper tincture, nonyl acid vanillamide, cantalis tincture, ginger tincture, peppermint oil, L-menthol, camphor, benzyl nicotinate, cinnarizine, trazoline, acetylcholine, verapamil, ectamol , Α-borneol, cyclandelate, nonyl acid wallenylamide, capsaicin, gingerone, assembly extract, garlic extract, carrot , Aloe extract, gentian extract, touki extract, ashitaba (tomorrow leaf) extract, arnica extract, ukiyagara (three ridges) extract, himeuki sakura extract, shrimp mandarin (chonse) extract, toucan extract (coconut) extract, oyster extract, cocoon extract , Kina extract, Ginseng extract, Anemone extract, Gubijinsou extract, Kouhone (river bone) extract, Burdock (beef bowl, beef coconut) extract, Sagaki (Yellow root) extract, Chinese syringa extract, Ginger (ginger) extract , Shobu extract, Japanese hawthorn extract, Seburi extract, Daidai extract, Tanjin extract, Thyme extract, Chikutsujinjin (Takebushi ginseng) extract, Tsurudokudami Extract, Carrot (Yotsu-san) Extract, Capsicum (Banban) Extract, Toki (Toki) Extract, Shiromumochi (Female Sadako) Extract, Natsumikan Extract, Elderberry (Bonegrass) Extract, Hazel (Zushi) Extract, Hashiridokoro (Roto Root) Extract, Pepper (Light Pack) , Light leaf) extract, Hamabou Fu (hama breeze) extract, Higotai extract, Fujimodoki (Chojizakura, Camellia flower) extract, black currant extract, Bodaiju extract, Merilot extract, Yuzu extract, Loby extract, bay jelly extract, Hibiscus Extract, rosehip extract and the like.

Antiandrogen Agent An antiandrogen agent can be added to the present invention. Specific examples of antiandrogens include follicular hormones (estrone, estradiol, ethinyl estradiol, etc.), isoflavones, oxendron, 4 ', 5,7-trihydroxy-8-prenylflavanone, 4', 5,7-trihydroxy-8 -Prenyl flavone, 3,3 ′, 4 ′, 5,7-pentahydroxy-8-prenyl flavone, nicorandil, cyclosporine and the like.

Structural proteolytic enzymes (matrix metalloproteases such as elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme) activity inhibitor / structural protein Decomposition enzyme expression inhibitor The present invention includes a matrix of structural proteolytic enzymes (elastase, collagenase, keratin protease, serine protease, integrin degrading enzyme, involucrin degrading enzyme, filaggrin degrading enzyme, laminin degrading enzyme, fibronectin degrading enzyme, proteoglycan degrading enzyme, etc. A metalloprotease) activity inhibitor / structural protease inhibitor can be added. Specific examples of structural protease inhibitors) and structural protease inhibitors include adenine derivatives (butanetriol-9-adenine and its phosphate adduct, propanediol-9-adenine and its phosphate adduct, Pentanetriol-9-adenine and its phosphate adducts), carbostyril derivatives or salts thereof, dicarboxylic acids (glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, 1,9-nonamethylenedicarboxylic acid) Acid, 1,10-decamethylenedicarboxylic acid), rosmarinic acid, ursolic acid, oleanolic acid, hydroxamic acid derivative, esculetin derivative, anthocyanidins, nordihydroguaiaretech acid, 20-carboxy-16-hydroxy-21-nor- 5 α-7,9 (11) -lanostadien-3,24-dione, ubiquinone, plastakino , Juglone, shikonin, quinizarin, alizarin, abietin, levopimaric acid, betulin, α-amylin, catechin compounds (catechin, epigallocatechin, epigallocatechin gallate, epicatechin gallate, catechin rhamnopyranoside catechin, etc.) , Diisopropyl fluorophosphate, (2R, 6R) -2,6-dihydroxy-4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate, N, N'-bis- [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydroxyheptanedicarboxylic acid-1,7-diamide, (2R, 6R)- 2,6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) Dimethyl heptane-1,7-dicarboxylate (2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N'-bis [(1S, 2R) -2- Hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N′-bis [( 1S, 2R) -2-Hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, N, N′-bis [( 1S, 2R) -2-Hydroxyindan-1-yl]-(2R, 6R) -2,4,6-trihydroxyheptane-1,7-dicarboxylic acid diamide, N, N'-bis [(1S, 2R ) -2-Hydroxyindan-1-yl]-(2S, 6S) -2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, (2S, 6S) -2,6-dihydroxy -4- (tert-butyldimethylsilyloxy)-(3Z) -heptene-1,7-dicarboxylate, (2S, 6S)- 2,6-dihydroxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylate, (2S, 6S) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) Dimethyl heptane-1,7-dicarboxylate, (2S, 6S) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyloxy) heptane-1,7-dicarboxylic acid, N, N'-bis [ (1S, 2R) -2-hydroxyindan-1-yl]-(2S, 6S) -2,6-dibenzyloxy-4- (tert-butyldimethylsilyl) oxyheptane-1,7-dicarboxylic acid diamide, N, N′-bis [(1S, 2R) -2-hydroxyindan-1-yl]-(2R, 6R) -2,6-dibenzyloxy-4-hydroxyheptane-1,7-dicarboxylic acid diamide, 3-[[4- (4-Fluorophenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclopentyl) -amino] -propionic acid, 4- [4- (4-fluorophenoxy) -benzenes Sulfonylamino] -tetrahydropyran-4-carboxylic acid hydroxyamide, 4- [4- (4-chlorophenoxy) -benzenesulfonylmethyl] -tetrahydropyran-4-carboxylic acid hydroxyamide, 3-[[4- (4-fluoro Phenoxy) -benzenesulfonyl]-(1-hydroxycarbamoylcyclobutyl) -amino] -propionic acid, 4- (4′-chlorobiphenyl-4-yl) -2- [2- (1,3-dioxo-1, 3-Dihydroisoindol-2-yl) -ethyl] -4-oxobutyric acid, 1- [4- (4-fluorobenzyloxy) -benzenesulfonyl] -2-hydroxycarbamoylpiperidin-3-yl) -isopropyl carbamate Ester, 2- [4- (4-Fluorophenoxy) -benzenesulfonylamino] -N-hydroxy-2-methylpropionamide, 3- [4- (4-Fluorophenoxy) -benzenesulfonyl] -2, N-dihydroxy Propionamide 3- (4-Phenoxybenzenesulfonyl) -7-oxabicyclo [2.2.1] heptane-2-carboxylic acid hydroxyamide, (4-benzylbenzyl)-[2- (2,2-dimethyl-1-methylcarbamoylpropyl) Carbamoyl) -4- (4'-fluorobiphenyl-4-yl) -butyl] -phosphinic acid, 2-amino-3- [4- (4-fluorophenoxy) -benzenesulfonyl] -N-hydroxypropionamide, N -Hydroxy-2- (4-phenylpiperidine-1-sulfonyl) -acetamide, Iris japonicum extract, Nepenthes (Summer hay) extract, Greater Crape myrtle (Banaba) extract, Large hawthorn extract, Hawthorn (Yamako) extract, Calahoo ) Extract, guava extract, trash (gomi-cho) extract, red-billed extract, rose extract, chickweed extract, chickweed extract Honoki (Japanese Kokaku, Park) Extract, American Grape Extract, European Grape Extract, Yama Grape Extract, Mandarin Extract, Mishima Psycho (Shibahu) Extract, Ogon Extract, Clara Extract, Mulberry Extract, Keihi Extract, Gennoshokko Extract, Comfrey Extract, Salvia Extract, Elderberry Extract, Bodge Extract, Buttonpi Extract, Aozuzuran Extract, Sakaneran Extract, Sasabagin Extract, Husambird (including varieties and origins) extract, Blue-tailed Agave Extract, Sisal Extract, Crimson Carrot Extract, etc. .

Structural protein synthesis promoter A structural protein synthesis promoter can be added to the present invention. Specific examples of the structural protein synthesis accelerator include ethanolamine derivatives, pentoxyphyllin, serine derivatives, geraniol, crocetin, methyl 4- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-4- (3, 5,5-Trimethylhexyloxy) methyl benzoate, methyl 4-cyclohexylmethoxy-2-hydroxybenzoate, methyl 4- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4- (3,7-dimethyl-6 -Octenyloxy) methyl 2-hydroxybenzoate, ethyl 3- (2-ethylhexyloxy) -5-hydroxybenzoate, methyl 5- (2-ethylhexyloxy) -2-hydroxybenzoate, 2-hydroxy-5 -(3,5,5-trimethylhexyloxy) methyl benzoate, methyl 5- (2-cyclohexylethoxy) -2-hydroxybenzoate, 4-N-hexyloxy-2-hydroxy Methyl benzoate, methyl 2-hydroxy-4-N-octyloxybenzoate, methyl 4-N-decyloxy-2-hydroxybenzoate, methyl 5-N-hexyloxy-2-hydroxybenzoate, 4- (2 -Ethylhexyloxy) -2-hydroxybenzoic acid, 2-hydroxy-4- (2,5,5-trimethylhexyloxy) benzoic acid, 4-cyclohexylmethoxy-2-hydroxybenzoic acid, 4- (2-cyclohexylethoxy) 2-hydroxybenzoic acid, 4- (3,7-dimethyl-6-octenyloxy) -2-hydroxybenzoic acid, 3- (2-ethylhexyloxy) -5-hydroxybenzoic acid, 5- (2-ethylhexyl) Oxy) -2-hydroxybenzoic acid, 5- (2-ethylhexyloxy) -2-hydroxybenzoic acid, 2-hydroxy-5- (3,5,5-trimethylhexyloxy) benzoic acid, 5- (2-cyclohexyl) Ethoxy) -2-hydroxybenzoic acid, 4-N-hexyl Xyl-2-hydroxybenzoic acid, 5-N-hexyloxy-2-hydroxybenzoic acid, 2-hydroxy-4-N-octyloxybenzoic acid, 4-N-decyloxy-2-hydroxybenzoic acid, N- (2 -Hydroxyethyl) -4- (2-ethylhexyloxy) -2-hydroxybenzamide, N-ethyl-4- (2-ethylhexyloxy) -2-hydroxybenzamide, 2-acetoxy-4-cyclohexylmethoxybenzoic acid, 4- Sodium (2-ethylhexyloxy) -2-hydroxybenzoate, methyl 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoate, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoate, 5-[(2E) -3,7 dimethyl-2,6-octadienyloxy] -2-hydroxybenzoate Ethyl 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoate, 3- [ 2E) -3,7-dimethyl-2,6-octadienyloxy] -5-hydroxybenzoate, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -3 Ethyl 4-methoxybenzoate, methyl 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzoate, 4-[(2E) -3 , 7-Dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid (2E) -3,7-dimethyl-2,6-octadienyl, 4-[(2E) -3,7-dimethyl-2 , 6-Octadienyloxy] -2-hydroxybenzoic acid, 5-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -5-hydroxybenzoic acid Acid, 2-hydroxy-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzoic acid, 4-[(2E) -3,7-dimethyl -2,6-octadienyloxy] -3-methoxybenzoic acid, 2-acetoxy-4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, N- (2 -Hydroxyethyl) -4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] -2-hydroxybenzamide, 4-[(2E) -3,7-dimethyl-2,6- Octadienylamino] -2-hydroxybenzoic acid, dimethyl-2,6-octadienyloxybenzoic acid, N- (2-hydroxyethyl) -4-[(2E) -3,7-dimethyl-2,6 -Octadienyloxy] -2-hydroxybenzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienylamino] -2-hydroxybenzoic acid, 3-dodecyloxybenzoic acid, 3- (12-hydroxydodecyloxy) benzoic acid, 4-dodecyloxybenzoic acid, 4- (12-hydroxydodecyloxy) benzoic acid, 3- (12-hydroxyoctadecyloxy) benzoic acid, 4- (12-hydroxyoctadede Siloxy) benzoic acid, 3- (11-hydroxyundecyloxy) benzoic acid, 4- (11-hydroxyundecyloxy) benzoic acid, 3-[(2E) -3,7-dimethyl-2,6-octadi Enyloxy] benzoic acid, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzoic acid, 3-[(2E, 6E) -3,7,11-trimethyl-2, 6,10-dodecatrienyloxy] benzoic acid, 4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzoic acid, 4- [3,7- Dimethyl-9- (2,6,6-trimethyl-1-cyclohexen-1-yl) -2,4,6,8-nonatetraenyloxy] benzoic acid, 4- [3,4-dihydro-2,5 , 7,8-Tetramethyl-2- (4,8,12-trimethyltridecyl) -2H-1-benzopyran-6-oxy] benzoic acid, 4-[(2E, 6E) -3,7,11- Trimethyl-2,6,10-dodecatrienyloxy] benzamide, 4-[(2E) -3,7-dimethyl-2,6-octadienyloxy] benzamide, 4- (2-methyl-2-bu Tenenyloxy) benzamide, 4- (2-ethylhexyloxy) benzamide, 4-dodecyloxybenzamide, 4- (12-hydroxydodecyloxy) benzamide, 4- (12-hydroxyoctadecyloxy) benzamide, 4- (11-hydroxyundecyl) Oxy) benzamide, 4- (10-hydroxydecyloxy) benzamide, 4-isostearyloxybenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2, 6,10-dodecatrienyloxy] benzamide, N, N-dimethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] benzamide, N, N -Di [(2E) -3,7-dimethyl-2,6-octadienyl] -4-aminobenzamide, 4- [N'-methoxycarbonyl-N-[(2E) -3,7-dimethyl-2,6 -Octadienylamino] benzamide, 4- [N-acetyl-N-[(2E) -3,7-dimethyl-2,6-oct Dienyl]] aminobenzamide, N- (2-hydroxyethyl) -4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, N , N-diethyl-4-[(2E, 6E) -3,7,11-trimethyl-2,6,10-dodecatrienyloxy] -2-hydroxybenzamide, pea extract, Tosakamodoki extract, Ikanoashi extract, Hosoivo Nori Extract, Novonori Extract, Igis Extract, Keigi Extract, Harigi Extract, Hanegisu Extract, Usuba Watanagi Extract, Moray Togusa Extract, Fuyugusa Extract, Willow Willow Extract, Willow Tree Extract, Moyuyurena Extract, Vulgaris Extract, Mosayanagi Examples include extract, Sasabayana chinori extract, wasabi extract, merbou extract and the like.

Mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitor A mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitor can be added to the present invention. Specific examples of mucopolysaccharide (hyaluronic acid, chondroitin sulfate, etc.) degrading enzyme inhibitors include anacardic acid or derivatives thereof (6-pentadecatrienylsalicylic acid methyl ether, 6-pentadecatrienylsalicylic acid ethyl ether, 6-pentadeca Trienyl salicylic acid propyl ether, 6-pentadecatrienyl salicylic acid butyl ether, 6-pentadecatrienyl salicyl alcohol methyl ether, 6-pentadecatrienyl salicyl alcohol ethyl ether, 6-pentadecatrienyl salicyl alcohol propyl ether, 6- Pentadecatrienyl salicyl alcohol butyl ether, 6-pentadecatrienyl salicylaldehyde methyl ether, 6-pentadecatrienyl salicylaldehyde ethyl ether, 6-pentadecatrienyl salicyl aldehyde Hydropropyl ether, 6-pentadecatrienyl salicylaldehyde butyl ether, 2-methyl ether-6-pentadecatrienyl cinnamic acid, 2-ethyl ether-6-pentadecatrienyl cinnamic acid, 2-propyl ether-6 -Pentadecatrienyl cinnamate, 2-butyl ether-6-pentadecatrienyl cinnamate, 2-methyl ether-6-pentadecatrienyl cinnamate alcohol, 2-ethyl ether-6-pentadecatrienyl cinnamate Skin alcohol, 2-propyl ether-6-pentadecatrienyl cinnamon alcohol, 2-butyl ether-6-pentadecatrienyl] cinnamon alcohol), polyisoprenylated benzophenone derivatives (garcinol, isogarcinol, xantho) Thymol, isoxanthothymol, gucciferon, etc.), Ikarisou extract, Yachima Taikiso Inyo-kaku extract, Narco lily extract, Snapper extract, Yellow orchid extract, Oshida extract, Onji extract, Spruce extract, Crow birch extract (half-summer) extract, pheasant extract Skin) extract, goshuyu extract, senega extract, sendan extract, tamarind extract, tarragon extract, ginkgo biloba extract, bee extract, daisy extract, mirabaran extract, himebara extract, Mockin Extract, Laurel Extract, Yab Cycad Extract, Anaaaosa Extract, Macrocystis Integrifolia Extract, Neocities Ruetkeana Extract, Nettle Extract, Pterosa Extract, Kata Duck Extract, Yatabegusa Extract, Primrose extract, Ezotsunomata extract, Totsunomata extract, Fusaiwata mushroom extract, Hanemo extract, Mill extract, Chromel extract, Nagamil extract, Hiramil extract, Matsumo extract, Okinawa mozuku extract, Mozuku extract, Fukuronori extract, Kajime extract, Fukurofunori extract, Makuhori extract, grape leaves Examples include extracts, salamander extracts, and astragalus extract.

Mucopolysaccharide synthesis promoter A mucopolysaccharide synthesis promoter can be added to the present invention. Specific examples of mucopolysaccharide synthesis promoters include stilbene derivatives or salts thereof, morgin or salts thereof and derivatives thereof, N-acetylglucosamine, flax extract, cinnamon extract, mulberry extract, scotch extract, breadfruit extract, hirakotoji extract , Kotojitsu no Mata Extract, Yaleus Banori Extract, Kagiosu Banori Extract, Susius Banori Extract, Amiaosa Extract, Nagaaosa Extract, Hosobanosakamodoki Extract, Hirohatosakamodoki Extract, Yatsudegatatosakamodoki Extract, Kurotosakamodoki Examples include extract, Nezushinosakamodoki extract, Yusora extract, Etsukinotosakamodoki extract, Nankaitosakamodoki extract, Himetosakamodoki extract, and the like.

Intercellular lipid production promoter / intercellular lipid state improver An intercellular lipid production promoter / intercellular lipid state improver can be added to the present invention. Specific examples of intercellular adipogenesis promoters and intercellular lipid state improvers include phospholipids (phosphatidylethanol, phosphatidylcholine, phosphatidyltriethanolamine, phosphatidylserine, phosphatidic acid, phosphatidylglycerin, phosphatidylinositol, diacylphosphatidylcholine, diacylphosphatidylethanol Amine, diacylphosphatidylinositol, diacylphosphatidylserine, 1-cysteinylphosphatidic acid, 2-cysteinylphosphatidic acid, 1-glutathionylphosphatidic acid, 2-glutathionylphosphatidic acid, 1-azelaoylphosphatidic acid, 2- Azela oil phosphatidic acid, 1-hydroxyacyl phosphatidic acid, 2-hydroxyacyl phosphatidic acid, ceramide, glucosyl Ceramide, Galactosylceramide, Cerebroside, Phosphatidylglucosylacylglycerol, N-oleoylsphingosine, N- (12-hydroxyoctadecanoyl) sphingosine, N- (16-hydroxyhexadecanoyl) sphingosine, N-salicyloylphytosphingosine, Sphingomyelin, soybean lecithin, egg yolk lecithin, etc.), sterins (cholesterol, dihydrocholesterol, cholesteryl stearate, cholesteryl hydroxystearate, macadamia nut oil fatty acid cholesteryl, β-sitosterol, stigmasterol, campesterol, ergosterol, 5-dihydro Ergosterol, phytosterol, 25-hydroxycholesterol, 26-hydroxycholesterol, 19-hydroxycholesterol, 22-ke Tocholesterol oxime, 6-ketocholesterol and 7-ketocholesterol or their derivatives), N-acetylneuraminic acid (sialic acid), N-glucosolneuraminic acid, gangliosides (gangliotriose, gangliotetra Ose, globotetraose, neolactotetraose, neolactohexaose, neolactooctaose, etc.), oligosulfated hyaluronic acid, hydroxytamoxifen compounds, glyceroglycolipids, pentoxyphyllin, 3-deazaadenosine, carboxamide derivatives , Inositol polyamines, Sialic acid, Triterpenic acid derivatives, Lactose, Lactosamine derivatives, Sulfated chitin derivatives, Albumin, Panax ginseng extract, Tochiban ginseng extract, Tiger lily extract, Sasayuri extract, Hakata Yurieki And dairy extract.

Keratin solubilizer and stratum corneum peeling accelerator A keratolytic agent and stratum corneum peeling accelerator can be added to the present invention. Specific examples of keratolytic agents and stratum corneum exfoliation accelerators include tropolone and its derivatives, resorcin, lactic acid, urea, salicylic acid, guanidine, ethanolamine, kikarasuuri extract, fenugreek extract, wisteria bean extract, and lentil extract. Chickpea extract, mungbean extract and the like.

Plasminogen activator antagonist inhibitor A plasminogen activator antagonist inhibitor can be added to the present invention. Specific examples of the plasminogen activator antagonist inhibitor include rabbit daisy extract, canamgra extract, caladium extract, raspberry extract and the like.

Maillard reaction inhibitor A Maillard reaction inhibitor may be added to the present invention. Specific examples of Maillard reaction inhibitors include aminoguanidine, flavanones (naringin, naringenin, liquiritin, liquiritigenin, digallic acid, luteoic acid, ellagic acid, chlorogenic acid, glucogallin, tetralin, hamamelitannin, gallic tannin, tannic acid, Geraniin, gallic acid, galloyl gallic acid, ellagitannin, hexagalloyl glucose, heptagalloyl glucose, tetragalloyl glucose, trigalloyl glucose, pentagalloyl glucose, digalloyl quinic acid, trigalloyl quinic acid), 2-hydroxyphenylalkylamine Derivatives or salts thereof, phenylpropenoic acid derivatives (3- [2,3-bis (methoxymethoxy) phenyl] propenoic acid, 7- (4-hydroxy-3-methoxyphenyl) hepta-2,4,6-trienoic acid, 3- (3,5-dimension Xyl-4-hydroxyphenyl) propenohydrazide, N'-isopropylidene-3- (2-methoxyphenyl) propenohydrazide, etc.), citric acid or its salts, gypsum extract, sandalwood extract, red clover extract , Persimmon (including persimmon) extract, mulberry extract, camellia extract, garega extract, yaba santa extract, rosehip extract, asunalo extract, itadori extract, yakuyaku extract, quail extract, birch extract, hawthorn extract, yarrow extract Examples include Tarayo extract, Dokudami extract, Tormentilla extract, Bakumondo extract, Hiba extract, Grape extract, Japanese willow extract, Mukuroji extract, Karin extract, Mokka extract, Roman chamomile extract and the like.

Testosterone 5α reductase activity inhibitor / hair papilla activator / hair growth promoter A testosterone 5α reductase activity inhibitor / hair papilla activator / hair growth promoter can be added to the present invention. Specific examples of testosterone 5α reductase activity inhibitor, hair papilla activator and hair growth promoter include γ-amino-β-hydroxybutyric acid esters (γ-amino-β-hydroxybutyric acid methyl ester, γ-amino-β- Hydroxybutyric acid ethyl ester, γ-amino-β-hydroxybutyric acid propyl ester, γ-amino-β-hydroxybutyric acid butyl ester, γ-amino-β-hydroxybutyric acid ethylhexyl ester, γ-amino-β-hydroxybutyric acid hexadecyl ester, γ-amino-β-hydroxybutyric acid lauryl ester, γ-amino-β-hydroxybutyric acid stearyl ester, γ-amino-β-hydroxybutyric acid oleyl ester, γ-amino-β-hydroxybutyric acid benzyl ester, γ-amino-β- Hydroxybutyric acid phenyl ester, γ-amino-β-hydroxybutyric acid ethyl glycol ester, γ-amino-β-hydroxy Butyric acid sorbitol ester, γ-amino-β-hydroxybutyric acid polyoxyethylene glycol ester, γ-amino-β-hydroxybutyric acid glycerin ester, etc.), amine oxides (oleyl dimethylamine oxide, stearyl dimethylamine oxide, palmityl dimethylamine oxide) , Myristyl dimethylamine oxide, lauryl dimethylamine oxide, dimethyl lauryl ethoxyamine oxide, dihydroxyethyl lauryl amine oxide, coconut oil alkyl dimethylamine oxide, etc.), alkyl betaines (coconut oil fatty acid amide propyl betaine, coconut oil alkyl betaine, lauryl dimethyl) Aminoacetic acid betaine, lauric acid amidopropyl betaine, lauryl hydroxysulfobetaine, 2-alkyl-N-carboxymethyl-N-hydroxy Cyethyl imidazolinium betaine), pyrimidine-N-oxide derivatives (2-amino-4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-6- (1-pyrrolidinyl) Pyrimidine-3-oxide, 2-amino-4-methyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-6- [1- (4-methylpiperazinyl)] pyrimidine-3- Oxide, 2-amino-4- (1-hexahydroazepinyl) -6-methylpyrimidine-1-oxide, 2-amino-4-dimethylamino-6-methylpyrimidine-1-oxide, 2-amino-4 -Allylamino-6-methylpyrimidine-1-oxide, 2-amino-4-benzylamino-6-methylpyrimidine-1-oxide, 2-amino-4,5-methyl-6-piperidinopyrimidine-3-oxide 2-amino-4-ethyl-6-morpholinopyrimidine-3-oxide, 2-amino-4-methyl-5-nitro-6-piperidinopyrimidine-3-oxy Sid, 2,5-diamino-4-methyl-6-piperidinopyrimidine-3-oxide, 2-amino-4-methyl-5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino -4-methyl-5-piperidino-6- (1-pyrrolidinyl) pyrimidine-3-oxide, 2-methyl-4-amino-6-piperidinopyrimidine-3-oxide, 2-methyl-4-amino-5 -Bromo-6- (1-pyrrolidinyl) pyrimidine-3-oxide, 2-methyl-4-amino-5-nitro-6-piperidinopyrimidine-3-oxide, 2-methyl-4,5-diamino-6 -Piperidinopyrimidine-3-oxide, 2-methyl-4-amino-5,6-bis (1-pyrrolidinyl) pyrimidine-3-oxide, 2-amino-4-methyl-6-piperidinopyrimidine-3 -Oxide monohydrochloride, 2-acetylamino-4-methyl-6-piperidinopyrimidine-3-oxide, 2,4-diamino-6-phenoxypyrimidine-3-oxide, 2,4-diamino-6- ( 2,4-dichloropheno C) Pyrimidine-3-oxide, 2,4-diamino-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitroso-6- (2,4-dichloro) Phenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro-6- (2,4,6-trichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-nitro-6- (2 , 4-Dichlorophenoxy) pyrimidine-3-oxide, 2,4,5-triamino-6- (2,4-dichlorophenoxy) pyrimidine-3-oxide, 2,4-diamino-5-bromo-6- (2 , 4-dichlorophenoxy) pyrimidine-3-oxide, etc.), p-menthane-3,8-diol, monoglyceryl-D-glucoside monotridecanoate, 1-oN-pentadecylglycero-D-glucoside, Glyceride sulfate such as monopentadecanoic acid glyceride sulfate, monopentadecyl glyceryl ether sulfate, 1-o-hexa Decyl-2-o-methylglycerin, 1-o-octadecyl-2-o-methylglycerin, 1-o-oleyl-2-o-methylglycerin, acetylcarnitine or its salt, geranylgeranylacetone, hydroxamic acid derivative or its salt , Gingerone glycosides, benzeneoxyacetic acid derivatives ([5- [2- [1-phenyl-1- (3-pyridyl) methylideneaminooxy] ethyl] -7,8-dihydronaphthalen-1-yloxy] acetic acid, etc. ), Isorhamnetin-3-robinobioside, xanthone derivatives, proanthocyanidins (grape seed extract proanthocyanidins, apple-derived proanthocyanidins, pine-derived proanthocyanidins, purified procyanidin oligomers, procyanidin B-2, procyanidins B-2, procyanidins B-3 , Procyanidin C-1 etc.), arakashi extract, angelica extract, apricot , Hong anzu extract, Ichiyakusou (one medicinal herb) extract, Enishida extract, psyllium (carlet child, car forerunner) extract, Psyllium extract Striped anteater extract, ginseng extract, scallop extract, cucumber nut extract, camphor extract, kubeba extract, buckthorn extract, oyster extract ) Extract, Sanekazura extract, Vinankazura extract, Matsubusa extract, Colombo extract, Condurango extract, Sasanqua extract, Sweet potato extract, Sanebutona Mei (acid soy sauce) extract, Sandskon (Yamazu-root) extract, Potato extract, Shishigashira extract, Sanshishi extract, Coriander extract, Stevia extract, Takatodai extract (Daisen) extract, Tarayo (Oba winter blue, Ichiha tea, bitter tea, bitter lantern Tea) extract, taranum extract, oyster tree extract, nullde (penta) extract, Hakama Labosi (bone crushing) extract, spider crab extract, scented squirrel extract, stag beetle extract, boxweed extract (rice plant) extract, lizard carrot ( Participant) extract, mangosteen extract, myoga extract, melaroika extract, jachabushi extract, himeya sabushi extract, oyabe sabushi extract, yakuso extract, yamanookiki (yamabeki) extract, longan (long-eye meat) extract, locon (reed, reed) extract, Logwood Ex And lantana extract.

Hair matrix growth inhibitor / hair growth inhibitor A hair matrix growth inhibitor / hair growth inhibitor may be added to the present invention. Specific examples of hair matrix growth inhibitor / hair growth inhibitor include phthalazinones, benzoxazinones, phosphonic acid derivatives, cyproterone, 5α-androstene-3α, 17β-diol, medroxyprogesterone, norethisterone, methanolone, and ichihatsu (First) extract, ash extract, kanto extract, sangiko extract, silamo extract, sardine extract, scabbard fern extract, fritillary extract, honeysuckle extract, seaweed extract, yoremok extract and the like.

Hair swelling agent / hair protecting agent A hair swelling agent / hair protecting agent can be added to the present invention. Specific examples of the hair swelling agent / hair protecting agent include ethanolamine, urea, guanidine, silicones, blueberry extract, mango extract and the like.

Odorous substance eliminating agent An odorous substance eliminating agent can be added to the present invention. Specific examples of the odorous substance eliminating agent include Inondo extract, Elemi extract, vanilla bins extract, pine extract and the like.

Other Additive Ingredients Specific examples of ingredients derived from plant-based materials used as additives to the present invention include Aokazura (Seifu Fuji) extract, Aotenma extract, Akasuguri extract, Aquine (crust) extract, Aguay Guasu extract, Abiyu extract, Abiurana extract, Yellow sapote extract, Ylang ylang extract, phalaenopsis extract, Uba tea extract, Ezo suzuran extract, Unboku extract, Elderberry extract, Ohisano Yuki extract, Sasa no Yuki extract, Toucan cactus extract, Omiya catechu extract, Onoelan extract, Crab extract, Karaya extract, Garyu extract, Kawaratake extract, Candelilla extract, Canna extract, Kidachi pepper extract, Kimenkaku extract, Cabb extract, Kiraja saponaria extract, Ginseca Extract, kimbsen extract, guapeba vermelha extract, kugenumaran extract, gooseberry extract, crity river extract, curcrigo latifolia extract, black moth (rescue) extract, cucumber extract, sapotea mariyo extract, salmon berry extract, salamander extract , Cactus Cactus Extract, Cranberry Extract, Shunran Extract, Shozuk Extract, Shirobanatsuta Extract, Cinchona Sacylbra Extract, Swimberry Extract, Star Apple Extract, Sulgaran (Oran) Extract, Scots Pine Extract, Plexus Japanese butterfly extract, mistletoe extract, sennin cactus extract, senboku extract, elephant shoot extract, prunus extract, somamonoimoe , Dark sweet cherry extract, prickly pear extract, chocolate nostay extract, ginseng extract, tsukusa kaneran extract, tsuchiakebi extract, duckweed extract, duberry extract, red squirrel extract, tragacanth extract, triacan Sos extract, Neiseria berry extract, Rapeseed extract, Plover-dough extract, Pau-dose extract, Hakuru berry extract, Batata extract, Hamakakiran extract, Balata extract, Harcan orchid extract, Pecan nut extract, Chicknut extract , Brazilian carrot extract, Branjen extract, Frucereria extract, Blond psyllium extract, Hetsukaran extract, Henken extract, Berry extract, Persea extract, Pervianburg extract, Perez Kia Grandifolia extract, Boysenberry extract, Hosairan extract, Pouteria sapota extract, Pouteria rukuma extract, Hosobabarengiku extract, Whataberry berry extract, Masaransuba extract, Masheira de Boyi extract, Matta auryo extract, Mulberry extract , Green sapote extract, purple corn extract, megacansa optica extract, mokukirin extract, maple leaf extract, morero cherry extract, yakawa potato extract, cornflower mint extract, rulitama thisami (urajiro higotai) extract, red currant extract, Examples include plant extracts such as red pitaya extract, wax palm extract, and logan berry extract.

  In addition, as specific examples of components derived from plant-based raw materials used as an additive to the present invention, Dunaliella genus Dunaliella extract, Kuwanomi genus Kuwanomimo extract, Volbox genus genus sunflower extract, Volbox genus Volbox extract, Palmera extract, Yotsumemo extract, Aomido genus Chrysanthemum extract, Vulgaris extract, Hibimidro spp. Genus Black Ivy Extract, Casanori Genus Casanori Extract, Mika Ichiki Extract, Collecaete Extract, Tsutsumi Mimo Extract, Duckweed Genus Duckweed Extract, Sayamidro Extract, Kunshomo Extract Green algae extract such as Sumiremo violet reed extract, Hosimidro extract, Fuchinasimidro extract Genus Isogawara extract, black moth genus black moth extract, mosquito genus mosquito extract, whip squirrel extract, scallop squirrel extract, squirrel squirrel squirrel extract, common squirrel genus extract, common squirrel genus genus Hiranamikurakura extract, Somerna spruce extract, Navarimo spruce extract, Chawomen spruce extract, Nagamatsu Genus Nagamatsumo extract, Niseft mozuku niseft mozuku extract, Futomozuku genus mozuku extract, Kuromo genus kuromo extract, Nisemo genus nisemozuku extract, Ichimegasa Ichimegasa extract, zelkova quail extract, Umibos genus Citrus genus Compositae extract, Haberomodo spp. Extract, genus Cyprus extract, genus genus genus extract, genus turmeric extract, genus chrome extract, chrysanthemum Brown algae extract such as Bucus spp. Milnobeni extract, Konahada spp. Sodegarami Sodegarami Extract, Hirohatamitaki Hirohatamitaki Extract, Tengusa Nambugusa Extract, Tengusa Kohira Extract, Tengusa Yohira Extract, Tengusa Kinukusa Extract, Billow hibishiro extract, Hibiro hibishiro extract, Rhizoma genus extract, Rhizome genus extract, Ryumon genus Ryumon extract, Ryumon genus Hera ryumon extract, Nisekarekigusa genus naruto Ganoderma spp. Centipede extract, Centipede spruce extract, Centipede spider extract, Centipede extract, Centipede extract, Centipede extract, Centipede extract Marubadara extract, Hiramitoki Hirakintoki extract, Matabouja Matabou extract, Kintoki Chabokintoki extract, Kintoki Kintoki extract, Kintoki Ginseng extract, Kintoki Tosaka pine extract, Kintoki Hamamatsu extract, Kintoki Fushikintoki extract, Kintoki Toki Tokiki extract Centipede extract, Kintoki spp., Kintoki sp. Pteridocarpus genus extract, Honoho genus Honoo extract, genus genus genus genus extract, genus genus Usuginu extract, Nikuhou Ganoderma genus extract, Venetian genus Venetianago extract, Suscabeni genus Suscabeni extract, Okamuragusa porcupine extract, Isomocca isomocca extract, Kizinogi genus extract, Isodantsu isodantsu extract, Atsunori genus Atsubanori extract, Ogonori genus Mizoogonori extract, Ogonori genus Beniogonori extract, Ogonori sp. Ogonori genus Ogonori extract, Ogonori genus tsutsuginu extract, Ogonori genus Ogonori extract, Ogonori Kubireogonori extract, Ogonori genus Mosaogonori extract, Ogonori genus Nukabanori extract, Namiiwatake spp. Goat's extract, Taogi's genus Hanasakura extract, Fukutsunagi genus Fukutsunagi extract, Fukutsunagi spp. , Benifukuronori genus Benifukuronori extract, Villus spp. Nori Egonori Extract, Egonori Futogigi Extract, Saeda Saeda Extract, Chirimomiji Chiri Momiji Extract, Habutaenori Extract, Coniferous Extract, Suzushironori Extract, Usbeni Usbeni Extract, Hasujiginu Hasujiginu Extract, Nagakonohigani Extract Genus Sugiginu extract, Sugiginu genus Atsubasjiginu extract, Heius banori Kagious banori extract, Heius banori genus Yaleus banori extract, haius banori genus Suus banori extract, haius banori genus euus banus extract, genus genus genus genus Ayanishiki extract, Ayaginu Ayaginu extract, Dadia Enashida extract, Shimadadia Isohagi extract, Shimadadia Shimadadia extract, Dajimodoki daji Modoki extract, Makuri genus extract, Hanegusa genus extract, Hanegusa genus extract, Kozanemo genus Kozanemo extract, Kozanemo genus Isomurasaki extract, Kozanemo genus Hozo moss extract, Himego genus Himegoke extract, Himego genus Kurohegoshi extract Hyodosig genus Hyodosigusa extract, Hyodosig genus Usubahiodoshi extract, Isomegusus genus Isomegusa extract, Suginassa genus Sugenashigusa extract, Isobasho genus Isobasho extract, Ideyugogome genus Yuukogome extract, Ochimomoku genus Ochichimokuzhizuzuri zukisuji Red algae extract, Shajikumo extract, Shiratamamo extract, Hoshitsurimo Hoshitsurimo extract, Rikunotamnusu extract, Flascus spp. , Axle algae extracts such as chabo flask extract and tripella extract, yellow algae extracts such as Hikarimo Hikarimo extract, and the like.

  Specific examples of ingredients derived from animal materials used as an additive to the present invention include chicken crown extract, cow, pig or human placenta extract, pig or cow stomach, duodenum, intestine, spleen extract or degradation product thereof, cow Or porcine brain tissue extract, water-soluble collagen, collagen derivatives such as acylated collagen, collagen hydrolyzate, elastin, elastin hydrolyzate, water-soluble elastin derivative, keratin and its degradation product or derivatives thereof, silk protein and Degradation products thereof or derivatives thereof, porcine or bovine blood cell protein degradation products (globin peptides), cattle or porcine hemoglobin degradation products (hemin, hematin, heme, protoheme, heme iron, etc.), milk, casein and degradation products thereof Derivatives thereof, skim milk powder and decomposition products thereof or derivatives thereof, lactoferrin or decomposition products thereof, egg component, fish meat Hydrolyzate, nucleic acid-related substance (ribonucleic acid, deoxyribonucleic acid), and the like.

  Specific examples of components derived from microbial raw materials used as additives for the present invention include yeast metabolites, yeast extract extracts, bacterial metabolites, bacterial extract extracts, metabolites such as fungi or mushrooms, actinomycetes metabolites, fungi Or extracts such as mushrooms, actinomycetes extract, natto metabolite, natto extract, rice fermented extract, rice bran (red rice cake, white birch) fermented extract, euglena extract or a decomposed product thereof, or their water-soluble derivatives, raw milk or defatted Examples include lactic acid fermented milk powder.

  Furthermore, any part, cell, tissue, organ, metabolite, etc. derived from a transgenic or cell fusion can be used as the plant, animal or microbial material. Furthermore, it is obtained by culturing cells of any site, cell, tissue, organ, etc., for example, cultured cells derived from each tissue (cultures derived from animals such as fibroblasts, Langerhans cells, macrophages, epidermal cells, hepatocytes, etc.) Cell etc.), undifferentiated cell group, cell group in the middle of differentiation, and their metabolites can also be used.

  Specific examples of ingredients of natural raw materials used as additives include inorganic salts (magnesium chloride, chloride) obtained from seawater such as deep seawater, for example, seawater salt, seawater dried product, Dead Sea or Atlantic Ocean or Pacific Ocean. Potassium etc.), sea mud or mud (Fango), for example, Italian mugo, German fungo, Eifel fungo, Freiburg fungo, etc. Sea mud or mud (containing components: silicon dioxide, titanium dioxide, aluminum oxide, iron oxide, Manganese oxide, sodium oxide, potassium oxide, magnesium oxide, calcium oxide, strontium oxide, sodium, potassium, magnesium, calcium, chromium, iron, copper, nickel, zinc, lead, manganese, arsenic, water), saintoku stone, natural smectite , Bentonite, hectorite and the like.

  Extracts derived from plant raw materials, animal raw materials, microbial raw materials, and other natural product raw materials used as additives are processed in a conventional manner according to the product type and form to be added (for example, pulverization, milling, Treatment, extraction, decomposition, fermentation or metabolic conversion by microorganisms, fractionation, purification, pressing, filtration, drying, pulverization, granulation, dissolution, sterilization, pH adjustment, deodorization, decolorization, etc. ) And arbitrarily select from various materials.

  The solvent used for the extraction may be selected in consideration of the intended purpose and type of the product to be provided, or the processing performed later. Usually, water, methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, isopropanol are used. Lower alcohol such as butanol or hydrous lower alcohol, propylene glycol, 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1, 3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, 1,2-hexanediol, 1,5-hexanediol, 1,6-hexanediol, pentylene glycol, hexylene glycol, Polyhydric alcohols such as glycerin and polyethylene glycol (molecular weight 100 to 100,000) or hydrous polyhydric alcohols, Various organic solvents such as seton, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene, chloroform, carbon tetrachloride, phenol, toluene, etc., and acids (hydrochloric acid, sulfuric acid, It is desirable to use one or a mixture of two or more selected from nitric acid, phosphoric acid, formic acid, acetic acid, etc.) and alkalis (sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonia, etc.). However, when it is not preferable to contain a solvent depending on the application, it is sufficient to use only water or ethanol that can be easily removed after extraction, and it may be used alone or in any mixture with water. It may be extracted after squeezing.

  Regarding the extraction method, the temperature of the solvent, the weight ratio of the solvent to the raw material, or the extraction time can be arbitrarily set for various raw materials and the solvent used. The temperature of the solvent can be arbitrarily set in the range of −4 ° C. to 100 ° C., but is preferably around 10 to 40 ° C. from the viewpoint of the stability of the components contained in the raw material. Further, the weight ratio of the solvent to the raw material can be arbitrarily set within the range of, for example, raw material: solvent 4: 1 to 1: 100, and a weight ratio of 1: 1 to 1:10 is particularly preferable.

  Decomposition mainly includes acid decomposition, alkali decomposition, enzyme decomposition, and high-temperature and high-pressure decomposition. In the decomposition with an acid, for example, it is preferable to use an inorganic acid or an organic acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, acetic acid, formic acid, oxalic acid, hydrogen bromide, perchloric acid, and periodic acid. In the decomposition by alkali, for example, sodium hydroxide, potassium hydroxide, calcium hydroxide, ammonium hydroxide, barium hydroxide, sodium carbonate, ammonium carbonate, calcium carbonate, magnesium hydroxide, sodium silicate, etc. are preferably used. In the decomposition with acid or alkali, the concentration, reaction time, reaction temperature, and the like can be arbitrarily set for the target raw material. In the enzymatic degradation, it is preferable to use an enzyme having a function of degrading proteins, polysaccharides, lipids or complexes thereof having an important function particularly with respect to cell structure, tissue structure, etc., for example, aminopeptidase, dipeptidase, dipeptide Peptidyl peptidase, tripeptidyl peptidase, carboxypeptidase, serine protease, trypsin, chymotrypsin, cysteine protease, thiol protease, papain, aspartate endopeptidase, metalloendopeptidase, bromelain, thermolysin, pronase, pepsin, rennin, pan Proteolytic enzymes (proteases) such as creatine, chymopapain, ficin, collagenase, elastase, amylase, takaamylase, cellulase, hemicellular Polysaccharide-degrading enzymes such as zectin, pectinase, polygalacturonase, dextranase, and planase, chicken egg white lysozyme, human lysozyme, papaya lysozyme, cabra lysozyme, barley lysozyme, zymolyce, lysozyme chloride, glucanase, chitinase Cell wall lytic enzymes such as In the degradation with an enzyme, the concentration, reaction time, reaction temperature, pH of the solution, etc. can be set arbitrarily, but it is particularly preferable to set the optimum value for the enzyme used.

  Fermentation or metabolic conversion by microorganisms can be performed by inoculating and growing at least one kind of microorganism on a raw material used as a substrate. Inoculation of microorganisms to the substrate can be done by adding microorganisms directly into the substrate, or by adsorbing them on a carrier such as alginic acid, polyvinyl, gelatin, etc., for example, in the form of fine beads composed of microorganisms and carrier. Further, it can be used by being fixed to the tube wall of the bioreactor. Fermentation or metabolic conversion by microorganisms is not particularly defined as a microorganism to be used, but can generally be defined as microorganisms other than pathogenic microorganisms that exhibit significant toxicity to living bodies. Examples of microorganisms to be used include microorganisms classified into yeasts: Aciculoconidium, Actonia, Aessosporon, Ambrosiozyma, Anthomyces, Apiotrichum, Arthroascus, Arxula, Ashbia, Ashbya, Asporomyces, Atelosaccharomyces Genus, Azymoprocandida, Babjevia, Ballistosporomyces, Bensingtonia, Blastobotrys, Blastodendrion, Blastoderma, Blastoschizomyces, Botryoascus, Botryozyma, Brettanomyces, Brettanomyces bruno Genus (Candida albicans, Candida amylolenta, Candida anomala, Candida boidinii, Candida entomaea, Candida etchellsii, Candida famata, Candida fermentati, Candida guilliermondii, Candida halophila, Candida krusei, Candida krusei, Candida krusei, Candida krusei, Candida krusei, Candida krusei Candida sake, Candida tropicalis, Candida versatilis, Candida vulgaris, etc.), Ca Stellania genus, Chlamydozyma genus, Chromotorula genus, Citeromyces genus, Cladosporium genus, Clavispora genus, Crebrothecium genus, Cryptococcus genus, Debaryomyces genus (Debaryomyces delbrueckii, Debaryomyces halotolerans, Debaryomyces hansenii genus, Debarymyces hansenii etc. Dipodascus, Eeniella, Endomyces, Endomycopsis, Eremascus, Eremothecium, Eutorulopsis, Fabospora, Fellomyces, Filobasidium, Galactomyces, Geotrichoides, Geotrichum, Guilliersen, Genus anomala, Hansenula kluyveri, Hansenula miso, Hansenula polymorpha, Hansenula wickerhamii, etc., Hypomyces, Issatchenkia, Kloeckera (Kloeckera brevis, Kloeckera fluoresceny, Kloeckera japonica, etc.) Etc.), Kockovaella genus, Kurtzmanomyces genus, Leucosporidium genus, Lipomy genus ces, Metschnikowia, Microanthomyces, Monilia, Monospora, Monosporella, Mrakia, Myceloblastanon, Mycocandida, Mycoderma, Mycotorula, Mycotoruloides, Myxozyma, Nadsonia, Nectaromyces, Nematospora , Ogataea, Oidium, Oospora, Oosporidium, Ochyporidium, Pachysolen, Parasaccharomyces, Paratorulopsis, Parendomyces, Petasopsora, Pichia , Procandida genus, Procandida genus, Proteomyces genus, Pseudomonilia genus, Pseudosaccharomyces genus, Pseudozyma genus, Rhodomyces genus, Rhodosporidium genus, Rhodotorula genus, Saccharomyces genus (Saccharomyces aceti, Saccharomyces cerasiy, , Genus Saccharomycodes, genus Saccharomycopsis, genus Saturnispora, genus Schizoblastosporion, Schizosaccha sp. Udeniomyces genus, Waltomyces genus, William genus, Willopsis genus, Wingea genus, Xanthophyllomyces genus, Yamadazyma genus, Zendera genus, Zygofabospora genus, Zygopichia genus, Zygosaccharomyces genus, Zymodebaryomyces genus and the like. Microorganisms classified as bacteria include Acetobacter genus (Acetobacter aceti, etc.), Achromobacter genus, Acidianus genus, Acidobacterium genus, Acidithiobacillus genus, Acrocarpospora genus, Actinoalloteichus genus, Actinocorallia genus, Actinokineospora genus, Actinomadspura genus, Actinomadspura Actinosynnema genus, Aerococcus genus, Aeromicrobium genus, Agrobacterium genus, Agromyces genus, Ahrensia genus, Alcaligenes genus, Alicyclobacillus genus, Alloiococcus spp. , Aureobacterium genus, Azotobacter genus, Bacillus genus (Bacillus brevis, Bacillus subtilis etc.), Bacteroides genus, Beneckea genus, Bifidobacterium genus (Bifidobacterium bifidum, Bifidobacterium longum, Bifidobacterium breve, Bifidobacterium infantis etc.), Brachybacterium genus, Brevicillus, Brevundimonas, Burkholderia, Carnobacterium, Catellat genus ospora, Cellulomonas, Chainia, Chromobacterium, Chryseobacterium, Citrobacter, Clavibacter, Corynebacterium, Couchioplanes, Cryptosporangium, Curtobacterium, Dactylosporangium, Deinococcus, Delftia, Dermatia, Dermatia , Elytrosporangium, Enterobacter, Erwinia, Escherichia, Eubacterium, Excellospora, Exiguobacterium, Faenia, Flammeovirga, Flavobacterium, Flexibacter, Geodermatophilus, Globicatella, Gluconacetobaceto, Gluconacetobacter Genus, Gordonia, Halobacterium, Halococcus, Herbidospora, Hydrogenophilus, Hyphomicrobium, Hyphomonas, Intrasporangium, Janibacter, Jonesia, Kibdelosporangium, Kineopocusato, Kitasposatos, Kitasposatos, Kitasposatos Klebsiella, Kocuria, Kurthia, Lactobacillus (Lactobacillus rimae, Lactobacillus dive rgens, Lactobacillus carnis, Lactobacillus piscicola, Lactobacillus acidophilus, Lactobacillus amylophilus, Lactobacillus animalis, Lactobacillus brevis, Lactobacillus casei, Lactobacillus curvatus, Lactobacillus bulgaricus, Lactobacillus delbrueckii, Lactobacillus fermentum, Lactobacillus fructivorans, Lactobacillus fructosus, Lactobacillus helveticus, Lactobacillus hilgardii, Lactobacillus homohiochii, Lactobacillus kefiri, Lactobacillus malefermentans, Lactobacillus murinus, Lactobacillus paracasei, Lactobacillus paracasei subsp. tolerans, Lactobacillus parakefiri, Lactobacillus pentosus, Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus, Lactobacillus sakei, Lactobacillus confusus, Lactobacillus viridescens, Lactobacillus johnsonii, Lactobacillus viscosus, Lactobacillus fermentatae , Lactobacillus acidophil-aerogenes, Lactobacillus leichmannii, Lactobacillus gasseri, Lactobacillus bifidus, Lactobacillus jugurt, Lactobacillu s caucasicus, Lactobacillus arabinosus, Lactobacillus kunkeei, Lactobacillus nagelii, Lactobacillus fornicalis, Lactobacillus pentoaceticus, Lactobacillus xylosus, Lactobacillus minutus, etc.), Leuconostoc genus (Leuconostoc lactis, Leuconostoc dextranicum, Leuconostoc mesenteroides, Leuconostoc oenos, Leuconostoc paramesenteroides, Leuconostoc cremoris, Leuconostoc citrovorum, etc. ), Listonella, Lucibacterium, Luteococcus, Magnetospirillum, Marinilabilia, Marinospirillum, Mesorhizobium, Metallosphaera, Methylobacterium, Microbispora, Micrococcus, Microellobosporia, Micromonospora, Mycobacterium, Nocoides, Nocoides, Cardio, Genus, Nonomuraea, Nonomuria, Oceanospirillum, Ochrobactrum, Oerskovia, Oligella, Paenibacillus, Pediococcus (Pediococcus cerevisiae, Pediococcus pentosaceus, Pediococcus urinae-octocus, genus Pedococcus Genus, Pimelobacter sp Rhodococcus sp , Streptococcus faecalis, Streptococcus faecium, Streptococcus bovis, Streptococcus equinus, Streptococcus mutans, Streptococcus salivarius, Streptococcus thermophilus, Streptococcus agalactiae, Streptococcus mitis, Streptococcus pyogenes, Streptococcus pneumoniae, Streptococcus lactis, Streptococcus dysgalactiae, Streptococcus sanguis, Streptococcus acidominimus, Streptoco ccus avium, Streptococcus uberis, Streptococcus cremoris, Streptococcus diacetilactis, etc.), Streptomyces genus, Streptosporangium genus, Streptoverticillium genus, Terrabacter genus, Thermoactifinos genus, Thermobiso genus, Thermobimo genus Examples include the genus Thiosphaera, the genus Weissella, the genus Xanthobacter, the genus Xanthomonas, and the genus Zymomonas. Microorganisms classified as non-yeast ascomycetes, basidiomycetes or incomplete fungi include Allomyces, Amoebidium, Amorphotheca, Arthroderma, Ascoidea, Ascobolus, Ascodesmis, Aspergillus, Aureobasidium, Botryosphaeria Botryotinia sp Genus, Dothidea genus, Endogone genus, Entomophthora genus, Emericella genus, Eupenicillium genus, Eurotium genus, Exobasidium genus, Gibberella genus, Glomus genus, Graphiola genus, Gymnoascus genus, Harpella genus, Helicomyces genus, Helvella genus, Hemicarpenteles genus, Hyphochytrium genus, Hyphochytrium Hypocrea, Laboulbenia, Labyrinthula, Leptosphaeria, Leptosphaerulina, Lophodermium, Melanotaenium, Microascus, Microstroma, Medeololaria, Melampsora , Melamsporella, Morchella, Monascus, Monilinia, Mycospharella, Nannizzia, Nectria, Neolecta, Neurospora, Nodulosphaeria, Olpidium, Peziza, Penicillium, Perenospora, Pestopolisis Genus, Pneumocystis genus, Preussia genus, Pleospora genus, Puccinia genus, Pythium genus, Ravenelia genus, Rickia genus, Rhinocladiella genus, Rhizidiomyces genus, Rhizoctonia genus, Sclerocleista genus, Saprolegnia genus, Sclerotinia genus, Sclerotum genus, Septobasidium genus, Septobasidium genus Examples include Sporidiobolus genus, Stigmatomyces genus, Sydowiella genus, Talaromyces genus, Taphrina genus, Thraustochytrium genus, Tolyposporium genus, Trichoglossum genus, Trichoma genus, Ustilago genus, Verticillium genus, Xylaria genus and the like.

  In fermentation or metabolic conversion by microorganisms, in addition to various raw materials such as plant-based materials, animal-based materials, and other natural product-based materials, the growth and metabolism of microorganisms are regulated or activated, and special biosynthesis or degradation pathways are induced. In order to achieve this, various compounds can be added to the raw material. For example, as a carbon source, sugar, ethane such as glucose, fructose, galactose, sucrose, maltose, mannose, lactose, glycerin, starch, etc. , Hydrocarbons such as methane, propane, butane, formic acid, acetic acid, propionic acid, lauric acid, palmitic acid, fatty acids such as oleic acid, linoleic acid, linolenic acid, etc., nitrogen sources such as ammonium sulfate, ammonium hydrochloride, ammonium phosphate, etc. Ammonium salts, urea, uric acid, amino acids, etc. Vitamins and compounds containing potassium, calcium, magnesium, sodium, sulfur, phosphorus, chlorine, etc., as well as iron, copper, zinc, cobalt, nickel, boron, manganese, molybdenum, tin, selenium, silicon It is possible to further add compounds contained in the composition such as arsenic, vanadium, chromium and fluorine. In addition, the optimum temperature, oxygen supply amount, pH, pressure, etc. that affect the growth and metabolic activities of various microorganisms can be arbitrarily set according to the characteristics inherent to various microorganisms. Can be arbitrarily set within the range of 10 to 50 ° C., and the pH can be arbitrarily set within the range of 1 to 14.

  In fractionation or purification, generally known techniques can be used as appropriate. In addition to solvent extraction, for example, liquid chromatography (ion exchange chromatography, ion exclusion chromatography, affinity chromatography, gel filtration chromatography, size exclusion chromatography, etc.). Chromatography, hydrophilic adsorption chromatography, hydrophobic adsorption chromatography, ligand exchange chromatography, etc.) fractionation using a single column or multiple columns, dialysis with semipermeable membranes, crystallization and recrystallization of components. Examples thereof include crystallization, filter paper, membrane filter, ultrafilter, filtration using activated carbon, filter aid, etc., centrifugal separation and its application, fractional precipitation method, density gradient separation method such as density gradient sedimentation equilibrium method, and the like.

Specific examples of other components other than the above used as additives in the present invention include silicic anhydride, magnesium silicate, talc, kaolin, bentonite, hectorite, natural or synthetic smectite, stevensite, mica, mica titanium, oxy Inorganic pigments such as bismuth chloride, zirconium oxide, magnesium oxide, zinc oxide, titanium oxide, calcium carbonate, magnesium carbonate, yellow iron oxide, bengara, black iron oxide, gunjou, chromium oxide, chromium hydroxide, carbon black, calamine, Hydrogen peroxide solution, sodium persulfate, ammonium persulfate, sodium perborate, urea peroxide, sodium percarbonate, sodium tripolyphosphate, sodium bromate, potassium bromate, sodium pyrophosphate, sodium orthophosphate , Silicic acid Thorium hydrogen peroxide adduct, sodium sulfate hydrogen peroxide adduct, sodium chloride hydrogen peroxide adduct, β-tyrosinase enzyme solution, mushroom extract, strontium sulfate, sodium sulfide, barium sulfide, calcium sulfide and other inorganic reducing agents , Redox agents such as thioglycolic acid or its salts (calcium thioglycolate, sodium thioglycolate, lithium thioglycolate, magnesium thioglycolate, strontium thioglycolate), 5-aminoorthocresol, 2-amino-4 -Nitrophenol, 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, 2,4-diaminophenoxyethanol hydrochloride, 2,4-diaminophenol hydrochloride, toluene hydrochloride -2,5-diamine, nitroparaphenylenedia hydrochloride , Paraphenylenediamine hydrochloride, N-phenylparaphenylenediamine hydrochloride, metaphenylenediamine hydrochloride, orthoaminophenol, N-phenylparaphenylenediamine acetate, 1,4-diaminoanthraquinone, 2,6-diaminopyridine, 1,5- Dihydroxynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, nitroparaphenylenediamine, paraaminophenol, paranitroorthophenylenediamine, paraphenylenediamine, paramethylaminophenol, picramic acid, sodium picrate, N , N′-bis (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, 5- (2-hydroxyethylamino) -2-methylphenol, N-phenylparaphenylenediamine, metaaminophenol, Metaphenylenediamine, 5-aminoorthocreso sulfate 2-amino-5-nitrophenol sulfate, orthoaminophenol sulfate, orthochloroparaphenylenediamine sulfate, 4,4'-diaminodiphenylamine sulfate, 2,4-diaminophenol sulfate, toluene-2,5-diamine sulfate, Nitroparaphenylenediamine sulfate, paraaminophenol sulfate, paranitroorthophenylenediamine sulfate, paranitrometaphenylenediamine sulfate, paraphenylenediamine sulfate, paramethylaminophenol sulfate, metaaminophenol sulfate, metaphenylenediamine, catechol, diphenylamine, α -Naturol, hydroquinone, phloroglucin, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzene-5'-sodium sulfonate, dyes such as hematein, natural materials such as musk, civet, castrium, ambergris Animal flavors, anise essential oil, angelica essential oil, ylang ylang essential oil, iris essential oil, fennel essential oil, orange essential oil, cananga essential oil, caraway essential oil, cardamom essential oil, guaiac wood essential oil, cumin essential oil, black letter essential oil, cinnamon essential oil, geranium essential oil, copaiba balsam Essential oil, Koreanel essential oil, Perilla essential oil, Cedarwood essential oil, Citronella essential oil, Jasmine essential oil, Gingergrass essential oil, Cedar essential oil, Spearmint essential oil, Western peppermint essential oil, Otsuka perfume essential oil, Cube rose essential oil, Clove essential oil, Orange flower essential oil, Winter green essential oil, Truval Sam Essential Oil, Baturi Essential Oil, Rose Essential Oil, Palmarosa Essential Oil, Crude Essential Oil, Hiba Essential Oil, Sandalwood Essential Oil, Petit Glen Essential Oil, Bay Essential Oil, Bechiba Essential Oil, Bergamot Essential Oil, Peruvian Sam Essential Oil, Boadrose Essential Oil, Mango Essential Oil, Mandarin Essential Oil, Eucalyptus Essential Oil Lime essential oil, lavender essential oil, Linaroe essential oil, lemon essential oil, rosemary essential oil, vegetable flavors such as Japanese mint mint essential oil, other synthetic flavors, 5-amino-o-cresol, o-aminophenol, m-aminophenol , P-aminophenol, 2,6-diaminopyridine, 5- (2-hydroxylethylamino) -2-methylphenol, N, N-bis (β-hydroxyl) -p-phenylenediamine sulfate, N, N- Bis (2-hydroxyethyl) -p-phenylenediamine, p-nitro-o-phenylenediamine, p-phenylenediamine, m-phenylenediamine, N-phenyl-p-phenylenediamine, 2-hydroxy-5-nitro-2 ', 4'-diaminoazobenzenesulfate sodium, toluene-2,5-diamine, 2- (2'-hydroxyethylamino) -5-aminotoluene, N, N-bis (β-hydroxyl) -p-phenylenediamine, N, N-Bis 2-hydroxyethyl) -p-phenylenediamine sulfate, 5-amino-o-cresol sulfate, p-aminophenol sulfate, o-chloro-p-phenylenediamine sulfate, 2- (2'-hydroxyethylamino) ) -5-aminotoluene sulfate, 4,4'-diaminodiphenylamine sulfate, p-methylaminophenol sulfate, p-phenylenediamine sulfate, m-phenylenediamine sulfate, toluene-2,5-diamine sulfate 2,4-diaminophenoxyethanol hydrochloride, toluene-2,5-diamine hydrochloride, m-phenylenediamine hydrochloride, 2,4-diaminophenol hydrochloride, 3,3'-iminodiphenol, p-phenylenediamine hydrochloride Salt, N-phenyl-p-phenylenediamine hydrochloride, N-phenyl-p-phenylenediamine acetate, 1,5-dihydroxynaphthalene, toluene-3,4-diamine, p-methylaminophenol, N, N'- Screw (4-aminophenyl) -2,5-diamino-1,4-quinonediimine, o-aminophenol sulfate, 2,4-diaminophenol sulfate, m-aminophenol sulfate, 2-amino-4-nitrophenol , 2-amino-5-nitrophenol, 1-amino-4-methylaminoanthraquinone, nitro-p-phenylenediamine hydrochloride, 1,4-diaminoanthraquinone, nitro-p-phenylenediamine, picramic acid, sodium picrate 2-Amino-5-nitrophenol sulfate, resorcinol, nitro-p-phenylenediamine sulfate, p-nitro-o-phenylenediamine sulfate, p-nitro-m-phenylenediamine sulfate, Red No. 2, Red 3 No., Red No. 102, Red No. 104 (1), Red No. 105 (1), Red No. 106, Red No. 201, Red No. 227, Red No. 230 (1), Red No. 230 (2), Red No.231, Red No.232, Red No.401, Red No.502, Color 503, Red 504, Red 506, Yellow 4, Yellow 5, Yellow 202 (1), Yellow 202 (2), Yellow 203, Yellow 402, Yellow 403 (1 ), Yellow 406, yellow 407, orange 205, orange 207, orange 402, green 3, green 204, green 205, green 401, green 402, brown 201, purple 401, Blue No. 1, Blue No. 2, Blue No. 202, Blue No. 203, Blue No. 205, Black No. 401, Red Cabbage Dye, Red Shrimp Dye, Catechol Tannin, Red Rice Dye, Akane Dye, Anato Dye, Squid Dye, Turmeric Dye , Enju pigment, Krill pigment, Amber pigment, Caramel, Gold, Silver, Gardenia pigment, Corn pigment, Onion pigment, Tamarind pigment, Spirulina pigment, Cherry pigment, Nori pigment, Hibiscus pigment, Grape juice pigment, Grape skin pigment, Marigold Pigment, purple potato pigment, purple yam pigment, lac pigment, rutin Pigments and colorants, avocado oil, almond oil, fennel oil, sesame oil, olive oil, orange oil, orange rafa oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, beef tallow fatty acid, cucumber nut oil, safflower Oil, shea fat, liquid shea fat, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, owl, Oils and fats such as coconut oil, beef tallow, pork fat and hydrogenated products (hardened oil etc.) of these fats, beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice Waxes such as wax, squalene, squalane, pristane, liquid paraffin, petroleum jelly Mineral oils such as paraffin, ozokelide, ceresin, and microcristan wax, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, linoleic acid, linolenic acid, docosahexaenoic acid, eicosapentaenoic acid, 12-hydroxystearic acid , Natural fatty acids such as undecylenic acid, tall oil, lanolin fatty acid, fatty acids such as isononanoic acid, caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-methylpentanoic acid, 2-ethylhexanoic acid, isopentanoic acid, and other synthetic fatty acids , Ethanol, isopyropanol, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, lanolin alcohol, cholesterol, phytosterol, phenoxyethanol, and other natural alcohols, 2-hexyldecanol, isostere Alcohols such as allyl alcohol and synthetic alcohols such as 2-octyldodecanol, isopropyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, oleyl oleate, decyl oleate, octyldodecyl myristate, Hexyldecyl dimethyloctanoate, diisobutyl adipate, 2-hexyldecyl adipate, diheptylundecyl adipate, N-alkyl glycol monoisostearate, isocetyl isostearate, trimethylolpropane triisostearate, ethylene glycol diethylhexanoate, diethylhexane Neopentyl glycol acid, cetyl 2-ethylhexanoate, trimethylolpropane triethylhexanoate, penicyl tetraethylhexanoate Erythritol, cetyl octanoate, octyldodecyl gum, cetyl lactate, myristyl lactate, diethyl phthalate, dibutyl phthalate, lanolin acetate, ethylene glycol monostearate, propylene glycol monostearate, propylene glycol dioleate, stearic acid Metal soaps such as aluminum, magnesium stearate, zinc stearate, calcium stearate, zinc palmitate, magnesium myristate, zinc laurate, zinc undecylenate, anionic surfactants (alkyl carboxylates, alkylsulfonates, alkyls) Sulfate ester, alkyl phosphate ester salt), alkyl sulfate ester salt (sodium lauryl sulfate, potassium lauryl sulfate, triethanolamine lauryl sulfate) , Ammonium lauryl sulfate, sodium cetyl sulfate, sodium stearyl sulfate, etc., secondary alcohol sulfate, alkyl ether sulfate (eg, polyoxyethylene lauryl sulfate triethanolamine, polyoxyethylene sodium lauryl sulfate), alkyl and alkyl Allyl ether sulfate (N-acylmethylalanine, N-acylglutamate, N-acylmethyltaurine, N-acylisethionate, N-acylglycine, alkylphosphate, alkylethercarboxylate, alkyl Sulfonates, alkylsulfosuccinates, polyoxyethylene lauryl ether sodium sulfate, polyoxyethylene lauryl ether triethanolamine, polyoxyethylene lauryl ether ammonium sulfate Sodium, polyoxyethylene alkyl ether sulfate sodium, polyoxyethylene alkyl ether sulfate triethanolamine, polyoxyethylene alkyl ether sulfate diethanolamine, polyoxyethylene alkyl ether sulfate ammonium, etc.), higher fatty acid alkylolamide sulfate, higher fatty acid ester sulfate Ester salts (hardened coconut oil fatty acid sodium glyceryl sulfate, etc.), polyoxyethylene alkyl ether carboxylic acids, polyoxyethylene alkyl allyl ether carboxylates, sulfated castor oils, mono or dialkyl or alkenyl phosphate ester salts Polyoxyethylene mono or dialkyl or alkenyl phosphate esters (sodium monolauryl phosphate, sodium isostearyl phosphate, 2- Shirudeshirurin acid arginine, potassium 2-heptyl undecyl phosphoric acid, Po
Reoxyethylene (4-10) sodium lauryl ether phosphate, sodium monocetyl phosphate, arginine monomyristyl phosphate, sodium monooleyl phosphate, polyoxyethylene (2-10) potassium lauryl ether phosphate, sodium dioctyl phosphate, etc.) , Phosphoric acid ester salt of polyoxyethylene alkyl ether (polyoxyethylene lauryl ether phosphoric acid, polyoxyethylene oleyl ether phosphoric acid, polyoxyethylene cetyl ether phosphoric acid, polyoxyethylene stearyl ether phosphoric acid, polyoxyethylene alkyl ether phosphorous Acid, polyoxyethylene alkylphenyl ether phosphoric acid, etc.), sulfonate of higher fatty acid amide or sulfonate of higher fatty acid ester (α-olefin sulfonate, N-myristoyl-N -Methyl taurine sodium, coconut oil fatty acid methyl taurine sodium, lauroyl methyl taurine sodium, etc., alkylbenzene sulfonate (dodecylbenzenesulfonic acid, dodecylbenzenesulfonic acid monoethanolamine, dodecylbenzenesulfonic acid diethanolamine, dodecylbenzenesulfonic acid triethanolamine) , Sodium dodecylbenzenesulfonate, etc.), sulfosuccinate (sodium diethylhexylsulfosuccinate, sodium sulfosuccinate, disodium lauryl sulfosuccinate, disodium polyoxyethylene sulfosuccinate, disodium lauryl polyoxyethylene sulfosuccinate, polyoxysulfosuccinate polyoxy Ethylene lauroyl ethanolamide ester disodium, undecylenoyl Midoethyl sulfosuccinate disodium, monolauroyl monoethanolamide polyoxyethylene sodium sulfosuccinate, sodium lauryl polypropylene glycol sulfosuccinate, etc.), N-acyl sarcosine salts (such as sodium lauroyl sarcosine, palmitoyl sarcosine sodium), condensation of higher fatty acids and amino acids (N-acyl glutamate, sodium N-stearoyl glutamate, potassium N-palmitoyl glutamate, sodium N-lauroyl-L-glutamate, disodium N-stearoyl-L-glutamate, N-myristoyl-sodium L-glutamate, myristoyl methyl Taurine sodium, palmitoylmethyl taurine sodium, stearoylmethyl taurine sodium, N-palmitoyl-β-alanine arginine, N- Anionic surfactants such as fatty acid soaps such as palmitoyl aspartate ditriethanolamine), oleate, suarenate, laurate, palmitate, etc. (for example, sodium salts, Alkali metal salts such as potassium salts, monoethanolamine salts, diethanolamine salts, triethanolamine salts, organic ammonium salts such as L-lysine salts and L-arginine salts, ammonium salts, etc.), quaternary ammonium salts ( Alkyl trimethyl ammonium chloride, cetyl ammonium chloride, cetyl ammonium bromide, lauryl ammonium chloride, lauryl ammonium bromide, stearyl ammonium chloride, stearyl ammonium bromide, cetyl dimethyl ammonium chloride, cetyl dimethyl ammonium bromide, salt Lauryl dimethyl ammonium, stearyl dimethyl ammonium chloride, lauryl trimethyl ammonium chloride, lauryl trimethyl ammonium bromide, stearyl dimethyl cetyl ditallow dimethyl ammonium chloride, dicetyl ammonium chloride, dicetyl ammonium bromide, dilauryl ammonium chloride, dilauryl ammonium bromide , Distearylammonium chloride, distearylammonium bromide, dicetylmethylammonium chloride, dicetylmethylammonium bromide, dilaurylmethylammonium chloride, dilaurylmethylammonium bromide, distearylmethylammonium chloride, distearylmethylammonium bromide , Cetyltrimethylammonium chloride, cetyltrimethylammonium bromide, stearyltrimethylammonium chloride Nitrogen, stearyltrimethylammonium bromide, lauryltrimethylammonium bromide, dialkyldimethylammonium chloride, dicetyldimethylammonium chloride, distearyldimethylammonium chloride, dicocoyldimethylammonium chloride, myristyldimethylbenzylammonium chloride, stearyldimethylbenzylammonium chloride, ethyl Lanolin sulfate fatty acid aminopropylethyldimethylammonium chloride, cetyltrimethylammonium chloride, stearyltrimethylammonium chloride, behenyltrimethylammonium chloride, behenyldimethylhydroxyethylammonium chloride, stearyldimethylbenzylammonium chloride, distearyldimethylammonium chloride, distearoylethylhydroxyethylmonium Sulfate, dicocoylethylhydroxyethylmonium metasulfate, dipalmitoylethylhydroxyethylmonium metasulfate, and cetyltriethylammonium methylsulfate, alkyltrimethylammonium chloride, alkyldimethylbenzylammonium chloride, dialkyldimethylammonium chloride, alkyltrimethylammonium bromide, chloride Alkylpentaethoxyammonium, ditallowdimethylammonium chloride, ditallowdimethylammonium methylsulfate, ditallowdipropylammonium phosphate, ditallowdimethylammonium nitrate, di (coconutalkyl) dimethylammonium chloride, di (coconutalkyl) dimethylammonium bromide, coconut Ammonium chloride, steer Amidopropyl chloride PG-dimonium phosphate, stearamide propyl ethyl dimonium esulphate, stearamide propyl dimethyl (myristyl acetate) ammonium chloride, stearamide propyl dimethyl cetearyl ammonium tosylate, stearamide propyl dimethyl ammonium chloride, Stearamidopropyldimethylammonium lactate, lanolin ethylsulfate fatty acid aminopropylethyldimethylammonium, cationized cellulose, acyldiethylaminoethylamide, acyldimethylaminopropylamide, polyoxyethylene fatty acid amide, myristyldimethylamine oxide, N-lauryldimethylaminoacetic acid Betaine, N-myristyldimethylaminoacetic acid betaine, N-stearyldimethylaminoacetic acid betaine Bis) fatty acid ester salts (hydroxypropyl-bis-lauramide amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-myristate amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis- Amidopropyl palmitate-N, N-dimethylammonium chloride, hydroxypropyl-bis-amidopropyl stearate-N, N-dimethylammonium chloride, hydroxypropyl-bis-behenic acid amidopropyl-N, N-dimethylammonium chloride, hydroxy Propyl-bis-oleic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-isostearic acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amide propylene -N, N-dimethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis-tallow fatty acid amidopropyl-N, N-dimethylammonium chloride, hydroxypropyl-bis- Amidoethyl laurate-N, N-diethylammonium chloride, hydroxypropyl-bis-myristate amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-amidoethyl palmitate-N, N-diethylammonium chloride, hydroxypropyl-bis -Stearic acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-behenic acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-oleic acid amidoethyl ammonium Muchloride, hydroxypropyl-bis-isostearic acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidoethyl-N, N-diethyl Ammonium chloride, hydroxypropyl-bis-tallow fatty acid amidoethyl-N, N-diethylammonium chloride, hydroxypropyl-bis-lauramidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-myristate amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palmitic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-stearic acid amidopropyl-N, N-diethylammoni Muchloride, hydroxypropyl-bis-behenic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-oleic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-isostearic acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-coconut fatty acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-palm fatty acid amidopropyl-N, N-diethylammonium chloride, hydroxypropyl-bis-tallow fatty acid amide Propyl-N, N-diethylammonium chloride, etc.), stearamidepropyl PG-dimonium chloride phosphate, behenamidopropyl PG dimonium chloride, stearamidepropylethyldimonium ethosulphate Cationic surfactants such as stearamidepropyldimethyl (myristyl acetate) ammonium chloride, stearamidepropyldimethylcetearylammonium tosylate, stearamidepropyldimethylammonium chloride, stearamidepropyldimethylammonium lactate, glycerin fatty acid ester (Glyceryl monoundecylenate, glyceryl diundecylenate, glyceryl monomyristate, glyceryl dimyristate, glyceryl monopalmitate, glyceryl dipalmitate, glyceryl monostearate, glyceryl distearate, glyceryl monooleate, mono-cotton oil fatty acid glycerin, Glycerol monoerucate, glyceryl sesquioleate, glyceryl monostearate, α, α'-oleic acid pyroglutami Glyceryl acid, glyceryl monostearate, malic acid, etc.), polyglyceryl fatty acid ester (diglyceryl monomyristate, diglyceryl dimyristate, diglyceryl trimyristate, diglyceryl monopalmitate, diglyceryl dipalmitate, tripalmitic acid Diglyceryl, diglyceryl monostearate, diglyceryl distearate, diglyceryl tristearate, diglyceryl monooleate, diglyceryl dioleate, diglyceryl trioleate, tetraglyceryl monopalmitate, tetraglyceryl dipalmitate, tri Tetraglyceryl palmitate, tetraglyceryl tetrapalmitate, tetraglyceryl pentapalmitate, tetraglyceryl monostearate, tetraglyceryl distearate , Tetraglyceryl tristearate, tetraglyceryl tetrastearate, tetraglyceryl pentastearate, tetraglyceryl monooleate, tetraglyceryl dioleate, tetraglyceryl trioleate, tetraglyceryl tetraoleate, tetraglyceryl pentaoleate, monopalmitin Hexaglyceryl acid, hexaglyceryl dipalmitate, hexaglyceryl tripalmitate, hexaglyceryl tetrapalmitate, hexaglyceryl pentapalmitate, hexaglyceryl monostearate, hexaglyceryl distearate, hexaglyceryl tristearate, hexaglyceryl tetrastearate , Hexaglyceryl pentastearate, Hexaglyceryl monooleate, Dioleic acid hexag Lyseryl, hexaglyceryl trioleate, hexaglyceryl tetraoleate, hexaglyceryl pentaoleate, decaglyceryl monopalmitate, dipalmi
Decaglyceryl tin, decaglyceryl tripalmitate, decaglyceryl tetrapalmitate, decaglyceryl pentapalmitate, decaglyceryl hexapalmitate, decaglyceryl heptapalmitate, decaglyceryl octapalmitate, decaglyceryl nonapalmitate, decapalmitic acid Decaglyceryl, decaglyceryl monostearate, decaglyceryl distearate, decaglyceryl tristearate, decaglyceryl tetrastearate, decaglyceryl pentastearate, decaglyceryl hexastearate, decaglyceryl heptearate, decaglyceryl octastearate, Nona stearate decaglyceryl, decastearate decaglyceryl, monooleic acid decaglyceryl, dioleic acid decagli Ril, trioleic acid decaglyceryl, tetraoleic acid decaglyceryl, pentaoleic acid decaglyceryl, hexaoleic acid decaglyceryl, heptaoleic acid decaglyceryl, octaoleic acid decaglyceryl, nonaoleic acid decaglyceryl, dekaleic acid decaglyceryl, monohydroxy Decaglyceryl stearate, decaglyceryl dihydroxystearate, decaglyceryl trihydroxystearate, decaglyceryl tetrahydroxystearate, decaglyceryl pentahydroxystearate, decaglyceryl hexahydroxystearate, decaglyceryl heptahydroxystearate, octahydroxystearic acid Decaglyceryl, nonahydroxystearate decaglyceryl, decahydroxystearyl Decaglyceryl acid, hexaglyceryl polyricinoleate, decaglyceryl polyricinoleate, polyoxyethylene glyceryl monostearate, polyoxyethylene glyceryl distearate, polyoxyethylene glyceryl monooleate, polyoxyethylene glyceryl monomyristate), poly Oxyethylene glycerol fatty acid esters (polyoxyethylene glycerol monostearate, polyoxyethylene glycerol monoisostearate, polyoxyethylene glycerol triisostearate, etc.), sorbitan fatty acid esters (sorbitan monolaurate, sorbitan monooleate, sesquioleic acid) Sorbitan, sorbitan trioleate, sorbitan monopalmitate, sorbitan monostearate, sodium distearate Rubitan, sorbitan dioleate, sorbitan monopalmitate, sorbitan tristearate, sorbitan trioleate, diglycerin sorbitan penta-2-ethylhexylate, diglycerine sorbitan tetra-2-ethylhexylate, polyoxyethylene sorbitan monooleate, mono Polyoxyethylene sorbitan stearate, polyoxyethylene sorbitan monopalmitate, polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan trioleate, polyoxyethylene sorbitan pentaoleate, propylene glycol fatty acid ester (propylene glycol monooctanoate) , Propylene glycol monodecanoate, propylene glycol monostearate, etc.), sucrose fatty acid ester (monolauri) Acid sucrose ester, dilauric acid sucrose ester, monopalmitic acid sucrose ester, dipalmitic acid sucrose ester, monostearic acid sucrose ester, distearic acid sucrose ester, etc.), dextrin fatty acid ester (such as dextrin palmitate), Palm oil fatty acid alkanolamide, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid Monoisostearic acid diester, polyoxyethylene hydrogenated castor oil maleic acid, polyoxyethylene alkyl ether (alkyl polyglucoside, polyoxyethylene cetyl ether, polyoxyethylene Tealyl ether, polyoxyethylene behenyl ether, polyoxyethylene oleyl ether, polyoxyethylene lauryl ether, polyoxyethylene-2-octyldodecyl ether, polyoxyethylene cholestanol ether, etc.), polyoxyethylene alkylphenyl ether (polyoxyethylene) Nonylphenyl ether, polyoxyethylene octylphenyl ether, etc.), polyoxyethylene fatty acid esters (polyethylene glycol monooleate, polyethylene glycol monostearate, polyethylene glycol monolaurate, etc.), lanolin derivatives (polyoxyethylene lanolin, polyoxyethylene lanolin) Alcohol, polyoxyethylene sorbitol lanolin, etc.), POE / POP-alkyl ether (POE / POP-serum) Luether, POE / POP-2-decyltetradecyl ether, POE / POP-monobutyl ether, POE / POP-hydrogenated lanolin, POE / POP-glycerin ether, Tetronic, etc.), alkanolamide (coconut oil fatty acid diethanolamide, laurin) Nonionic surfactants such as acid monoethanolamide, fatty acid isopropanolamide, etc., betaine-type amphoteric surfactants (2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetic acid betaine, Undecylcarboxymethoxyethylcarboxymethylimidazolinium betaine sodium, undecylhydroxyethylimidazolinium betaine sodium, undecyl-N-hydroxyethyl-N-carboxymethylimidazolinium betaine, alkyldiaminoethylglycol hydrochloride Thin liquid, stearyl dihydroxyethyl betaine, stearyl dimethylaminoacetic acid betaine, sodium stearyldimethylbetaine, coconut oil alkyl-N-carboxyethyl-N-hydroxyethylimidazolinium betaine sodium, coconut oil alkylbetaine, coconut oil alkyldimethylaminoacetic acid Betaine, coconut oil fatty acid amidopropyl betaine, coconut oil fatty acid-N-carboxymethoxyethyl-N-carboxyethylimidazolinium betaine sodium, N-lauroyl-N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium, N-cocoyl -N'-carboxymethyl-N'-hydroxyethylethylenediamine sodium, lauryldimethylaminoacetic acid hydroxysulfobetaine, coconut oil alkyldimethylaminoacetic acid hydroxysulfobetaine, Triethanolamine urylaminopropionate, sodium β-laurylaminopropionate, amidopropyldimethylaminoacetic acid betaine laurate, amidopropyldimethylaminoacetic acid hydroxysulfobetaine, coconut oil fatty acid amidopropyldimethylaminoacetic acid hydroxysulfobetaine, palm oil Fatty acid amidopropyldimethylaminoacetic acid hydroxysulfobetaine, palm oil fatty acid amidopropyldimethylaminoacetic acid betaine, palm oil fatty acid amidopropyldimethylaminoacetic acid betaine, lauryl-N-carboxymethoxyethyl-N-carboxymethylimidazolinium disodium dodecanoyl sarcosine , Sodium lauryl diaminoethylglycine, amidopropyl betaine laurate solution, lauryl sulfobetaine, Urylhydroxysulfobetaine, 2-heptadecyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, cocodimethylcarboxymethylbetaine, lauryldimethylcarboxymethylbetaine, lauryldimethylalphacarboxyethylbetaine, cetyldimethylcarboxymethylbetaine, cetyldimethyl Betaine, lauryl bis- (2-hydroxyethyl) carboxymethyl betaine, stearyl bis- (2-hydroxypropyl) carboxymethyl betaine, oleyldimethylgamma-carboxypropyl betaine, lauryl bis- (2-hydroxypropyl) alpha-carboxyethyl betaine, coco Dimethyl sulfopropyl betaine, stearyl dimethyl sulfopropyl betaine, lauryl dimethyl sulfoethyl betaine, Urilbis- (2-hydroxyethyl) sulfopropylbetaine, Levon 2000 (Sanyo Kasei Co., Ltd.), coconut oil fatty acid amidopropyldimethylbetaine, coconut oil fatty acid amidopropylsulfobetaine, imidazolinium type amphoteric surfactant (bis (stearyl- N-hydroxyethylimidazoline) chloroacetic acid complex, N-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, N-alkyl-N-carboxymethyl-N-hydroxyethylethylenediamine / lauryl sulfate and its salt, palm Oil alkyl-N-carboxyethoxyethyl-N-carboxyethyl imidazolinium disodium hydroxide, coconut oil alkyl-N-carboxymethoxyethyl-N-carboxyethyl imidazolinium disodium hydroxide, coconut oil alkyl-N-carboxy Methoxy Ethi -N-carboxyethyl imidazolinium disodium lauryl sulfate, 2-undecyl-N, N, N- (hydroxyethylcarboxymethyl) -2-imidazoline sodium, 2-cocoyl-2-imidazolinium hydroxide-1-carboxy Ethyloxy disodium salt, ovazoline 662 (Toho Chemical Co., Ltd.), Swanol AM-101 (Nikko Chemicals Co., Ltd.), aminopropionic acid type amphoteric surfactants (alkylaminopropionic acid such as sodium dodecylaminopropionate, alkylaminodipropion) Acid), sodium dodecylaminopropane sulfonate, N-higher alkylaspartic acid or its salt, coamidopropyl chlorinated polyethylene glycol dimonium phosphate, cocamidopropyl hydroxysultain, sodium lauroyl sarcosinate, alkylamine oxide (de Amphoteric surfactants such as ruamine oxide, cocoamine oxide, myristoylamine oxide, palmitoylamine oxide, alkyldimethylamine oxide, alkylamidopropylamine oxide), natural surfactants (lecithin, sodium caseinate, sphingolipid, saponin, Mannosyl polyhydric alcohol fatty acid ester, glucosyl polyhydric alcohol fatty acid ester, monosaccharide polyhydric alcohol fatty acid ester such as galactosyl polyhydric alcohol fatty acid ester, disaccharide polyhydric alcohol fatty acid ester, oligosaccharide polyhydric alcohol fatty acid ester, etc.) Surfactant (capric acid chloride, lauric acid chloride, myristic acid chloride, palmitic acid chloride, stearic acid chloride, oleic acid chloride, beheny Reactions of fatty acid chlorides such as acid chloride and coconut oil fatty acid chloride with amino acids such as glycine, sarcosine, β-alanine, N-methyl-β-alanine, taurine and N-methyltaurine), silicone surfactants (Silicon KF-6011 (Shin-Etsu Chemical Co., Ltd.), KF-6012 (Shin-Etsu Chemical Co., Ltd.), KF-6013 (Shin-Etsu Chemical Co., Ltd.), KF-6015 (Shin-Etsu Chemical Co., Ltd.), KF-6016 ( Shin-Etsu Chemical Co., Ltd.), KF-6017 (Shin-Etsu Chemical Co., Ltd.), X-22-4991 (Shin-Etsu Chemical Co., Ltd.), NUC Silicon L7002 (Nihon Unicar Co., Ltd.), SH-3772C (Toray Dow Corning Silicone Co., Ltd.) ), SH-3775C (manufactured by Toray Dow Corning Silicone), and other polyoxyalkylene-modified organopolysiloxanes, ABIL EM-90 (manufactured by Gold Schmidt), ABIL B9806 (manufactured by Gold Schmidt), silicon KF-6026 ( (Shin-Etsu Chemical Co., Ltd.) Long chain alkyl-containing polyoxyalkylene-modified organopolysiloxane, etc.), polyether-modified silicone (polyoxyethylene / methylpolysiloxane copolymer, poly (oxyethylene / oxypropylene) methylpolysiloxane copolymer, etc.), oxazoline-modified Organopolysiloxane, alkyl-modified organopolysiloxane, styryl ketone silicone derivative, dimethylpolysiloxane, methylphenylpolysiloxane, epoxy-modified silicone, fluorine-modified silicone, alcohol-modified silicone, alkyl-modified silicone, alkoxy-modified silicone, amino-modified silicone, ammonium-modified High molecular silicone, organopolysiloxane, methylphenyl polysiloxane, polysiloxane, poly (N-acylalkyleneimine) Modified silicone, dimethylpolysiloxane, nitrogen-containing acrylic - silicone-based graft copolymer, decamethylcyclopentasiloxane, fluorinated Al
Kill-modified silicone, organopolysiloxanylsilylalkyl-modified silicone, tricyclic diterpenecarboxylic acid-modified silicone, trifluoroalkyl-modified silicone, divinylpolydimethylsiloxane, dihydrogenopolydimethylsiloxane, dihydrogenopolydimethylsiloxane divinylpolydimethylsiloxane Polymer, trimethylsiloxysilicic acid, polyoxypropylene / methylpolysiloxane copolymer, ethylpolysiloxane, ethylmethylpolysiloxane, ethylphenylpolysiloxane, octamethylcyclotetrasiloxane, diorganopolysiloxane, octamethylcyclotetrasiloxane, Tetramethyltetraphenyltetracyclosiloxane, polyether-modified polysiloxane, amino-modified polysiloxane, epoxy modification Silicone compounds such as polysiloxane, fluorine-modified polysiloxane, alcohol-modified polysiloxane, alkyl-modified polysiloxane, dodecamethylcyclohexasiloxane, laurylmethicone copolyol, aminoethylaminopropylsiloxane / dimethylsiloxane copolymer, eugenol-modified silicone And hair treatment agents such as selenium disulfide, alkylisoquinolinium bromide solution, zinc pyrithione, biphenamine, thianthol, quinine hydrochloride, and strong ammonia water.

  Others, hormones, sequestering agents, pH adjusters, chelating agents, antiseptic / antibacterial agents, refreshing agents, stabilizers, emulsifiers, animal / plant proteins and their degradation products, animal / plant polysaccharides and their Degradation products, animal / plant glycoproteins and their degradation products, anti-inflammatory agents, antiallergic agents, wound treatment agents, foaming agents, thickeners, enzymes, purified water (electronic water, small clusters, etc.), deodorant / A deodorant etc. can be used in combination.

  Hereinafter, the present invention will be described in more detail with reference to examples, but the present invention is not limited thereto.

(Production Example 1)
Crush the dried product of Asparagus linealice leaf, the dried product of Hypericum perforatum, and the dried product of Lemongrass leaf, and 100g each is heated and extracted with purified water (about 30 ° C) for about 5 hours, and filtered. To obtain about 1.0 kg of extract.

(Production Example 2)
Crush the dried product of Asparagus linealice leaf, the dried product of above-ground hypericum, and the dried product of lemongrass, and heat extract 100g each with purified water (about 80 ° C) for about 5 hours and filter. To obtain about 1.0 kg of extract.

(Production Example 3)
After pulverizing the dried leaves of Asparagus lineias, dried flowers and leaves of stems, dried leaves of stems, and dried leaves of lemongrass, each 100g was immersed in 50% ethanol solution and extracted at room temperature for 5 days and nights. Filter to obtain about 1.0 kg of extract.

(Production Example 4)
Crush the dried product of Asparagus linen alice whole grass, dried leaves of hypericum leaves and rhizomes, dried material of whole grass of lemongrass, soak 100g each in 50% 1,3-butylene glycol solution at room temperature Extract 5 days and nights and filter to obtain about 1.0 kg of extract.

(Production Example 5)
Asparagus Linearis leaves and stems dried, Hypericum leaves and rhizomes dried, lemongrass leaves and stems dried, crushed 100g each in 50% propylene glycol solution, 5 days and night at room temperature After extraction, filtration is performed to obtain about 1.0 kg of an extract.

(Test 1) Kinesin inhibitory action test The inventor decided to evaluate the kinesin inhibitory action of human epidermis-derived pigment cells.

"Test method and evaluation method"
After culturing human epidermis-derived pigment cells in a culture dish, each plant extract was added. After 72 hours, cells were harvested with phosphate buffered saline (PBS). The collected cells were lysed with RIPA buffer (50 mM Tris-HCl, pH 7.5, 1% NP-40, 150 mM NaCl, 0.1% SDS, 0.5% deoxycholate and 1 mM PMSF). Boiled for a minute. Subsequently, electrophoresis was performed by SDS-10% PAGE, and transferred to a PVDF membrane (BioRad, Hercules, CA). The PVDF membrane was blocked with 0.05% Tween 20 and 5% (w / v) non-fat milk overnight, and then reacted by adding a kinesin antibody. After washing the PVDF membrane, an anti-mouse IgG antibody (Amersham Pharmacia Biotech) was reacted, and the expression level was detected with an ECL detection reagent (Amersham Pharmacia Biotech). From the photographed photograph, the expression level of kinesin was calculated by image analysis, and the inhibition rate relative to the control group was determined. The results are shown in FIG.
"sample"
In addition, the sample of the kinesin inhibitory action test added 0.5% of each extract of the Asparagus linenalis extract, the hypericum extract, and the lemongrass extract which were obtained by manufacture example 3 of this invention, and used for the test. Moreover, as a comparative sample, other plant extracts (senkyu extract and safflower extract) were prepared under the same conditions and used for the test.

(Test results)
The results were as shown in FIG. 1, and it was confirmed that the Asparagus linenalis extract, hypericum extract, and lemongrass extract of the present invention had a very strong effect of suppressing kinesin. In addition, the effect which suppresses kinesin was not recognized by the other plant extract (senkyu extract, safflower extract) used as the comparative sample. In addition, the same result which suppresses kinesin was obtained also for the Asparagus linenalis extract, the hypericum extract, and the lemongrass extract obtained in Production Examples 1-2 and 4-5 of the present invention.

(Formulation Example 1) Emulsion
weight%
1. Squalane 8.0
2. Jojoba oil 7.0
3.Cetyl alcohol 2.0
4.Glycerin monostearate 2.0
5. Polyoxyethylene (20) cetyl ether 3.0
6.1,3-Butylene glycol 1.0
7.Glycerin 1.0
8. A: Asparagus linenalis extract of Production Example B B: Hypericum extract of Production Example 3 C: Lemongrass extract of Production Example 3 * Extract of any one of A to C 5.0
9. Preservative (methyl paraoxybenzoate) appropriate amount
10. Residue with 100 purified water

(Test 2) Use effect test The effect at the time of actually using the emulsion of this invention was examined. The use test is a panel of 20 women aged 30-60 years old who suffer from pigmentation, and every day, morning and night, after the face wash, apply the appropriate amount of the emulsion of Formulation Example 1 to the face for 3 months. It was done by doing. In addition, the thing which remove | excluded each plant extract of this invention from the emulsion by the same method was used for the control. The evaluation method is based on the following criteria, and the results are as shown in Table 1. The numerical values in the table represent the number of people. No one complained of skin abnormalities during the period of use.

"Blemish Sobacus & Pigmentation Improvement Effect"
Effective: Blemish freckles and pigmentation improved.
Slightly effective: Slight freckles and pigmentation were slightly improved.
Invalid: No change before use.

(Test results)
As shown in Table 1, it was confirmed that the emulsion containing the asparagus linenalis extract, hypericum extract, and lemongrass extract of the present invention significantly improved spots and freckles and also improved pigmentation.

(Formulation Example 2) Flexible lotion mass%
1.Glycerin 5.0
2.1,3-Butylene glycol 5.0
3.Polyoxyethylene sorbitan monolaurate (20E.O) 1.0
4.Ethanol 15.0
5. A: Asparagus linenalis extract of Production Example 4 B: Hypericum extract of Production Example 4 C: Lemongrass extract of Production Example 4 * Extract of any one of A to C 5.0
6. Loquat leaf 60% 1,2-pentanediol extract 1.0
7. Artichoke whole plant 60% 1,2-pentanediol extract 1.0
8. Antibacterial and antiseptic (paraoxybenzoic acid ester) appropriate amount
9. Fragrance (Western light load water) appropriate amount
10. Residue with 100 purified water

(Formulation example 3) Pasta mass%
1. Flour 80.0
2.Bacon 15.0
3.Reiko 5.0
4. A: Asparagus linenalis extract of Production Example 1 B: Hypericum extract of Production Example 1 C: Lemongrass extract of Production Example 1 * Extract of any one of A to C 5.0
5.Salt / Pepper appropriate amount
6.Butter proper amount
7.Green seaweed
8.Olive oil

(Formulation example 4) Beverage mass%
1.Glucose liquid sugar 30.0
2. Grapefruit juice 55.0
3. Extract from Asparagus sulinarias of Production Example 2 5.0
4. Orange fruit hot water extract dry powder 5.0
5. Mucopolysaccharide solution 3.0
6. Iyokan Juice 2.0
7.Perfume appropriate amount
8. Suitable amount of acidulant

  The present invention relates to a kinesin inhibitor containing a specific plant extract (asparagus linenalis extract, hypericum extract, lemongrass extract) as an active ingredient, and a pigmentation inhibitor based on a kinesin inhibitory action. Furthermore, various compositions (pharmaceutical composition, food composition, cosmetic composition) containing a kinesin inhibitor can be provided.

Claims (12)

  The kinesin inhibitor which uses as an active ingredient at least 1 or more types of extract chosen from an asparagus linen alice extract, a hypericum extract, and a lemongrass extract.   A pigmentation inhibitor comprising the kinesin inhibitor according to claim 1.   A pigmentation inhibitor produced by inhibiting kinesin, comprising the kinesin inhibitor according to claim 1.   A pharmaceutical composition comprising the kinesin inhibitor according to claim 1.   A pharmaceutical composition comprising the pigmentation inhibitor according to claim 2.   A pharmaceutical composition comprising a pigmentation inhibitor produced by inhibiting kinesin according to claim 3.   A food composition comprising the kinesin inhibitor according to claim 1.   A food composition comprising the pigmentation inhibitor according to claim 2.   A food composition comprising a pigmentation inhibitor produced by inhibiting kinesin according to claim 3.   A cosmetic composition comprising the kinesin inhibitor according to claim 1.   A cosmetic composition comprising the pigmentation inhibitor according to claim 2.   A cosmetic composition comprising a pigmentation inhibitor produced by inhibiting kinesin according to claim 3.

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