JP2014133739A5 - - Google Patents
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- JP2014133739A5 JP2014133739A5 JP2013256668A JP2013256668A JP2014133739A5 JP 2014133739 A5 JP2014133739 A5 JP 2014133739A5 JP 2013256668 A JP2013256668 A JP 2013256668A JP 2013256668 A JP2013256668 A JP 2013256668A JP 2014133739 A5 JP2014133739 A5 JP 2014133739A5
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- JP
- Japan
- Prior art keywords
- group
- optionally substituted
- oxadiazol
- fluoro
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000005843 halogen group Chemical group 0.000 claims description 92
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 86
- 125000003118 aryl group Chemical group 0.000 claims description 85
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 84
- 125000004767 (C1-C4) haloalkoxy group Chemical group 0.000 claims description 83
- 125000004765 (C1-C4) haloalkyl group Chemical group 0.000 claims description 80
- 125000001072 heteroaryl group Chemical group 0.000 claims description 76
- 125000003545 alkoxy group Chemical group 0.000 claims description 71
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 70
- 125000001424 substituent group Chemical group 0.000 claims description 69
- 125000000623 heterocyclic group Chemical group 0.000 claims description 59
- 125000004433 nitrogen atom Chemical group N* 0.000 claims description 59
- 125000002950 monocyclic group Chemical group 0.000 claims description 56
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 52
- 125000000081 (C5-C8) cycloalkenyl group Chemical group 0.000 claims description 52
- 125000002252 acyl group Chemical group 0.000 claims description 52
- 229910052757 nitrogen Inorganic materials 0.000 claims description 51
- 125000004043 oxo group Chemical group O=* 0.000 claims description 50
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims description 49
- 125000002619 bicyclic group Chemical group 0.000 claims description 49
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims description 39
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 38
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 36
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 36
- 125000003277 amino group Chemical group 0.000 claims description 33
- 150000003839 salts Chemical class 0.000 claims description 33
- 125000004191 (C1-C6) alkoxy group Chemical group 0.000 claims description 32
- 125000003342 alkenyl group Chemical group 0.000 claims description 32
- -1 phenacyl group Chemical group 0.000 claims description 30
- 125000000304 alkynyl group Chemical group 0.000 claims description 29
- 125000004430 oxygen atom Chemical group O* 0.000 claims description 28
- 125000004104 aryloxy group Chemical group 0.000 claims description 25
- 125000004432 carbon atom Chemical group C* 0.000 claims description 23
- 125000000217 alkyl group Chemical group 0.000 claims description 21
- 229910052799 carbon Inorganic materials 0.000 claims description 21
- 125000005842 heteroatom Chemical group 0.000 claims description 18
- 229920006395 saturated elastomer Polymers 0.000 claims description 18
- 125000003107 substituted aryl group Chemical group 0.000 claims description 18
- 229910052717 sulfur Inorganic materials 0.000 claims description 18
- 125000004434 sulfur atom Chemical group 0.000 claims description 15
- 125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 claims description 6
- 125000004739 (C1-C6) alkylsulfonyl group Chemical group 0.000 claims description 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 6
- 125000000392 cycloalkenyl group Chemical group 0.000 claims description 5
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims description 3
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims description 3
- 125000004122 cyclic group Chemical group 0.000 claims description 3
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 3
- 125000004438 haloalkoxy group Chemical group 0.000 claims description 3
- 125000001188 haloalkyl group Chemical group 0.000 claims description 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 3
- 150000003413 spiro compounds Chemical class 0.000 claims description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
- 125000004429 atom Chemical group 0.000 claims description 2
- 150000001875 compounds Chemical class 0.000 claims 29
- 239000003814 drug Substances 0.000 claims 15
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 229940124597 therapeutic agent Drugs 0.000 claims 5
- 208000024827 Alzheimer disease Diseases 0.000 claims 4
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- NYCVCXMSZNOGDH-UHFFFAOYSA-N pyrrolidine-1-carboxylic acid Chemical compound OC(=O)N1CCCC1 NYCVCXMSZNOGDH-UHFFFAOYSA-N 0.000 claims 3
- OESVOUZRYHMLHI-UHFFFAOYSA-N 1-[4-[4-[3-(3-ethyl-7-fluoroindazol-1-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-4-methylpiperidin-1-yl]-2-methoxyethanone Chemical compound C12=C(F)C=CC=C2C(CC)=NN1C(N=1)=NOC=1C(CC1)CCN1C1(C)CCN(C(=O)COC)CC1 OESVOUZRYHMLHI-UHFFFAOYSA-N 0.000 claims 2
- ANJNIJQFOWNGMN-UHFFFAOYSA-N 3-(3-ethylindazol-1-yl)-5-[1-(2-methylpropyl)piperidin-4-yl]-1,2,4-oxadiazole Chemical compound C12=CC=CC=C2C(CC)=NN1C(N=1)=NOC=1C1CCN(CC(C)C)CC1 ANJNIJQFOWNGMN-UHFFFAOYSA-N 0.000 claims 2
- IKHGUXGNUITLKF-UHFFFAOYSA-N Acetaldehyde Chemical compound CC=O IKHGUXGNUITLKF-UHFFFAOYSA-N 0.000 claims 2
- 229940100578 Acetylcholinesterase inhibitor Drugs 0.000 claims 2
- 239000004480 active ingredient Substances 0.000 claims 2
- 239000000544 cholinesterase inhibitor Substances 0.000 claims 2
- 229960003530 donepezil Drugs 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- BFGQFILTMVCOFW-INIZCTEOSA-N (2s)-1-[4-[4-[3-(3-ethyl-7-fluoroindazol-1-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-4-methylpiperidin-1-yl]-2-hydroxypropan-1-one Chemical compound C12=C(F)C=CC=C2C(CC)=NN1C(N=1)=NOC=1C(CC1)CCN1C1(C)CCN(C(=O)[C@H](C)O)CC1 BFGQFILTMVCOFW-INIZCTEOSA-N 0.000 claims 1
- MBHLLEMPOJORAC-DLBZAZTESA-N 1-[(2r)-2-[[(3s)-3-[[3-(7-fluoro-3-propan-2-ylindazol-1-yl)-1,2,4-oxadiazol-5-yl]methyl]pyrrolidin-1-yl]methyl]pyrrolidin-1-yl]-2-hydroxyethanone Chemical compound C([C@H](C1)CC=2ON=C(N=2)N2N=C(C3=CC=CC(F)=C32)C(C)C)CN1C[C@H]1CCCN1C(=O)CO MBHLLEMPOJORAC-DLBZAZTESA-N 0.000 claims 1
- QIDVQLREYCHXBT-QGZVFWFLSA-N 1-[(2r)-2-[[4-[3-(7-fluoro-3-propan-2-ylindazol-1-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]methyl]pyrrolidin-1-yl]-2-hydroxyethanone Chemical compound C12=C(F)C=CC=C2C(C(C)C)=NN1C(N=1)=NOC=1C(CC1)CCN1C[C@H]1CCCN1C(=O)CO QIDVQLREYCHXBT-QGZVFWFLSA-N 0.000 claims 1
- MBHLLEMPOJORAC-IRXDYDNUSA-N 1-[(2s)-2-[[(3s)-3-[[3-(7-fluoro-3-propan-2-ylindazol-1-yl)-1,2,4-oxadiazol-5-yl]methyl]pyrrolidin-1-yl]methyl]pyrrolidin-1-yl]-2-hydroxyethanone Chemical compound C([C@H](C1)CC=2ON=C(N=2)N2N=C(C3=CC=CC(F)=C32)C(C)C)CN1C[C@@H]1CCCN1C(=O)CO MBHLLEMPOJORAC-IRXDYDNUSA-N 0.000 claims 1
- VRQZMCLLJRPDFX-INIZCTEOSA-N 1-[(2s)-2-[[4-[3-(3-ethyl-7-fluoroindazol-1-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]methyl]pyrrolidin-1-yl]-2-hydroxyethanone Chemical compound C12=C(F)C=CC=C2C(CC)=NN1C(N=1)=NOC=1C(CC1)CCN1C[C@@H]1CCCN1C(=O)CO VRQZMCLLJRPDFX-INIZCTEOSA-N 0.000 claims 1
- CUDONWZUXRTGLR-IAGOWNOFSA-N 1-[(3r)-3-[[(3r)-3-[[3-(7-fluoro-3-propan-2-ylindazol-1-yl)-1,2,4-oxadiazol-5-yl]methyl]pyrrolidin-1-yl]methyl]pyrrolidin-1-yl]-2-hydroxyethanone Chemical compound C([C@@H](C1)CC=2ON=C(N=2)N2N=C(C3=CC=CC(F)=C32)C(C)C)CN1C[C@H]1CCN(C(=O)CO)C1 CUDONWZUXRTGLR-IAGOWNOFSA-N 0.000 claims 1
- HGZOAZODDJVYTO-QZTJIDSGSA-N 1-[(3r)-3-[[(3r)-3-[[3-(7-fluoro-3-propan-2-ylindazol-1-yl)-1,2,4-oxadiazol-5-yl]methyl]pyrrolidin-1-yl]methyl]pyrrolidin-1-yl]-2-methoxyethanone Chemical compound C1N(C(=O)COC)CC[C@@H]1CN1C[C@@H](CC=2ON=C(N=2)N2C3=C(F)C=CC=C3C(C(C)C)=N2)CC1 HGZOAZODDJVYTO-QZTJIDSGSA-N 0.000 claims 1
- CUDONWZUXRTGLR-DLBZAZTESA-N 1-[(3r)-3-[[(3s)-3-[[3-(7-fluoro-3-propan-2-ylindazol-1-yl)-1,2,4-oxadiazol-5-yl]methyl]pyrrolidin-1-yl]methyl]pyrrolidin-1-yl]-2-hydroxyethanone Chemical compound C([C@H](C1)CC=2ON=C(N=2)N2N=C(C3=CC=CC(F)=C32)C(C)C)CN1C[C@H]1CCN(C(=O)CO)C1 CUDONWZUXRTGLR-DLBZAZTESA-N 0.000 claims 1
- DBPUJDHYTDWYKN-OAHLLOKOSA-N 1-[(3r)-3-[[4-[3-(3-ethyl-7-fluoroindazol-1-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]methyl]pyrrolidin-1-yl]-2-hydroxyethanone Chemical compound C12=C(F)C=CC=C2C(CC)=NN1C(N=1)=NOC=1C(CC1)CCN1C[C@H]1CCN(C(=O)CO)C1 DBPUJDHYTDWYKN-OAHLLOKOSA-N 0.000 claims 1
- OEQYNZXSMQIWST-MRXNPFEDSA-N 1-[(3r)-3-[[4-[3-(3-ethyl-7-fluoroindazol-1-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]methyl]pyrrolidin-1-yl]-2-methoxyethanone Chemical compound C12=C(F)C=CC=C2C(CC)=NN1C(N=1)=NOC=1C(CC1)CCN1C[C@H]1CCN(C(=O)COC)C1 OEQYNZXSMQIWST-MRXNPFEDSA-N 0.000 claims 1
- KSHNUMSXRLBXDI-MRXNPFEDSA-N 1-[(3r)-3-[[4-[3-(3-ethyl-7-fluoroindazol-1-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]methyl]pyrrolidin-1-yl]ethanone Chemical compound C12=C(F)C=CC=C2C(CC)=NN1C(N=1)=NOC=1C(CC1)CCN1C[C@H]1CCN(C(C)=O)C1 KSHNUMSXRLBXDI-MRXNPFEDSA-N 0.000 claims 1
- HGZOAZODDJVYTO-MSOLQXFVSA-N 1-[(3s)-3-[[(3r)-3-[[3-(7-fluoro-3-propan-2-ylindazol-1-yl)-1,2,4-oxadiazol-5-yl]methyl]pyrrolidin-1-yl]methyl]pyrrolidin-1-yl]-2-methoxyethanone Chemical compound C1N(C(=O)COC)CC[C@H]1CN1C[C@@H](CC=2ON=C(N=2)N2C3=C(F)C=CC=C3C(C(C)C)=N2)CC1 HGZOAZODDJVYTO-MSOLQXFVSA-N 0.000 claims 1
- NWJMYBCZZZLUFH-MSOLQXFVSA-N 1-[(3s)-3-[[(3r)-3-[[3-(7-fluoro-3-propan-2-ylindazol-1-yl)-1,2,4-oxadiazol-5-yl]methyl]pyrrolidin-1-yl]methyl]pyrrolidin-1-yl]ethanone Chemical compound C([C@@H](C1)CC=2ON=C(N=2)N2N=C(C3=CC=CC(F)=C32)C(C)C)CN1C[C@@H]1CCN(C(C)=O)C1 NWJMYBCZZZLUFH-MSOLQXFVSA-N 0.000 claims 1
- CUDONWZUXRTGLR-IRXDYDNUSA-N 1-[(3s)-3-[[(3s)-3-[[3-(7-fluoro-3-propan-2-ylindazol-1-yl)-1,2,4-oxadiazol-5-yl]methyl]pyrrolidin-1-yl]methyl]pyrrolidin-1-yl]-2-hydroxyethanone Chemical compound C([C@H](C1)CC=2ON=C(N=2)N2N=C(C3=CC=CC(F)=C32)C(C)C)CN1C[C@@H]1CCN(C(=O)CO)C1 CUDONWZUXRTGLR-IRXDYDNUSA-N 0.000 claims 1
- HGZOAZODDJVYTO-ROUUACIJSA-N 1-[(3s)-3-[[(3s)-3-[[3-(7-fluoro-3-propan-2-ylindazol-1-yl)-1,2,4-oxadiazol-5-yl]methyl]pyrrolidin-1-yl]methyl]pyrrolidin-1-yl]-2-methoxyethanone Chemical compound C1N(C(=O)COC)CC[C@H]1CN1C[C@H](CC=2ON=C(N=2)N2C3=C(F)C=CC=C3C(C(C)C)=N2)CC1 HGZOAZODDJVYTO-ROUUACIJSA-N 0.000 claims 1
- DBPUJDHYTDWYKN-HNNXBMFYSA-N 1-[(3s)-3-[[4-[3-(3-ethyl-7-fluoroindazol-1-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]methyl]pyrrolidin-1-yl]-2-hydroxyethanone Chemical compound C12=C(F)C=CC=C2C(CC)=NN1C(N=1)=NOC=1C(CC1)CCN1C[C@@H]1CCN(C(=O)CO)C1 DBPUJDHYTDWYKN-HNNXBMFYSA-N 0.000 claims 1
- OEQYNZXSMQIWST-INIZCTEOSA-N 1-[(3s)-3-[[4-[3-(3-ethyl-7-fluoroindazol-1-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]methyl]pyrrolidin-1-yl]-2-methoxyethanone Chemical compound C12=C(F)C=CC=C2C(CC)=NN1C(N=1)=NOC=1C(CC1)CCN1C[C@@H]1CCN(C(=O)COC)C1 OEQYNZXSMQIWST-INIZCTEOSA-N 0.000 claims 1
- KSHNUMSXRLBXDI-INIZCTEOSA-N 1-[(3s)-3-[[4-[3-(3-ethyl-7-fluoroindazol-1-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]methyl]pyrrolidin-1-yl]ethanone Chemical compound C12=C(F)C=CC=C2C(CC)=NN1C(N=1)=NOC=1C(CC1)CCN1C[C@@H]1CCN(C(C)=O)C1 KSHNUMSXRLBXDI-INIZCTEOSA-N 0.000 claims 1
- OUFSOXKXMOXXLL-OAHLLOKOSA-N 1-[3-[[(3r)-3-[[3-(7-fluoro-3-propan-2-ylindazol-1-yl)-1,2,4-oxadiazol-5-yl]methyl]pyrrolidin-1-yl]methyl]azetidin-1-yl]-2-hydroxyethanone Chemical compound C([C@@H](C1)CC=2ON=C(N=2)N2N=C(C3=CC=CC(F)=C32)C(C)C)CN1CC1CN(C(=O)CO)C1 OUFSOXKXMOXXLL-OAHLLOKOSA-N 0.000 claims 1
- RLZYHVVQPIAASE-MRXNPFEDSA-N 1-[3-[[(3r)-3-[[3-(7-fluoro-3-propan-2-ylindazol-1-yl)-1,2,4-oxadiazol-5-yl]methyl]pyrrolidin-1-yl]methyl]azetidin-1-yl]-2-methoxyethanone Chemical compound C1N(C(=O)COC)CC1CN1C[C@@H](CC=2ON=C(N=2)N2C3=C(F)C=CC=C3C(C(C)C)=N2)CC1 RLZYHVVQPIAASE-MRXNPFEDSA-N 0.000 claims 1
- PFDBLDXPCWBDIO-MRXNPFEDSA-N 1-[3-[[(3r)-3-[[3-(7-fluoro-3-propan-2-ylindazol-1-yl)-1,2,4-oxadiazol-5-yl]methyl]pyrrolidin-1-yl]methyl]azetidin-1-yl]ethanone Chemical compound C([C@@H](C1)CC=2ON=C(N=2)N2N=C(C3=CC=CC(F)=C32)C(C)C)CN1CC1CN(C(C)=O)C1 PFDBLDXPCWBDIO-MRXNPFEDSA-N 0.000 claims 1
- RLZYHVVQPIAASE-INIZCTEOSA-N 1-[3-[[(3s)-3-[[3-(7-fluoro-3-propan-2-ylindazol-1-yl)-1,2,4-oxadiazol-5-yl]methyl]pyrrolidin-1-yl]methyl]azetidin-1-yl]-2-methoxyethanone Chemical compound C1N(C(=O)COC)CC1CN1C[C@H](CC=2ON=C(N=2)N2C3=C(F)C=CC=C3C(C(C)C)=N2)CC1 RLZYHVVQPIAASE-INIZCTEOSA-N 0.000 claims 1
- BAJCMSHWHVWULL-UHFFFAOYSA-N 1-[3-[[4-[3-(3-ethyl-7-fluoroindazol-1-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]methyl]azetidin-1-yl]-2-hydroxyethanone Chemical compound C12=C(F)C=CC=C2C(CC)=NN1C(N=1)=NOC=1C(CC1)CCN1CC1CN(C(=O)CO)C1 BAJCMSHWHVWULL-UHFFFAOYSA-N 0.000 claims 1
- BQPBKRHIEZFMSQ-UHFFFAOYSA-N 1-[3-[[4-[3-(3-ethyl-7-fluoroindazol-1-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]methyl]azetidin-1-yl]-2-methoxyethanone Chemical compound C12=C(F)C=CC=C2C(CC)=NN1C(N=1)=NOC=1C(CC1)CCN1CC1CN(C(=O)COC)C1 BQPBKRHIEZFMSQ-UHFFFAOYSA-N 0.000 claims 1
- ZWYWLDXUNIOMHJ-UHFFFAOYSA-N 1-[3-[[4-[3-(3-ethyl-7-fluoroindazol-1-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]methyl]azetidin-1-yl]ethanone Chemical compound C12=C(F)C=CC=C2C(CC)=NN1C(N=1)=NOC=1C(CC1)CCN1CC1CN(C(C)=O)C1 ZWYWLDXUNIOMHJ-UHFFFAOYSA-N 0.000 claims 1
- LWJGQBHNVKVSHJ-UHFFFAOYSA-N 1-[3-[[4-[3-(7-fluoro-3-propan-2-ylindazol-1-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]methyl]azetidin-1-yl]-2-methoxyethanone Chemical compound C1N(C(=O)COC)CC1CN1CCC(C=2ON=C(N=2)N2C3=C(F)C=CC=C3C(C(C)C)=N2)CC1 LWJGQBHNVKVSHJ-UHFFFAOYSA-N 0.000 claims 1
- JXNJLEXUJPZADT-UHFFFAOYSA-N 1-[3-[[4-[3-(7-fluoro-3-propan-2-ylindazol-1-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]methyl]azetidin-1-yl]ethanone Chemical compound C12=C(F)C=CC=C2C(C(C)C)=NN1C(N=1)=NOC=1C(CC1)CCN1CC1CN(C(C)=O)C1 JXNJLEXUJPZADT-UHFFFAOYSA-N 0.000 claims 1
- OOYQGQXAIOWLDW-QGZVFWFLSA-N 1-[4-[(3r)-3-[[3-(7-fluoro-3-propan-2-ylindazol-1-yl)-1,2,4-oxadiazol-5-yl]methyl]pyrrolidin-1-yl]piperidin-1-yl]-2-methoxyethanone Chemical compound C1CN(C(=O)COC)CCC1N1C[C@@H](CC=2ON=C(N=2)N2C3=C(F)C=CC=C3C(C(C)C)=N2)CC1 OOYQGQXAIOWLDW-QGZVFWFLSA-N 0.000 claims 1
- NIBZFXWOZKSFIT-INIZCTEOSA-N 1-[4-[(3s)-3-[[3-(3-ethyl-7-fluoroindazol-1-yl)-1,2,4-oxadiazol-5-yl]methyl]pyrrolidin-1-yl]piperidin-1-yl]ethanone Chemical compound C([C@H](C1)CC=2ON=C(N=2)N2N=C(C3=CC=CC(F)=C32)CC)CN1C1CCN(C(C)=O)CC1 NIBZFXWOZKSFIT-INIZCTEOSA-N 0.000 claims 1
- OOYQGQXAIOWLDW-KRWDZBQOSA-N 1-[4-[(3s)-3-[[3-(7-fluoro-3-propan-2-ylindazol-1-yl)-1,2,4-oxadiazol-5-yl]methyl]pyrrolidin-1-yl]piperidin-1-yl]-2-methoxyethanone Chemical compound C1CN(C(=O)COC)CCC1N1C[C@H](CC=2ON=C(N=2)N2C3=C(F)C=CC=C3C(C(C)C)=N2)CC1 OOYQGQXAIOWLDW-KRWDZBQOSA-N 0.000 claims 1
- IBZXBKUUTRWKLC-UHFFFAOYSA-N 1-[4-[4-[3-(3-ethyl-6-fluoroindazol-1-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]piperidin-1-yl]ethanone Chemical compound C12=CC(F)=CC=C2C(CC)=NN1C(N=1)=NOC=1C(CC1)CCN1C1CCN(C(C)=O)CC1 IBZXBKUUTRWKLC-UHFFFAOYSA-N 0.000 claims 1
- RAVCNWHAZVFEIU-UHFFFAOYSA-N 1-[4-[4-[3-(3-ethyl-7-fluoroindazol-1-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]-4-methylpiperidin-1-yl]-2-hydroxyethanone Chemical compound C12=C(F)C=CC=C2C(CC)=NN1C(N=1)=NOC=1C(CC1)CCN1C1(C)CCN(C(=O)CO)CC1 RAVCNWHAZVFEIU-UHFFFAOYSA-N 0.000 claims 1
- QSLDCXZFUZFZCZ-UHFFFAOYSA-N 1-[4-[4-[3-(3-ethyl-7-fluoroindazol-1-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]piperidin-1-yl]-2-hydroxyethanone Chemical compound C12=C(F)C=CC=C2C(CC)=NN1C(N=1)=NOC=1C(CC1)CCN1C1CCN(C(=O)CO)CC1 QSLDCXZFUZFZCZ-UHFFFAOYSA-N 0.000 claims 1
- HWKVHAKGQAKPSQ-UHFFFAOYSA-N 1-[4-[4-[3-(3-ethyl-7-fluoroindazol-1-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]piperidin-1-yl]-2-methoxyethanone Chemical compound C12=C(F)C=CC=C2C(CC)=NN1C(N=1)=NOC=1C(CC1)CCN1C1CCN(C(=O)COC)CC1 HWKVHAKGQAKPSQ-UHFFFAOYSA-N 0.000 claims 1
- PUMGOQSFPDZFCT-UHFFFAOYSA-N 1-[4-[4-[3-(3-ethyl-7-fluoroindazol-1-yl)-1,2,4-oxadiazol-5-yl]piperidin-1-yl]piperidin-1-yl]ethanone Chemical compound C12=C(F)C=CC=C2C(CC)=NN1C(N=1)=NOC=1C(CC1)CCN1C1CCN(C(C)=O)CC1 PUMGOQSFPDZFCT-UHFFFAOYSA-N 0.000 claims 1
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| EP3180344B1 (en) | 2014-08-12 | 2019-09-18 | Pfizer Inc | Pyrrolo[2,3-d]pyrimidine derivatives useful for inhibiting janus kinase |
| JOP20190024A1 (ar) | 2016-08-26 | 2019-02-19 | Gilead Sciences Inc | مركبات بيروليزين بها استبدال واستخداماتها |
| CA3091142C (en) | 2018-02-26 | 2023-04-11 | Gilead Sciences, Inc. | Substituted pyrrolizine compounds and uses thereof |
| US11351149B2 (en) | 2020-09-03 | 2022-06-07 | Pfizer Inc. | Nitrile-containing antiviral compounds |
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| WO2025045837A1 (en) | 2023-08-31 | 2025-03-06 | Syngenta Crop Protection Ag | Pesticidally active indazole compounds |
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