JP2014132019A5 - - Google Patents

Download PDF

Info

Publication number
JP2014132019A5
JP2014132019A5 JP2014036821A JP2014036821A JP2014132019A5 JP 2014132019 A5 JP2014132019 A5 JP 2014132019A5 JP 2014036821 A JP2014036821 A JP 2014036821A JP 2014036821 A JP2014036821 A JP 2014036821A JP 2014132019 A5 JP2014132019 A5 JP 2014132019A5
Authority
JP
Japan
Prior art keywords
amino acids
proteins
group
specifically binds
acid selected
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
JP2014036821A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014132019A (ja
Filing date
Publication date
Priority claimed from US09/148,712 external-priority patent/US6441140B1/en
Application filed filed Critical
Publication of JP2014132019A publication Critical patent/JP2014132019A/ja
Publication of JP2014132019A5 publication Critical patent/JP2014132019A5/ja
Withdrawn legal-status Critical Current

Links

JP2014036821A 1998-09-04 2014-02-27 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生 Withdrawn JP2014132019A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US09/148,712 US6441140B1 (en) 1998-09-04 1998-09-04 Production of motif-specific and context-independent antibodies using peptide libraries as antigens
US09/148,712 1998-09-04

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2012058996A Division JP5648007B2 (ja) 1998-09-04 2012-03-15 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016113229A Division JP2016210783A (ja) 1998-09-04 2016-06-07 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生

Publications (2)

Publication Number Publication Date
JP2014132019A JP2014132019A (ja) 2014-07-17
JP2014132019A5 true JP2014132019A5 (cg-RX-API-DMAC7.html) 2014-09-11

Family

ID=22527002

Family Applications (5)

Application Number Title Priority Date Filing Date
JP2000569230A Expired - Lifetime JP3732408B2 (ja) 1998-09-04 1999-08-26 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生
JP2005260207A Expired - Lifetime JP5013693B2 (ja) 1998-09-04 2005-09-08 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生
JP2012058996A Expired - Lifetime JP5648007B2 (ja) 1998-09-04 2012-03-15 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生
JP2014036821A Withdrawn JP2014132019A (ja) 1998-09-04 2014-02-27 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生
JP2016113229A Pending JP2016210783A (ja) 1998-09-04 2016-06-07 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生

Family Applications Before (3)

Application Number Title Priority Date Filing Date
JP2000569230A Expired - Lifetime JP3732408B2 (ja) 1998-09-04 1999-08-26 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生
JP2005260207A Expired - Lifetime JP5013693B2 (ja) 1998-09-04 2005-09-08 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生
JP2012058996A Expired - Lifetime JP5648007B2 (ja) 1998-09-04 2012-03-15 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2016113229A Pending JP2016210783A (ja) 1998-09-04 2016-06-07 抗原としてペプチドライブラリーを用いたモチーフ特異性および状況独立性抗体の産生

Country Status (6)

Country Link
US (5) US6441140B1 (cg-RX-API-DMAC7.html)
EP (3) EP1850131B1 (cg-RX-API-DMAC7.html)
JP (5) JP3732408B2 (cg-RX-API-DMAC7.html)
CA (1) CA2341143C (cg-RX-API-DMAC7.html)
DE (1) DE69936389T2 (cg-RX-API-DMAC7.html)
WO (1) WO2000014536A1 (cg-RX-API-DMAC7.html)

Families Citing this family (74)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6884597B1 (en) * 1998-01-20 2005-04-26 Medical & Biological Laboratories, Co., Ltd. Method for detecting acetyltransferase and deacetylase activities and method for screening inhibitors or enhancers of these enzymes
US7300753B2 (en) * 1998-09-04 2007-11-27 John Rush Immunoaffinity isolation of modified peptides from complex mixtures
US7198896B2 (en) * 1998-09-04 2007-04-03 Cell Signaling Technology, Inc. Immunoaffinity isolation of modified peptides from complex mixtures
US20120244594A9 (en) * 1998-09-04 2012-09-27 Cell Signaling Technology, Inc. Immunoaffinity isolation of modified peptides from complex mixtures
US6441140B1 (en) * 1998-09-04 2002-08-27 Cell Signaling Technology, Inc. Production of motif-specific and context-independent antibodies using peptide libraries as antigens
US9085609B2 (en) * 1998-09-04 2015-07-21 Cell Signaling Technology, Inc. Production of motif-specific and context-independent antibodies using peptide libraries as antigens
US7208581B1 (en) * 1999-11-05 2007-04-24 The Burnham Institute TRAF family proteins
AU2625201A (en) * 2000-01-03 2001-07-16 Ramot University Authority For Applied Research And Industrial Development Ltd. Glycogen synthase kinase-3 inhibitors
AU2001258093A1 (en) * 2000-05-04 2001-11-12 Mount Sinai Hospital Molecules that modulate ubiquitin-dependent proteolysis and methods for identifying same
US20020102248A1 (en) * 2000-09-06 2002-08-01 The Government Of The United States Of America Modulating response to genotoxic stress
WO2002077623A1 (fr) * 2001-03-23 2002-10-03 Japan Science And Technology Corporation Sonde pour visualiser la phosphorylation/dephosphorylation de proteines et procede de detection et de quantification de la phosphorylation/dephosphorylation de proteines
EP2339027A3 (en) 2001-06-21 2012-01-11 Cell Signaling Technology, Inc. Immunoaffinity isolation of modified peptides from complex mixtures
US20110111424A1 (en) 2001-06-21 2011-05-12 Cell Signaling Technology, Inc. Analysis of ubiquitinated polypeptides
US7378432B2 (en) 2001-09-14 2008-05-27 Tel Aviv University Future Technology Development L.P. Glycogen synthase kinase-3 inhibitors
US7166441B2 (en) * 2002-03-12 2007-01-23 Perseptive Biosystems Inc. Method and apparatus for the identification and quantification of biomolecules
GB0208104D0 (en) 2002-04-09 2002-05-22 Univ Dundee Method
AU2003286411A1 (en) 2002-12-12 2004-06-30 Tel Aviv University Future Technology Development L.P. Glycogen synthase kinase-3 inhibitors
CN1838954B (zh) * 2003-06-27 2013-01-16 特拉维夫大学未来科技开发有限公司 糖原合酶激酶-3抑制剂
CN1864068B (zh) * 2003-08-18 2010-10-13 特提斯生物科学公司 用小表位抗体降低样品复杂度的方法
US20070003977A1 (en) * 2003-08-20 2007-01-04 Amorfix Life Sciences Ltd Epitope protection assay and method for detecting protein conformations
US20050064507A1 (en) * 2003-09-11 2005-03-24 James Stephen Shaw Determining kinase specificity
WO2005050206A2 (en) * 2003-09-17 2005-06-02 Molecular Probes, Inc. Competitive immunoassay
US8852879B2 (en) 2004-04-29 2014-10-07 The Children's Hospital Of Philadelphia Materials and methods for the detection of nitrated fibrinogen
US20050244905A1 (en) * 2004-04-29 2005-11-03 Harry Ischiropoulos Nitrated fibrinogen as a marker for coronary artery disease and rapid blood clot formation
US7973134B2 (en) * 2004-07-07 2011-07-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways
US20070048797A1 (en) * 2004-08-11 2007-03-01 Xing Su Composite organic inorganic nanoclusters as carriers and identifiers of tester molecules
US7935790B2 (en) * 2004-10-04 2011-05-03 Cell Singaling Technology, Inc. Reagents for the detection of protein phosphorylation in T-cell receptor signaling pathways
US20070224662A1 (en) * 2004-12-17 2007-09-27 Jun Luo Post-translational modification of proteins in cell-free expression systems
US7807789B2 (en) * 2004-12-21 2010-10-05 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in EGFR-signaling pathways
WO2006106957A1 (ja) * 2005-04-01 2006-10-12 National University Corporation Hokkaido University ｐ５３翻訳後修飾部位を特異的に認識するモノクローナル抗体、及びその抗体を含む修飾部位測定キット
US20090099340A1 (en) * 2007-10-12 2009-04-16 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
WO2006117007A1 (en) * 2005-05-03 2006-11-09 The Antibody Project Aps Methods for obtaining antigen specific antibodies
US20060292642A1 (en) * 2005-06-24 2006-12-28 Javad Khosravi Immunoassay of phosphorylated proteins
US7906297B2 (en) 2005-07-20 2011-03-15 Cell Signaling Technology, Inc. Reagents for the detection of phosphorylated ATR kinase (Ser 428) and uses thereof
US20100151495A9 (en) * 2005-08-31 2010-06-17 Cell Signaling Technolgy, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
WO2007027906A2 (en) * 2005-08-31 2007-03-08 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in leukemia signaling pathways
WO2007079755A1 (en) * 2006-01-12 2007-07-19 Janus Beierholm Holding Aps Reimmunization and antibody design
WO2008076139A1 (en) * 2006-03-10 2008-06-26 Tethys Bioscience, Inc. Multiplex protein fractionation
US20090298093A1 (en) * 2006-04-27 2009-12-03 Roberto Polakiewicz Reagents for the Detection of Protein Phosphorylation in ATM & ATR Kinase Signaling Pathways
WO2007124755A1 (en) * 2006-05-02 2007-11-08 The Antibody Project Aps Method for immunizing an avian species
WO2007133689A2 (en) * 2006-05-12 2007-11-22 Cell Signaling Technology, Inc. Reagents for the detection of protein acetylation signaling pathways
US20150232540A1 (en) 2006-07-11 2015-08-20 Cell Signaling Technology, Inc. Analysis of ubiquitnated polypeptides
US7939636B2 (en) * 2006-08-11 2011-05-10 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in c-Src signaling pathways
WO2008021542A2 (en) * 2006-08-17 2008-02-21 Cell Signaling Technology, Inc. Lysine acteylation sites
US20090258442A1 (en) * 2006-08-31 2009-10-15 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in carcinoma signaling pathways
US20090068684A1 (en) * 2007-03-26 2009-03-12 Cell Signaling Technology, Inc. Serine and threoninephosphorylation sites
US20080238709A1 (en) * 2007-03-28 2008-10-02 Faramarz Vaziri One-way communication apparatus with dynamic key generation
US7977462B2 (en) 2007-04-19 2011-07-12 Cell Signaling Technology, Inc. Tyrosine phosphorylation sites
EP2453234B1 (en) 2007-10-29 2014-01-15 Eisai R&D Management Co., Ltd. Methods for prognosing the ability of a zearalenone analog compound to treat cancer
US20090220991A1 (en) * 2008-02-29 2009-09-03 Cell Signaling Technology, Inc. Reagents for the detection of protein phosphorylation in leukemia signaling pathways
EP2304439A4 (en) * 2008-05-29 2012-07-04 Nuclea Biotechnologies Llc ANTI-phospho-AKT ANTIBODY
US9868781B2 (en) * 2008-06-02 2018-01-16 Cornell University Antibodies for ubiquitinated proteins
US7933146B2 (en) * 2008-10-08 2011-04-26 Seagate Technology Llc Electronic devices utilizing spin torque transfer to flip magnetic orientation
US20110212119A1 (en) * 2008-10-31 2011-09-01 Proteonova, Inc. Methods for making hiv vaccines and related compositions
US8771693B2 (en) * 2009-10-27 2014-07-08 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the generation and use of conformation-specific antibodies
US9453845B2 (en) 2010-02-01 2016-09-27 Cell Signaling Technology, Inc. Mass spectroscopy analysis of mutant polypeptides in biological samples
EP2553150A4 (en) * 2010-04-02 2013-08-14 Kalobios Pharmaceuticals Inc GENERATION OF ANTIBODIES FOR CERTAIN EPITOPES
FI20105715A0 (fi) * 2010-06-18 2010-06-18 Helsingin Yliopisto Asetyloituun HMGB1:een sitoutuva polyklonaalinen vasta-aine
US9249231B2 (en) 2010-11-05 2016-02-02 Cell Signaling Technology, Inc. Motif-specific and context-independent antibodies that specifically bind to a cleaved caspase motif
US10487114B2 (en) 2011-04-27 2019-11-26 Beth Israel Deaconess Medical Center, Inc. Methods for administering peptides for the generation of effective c/s conformation-specific antibodies to a human subject in need thereof
JP2014527085A (ja) * 2011-09-17 2014-10-09 スーチョウ ナアオ ニュー マテリアル サイエンシーズ カンパニー リミテッド ペプチドにおける３個以上のアミノ酸残基の任意に設計されたエピトープを認識する抗体およびその生成方法
EP2573565A1 (en) 2011-09-23 2013-03-27 Gerhard Matthias Kresbach Immune detection method for common epitopes of two or more analytes in samples of complex compositions, device, and kit for enabling said immune detection method
WO2013125221A1 (ja) * 2012-02-21 2013-08-29 静岡県 抗体精製用アフィニティリガンド
JP6293409B2 (ja) * 2012-10-04 2018-03-14 国立大学法人富山大学 抗原特異的ウサギ抗体産生細胞の迅速な特定方法およびその利用
EP2968548B1 (en) 2013-03-15 2020-09-09 Beth Israel Deaconess Medical Center, Inc. Methods and compositions for the generation and use of conformation-specific antibodies
WO2015157530A2 (en) * 2014-04-09 2015-10-15 Brandeis University Enzymatically responsive magnetic particles and their use
CA2945263A1 (en) 2014-04-09 2015-10-15 Christopher Rudd Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity
EP3137482A1 (en) 2014-05-02 2017-03-08 MorphoSys AG Peptide libraries
EP3373950B1 (en) 2015-11-11 2024-05-01 Serimmune Inc. Methods and compositions for assessing antibody specificities
EP3661958A2 (en) * 2017-08-04 2020-06-10 Abcam Plc Methods and compositions for the development of antibodies specific to epitope post-translational modification status
US20230073946A1 (en) * 2020-01-20 2023-03-09 Arizona Board Of Regents On Behalf Of The University Of Arizona Affinity peptide conjugated with antioxidant for protection of proteins from oxidation
GB202012722D0 (en) * 2020-08-14 2020-09-30 Abcam Plc Validation method
US20240034785A1 (en) * 2020-12-07 2024-02-01 Nucmito Pharmaceuticals Co. Ltd. Rxr-alpha binders and rxr-alpha/plk1 modulators
CN116444677A (zh) * 2023-06-09 2023-07-18 中国人民解放军军事科学院军事医学研究院 一种FoxM1蛋白Y575磷酸化的多克隆抗体及其制备方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS61227596A (ja) * 1985-04-01 1986-10-09 Fujisawa Pharmaceut Co Ltd 抗リン酸化チロシンモノクロ−ナル抗体およびそれを産生するハイブリド−マ
EP0544942A1 (en) * 1991-12-06 1993-06-09 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Novel tools for the diagnosis and treatment of Alzheimer disease
JPH05244987A (ja) * 1992-02-28 1993-09-24 Unitika Ltd 抗硫酸化チロシン抗体，その製造方法及び抗硫酸化チロシンモノクローナル抗体を産生するハイブリドーマ
US5532167A (en) * 1994-01-07 1996-07-02 Beth Israel Hospital Substrate specificity of protein kinases
US5679769A (en) * 1994-03-15 1997-10-21 Sloan-Kettering Institute For Cancer Research Synthesis of asparagine-linked glycopeptides on a polymeric solid support
US6001580A (en) * 1995-03-28 1999-12-14 Takeda Chemical Industries, Inc. Method for assaying ERK2 map kinase
US5759787A (en) * 1996-08-26 1998-06-02 Tularik Inc. Kinase assay
FR2757864B1 (fr) 1996-12-30 1999-03-19 Centre Nat Rech Scient Anticorps reconnaissant specifiquement une proteine nitrosylee, leur procede de preparation, leur utilisation therapeutique et diagnostique
US5965352A (en) * 1998-05-08 1999-10-12 Rosetta Inpharmatics, Inc. Methods for identifying pathways of drug action
US6441140B1 (en) * 1998-09-04 2002-08-27 Cell Signaling Technology, Inc. Production of motif-specific and context-independent antibodies using peptide libraries as antigens
US9919577B2 (en) 2014-11-14 2018-03-20 Hyundai Motor Company Air-conditioning device for vehicle

Similar Documents

Publication Publication Date Title
JP2014132019A5 (cg-RX-API-DMAC7.html)
JP2013523703A5 (cg-RX-API-DMAC7.html)
JP2013172734A5 (cg-RX-API-DMAC7.html)
HUE058975T2 (hu) CD73-ellenes antitestek és alkalmazásaik
IL261887A (en) Compositions containing tannic acids and uses thereof
HUE054180T2 (hu) Egykarú I. típusú és II. típusú receptorral rendelkezõ fúziós fehérjék, illetve ezek alkalmazásai
JP2010143932A5 (cg-RX-API-DMAC7.html)
JP2016028081A5 (cg-RX-API-DMAC7.html)
JP2015038108A5 (cg-RX-API-DMAC7.html)
HUE062980T2 (hu) Anti-N3pGlu amiloid béta peptid antitestek és azok alkalmazásai
JP2017501211A5 (cg-RX-API-DMAC7.html)
IL250646A0 (en) A process for conjugating a peptide or protein with a reagent containing a leaving group that includes a peg moiety
JP2014518898A5 (cg-RX-API-DMAC7.html)
JP2018533683A5 (cg-RX-API-DMAC7.html)
JP2016540360A5 (ja) 基板処理システム及び基板処理方法
EP3288952A4 (en) Organotrifluoroborate mimics of amino acids and uses thereof
WO2015092335A3 (fr) Proteines recombinantes possedant une activite de facteur h
EP4269562A3 (en) Antigen binding molecules and methods of use thereof
IL258924A (en) Humanized anti-dkk2 antibody and uses thereof
EP3237374A4 (en) Amino acid and peptide conjugates and uses thereof
WO2015001045A3 (en) Pro-apoptotic ras and raf peptides
JP2017528459A5 (cg-RX-API-DMAC7.html)
DK3429577T3 (da) N-lipoinaminosyre eller peptid, derivater og anvendelser deraf
WO2015117057A3 (en) Protein m related immunoglobulin-binding polypeptides
EP3155438A4 (en) Quantitative peptide or protein assay