JP2014061155A - Radioactive drug administration device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a radioactive drug administration device capable of improving accuracy of administering a radioactive drug.SOLUTION: A radioactive drug administration device 1 comprises a radioactivity amount detection part 100 that is arranged at a middle position of a tube 57 for connecting a filter 51 and an administration member 52 and detects a radioactivity amount of a radioactive drug 30 flowing within the tube 57. Accordingly, the radioactivity amount detection part 100 can detect, on the downstream side of the filter 51, the radioactivity amount of the radioactive drug 30 at the time just before the administration to a subject. When there is a shortage of the drug, the device achieves the administration of an accurate amount of the radioactive drug 30 by additionally administering an amount as much as the shortage. Even if the radioactivity amount detection part 100 is arranged at the middle position, the tube 57 having no seams can surely prevent the radioactive drug 30 from leaking between the filter 51 and the administration member 52.

Description

  The present invention relates to a radiopharmaceutical administration device for administering a radiopharmaceutical to a subject.

  As a conventional radiopharmaceutical administration device, one described in Patent Document 1 is known. This radiopharmaceutical administration device is provided with a chemical syringe for drawing a radiopharmaceutical in a vial, a filter provided downstream from the chemical syringe, and provided downstream from the filter, and administers the radiopharmaceutical to a subject. And a needle to perform.

JP 2002-306609 A

  Here, when administering a radiopharmaceutical to a subject, it is required that a desired amount of radioactivity be accurately administered to the subject. When dispensing a radiopharmaceutical, a conventional radiopharmaceutical administration device controls the dispensing amount by measuring the radioactivity of the radiopharmaceutical with a measuring instrument provided on the upstream side of the filter. For such a radiopharmaceutical administration device, further improvement in the accuracy of radiopharmaceutical administration has been demanded.

  Then, an object of this invention is to provide the radiopharmaceutical administration apparatus which can improve the precision of administration of a radiopharmaceutical.

  A radiopharmaceutical administration device according to the present invention is provided with an attachment portion to which a syringe in which a radiopharmaceutical is stored is attached, a filter provided on the downstream side of the attachment portion, and provided on a downstream side of the filter. A dosing member to be administered, a tube that does not have a joint connecting the filter and the dosing member, and a radioactivity amount detection unit that is provided in the middle of the tube and detects the radioactivity amount of the radiopharmaceutical flowing through the tube; Prepare.

  The radiopharmaceutical administration device according to the present invention includes a radioactivity detection unit that detects the radioactivity of a radiopharmaceutical flowing through the tube at a midway position of the tube connecting the filter and the administration member. Thereby, the radioactivity detection unit can detect the radioactivity of the radiopharmaceutical immediately before being administered to the subject on the downstream side of the filter. Therefore, even if the amount of radiopharmaceutical after dispensing is decreased, it is possible to accurately grasp the radioactivity amount of the radiopharmaceutical actually administered to the subject. Moreover, even if the radioactive quantity detection part is provided in the middle position, since the tube does not have a seam, leakage of the radiopharmaceutical between the filter and the administration member can be reliably prevented. As described above, the accuracy of administration of the radiopharmaceutical can be improved.

  Further, in the radiopharmaceutical administration device, a portion of the tube on the downstream side of the radioactivity detection unit may be extendable. Accordingly, the length can be adjusted by extending the tube without using an extension tube or the like to increase the seam.

  In the radiopharmaceutical administration device, the portion of the tube that is disposed in the radioactivity detection unit may meander. As a result, the tube can be easily arranged in the radioactivity detection unit, and the length of the tube in the radioactivity detection unit is lengthened, thereby effectively increasing the existence time of the radiopharmaceutical in the radioactivity detection unit. be able to.

  Further, in the radiopharmaceutical administration device, a portion of the tube that is disposed in the radioactivity detection unit may have a spiral shape. As a result, the tube can be easily arranged in the radioactivity detection unit, and the length of the tube in the radioactivity detection unit is lengthened, thereby effectively increasing the existence time of the radiopharmaceutical in the radioactivity detection unit. be able to.

  The radiopharmaceutical administration device may further include a warning unit that issues a warning based on the detection result of the radioactivity detection unit. Thereby, the user can easily know that the amount of radiopharmaceutical to be administered is insufficient.

  The radiopharmaceutical administration device may further include a control unit that performs control so as to dispense a shortage of radiopharmaceutical based on the detection result of the radioactivity amount detection unit. In the radiopharmaceutical administration device, the control unit may perform control so as to administer a shortage of radiopharmaceutical. Thereby, even if the amount of radiopharmaceutical to be administered is insufficient, the shortage can be easily compensated.

  In addition, the radiopharmaceutical administration device is connected to another tube provided between the mounting portion and the tube, another radioactivity detection unit for detecting the radioactivity of the radiopharmaceutical in the other tube, and the other tube. And a control unit that controls to discard the radiopharmaceutical into the waste bottle when the amount of radioactivity detected by the other radioactivity detection unit is larger than the set administration radioactivity amount. May be. When the radioactivity of the radiopharmaceutical contained in another tube is measured by another radioactivity detector, if the detected radioactivity is greater than the set dose radioactivity, it will be administered to the subject as it is Since it becomes excessive administration, a control part performs control so that the radiopharmaceutical accommodated in the other tube is discarded to a waste liquid bottle. Therefore, the radioactivity amount of the radiopharmaceutical sent to the tube connected to the administration member may be less than the set administration radioactivity amount, or more than the set administration radioactivity amount. Is prevented. Accordingly, it is possible to easily prevent overdosing and prevent underdosing, and to accurately administer the radiopharmaceutical according to the set dose radioactivity.

  According to the present invention, the accuracy of administration of a radiopharmaceutical can be improved.

It is a schematic block diagram which shows the structure of the radiopharmaceutical administration apparatus which concerns on embodiment of this invention. It is the schematic block diagram which shows the structure of the radiopharmaceutical administration apparatus which concerns on embodiment of this invention, Comprising: It is the figure which showed the structure of the administration part in detail. It is a figure which shows an example of how to bundle a tube. It is a figure which shows the other example of how to bundle a tube. It is a figure which shows the other example of how to bundle a tube.

As shown in FIG. 1, the radiopharmaceutical administration device 1 according to the present embodiment has a function of administering a radiopharmaceutical 30 to a subject. The radiopharmaceutical administration device 1 includes an administration device 200 and an administration unit 13 extending from the administration device 200 to the outside. In addition, the administration device 200 includes a drug transfer unit 11 and a drug adjustment unit 12. Examples of the radiopharmaceutical 30 include ¹⁸ F-FDG (fluorodeoxyglucose) labeled with a radionuclide, ¹³ N-ammonia, ¹¹ C-methionine, and the like.

  The drug transfer unit 11 is connected to the administration unit 13 and transfers the radiopharmaceutical 30 to the administration unit 13 as necessary. Further, a drug adjustment unit 12 is provided for the drug transfer unit 11. The drug adjustment unit 12 adjusts the radiopharmaceutical transported to the administration unit 13 by dilution using physiological saline or the like as necessary. In addition, each component of the radiopharmaceutical administration device 1 is installed in the radiation shielding partition 71 of the administration device 200 except for the raw food bag 41 and the administration unit 13. As the radiation shielding partition 71, lead, tungsten or the like is used.

  The radiopharmaceutical 30 is stored in a vial 32 installed in a state of being stored in a shielding container 33. The radiopharmaceutical 30 in the vial 32 is introduced into a piping system that constitutes the drug transfer unit 11 and the drug adjustment unit 12 through the catalan needle 34 a and the tube 34. Further, a radioactivity sensor 85 for detecting the presence / absence of the radiopharmaceutical 30 passing through the tube 34, the amount of radioactivity, and the like is disposed at a predetermined portion of the tube 34.

  The tube 34 is connected to a three-way stopcock (a valve with a three-way stopcock) 35. The three-way stopcock 35 is further connected with a tube 38 having the other end connected to the three-way stopcock 40 and a medicine syringe 36 driven by a syringe drive device 36a. In such a configuration, the required amount of the radiopharmaceutical 30 corresponding to the set dose radioactivity (the radioactivity to be administered to the subject) is driven via the tube 34 by driving the drug syringe 36. 32 (injection) into the medicine syringe 36. Then, the radioactive medicine 30 injected into the medicine syringe 36 is sent out to the three-way stopcock 40 and the tube 46 through the tube 38. In addition, a shielding portion 37 that shields radiation emitted from the radiopharmaceutical 30 in the medicine syringe 36 is provided around the medicine syringe 36.

  The medicine syringe 36 is detachable from the administration device 200. The administration device 200 is provided with an attachment portion 20 to which the medicine syringe 36 is attached. However, in the administration device 200 according to the present embodiment, the radiopharmaceutical 30 in the vial 32 is dispensed by the pharmaceutical syringe 36 and the dispensed radiopharmaceutical 30 in the pharmaceutical syringe 36 is used. In some cases, the medicine syringe 36 remains attached to the attachment portion 20. For example, during maintenance (due to sterility assurance or failure), the medicine syringe 36 is removed from the attachment portion 20 and a new medicine syringe 36 is attached. The attachment portion 20 includes a structure that supports the medicine syringe 36, the above-described syringe drive device 36a, and a shielding portion 37. The radioactive medicine 30 is placed in the medicine syringe 36 by driving the syringe driving device 36a.

  Two tubes 45 and 46 are further connected to the three-way cock 40. The tube 45 is connected to a raw food bag 41 containing physiological saline through a three-way stopcock 43, a tube 42, and an injection needle 42a. The three-way stopcock 43 is further connected with a edible syringe 44 driven by a syringe drive device 44a. In such a configuration, by driving the edible syringe 44, physiological saline supplied from the edible bag 41 by the tube 42 is injected into the three-way stopcock 40 through the three-way stopcock 43 and the tube 45.

  The edible syringe 44 is detachable from the administration device 200. The administration device 200 is provided with an attachment portion 25 to which the raw edible syringe 44 is attached. The attachment portion 25 includes a structure that supports the edible syringe 44 and the above-described syringe drive device 44a.

  On the other hand, the other tube 46 connected to the three-way stopcock 40 is connected to the three-way stopcock 48 at the other end, and a predetermined part in the middle is a coiled buffer loop 47. The buffer loop 47 is configured to be able to temporarily store the radiopharmaceutical 30 transferred to the administration unit 13. Further, a passage sensor 86 that detects passage of the radiopharmaceutical 30 is disposed at a predetermined portion between the three-way cock 40 and the buffer loop 47 of the tube 46.

  Furthermore, a radioactivity amount detector 80 is installed as a radioactivity amount detection means for detecting the radioactivity amount of the radiopharmaceutical 30 accommodated in the buffer loop 47 with respect to the buffer loop 47. Thereby, the radioactivity amount of the radiopharmaceutical 30 sent out from the syringe 36 for medicines is detected, and the radiopharmaceutical 30 is supplied to the administration unit 13 exactly according to the required amount of the radiopharmaceutical 30 corresponding to the set administration radioactivity amount. It is possible to do. That is, when the difference between the radioactivity amount of the radiopharmaceutical 30 accommodated in the buffer loop 47 and the set administration radioactivity amount is within an allowable range, the radiopharmaceutical 30 in the buffer loop 47 is supplied to the administration unit 13. Is done. Conversely, if the difference between the radioactivity amount of the radiopharmaceutical 30 accommodated in the buffer loop 47 and the set administration radioactivity amount is not within the allowable range, the radiopharmaceutical 30 in the buffer loop 47 is transferred to the waste liquid bottle 56. Supplied and discarded. Further, around the buffer loop 47, a shielding portion 81 that shields radiation emitted from the radiopharmaceutical 30 accommodated in the buffer loop 47 is provided.

  The above tubes, three-way stopcocks, syringes, and the like constitute a piping system that functions as the drug transfer unit 11 and the drug adjustment unit 12. In addition to the tube 46 having the buffer loop 47 described above, a tube 49 on the administration unit 13 side and a tube 53 on the waste liquid bottle 56 side are connected to the three-way cock 48. The tube 49 extends to the outside from the radiation shielding partition wall 71, and a pinch valve 50 is provided in the middle of the tube 49 in the radiation shielding partition wall 71. A passage sensor 87 is arranged for a predetermined part of the tube 49. The passage sensor 87 is used for detecting passage of the radiopharmaceutical 30. The tube 53 is connected to a waste liquid bottle 56 which is a waste liquid storage means for storing the waste liquid. As a result, the three-way cock 48 functions as a switching valve for switching whether the radiopharmaceutical is transferred to the administration unit 13 to be administered to the subject or transferred to the waste liquid bottle 56.

  Next, the configuration of the administration unit 13 will be described in detail with reference to FIG.

  FIG. 2 is a schematic configuration diagram of the radiopharmaceutical administration device 1 according to the present embodiment, and shows the configuration of the administration unit 13 in detail. As shown in FIG. 2, the administration unit 13 of the radiopharmaceutical administration device 1 includes a tube 49 extending from the administration device 200 to the outside, a filter 51, an administration member 52, a tube 57, and a radioactivity amount detection unit 100. I have.

  The filter 51 is provided on the downstream side of the administration device 200 having the attachment portion 20 and is connected to a tube 49 extending from the administration device 200. The filter 51 removes impurities in the radiopharmaceutical 30 by allowing the radiopharmaceutical 30 flowing through the tube 49 from the administration device 200 to pass through.

  The administration member 52 is provided on the downstream side of the filter 51 and the radioactive quantity detection unit 100, and is provided on the distal end portion on the downstream side of the administration unit 13. The administration member 52 is attached (stabbed) to the subject and administers the radiopharmaceutical 30 that has passed through the filter 51 to the subject. Specifically, the administration member 52 includes a needle (such as a winged needle or a vein indwelling needle). In the figure, a winged needle is illustrated as the administration member 52.

  The tube 57 connects the filter 51 and the administration member 52. The distal end portion 57 a on the downstream side of the tube 57 is connected to the administration member 52, and the distal end portion 57 b on the upstream side of the tube 57 is connected to the filter 51. The inlet of the filter 51 is connected to the tube 49, and the outlet of the filter 51 is connected to the tube 57. The tube 57 is made of an elastically deformable material such as polyvinyl chloride or silicon rubber. The tube 57 may have an inner diameter of 1 to 5 mm and a tube thickness of 0.5 to 1 mm.

  The tube 57 has a first portion 57A, a second portion 57B, and a third portion 57C. The first portion 57 </ b> A is a portion on the downstream side of the radioactivity level detection unit 100 and extends between the administration member 52 and the radioactivity level detection unit 100. The second portion 57 </ b> B is a portion upstream of the radioactivity amount detection unit 100 and extends between the filter 51 and the radioactivity amount detection unit 100. The third portion 57 </ b> C is a portion disposed in the radioactive quantity detection unit 100. The third portion 57C is wound a predetermined number of times in a spiral shape. The third portion 57C is configured to be solved so as to reduce the number of windings. Therefore, the length of the first portion 57A can be extended by pulling the tube 57 toward the first portion 57A and taking it out of the radioactivity amount detection unit 100 while releasing the third portion 57C. It has become. Thus, the first portion 57A can be stretched. Details of the configuration of the third portion 57C will be described later. For example, the length L of the first portion 57A before stretching may be set to 50 to 100 cm. The length L of the first portion 57A after stretching may be set to 100 to 200 cm.

  The tube 57 does not have a seam over its entire length. That is, the tube 57 is configured (integrated) with only one tube without a joint from the upstream tip portion 57a to the downstream tip portion 57b. The joint portions in the administration unit 13 are only a connection part between the tube 49 and the filter 51, a connection part between the filter 51 and the tube 57, and a connection part between the tube 57 and the administration member 52. . However, a seam may be provided in the middle of the tube 49 upstream of the filter 51.

  The radioactivity detection unit 100 is provided in the middle of the tube 57 and has a function of detecting the radioactivity of the radiopharmaceutical 30 flowing through the tube 57. The radioactive quantity detection unit 100 has an internal space SP in which the third portion 57C of the tube 57 can be accommodated. The radioactivity amount detection unit 100 detects the radioactivity amount of the radiopharmaceutical 30 flowing in the third portion 57C accommodated in the internal space SP. Specifically, the radioactivity amount detection unit 100 is configured by a well-type radioactivity detector. Note that the radioactivity amount detection unit 100 may be housed in the housing 104, for example, as indicated by a one-dot chain line in FIG. The radioactivity detection unit 100 includes a side wall 101 that surrounds the inner space SP over the entire circumference, and a bottom wall 102 that seals the bottom. The side wall portion 101 has, for example, a cylindrical shape, but the shape is not particularly limited, and may be a polygonal cylindrical shape.

  In addition, the radioactivity amount detection unit 100 includes a control unit 150 that controls the radiopharmaceutical administration device 1 using the detection result of the radioactivity amount detection unit 100. The control unit 150 includes, for example, a CPU, a ROM, a RAM, and the like. The controller 150 is electrically connected to the administration device 200, is electrically connected to sensors and devices in the administration device 200, and controls the administration device 200. For example, the control unit 150 is electrically connected to the driving devices 36a and 44a, the three-way cocks 35, 40, 43, and 48, the radioactivity detection unit 80, and the sensors 85, 86, and 87. The control unit 150 controls the driving devices 36a and 44a and the three-way cocks 35, 40, 43, and 48 so as to dispense and administer a predetermined amount of the radiopharmaceutical 30. Note that a part or all of the radioactivity detector 80 and the sensors 85, 86, and 87 may be omitted.

  The control unit 150 calculates the amount of the radiopharmaceutical 30 to be administered to the subject based on the detection result of the radioactivity amount detection unit 100. Further, the control unit 150 determines whether or not the radiopharmaceutical 30 to be administered to the subject is insufficient with respect to the required amount of the radiopharmaceutical 30 corresponding to the set dose radioactivity, and calculates the deficiency. May be. The control unit 150 may calculate the deficient amount by comparing the amount of the radiopharmaceutical 30 delivered from the administration device 200 with the amount detected by the radioactivity amount detection unit 100 downstream from the filter 51. When the administration device 200 has a dispensing function, the control unit 150 controls each device in the administration device 200 to dispense the insufficient amount of radiopharmaceutical based on the detection result of the radioactivity amount detection unit 100. May be. Further, the control unit 150 may control each device of the administration device 200 to administer the insufficient amount of the radiopharmaceutical 30 based on the detection result of the radioactivity amount detection unit 100. In addition, when the control unit 150 detects the shortage of the radiopharmaceutical 30 and automatically dispenses / administers the deficiency, the control unit 150 inquires the user whether or not the control is necessary before executing the dispensing / administration control. May be.

  The control unit 150 is electrically connected to a warning unit 151 that issues a warning using the detection result of the radioactivity amount detection unit 100. The warning unit 151 issues a warning when it is determined by the control unit 150 that the radiopharmaceutical 30 administered to the subject is insufficient with respect to the required amount of the radiopharmaceutical 30 corresponding to the set dose radioactivity. . As the warning unit 151, for example, a monitor that displays a warning message, a lamp that lights or blinks a warning lamp, a speaker that emits a warning sound or a warning message, a buzzer, or the like may be used.

  An information output unit 152 that outputs various information in the radiopharmaceutical administration device 1 is electrically connected to the control unit 150. The control unit 150 outputs at least information based on the detection result of the radioactivity amount detection unit 100. The information based on the detection result includes, for example, the radioactivity amount detected by the radioactivity amount detection unit 100 and the deficient radioactivity amount (the set administration radioactivity amount and the radioactivity amount detected by the radioactivity amount detection unit 100). Difference), administration rate (radioactivity detected by the radioactivity detector 100 / set dose radioactivity), and the like. The information output unit 152 may output information in any manner, and may be a monitor (operation panel) that displays information, a printer that prints out information, a speaker that outputs information by voice, or a combination thereof. Good.

  In addition, although the control part 150 may control the administration device 200 using the detection result of the radioactive quantity detection part 100, it is not necessary to reflect a detection result in control of the administration device 200. FIG. Further, the warning in the warning unit 151 may not be performed. The control unit 150 may be divided into a unit that controls the administration device 200 and a unit that calculates the detection result of the radioactivity amount detection unit 100.

  Next, a detailed configuration of the third portion 57C of the tube 57 will be described with reference to FIGS.

  The tube 57 of the third portion 57 </ b> C is bundled in a state that can be stored in the radioactivity amount detection unit 100. The method of bundling the tube 57 of the third portion 57C is not particularly limited, but is bundled so that the tube 57 is not crushed and the flow of the radiopharmaceutical 30 is not inhibited. The total tube length in the third portion 57C (that is, the total tube length arranged in the internal space SP of the radioactivity detector 100) is the radioactivity of the radiopharmaceutical 30 passing therethrough. It is set to such an extent that the detection unit 100 can detect it. The total tube length in the third portion 57C is the time until the radiopharmaceutical 30 that has flowed into the third portion 57C of the tube 57 leaves the third portion 57C (that is, the amount of radioactivity of the radiopharmaceutical 30). The presence time in the internal space SP of the detection unit 100 is set to be at least 1 second. Specifically, the total tube length of the third portion 57C is set to 40 to 70 cm.

  The tube 57 of the third portion 57C can be partially released from the bundled state so that the tube 57 of the first portion 57A can be extended. A part of the downstream side of the tube 57 of the third portion 57C can be released. However, the tube 57 of the third portion 57C may be fixed in a state where it is bundled as a whole, and the first portion 57A may not be stretched.

  FIG. 3A is a diagram illustrating an example of how to bundle the tubes 57 in the third portion 57C. FIG. 3B is a diagram illustrating a state in which a part of the tube 57 of the third portion 57C of FIG. 3A is released and the tube 57 of the first portion 57A is extended. As shown in FIG. 3A, the tube 57 has a spiral shape in the third portion 57C. In the third portion 57C, the tube 57 is spirally wound a plurality of times so as to have the same diameter in each step. In addition, it does not need to be the same diameter in each step | level, and a diameter may become small or may become large. In the example of Fig.3 (a), the tube 57 comprises the wound body RB by being wound helically from the upper part toward the downward direction from the upstream part. The tube 57 extends upward from a portion where the spiral winding ends at the lowermost stage of the wound body RB. The tube 57 extending upward passes through the inside of the spirally wound wound body RB (however, it may be outside the wound body RB) and is led out from the internal space SP of the radiation amount detection unit 100. . In FIG. 3, the wound body RB is wound clockwise as viewed from above, but may be wound counterclockwise.

  In the wound body RB, the tube 57 according to one step is fixed to the stepped adjacent tube 57 by bonding or the like. In each stage on the upstream side (here, the upper stage side) of the wound body RB, the fixing part FP (the hatched part in the drawing) is formed over substantially the entire circumference, thereby the tube 57. The winding of can not be released. On the other hand, in each stage on the downstream side (here, on the lower stage side), fixed portions FP are partially formed in several places in the circumferential direction. Thereby, as shown in FIG.3 (b), by pulling the tube 57 in the 1st part 57A, fixation by the fixing | fixed part FP scattered is cancelled | released and winding of the wound body RB is cancelled | released. . Accordingly, the tube 57 of the first portion 57A extends. As another fixing method, a method of locking the tube 57 to the inner surface of the side wall portion 101 of the radioactivity amount detection unit 100 may be employed. For example, a groove or a claw may be provided on the inner surface of the side wall portion 101, and the tube 57 may be locked to the groove or the claw.

  FIG. 4A shows another example of how the tubes 57 are bundled in the third portion 57C. FIG. 4B is a diagram illustrating a state in which a part of the tube 57 of the third portion 57C of FIG. 4A is released and the tube 57 of the first portion 57A is extended. As shown in FIG. 4A, in the third portion 57C, the tube 57 has a spiral shape. In the third portion 57C, the tube 57 is spirally wound a plurality of times so as to have the same diameter in each step. In addition, it does not need to be the same diameter in each step | level, and a diameter may become small or may become large. In the example of FIG. 4A, the tube 57 has an upstream portion that enters the internal space SP from the opening at the upper end of the radiation amount detection unit 100 and extends downward, and is upward from below the bottom wall portion 102 side. The wound body RB is configured by being spirally wound toward the top. The tube 57 is led out from the internal space SP of the radiation amount detection unit 100 from the portion where the winding ends at the uppermost stage of the wound body RB. In FIG. 4, the wound body RB is wound clockwise as viewed from above, but may be wound counterclockwise.

In the wound body RB, the tube 57 according to one step is fixed to the stepped adjacent tube 57 by bonding or the like. In each stage on the upstream side (here, the lower stage side) of the wound body RB, the fixing part FP (the hatched part in the drawing) is formed over substantially the entire circumference, thereby the tube 57. The winding of can not be released. On the other hand, in each stage on the downstream side (here, the upper stage side), fixed portions FP are partially formed in several places in the circumferential direction. Thereby, as shown in FIG.4 (b), by pulling the tube 57 in the 1st part 57A, fixation by the fixing | fixed part FP scattered is cancelled | released and winding of the wound body RB is cancelled | released. . Accordingly, the first portion 57A extends.

  FIG. 5A is a diagram illustrating another example of how the tubes 57 are bundled in the third portion 57C. In the example shown in FIGS. 3 and 4, the wound body RB is housed in the internal space SP of the radiation amount detection unit 100 with the central axis extending in the vertical direction. On the other hand, in FIG. 5A, the center line of the wound body RB is housed in the internal space SP in a state extending in the horizontal direction.

  FIG. 5B is a diagram showing another example of how the tubes 57 are bundled in the third portion 57C. As shown in FIG. 5B, the tube 57 meanders in the third portion 57C. FIG. 5B is a schematic diagram showing the state of meandering, and meandering is performed in a line. However, as long as it can be stored in the internal space SP of the radiation amount detection unit 100, any mode is possible. May meander. For example, the tubes 57 may be bundled so as to meander in a state where they are not arranged in a certain pattern. Even when the tube 57 is meandering as shown in FIG. 5B, the tubes 57 may be fixed together using an adhesive. Alternatively, the tubes 57 may be fixed using a binding band or the like. When the tube 57 of the first portion 57A is extended, a part of the tube 57 of the third portion 57C is released from the binding of the binding band. In addition, it is good also as a structure which arrange | positions the tube 57 bundled simply in the radioactivity amount detection part 100, without fixing.

  Next, an example of a method for using the radiopharmaceutical administration device 1 will be described.

  (1) First, disposable parts (syringe, three-way stopcock, tube, needle, filter), which are components that are exchanged about once a day, are set in the radiopharmaceutical administration device 1.

  (2) The vial 32 containing the radiopharmaceutical 30 is set in the radiopharmaceutical administration device 1 while being stored in the shielding container 33.

  (3) A certain amount of the radiopharmaceutical 30 contained in the vial 32 is drawn by the drug syringe 36 through the tube 34 and the three-way cock 35. Next, the radiopharmaceutical 30 is pushed in until the passage sensor 86 detects the passage of the radiopharmaceutical 30 through the three-way stopcock 35, the tube 38, and the three-way stopcock 40. Thereby, the path from the tube 34 to the passage sensor 86 is filled with the radiopharmaceutical 30, and at the same time, air is expelled from the path.

  (4) Next, the saline from the three-way stopcock 43 to the tube 53 is filled with physiological saline using the edible syringe 44, and at the same time, the radiopharmaceutical in the tube 46 downstream of the three-way stopcock 40 in (3). 30 is discharged into the waste liquid bottle 56. Furthermore, the line from the three-way cock 48 to the administration member 52 is also filled with physiological saline. These things fill the entire path with liquid and extrude air.

  (5) When various setting conditions (administration radioactivity amount, volume, administration speed) are input by the control unit 150, the radioactivity corresponding to the radioactivity concentration always read by the radioactivity sensor 85 and the set administration radioactivity amount From the required amount of 30, the amount of the radiopharmaceutical 30 to be injected into the drug syringe 36 is calculated, and the radiopharmaceutical 30 is injected (dispensed) into the drug syringe 36. Then, the driving of the medicine syringes 36 and 44 and the three-way cock are switched, and the dispensed amount of the radioactive medicine 30 is filled in the buffer loop 47.

  (6) The radioactivity amount of the radiopharmaceutical 30 filled in the buffer loop 47 is detected by the radioactivity amount detection unit 80, and it is confirmed whether the difference between the detected value and the set administration radioactivity amount is within an allowable range. If the difference exceeds the allowable range, the radiopharmaceutical 30 in the buffer loop 47 is discarded into the waste liquid bottle 56, and the dispensing of (5) is performed again.

  (7) The radiopharmaceutical 30 in the buffer loop 47 is sent to the administration unit 13 at the set speed by the operation of the control unit 150.

  (8) The radioactivity amount detection unit 100 detects the radioactivity amount of the radiopharmaceutical 30 flowing through the third portion 57 </ b> C of the tube 57.

  (9) The radioactivity amount of the radiopharmaceutical 30 administered to the subject or the radioactivity amount of the radiopharmaceutical 30 scheduled to be administered to the subject (in this case, before the radiopharmaceutical 30 is administered, the radioactivity amount detection unit 100 Various kinds of information are output to the information output unit 152.

  (10) If the radioactivity of the radiopharmaceutical 30 administered to the subject is insufficient from the specified amount, dispense and administer the deficiency.

  (11) The above dispensing, measuring, and administration operations are repeatedly performed.

  Next, the operation and effect of the radiopharmaceutical administration device 1 according to this embodiment will be described.

  Here, in the radiopharmaceutical administration device that does not have the radioactive quantity detection unit 100, even if the radiopharmaceutical 30 is dispensed by the administration device 200, in the unlikely event that the radiopharmaceutical 30 is administered to the subject, The amount of can be reduced. For example, when the radiopharmaceutical 30 adheres to the filter 51, or at a joint (a connection portion between the filter 51 and the tube 49, a connection portion between the filter 51 and the tube 57, a connection portion between the tube 57 and the administration member 52, etc.) If a leak occurs, the amount of radiopharmaceutical 30 that is actually administered to the subject is reduced. Even in such a case, it is required to administer an accurate amount of the radiopharmaceutical 30.

  On the other hand, the radiopharmaceutical administration device 1 according to the present embodiment detects the radioactivity amount of the radiopharmaceutical 30 flowing in the tube 57 at a midway position of the tube 57 connecting the filter 51 and the administration member 52. A detection unit 100 is provided. Thereby, the radioactivity amount detection unit 100 can detect the radioactivity amount of the radiopharmaceutical 30 immediately before being administered to the subject on the downstream side of the filter 51. Therefore, even if the amount of the radiopharmaceutical 30 after dispensing may decrease, the radioactivity amount of the radiopharmaceutical 30 actually administered to the subject can be accurately grasped. When it is insufficient, the radiopharmaceutical 30 can be administered in an accurate amount by additionally administering the shortage. Even if the radioactive quantity detection unit 100 is provided in the middle of the tube 57, the tube 57 does not have a joint, so that the radiopharmaceutical 30 can be surely leaked between the filter 51 and the administration member 52. Can be prevented. As described above, the accuracy of administration of the radiopharmaceutical 30 can be improved.

  In the radiopharmaceutical administration device 1, the first portion 57 </ b> A on the downstream side of the radioactivity amount detection unit 100 in the tube 57 can be extended. Thus, the length can be adjusted by extending the tube 57 without using an extension tube or the like to increase the seam. For example, the distance from the radiopharmaceutical administration device 1 to the table on which the subject is placed or the table on which the subject sits varies depending on the facility. Therefore, by extending the first portion 57A of the tube 57, the administration member 52 of the administration unit 13 can be attached to the subject without moving the radiopharmaceutical administration device 1.

  Moreover, in the radiopharmaceutical administration apparatus 1, the part arrange | positioned in the radioactivity amount detection part 100 among the tubes 57 may meander. Accordingly, the third portion 57C of the tube 57 can be easily disposed in the radioactivity amount detection unit 100, and the length of the tube 57 in the radioactivity amount detection unit 100 is increased to increase the length of the radiopharmaceutical 30. The existence time in the radioactive quantity detection part 100 can be lengthened efficiently.

  Moreover, in the radiopharmaceutical administration device 1, the part arrange | positioned in the radioactive amount detection part 100 among the tubes 57 may have comprised the helical form. Accordingly, the third portion 57C of the tube 57 can be easily disposed in the radioactivity amount detection unit 100, and the length of the tube 57 in the radioactivity amount detection unit 100 is increased to increase the length of the radiopharmaceutical 30. The existence time in the radioactive quantity detection part 100 can be lengthened efficiently.

  Moreover, the radiopharmaceutical administration device 1 includes a warning unit 151 that issues a warning based on the detection result of the radioactivity amount detection unit 100. Thereby, the user can easily know that the amount of the radiopharmaceutical 30 to be administered is insufficient.

  Further, the radiopharmaceutical administration device 1 includes a control unit 150 that performs control so as to dispense the insufficient amount of the radiopharmaceutical 30 based on the detection result of the radioactivity amount detection unit 100. Further, in the radiopharmaceutical administration device 1, the control unit 150 performs control to administer the shortage of radiopharmaceutical 30. Thereby, even if the amount of radiopharmaceutical 30 to be administered is insufficient, the shortage can be easily compensated.

  The radiopharmaceutical administration device 1 includes tubes (other tubes) 38, 46, 49 and a buffer loop (other tubes) 47 provided between the attachment portion 20 and the tube 57, and the radiopharmaceutical in the buffer loop 47. A radioactivity amount detection unit (another radioactivity amount detection unit) 80 for detecting 30 radioactivity amounts, a waste bottle 56 connected to the tubes 46 and 49, and a radioactivity amount detected by the radioactivity amount detection unit 80 are set. And a control unit 150 that controls the radiopharmaceutical 30 to be disposed of in the waste liquid bottle 56 when the dose is greater than the administered radioactivity amount.

  When the radioactivity amount of the radiopharmaceutical 30 accommodated in the buffer loop 47 is measured by the radioactivity amount detection unit 80, if the detected radioactivity amount is larger than the set administration radioactivity amount, it is administered to the subject as it is. Because of excessive administration, the control unit 150 performs control so that the radiopharmaceutical 30 accommodated in the buffer loop 47 is discarded in the waste liquid bottle 56. Therefore, the radioactivity amount of the radiopharmaceutical 30 sent to the third portion 57C of the tube 57 of the administration unit 13 is equal to or less than the set administration radioactivity amount, and the set administration radiation is set. It is prevented from exceeding the capacity.

  Since the radioactivity amount of the radiopharmaceutical 30 sent to the third portion 57C of the tube 57 does not exceed the set dose radioactivity amount, a three-way cock is provided downstream of the tube 57 and connected to the waste liquid bottle. There is no need. Since there is no need to provide a three-way cock on the downstream side of the tube 57, leakage of the radiopharmaceutical 30 on the downstream side of the tube 57 can be suppressed, and accurate administration can be performed according to the set dose radioactivity.

  As described above, when the radioactivity amount of the radiopharmaceutical 30 in the buffer loop 47 is larger than the administration radioactivity amount, the radiopharmaceutical 30 is discarded in the waste liquid bottle 56 on the upstream side of the administration section 13 and administered. By detecting the radioactivity amount of the radiopharmaceutical 30 again by the unit 13, it is possible to easily prevent overdosing and prevent underdosing, and to administer the radiopharmaceutical 30 exactly according to the set administration radioactivity amount.

  It is also possible to prevent overdosing without providing the waste liquid bottle 56 upstream of the administration unit 13. When the radioactivity detected by the radioactivity detector 100 of the administration unit 13 is greater than the set administration radioactivity, the administration member 52 is removed from the subject without administration to the subject, and the prepared waste bottle is dispensed By discarding the radiopharmaceutical 30 in the third portion 57C, overdose can be prevented. In addition, since this method requires time and effort such as removing the administration member 52 from the subject, the method of disposing the waste liquid bottle 56 upstream of the administration unit 13 and automatically discarding it is simpler.

  The radiopharmaceutical synthesis administration device according to the present invention is not limited to the above-described embodiments and configuration examples, and various modifications are possible. For example, various configurations other than the configuration shown in FIG. 3 may be used as a specific configuration such as a piping system used for the drug transfer unit 11 and the drug adjustment unit 12.

  Further, the configuration of the administration device 200 is not particularly limited. The administration device 200 only needs to have at least the attachment portion 20 to which the medicine syringe 36 containing the radioactive medicine 30 is attached. The radiopharmaceutical administration device 1 according to the above-described embodiment has a configuration in which a dispensing device (dispensing function) and an administration device (administration function) are integrated. On the other hand, a configuration in which the dispensing device and the administration device are not integrated may be adopted. In such a case, the radiopharmaceutical administration device 1 functions as a device dedicated to administration that does not have a dispensing function, and the vial 32 The shielding container 33, the tube 34, the radioactivity sensor 85, etc. are not provided in the administration device 200, and the attachment portion 20 of the medicine syringe 36 and the tube connecting the medicine syringe 36 and the administration portion 13 are provided. It becomes. In this case, the radiopharmaceutical 30 is injected into the pharmaceutical syringe 36 by a dispensing device that is a separate device from the radiopharmaceutical administration device 1, and the pharmaceutical syringe 36 is transported to the radiopharmaceutical administration device 1 (shielded container). Is transported strictly in a state of being housed inside.) Thus, the medicine syringe 36 in which a necessary amount of the radiopharmaceutical 30 is stored in advance is attached to the attachment section 20, and the syringe driving device 36 a is driven to administer the radiopharmaceutical 30 from the administration section 13 to the subject. The After the administration is completed, the empty medicine syringe 36 is removed, a new medicine syringe 36 into which the radioactive medicine 30 is injected is attached, and the next administration is performed.

  DESCRIPTION OF SYMBOLS 1 ... Radiopharmaceutical administration apparatus, 20, 25 ... Attachment part, 30 ... Radiopharmaceutical, 36 ... Syringe for medicine, 38, 46, 49 ... Tube (other tube), 47 ... Buffer loop (other tube), 51 ... Filter, 52 ... administration member, 57 ... tube, 80 ... radioactivity detection unit (other radioactivity detection unit), 100 ... radioactivity detection unit, 150 ... control unit, 151 ... warning unit.

Claims (8)

A mounting part to which a syringe for storing a radiopharmaceutical is attached;
A filter provided downstream of the mounting portion;
An administration member provided downstream of the filter and for administering the radiopharmaceutical to a subject;
A tube without a seam connecting the filter and the dosing member;
A radiopharmaceutical administration device comprising: a radioactivity amount detection unit that is provided in a midway position of the tube and detects the radioactivity amount of the radiopharmaceutical flowing through the tube.   The radiopharmaceutical administration device according to claim 1, wherein a portion of the tube on the downstream side of the radioactivity amount detection unit is extendable.   The radiopharmaceutical administration device according to claim 1 or 2, wherein a portion of the tube disposed in the radioactivity detector is meandering.   The radiopharmaceutical administration device according to claim 1 or 2, wherein a portion of the tube that is disposed in the radioactivity detection unit has a spiral shape.   The radiopharmaceutical administration device according to any one of claims 1 to 4, further comprising a warning unit that issues a warning based on a detection result of the radioactivity detection unit.   The radiopharmaceutical administration device according to any one of claims 1 to 5, further comprising a control unit that performs control so as to dispense a shortage of radiopharmaceutical based on a detection result of the radioactivity amount detection unit.   The radiopharmaceutical administration device according to claim 6, wherein the control unit performs control to administer the shortage of radiopharmaceutical. Another tube provided between the mounting portion and the tube;
Other radioactivity detectors for detecting the radioactivity of the radiopharmaceutical in the other tube;
A waste bottle connected to the other tube;
And a control unit that controls to discard the radiopharmaceutical into the waste liquid bottle when the radioactivity amount detected by the other radioactivity amount detection unit is larger than a set administration radioactivity amount. Item 8. The radiopharmaceutical administration device according to any one of Items 1 to 7.

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