JP2000350783A - Injection method and apparatus of radioactive liquid - Google Patents

Abstract

PROBLEM TO BE SOLVED: To reduce exposure quantity to a handling person and measure the dose simply and accurately by temporarily keeping the whole radioactive liquid in a radiation shielding liquid retainer immediately before injection, measuring the radiation dose, then injecting the whole quantity into a human body. SOLUTION: A medicine liquid of a precalculated quantity is pushed in a medicine retainer 30 by lightly pushing a medicine injecting cylinder 26. And, the medicine liquid remaining in a valve 16 and the inlet of a coil-form medicine retainer 30 is pushed in the medicine retainer 30 by quantitative discharge of distilled water for injection or saline by a pushing cylinder 22. Thereby the whole quantity is pushed in the retainer 30. Then, inspection preparation is arranged by attaching an injection needle 20 at the tip of a tube 12 to a subject, and the radiation dose is measured by a radioactivity measuring instrument 32. Then the total radioactive medicine is administered to the subject by feeding distilled water for injection or saline with the pushing cylinder 22. Thus accurate administration is possible with reduced exposure quantity to a handling person.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a method and an apparatus for injecting a radioactive liquid, and more particularly to a radiopharmaceutical labeled with a highly radioactive nuclide having a short half-life and suitable for use in administering to a subject. The present invention relates to a method and an apparatus for injecting a radioactive liquid for injecting a radioactive liquid into a human body.

[0002]

2. Description of the Related Art When a radiopharmaceutical labeled with a highly radionuclide with a short half-life is administered to a subject in a laboratory or the like of a hospital, it is necessary to prevent the operator from being exposed to radiation and to set a predetermined dose. A mechanism for precisely administering the drug at a constant rate is required, and an automatic and remote control device is required. Therefore, as a device for automatically administering a radiopharmaceutical to a subject, an MR contrast agent injection device, a radiopharmaceutical automatic injection device, and the like have been put to practical use.

[0003] These injection devices basically include a syringe filled with a certain amount of a drug solution, a tube up to a subject, and filling the tube with distilled water for injection or physiological saline.
It consists of a syringe for the final push-in injection for administering the whole amount of the drug solution, an automatic or manual valve for switching the liquid flow, an operation mechanism for administering at a constant speed, a controller, and the like.

[0004] Using such an implanter, short-lived nuclides (for example, as a positron-emitting nuclide, 150 O is 2 minutes, 11
C has a half-life of 20 minutes and 18F has a half-life of 110 minutes.) 15 O-water or 11 C-methionine or 18 F-
Conventionally, when a drug such as FDG (fluorodeoxyglucose) is administered to a subject, the radioactivity is measured with the drug in a syringe before administration, and the radioactivity remaining in the syringe is again measured after the administration. The amount of radioactivity administered to the subject was measured by determining the amount of radioactivity at the time of measurement and administration (reference time) by correcting for radioactivity decay.

Usually, the concentration of a vial of a drug solution is known, and in order to obtain a desired amount of radioactivity, a predetermined volume calculated and calculated is aspirated. In this case, it is also possible to inject a certain amount of a chemical solution from another device without using a vial. In any case, it is necessary to accurately measure the syringe that has been inhaled in a certain amount. It was transported, attached to the device, and after administration was completed, the amount of radioactivity remaining in the syringe was measured again to determine the dose.

[0006]

Therefore, it is necessary to accurately measure the amount of radioactivity twice before and after administration, which is not only troublesome and troublesome, but also involves measuring the amount of radioactivity contained in a syringe. When doing so, the measurer will be exposed. Moreover, by measuring the syringe after administration, there is also a danger of being exposed and causing the administration solution to adhere to the body.

SUMMARY OF THE INVENTION The present invention has been made to solve the above-mentioned conventional problems, and can reduce the dose of radiopharmaceuticals and radioactive compounds labeled with short-lived nuclides by reducing the radiation exposure of the operator. Another object is to measure accurately.

[0008]

According to the present invention, there is provided a method for injecting a radioactive liquid for injecting a radioactive liquid into a human body, comprising the steps of:
Immediately before injection, the entire amount of the radioactive liquid is temporarily stored in the radiation-shielded liquid holding unit, and the radioactivity of the radioactive liquid stored in the liquid holding unit is measured. This problem has been solved by injecting.

According to the present invention, in a radioactive liquid injection device for injecting a radioactive liquid into a human body, a liquid holding portion capable of temporarily storing the entire amount of the radioactive liquid immediately before injection is provided, and the liquid holding portion is shielded. Radiation shielding means, radioactivity measuring means for measuring the radioactivity amount of the radioactive liquid contained in the liquid holding part, and liquid pushing means for injecting the whole radioactive liquid after the radioactivity measurement into a human body. By doing
This has solved the above-mentioned problem.

Further, there is provided a radiation shielding means for shielding a radioactive liquid feeding means for feeding a radioactive liquid into the liquid holding portion.

Further, all of the means are mounted on a movable cart.

[0012]

Embodiments of the present invention will be described below in detail with reference to the drawings.

FIG. 1 shows a first embodiment corresponding to the basic configuration of the present invention.

In this embodiment, a bag 10 containing physiological saline or distilled water for injection is connected to the bag 10 at the rear end, and two valves with a three-way stopcock are arranged in the middle from the bag 10 side. 14 and 16 and a filter 18 are disposed, and the saline 12 or the distilled water for injection is pushed into the tube 12 through the tube 12 to which the injection needle 20 is connected at the tip and the valve 14 with the three-way cock. For example, through a push-in syringe 22 with a servo actuator 24 by an ultrasonic motor and a valve 16 with a three-way cock, for injecting a radiopharmaceutical into the tube 12, for example, in a shield container 28 made of lead. The contained injection device, for example, provided with a servo actuator with an ultrasonic motor or a syringe 26 for manually injecting a radioactive drug, Between the syringe 26 and the filter 18, for example, a coil-shaped medicine holding part 30 capable of temporarily containing the whole amount of the radiopharmaceutical just before injection, and measuring the radioactivity of the radiopharmaceutical contained in the medicine holding part 30 In order to measure the radioactivity of the radiopharmaceutical stored in the drug holding unit 30 by providing a radioactivity measuring device 32 having a display unit 34, the total amount of the radiopharmaceutical,
The injection syringe 22 is used to inject into the subject.

The syringe 26 for drug injection is stored in a shield container 28 whose tip (lower end in the figure) is open, and is stored in the shield container 28.
It is detachable from the device. The entire amount of the drug solution in the drug injection syringe 26 is automatically or manually pushed into the tube 12 by switching the valve 16, and the entire amount of the drug solution is directed toward the coil-shaped drug holding unit 30 provided in the middle of the tube 12. Is input. Further, the drug solution remaining at the inlet of the valve 16 and the coil-shaped drug holding unit 30 discharges a predetermined amount of distilled water for injection or physiological saline with the pushing syringe 22, and pushes the whole drug solution into the drug holding unit 30. .

The medicine holding section 30 secures a coil capacity such that the medicine does not reach the subject when the entire amount of the medicine is charged by the medicine injection cylinder 26.

As the radioactivity measuring device 32, a well-type dose (radiation dose) calibrator is suitable for accurate measurement. However, for some purposes,
It is also effective to use a simple detector such as a NaI scintillation detector or a GM detector to detect the value with a rate meter, a radiation counter, or the like.

Hereinafter, the operation of the present embodiment will be described.

After the device is attached to the apparatus, the syringe 26 for drug injection is lightly pushed in, a predetermined amount is discharged, and the whole amount of the drug solution is pushed into the drug holding section 30. Further, the valve 16
The drug solution remaining at the entrance of the coil-shaped drug holding unit 30 discharges a predetermined amount of distilled water for injection or physiological saline with the pushing syringe 22, and pushes the entire drug solution into the drug holding unit 30.

Next, the injection needle 20 at the tip of the tube 12 is attached to the subject.

After preparation for inspection, the radioactivity measuring device 32
The accurate amount of radioactivity is measured with a syringe 22
Then, distilled water for injection or physiological saline is flowed, and the entire amount of the radiopharmaceutical held in the drug holding unit 30 is administered to the subject.

After administration, preparation for the next administration is started. At this time, since the entire amount has been administered, it is not necessary to measure the residual amount of radioactivity of the drug injection syringe 26 used for the administration, unlike the related art.

Next, a specific second embodiment suitable for use in an actual hospital will be described in detail.

In this embodiment, FIG. 2 (vertical sectional view as viewed from the front), FIG. 3 (transverse sectional view as viewed from above), FIG. 4 (longitudinal sectional view as viewed from the right side of FIG. 2), and FIG. As shown in the back view of the main part), the bag 10, the tube 12, the valves 14 and 16 with the three-way cock, the filter 18, the pushing syringe 22, the medicine injecting syringe 26, and the medicine holding part 30 are the same as those in the first embodiment. The radioactivity measuring devices 32 are all mounted on a wagon 40 equipped with a fixed caster 42, a freely adjustable caster 44 with a brake, and a handle 46 to facilitate movement in a hospital.

In the drawing, reference numeral 50 denotes a stand for the bag 10 which can swing in the range of the arrow A shown in FIG. 3, 52 denotes a fixed base for the filter 10, and 54 denotes a holder for holding the pushing syringe 22. Is a syringe holder for holding the syringe 26 for medicine injection whose tip is shielded by a shield container 28 made of, for example, tungsten, and 58 is a syringe holder for the syringe 26 for medicine injection.
As shown by an arrow B in FIG. 3, a servo actuator for driving, 60 is a tube winding tube constituting the medicine holding section 30, and 62 is a radioactivity measuring device 32
The dose calibrator 64 is a shield thereof, the reference numeral 66 is a panel fixed to the rear side of FIG. 2, and the controller of the dose calibrator 62, 68 is also provided on the rear side of FIG. The panel-pull-out type operation panel 70 which can be pulled out as shown by arrow C, 70 is a wagon 4
0, a main control panel 72 disposed below the main control panel 7.
The sub-control panel 74 provided above the zero is provided with the tube 12, the three-way cock with valves 14, 16,
As shown by an arrow D, the filter 18 and the syringe 26 for drug injection can be slid horizontally, as shown by an arrow D.
For example, a lead shield having a thickness of 10 mm and a lead cover 76 having a thickness of 20 mm, for example, a lead shield 78 having a thickness of 20 mm, a radiation sensor 78 provided on the exit side of the tube 12 for confirming passage of a radiopharmaceutical, and a drainage liquid 80 Bottle 82, its holder, 84, a case for accommodating the pushing cylinder 22, 86, its transparent PVC door,
Reference numeral 88 denotes a buffer solution disposal stand.

In using this embodiment, first,
The drug injection syringe 26 containing the radioactive liquid is set by opening the upper door 76 of the slidable lead shield 74.

After the upper door 76 is closed to complete the shielding state, the servo actuator 58 is driven to send the entire amount of the radioactive liquid to the medicine holding section 30 wound around the tube winding pipe 60. Further, the drug solution remaining at the inlet of the valve 16 and the coil-shaped drug holding unit 30 discharges a predetermined amount of distilled water for injection or physiological saline with the pushing syringe 22, and pushes the whole drug solution into the drug holding unit 30. .

Next, the amount of radioactivity is measured with the pipe 60 lowered as shown by the arrow E and put in the dose calibrator 62.

After the radioactivity measurement, the radiopharmaceutical is pushed into the pushing syringe 2 driven by the servo actuator 24.
By 2 it is flushed out and the whole amount is sent to the subject.

In this embodiment, the passage of the radiopharmaceutical is confirmed by the radiation sensor 78 at this time. The radiation sensor 78 can be omitted.

In this embodiment, the operation is automated,
Since the passage of the radioactive liquid is almost completely shielded, the effect of reducing the exposure is high. In particular, filters in the wetted part,
The tubes, three-way stopcock valves, and syringes can all be sterilized and disposable, and can be easily maintained aseptically. In addition, replacement of the line can be easily performed.

It should be noted that accurate measurement is not difficult for radiopharmaceuticals that do not have a short life because they do not need to be so exposed, but it is clear that the present invention can be applied.

[0033]

According to the present invention, the radiation exposure dose of the operator can be reduced, and the dose can be measured simply and accurately.

[Brief description of the drawings]

FIG. 1 is a configuration diagram of a first embodiment showing a basic configuration of the present invention.

FIG. 2 is a longitudinal sectional view showing a second embodiment as a specific configuration example of the present invention, viewed from the front.

FIG. 3 is a cross-sectional view of the same seen from above.

FIG. 4 is a vertical sectional view of the same seen from the right side.

FIG. 5 is a rear view of the same main part.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 10 ... Back 12 ... Tube 14, 16 ... Three-way stopcock valve 18 ... Filter 20 ... Injection needle 22 ... Push-in syringe 26 ... Syringe for radiopharmaceutical injection 30 ... Drug holding part 32 ... Radioactivity measuring instrument 40 ... Wagon 60 ... Tube Winding pipe 62 ... Dose calibrator 28, 64, 74, 76 ... Shield

 ────────────────────────────────────────────────── ─── Continued on the front page (72) Inventor Hirofumi Suzuki 5-2 Sokai-cho, Niihama-shi, Ehime Prefecture F-term in the Niihama Works, Sumitomo Heavy Industries, Ltd. 4C066 AA07 BB01 CC03 DD12 FF05 HH02 LL06 LL19 QQ43

Claims (4)

[Claims] 1. A method for injecting a radioactive liquid into a human body for injecting the radioactive liquid into a human body, wherein immediately before the injection, the entire amount of the radioactive liquid is temporarily stored in a radiation-shielded liquid holding unit, and the liquid holding unit A method for injecting a radioactive liquid, comprising measuring the amount of radioactivity of a contained radioactive liquid, and then injecting the entire amount of the radioactive liquid into a human body. 2. An apparatus for injecting a radioactive liquid into a human body for injecting the radioactive liquid into a human body, comprising: a liquid holding portion capable of temporarily storing the entire amount of the radioactive liquid immediately before injection; and a radiation shielding means for shielding the liquid holding portion. And radioactivity measuring means for measuring the radioactivity of the radioactive liquid stored in the liquid holding part; and liquid pushing means for injecting the entire amount of the radioactive liquid after the radioactivity measurement into a human body. Characteristic radioactive liquid injection device. 3. An apparatus for injecting a radioactive liquid according to claim 2, further comprising radiation shielding means for shielding a radioactive liquid feeding means for feeding the radioactive liquid into said liquid holding section. 4. An apparatus for injecting a radioactive liquid, wherein all of the means according to claim 2 or 3 is mounted on a movable carriage.