JP6564600B2 - Chemical injection device - Google Patents

Description

  The present invention relates to a chemical liquid injector.

  Patent Documents 1 to 3 describe a technique related to a device for dispensing and administering a radioactive drug solution in a container. For example, the device described in Patent Document 1 includes a vial container, an injection syringe, and a filter with an air vent. The vial container contains the radiopharmaceutical. The injection syringe sucks the radiopharmaceutical in the vial container together with the gas, and pushes out the radiopharmaceutical using the gas as a carrier medium. The filter with an air vent removes only the gas from the radiopharmaceutical and the gas pushed out from the injection syringe and allows the radiopharmaceutical to pass through.

  The device described in Patent Document 2 includes a radioactivity concentration detection unit, a dispensing device, a liquid holding unit, a radioactivity amount measurement unit, and an administration unit. The radioactive concentration detection means measures the radioactive concentration of the radioactive liquid in the container immediately before administration. The dispensing device has means for controlling the dispensing amount based on the measurement result. The liquid holding part temporarily stores the entire amount of the radioactive liquid immediately after dispensing. The radioactive quantity measuring means measures the radioactive quantity of the radioactive liquid stored in the liquid holding part. The administration means administers the entire amount of the radioactive liquid after the radioactivity measurement.

Japanese Patent No. 3233628 Japanese Patent No. 4034528

  Conventionally, for example, PET measurement using a radiopharmaceutical solution such as O-15 water has been performed for evaluation of cerebral blood flow in a living body. In such a PET measurement, the radiopharmaceutical solution may be repeatedly administered, and it is desirable to use an automatic administration device in order to reduce the exposure of the operator. The radiopharmaceutical injection device described in Patent Document 1 is one of automatic administration devices. The radiopharmaceutical injection device described in Patent Document 1 can be used for medium-sized animal experiments such as macaque monkeys in addition to large animals.

  The administration target of the drug solution injector is not limited to large animals and medium-sized animals, but also includes small animals such as marmosets. However, the amount of drug solution to be administered varies depending on the size of the animal to be administered (mainly dependent on body weight). Therefore, in order to deal with more kinds of animals, it is desirable to administer an accurate amount of medicinal solution suitable for the size of the animal.

  This invention is made | formed in view of such a problem, and it aims at providing the chemical | medical solution injection device which can administer the exact chemical | medical solution amount suitable for the magnitude | size of the animal.

In order to solve the above-described problems, a chemical solution injection device according to the present invention is a chemical solution injection device that injects a radioactive chemical solution into a living body, and a chemical solution container that stores the radioactive chemical solution, and a radioactive chemical solution in the chemical solution container is aspirated. Later, a chemical solution delivery syringe that sends out the radioactive chemical solution, a holding unit that holds a predetermined amount of the radioactive chemical solution sent from the chemical solution delivery syringe, and an air syringe that pushes out the radioactive chemical solution held in the holding unit by sending air to the holding unit And an injection part that injects the radioactive drug solution pushed out from the holding part into the living body, and the injection part is connected to the holding part via an air vent filter .

  In this chemical solution injector, a radioactive chemical solution is first stored in a chemical solution container. Next, the radioactive chemical solution is sucked from the chemical solution container by the chemical solution delivery syringe, and the radioactive chemical solution is held in the chemical solution delivery syringe. Subsequently, the radioactive chemical solution is delivered from the chemical solution delivery syringe, and this radioactive chemical solution is held by the holding unit. At this time, since the holding portion has a fixed volume, the radioactive chemical solution is held by a predetermined amount. Thereafter, the radioactive drug solution is pushed out by the air sent from the air syringe to the holding unit, and the radioactive drug solution is injected into the living body through the injection unit. As described above, in the above-described chemical solution injector, a certain amount of the radioactive chemical solution determined by the volume of the holding unit is injected into the living body. Therefore, an accurate amount of the radiopharmaceutical solution can be administered according to the size of the animal.

  Moreover, said chemical | medical solution injection apparatus may be characterized by the holding | maintenance part being exchangeable for another holding | maintenance part from which volume differs. Thereby, even if it is a case where the magnitude | size of the animal used as administration object changes, the dosage of a radioactive chemical | medical solution can be changed by simple operation.

  In addition, the above-described chemical liquid injector may have a tubular holding part, and receive the radioactive chemical liquid sent from the chemical liquid delivery syringe from one end and discharge it from the other end. When the holding portion has such a shape, the holding portion becomes part of the flow path of the radioactive chemical solution, and the above-described operation of the holding portion can be suitably performed.

  In addition, the chemical liquid injector may be characterized in that the holding portion is wound in a loop shape. Thereby, the holding | maintenance part which has various volumes can be reduced in size.

  According to the drug solution injection device of the present invention, an accurate drug solution amount suitable for the size of an animal can be administered.

It is a figure which shows the structure of the chemical injection device which concerns on one Embodiment of this invention. It is a figure which shows the various states of a 3 port valve. It is a figure which shows operation | movement of a chemical injection device. It is a figure which shows operation | movement of a chemical injection device. It is a figure which shows operation | movement of a chemical injection device. It is a figure which shows operation | movement of a chemical injection device. It is a figure which shows operation | movement of a chemical injection device. It is a figure which shows operation | movement of a chemical injection device. It is a figure which shows operation | movement of a chemical injection device. It is a figure which shows operation | movement of a chemical injection device. It is a figure which shows operation | movement of a chemical injection device. It is a figure which shows operation | movement of a chemical injection device. It is a figure which shows operation | movement of a chemical injection device. It is a figure which shows the structure of the chemical injection device which concerns on one modification.

  Embodiments of a chemical liquid injector according to the present invention will be described below in detail with reference to the accompanying drawings. In the description of the drawings, the same elements are denoted by the same reference numerals, and redundant description is omitted.

  FIG. 1 is a diagram showing a configuration of a chemical liquid injector 1A according to an embodiment of the present invention. This chemical injection device 1A is a device for injecting a radiopharmaceutical labeled with a radioisotope (RI) into a living body in order to perform a physiological examination of the living body, and the injected RI uses a radiation detector. Measured.

  The chemical liquid injector 1A includes an RI vial 12, a water container 14, an RI syringe 16, an air syringe 18, an air suction port 20, a loop tube 22, and an injection needle 26. Moreover, 1 A of chemical | medical solution injection apparatuses are provided with five 3 port valves (three-way cock) 31-35 and the tubes 41-54.

  Here, the structure of the three-port valves 31 to 35 will be described in advance. 2A to 2E show various states of the three-port valve, and FIGS. 2F to 2J show the abbreviations corresponding to FIGS. 2A to 2E, respectively. Show. The three-port valve has a first port 30a, a second port 30b, and a third port 30c. In the state of FIG. 2A, the first port 30a and the second port 30b are connected to each other, and the third port 30c is not connected to any port. In the state of FIG. 2B, the second port 30b and the third port 30c are connected to each other, and the first port 30a is not connected to any port. In the state of FIG. 2C, the first port 30a, the second port 30b, and the third port 30c are connected to each other. In the state of FIG. 2D, the first port 30a and the third port 30c are connected to each other, and the second port 30b is not connected to any port. In the state of FIG. 2E, the first port 30a, the second port 30b, and the third port 30c are not connected to each other.

  Refer to FIG. 1 again. The RI vial 12 is an example of a chemical solution container in the present embodiment, and stores a radioactive chemical solution. The RI vial 12 is a glass container having an opening, for example, and the opening is sealed with a rubber cap. And three injection needles have penetrated this cap. One end of each of the tubes 41 to 43 is connected to each of these injection needles, and a flow path for liquid and gas flowing inside the tubes is ensured. The other end of the tube 41 is connected to the cyclotron 10. The other end of the tube 42 is connected to an exhaust device (not shown). The other end of the tube 43 is connected to the first port of the valve 31. The RI vial 12 is provided with a radiation measuring device (dose calibrator) 13 to measure the radiation dose in the RI vial 12.

  The water container 14 stores and delivers physiological saline. The water container 14 is connected to the second port of the valve 31 via the tube 44. The radioactive gas produced by the cyclotron 10 is mixed with the physiological saline to become a radioactive chemical solution.

  The RI syringe 16 is an example of a chemical solution delivery syringe in the present embodiment. The RI syringe 16 is connected to the second port of the valve 32 via the tube 46. The first port of the valve 32 is connected to the third port of the valve 31 through the tube 45. The RI syringe 16 sucks and holds the radioactive drug solution from the RI vial 12. Thereafter, the RI syringe 16 delivers this radioactive chemical solution.

  The loop tube 22 is an example of a holding unit in the present embodiment, and holds a predetermined amount of the radioactive chemical solution delivered from the RI syringe 16. The loop tube 22 is tubular and is wound in a loop shape. The loop tube 22 receives the radiopharmaceutical solution delivered from the RI syringe 16 from one end and discharges it from the other end. One end of the loop tube 22 is connected to the third port of the valve 34 via the tube 50. The first port of the valve 34 is connected to the third port of the valve 32 through a tube 47. The other end of the loop tube 22 is connected to the first port of the valve 35 via the tube 51. The loop tube 22 can be replaced with another loop tube 22 having a different volume (for example, the same inner diameter and different length). Specifically, one end of the loop tube 22 is detachably connected to the tube 50, and the other end of the loop tube 22 is detachably connected to the tube 51.

  The air syringe 18 pushes out the radioactive chemical liquid held in the loop tube 22 by sending air to the loop tube 22. The air syringe 18 is connected to the first port of the valve 33 via the tube 48. A second port of the valve 33 is connected to the air inlet 20. The third port of the valve 33 is connected to the second port of the valve 34 through the tube 49.

  The injection needle 26 is an example of an injection unit in the present embodiment, and injects a radioactive drug solution pushed out from the loop tube 22 into the living body. The injection needle 26 is connected to the third port of the valve 35 via the tube 54, the air vent filter 24, and the tube 53. The second port of the valve 35 is connected to one end of the tube 52. The other end of the tube 52 is connected to a waste vial (not shown).

  Operation | movement of 1 A of chemical | medical solution injection devices of this embodiment provided with the above structure is demonstrated. 3-13 is a figure which shows operation | movement of 1 A of chemical | medical solution injection apparatuses. In these drawings, the flow path filled with physiological saline or radioactive chemical is indicated by a broken line.

  First, a loop tube 22 having a volume corresponding to the size (mainly body weight) of an animal to be administered is attached. Next, as shown in FIG. 3, the flow path from the air vent filter 24 to the injection needle 26, specifically, the tube 54 is filled with physiological saline and waits in that state. Subsequently, as shown in FIG. 4, the physiological saline in the water container 14 in a state where the second port and the third port of the valve 31 are electrically connected and the first port and the second port of the valve 32 are electrically connected. The RI syringe 16 sucks water. At this time, the physiological saline reaches the RI syringe 16 through the tubes 44, 45 and 46.

  Subsequently, as shown in FIG. 5, the physiological saline W1 in the RI syringe 16 is sent to the RI vial 12 in a state where the first port and the third port of the valve 31 are conducted. At this time, the physiological saline W1 reaches the RI vial 12 through the tubes 46, 45 and 43. Subsequently, as shown in FIG. 6, after the valve 31 is turned off, the radioactive gas G <b> 1 produced by the cyclotron 10 is collected by physiological saline in the RI vial 12. Thereby, a radioactive chemical solution is generated. At the same time, the radiation measuring instrument 13 measures the amount of radioactivity of the radioactive chemical solution. The movement of the radioactive gas G1 to the RI vial 12 is continued until the radiation dose of the radiopharmaceutical solution in the RI vial 12 reaches a necessary amount.

  Subsequently, as shown in FIG. 7, the RI syringe 16 sucks the radiopharmaceutical solution R <b> 1 in the RI vial 12 in a state where the first port and the third port of the valve 31 are conducted again. At this time, the radiochemical solution R1 reaches the RI syringe 16 through the tubes 43, 45, and 46. Subsequently, as shown in FIG. 8, the RI syringe 16 is connected to the radioactive drug solution R <b> 1 in a state where the second port and the third port of the valve 32 are electrically connected and the first port and the third port of the valve 34 are electrically connected. Is sent to the loop tube 22. At this time, the radioactive chemical R1 reaches the loop tube 22 through the tubes 46, 47 and 50. At this time, the first port and the second port of the valve 35 are electrically connected, and the surplus radioactive chemical R1 is sent to the waste vial through the tubes 51 and 52. Accordingly, the amount of radioactive chemical R1 set by the loop tube 22 remains in the flow path to the valve 35.

  Subsequently, as shown in FIG. 9, the first port and the second port of the valve 33 are conducted, and the air syringe 18 sucks air. At this time, the air reaches the air syringe 18 through the air inlet 20 and the tube 48. Subsequently, as shown in FIG. 10, the first port and the third port of the valve 33 are electrically connected, the second port and the third port of the valve 34 are electrically connected, and the first port and the third port of the valve 35 are electrically connected. The air syringe 18 pushes out air in a state where the port is conducted. Thereby, the air A1 is exhausted to the loop tube 22, and the radioactive drug solution R1 in the loop tube 22 passes through the tube 53, the air vent filter 24, and the tube 54, and is administered from the injection needle 26 to the administration subject. Air is blocked by the air vent filter 24 and does not reach the administration target.

  After the administration is completed, as shown in FIG. 11, all the radioactive drug solution R1 remaining in the RI syringe 16 is sent out with the first port and the second port of the valve 35 conducting. This radiochemical solution R1 is sent to the waste vial through the tubes 46, 47 and 50, the loop tube 22, and the tubes 51 and 52. Subsequently, as shown in FIG. 12, the air syringe 18 sucks air again while the first port and the second port of the valve 33 are electrically connected. Finally, as shown in FIG. 13, with the first port and the third port of the valve 33 conducting and the second port and the third port of the valve 34 conducting, the air syringe 18 removes the air A1. Extrude. As a result, the radiochemical solution R1 remaining in the tube 50, the loop tube 22, and the tubes 51 and 52 is all discharged into the waste vial. The radioactivity amount of the radioactive drug solution remaining in the flow path from the air vent filter 24 to the injection needle 26 is attenuated with time. Thus, the chemical liquid injector 1A returns to the standby state.

  The effect obtained by the chemical injection device 1A of the present embodiment described above will be described. In the drug solution injector 1A, a certain amount of radioactive drug solution determined by the volume of the loop tube 22 as a holding unit is injected into the living body. Therefore, an accurate amount of the radiopharmaceutical solution can be administered according to the size of the animal to be administered.

  Moreover, like this embodiment, the loop tube 22 may be exchangeable for another loop tube 22 having a different volume. Thereby, even if it is a case where the magnitude | size of the animal used as administration object changes, the dosage of a radioactive chemical | medical solution can be changed by simple operation.

  Further, as in the present embodiment, the loop tube 22 is tubular, and the radioactive chemical solution delivered from the RI syringe 16 may be received from one end and discharged from the other end. When the loop tube 22 as the holding portion has such a shape, the holding portion becomes a part of the flow path of the radioactive chemical solution, and the operation as the holding portion can be suitably performed.

  Moreover, like this embodiment, the loop tube 22 which is a holding | maintenance part may be wound by the loop shape. Thereby, the holding | maintenance part which has various volumes can be reduced in size.

  In the device described in Patent Document 2 described above, the amount of drug solution is controlled while monitoring the amount of radioactivity so that the amount of radiopharmaceuticals produced in large quantities is always constant. In contrast, the amount of the chemical solution changes. Such a configuration is used, for example, when preparing a drug having a long half-life. In contrast, in the chemical liquid injector 1A of the present embodiment, the loop tube 22 always holds a certain amount of radioactive chemical liquid. This is because the chemical injection device 1A of the present embodiment aims to accurately dispense a certain amount of chemical corresponding to the size of the animal. In this embodiment, a new (fresh) radiopharmaceutical is produced for each administration, and a certain amount of the drug is supplied. Therefore, the radioactivity concentration of the drug does not change or is negligible.

(Modification)
FIG. 14 is a diagram showing a configuration of a modification of the above embodiment. The difference between this modified example and the above embodiment is the shape of the holding portion. The chemical injection device 1B of the present modification includes a replaceable container (cartridge) 23 instead of the loop tube 22 of the above embodiment as a holding unit. The replaceable container 23 can hold a predetermined amount of the radioactive chemical solution delivered from the RI syringe 16. The replaceable container 23 receives the radioactive chemical solution delivered from the RI syringe 16 from one end and discharges it from the other end. One end of the replaceable container 23 is connected to the third port of the valve 34 via the tube 50. The other end of the replaceable container 23 is connected to the first port of the valve 35 via the tube 51. The replaceable container 23 can be replaced with another replaceable container 23 having a different volume. Specifically, one end of the replaceable container 23 is detachably connected to the tube 50, and the other end of the replaceable container 23 is detachably connected to the tube 51. According to the chemical injection device 1B of the present modification, the same effects as in the above embodiment can be obtained.

  The chemical injection device according to the present invention is not limited to the above-described embodiment, and various other modifications are possible. For example, in the above embodiment, a loop tube is exemplified as the holding portion, and in the above modification, an exchangeable container is exemplified as the holding portion. However, the holding portion of the present invention can have various configurations other than these.

  DESCRIPTION OF SYMBOLS 1A, 1B ... Chemical injection device, 10 ... Cyclotron, 12 ... RI vial, 13 ... Radiation measuring device, 14 ... Water container, 16 ... RI syringe, 18 ... Air syringe, 20 ... Air inlet, 22 ... Loop tube, 23 ... replaceable container, 24 ... air vent filter, 26 ... injection needle, 31-35 ... 3-port valve, 41-54 ... tube, A1 ... air, G1 ... radioactive gas, R1 ... radioactive drug solution, W1 ... physiological saline.

Claims (4)

A chemical injection device for injecting a radioactive chemical into a living body,
A chemical solution container containing the radioactive chemical solution;
A chemical solution delivery syringe for delivering the radioactive chemical solution after aspirating the radioactive chemical solution in the chemical solution container;
A holding unit for holding a predetermined amount of the radioactive chemical solution delivered from the chemical solution delivery syringe;
An air syringe that pushes out the radioactive drug solution held in the holding unit by sending air to the holding unit;
An injection part for injecting the radioactive drug solution pushed out from the holding part into the living body;
Equipped with a,
The chemical injection device, wherein the injection portion is connected to the holding portion via an air vent filter .   The chemical liquid injector according to claim 1, wherein the holding unit is replaceable with another holding unit having a different volume.   The chemical liquid injector according to claim 1 or 2, wherein the holding portion is tubular and receives the radioactive chemical liquid delivered from the chemical liquid delivery syringe from one end and discharges it from the other end.   The chemical injection device according to claim 3, wherein the holding portion is wound in a loop shape.

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