JP2014055156A5 - - Google Patents

Download PDF

Info

Publication number
JP2014055156A5
JP2014055156A5 JP2013230960A JP2013230960A JP2014055156A5 JP 2014055156 A5 JP2014055156 A5 JP 2014055156A5 JP 2013230960 A JP2013230960 A JP 2013230960A JP 2013230960 A JP2013230960 A JP 2013230960A JP 2014055156 A5 JP2014055156 A5 JP 2014055156A5
Authority
JP
Japan
Prior art keywords
cancer
pharmaceutical composition
composition according
leukemia
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2013230960A
Other languages
English (en)
Japanese (ja)
Other versions
JP2014055156A (ja
Filing date
Publication date
Priority claimed from US11/600,332 external-priority patent/US7842815B2/en
Application filed filed Critical
Publication of JP2014055156A publication Critical patent/JP2014055156A/ja
Publication of JP2014055156A5 publication Critical patent/JP2014055156A5/ja
Pending legal-status Critical Current

Links

JP2013230960A 2006-11-15 2013-11-07 Ｂｃｌタンパクの結合パートナーとの相互作用を阻害するための化合物および方法 Pending JP2014055156A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US11/600,332 US7842815B2 (en) 2004-06-17 2006-11-15 Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
US11/600,332 2006-11-15

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2009537198A Division JP2010510214A (ja) 2006-11-15 2007-11-14 Ｂｃｌタンパクの結合パートナーとの相互作用を阻害するための化合物および方法

Publications (2)

Publication Number Publication Date
JP2014055156A JP2014055156A (ja) 2014-03-27
JP2014055156A5 true JP2014055156A5 (OSRAM) 2014-07-03

Family

ID=39064388

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2009537198A Pending JP2010510214A (ja) 2006-11-15 2007-11-14 Ｂｃｌタンパクの結合パートナーとの相互作用を阻害するための化合物および方法
JP2013230960A Pending JP2014055156A (ja) 2006-11-15 2013-11-07 Ｂｃｌタンパクの結合パートナーとの相互作用を阻害するための化合物および方法

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2009537198A Pending JP2010510214A (ja) 2006-11-15 2007-11-14 Ｂｃｌタンパクの結合パートナーとの相互作用を阻害するための化合物および方法

Country Status (20)

Country Link
US (2) US7842815B2 (OSRAM)
EP (1) EP2094673B1 (OSRAM)
JP (2) JP2010510214A (OSRAM)
KR (1) KR101530721B1 (OSRAM)
CN (1) CN101583606B (OSRAM)
AU (1) AU2007319848B2 (OSRAM)
BR (1) BRPI0718606A2 (OSRAM)
CA (1) CA2669596C (OSRAM)
EC (1) ECSP099398A (OSRAM)
ES (1) ES2537762T3 (OSRAM)
GT (1) GT200900123A (OSRAM)
IL (1) IL198597A (OSRAM)
MA (1) MA31067B1 (OSRAM)
MX (1) MX2009005184A (OSRAM)
MY (1) MY156754A (OSRAM)
NO (1) NO20092306L (OSRAM)
NZ (1) NZ577243A (OSRAM)
RU (1) RU2449996C2 (OSRAM)
TN (1) TN2009000182A1 (OSRAM)
WO (1) WO2008060569A1 (OSRAM)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2118123T3 (pl) 2007-01-31 2016-06-30 Dana Farber Cancer Inst Inc Stabilizowane peptydy p53 i ich zastosowania
KR101525754B1 (ko) 2007-03-28 2015-06-09 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 스티칭된 폴리펩티드
CN104474529A (zh) * 2008-02-08 2015-04-01 爱勒让治疗公司 治疗性的拟肽大环化合物
US8314250B2 (en) * 2009-11-24 2012-11-20 Hoffmann-La Roche Inc. Sultam derivatives
TW201806968A (zh) 2011-10-18 2018-03-01 艾利倫治療公司 擬肽巨環化合物
WO2013119579A1 (en) 2012-02-06 2013-08-15 Discoveryx Corporation Detection of intracellular binding events by measuring protein abundance
BR112014020103A2 (pt) 2012-02-15 2018-10-09 Aileron Therapeutics, Inc. macrociclos peptidomiméticos
CA2864120A1 (en) 2012-02-15 2013-08-22 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
CN103656642A (zh) * 2012-08-31 2014-03-26 中国科学院上海生命科学研究院 预防和治疗结直肠癌的方法和试剂
US20160068463A1 (en) 2012-11-14 2016-03-10 Metabolix, Inc. Production of salts of 4-hydroxybutyrate using biobased raw materials
WO2014138429A2 (en) 2013-03-06 2014-09-12 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and use thereof in regulating hif1alpha
US9993472B2 (en) 2014-01-28 2018-06-12 Unity Biotechnology, Inc. Treatment for osteoarthritis in a joint by administering a means for inhibiting MDM2
US20150320755A1 (en) 2014-04-16 2015-11-12 Infinity Pharmaceuticals, Inc. Combination therapies
MX2017003797A (es) 2014-09-24 2017-06-15 Aileron Therapeutics Inc Macrociclos peptidomimeticos y usos de los mismos.
US10253067B2 (en) 2015-03-20 2019-04-09 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
CN108368161A (zh) 2015-09-10 2018-08-03 艾瑞朗医疗公司 作为mcl-1调节剂的拟肽大环化合物
KR102599512B1 (ko) 2016-03-28 2023-11-07 프레시지 바이오싸이언시스, 인크. 암 치료를 위한 제약학적 조합물
CN109641874A (zh) 2016-05-10 2019-04-16 C4医药公司 用于靶蛋白降解的c3-碳连接的戊二酰亚胺降解决定子体
WO2017197055A1 (en) 2016-05-10 2017-11-16 C4 Therapeutics, Inc. Heterocyclic degronimers for target protein degradation
EP3454862B1 (en) 2016-05-10 2024-09-11 C4 Therapeutics, Inc. Spirocyclic degronimers for target protein degradation
CN109790143A (zh) 2016-05-10 2019-05-21 C4医药公司 用于靶蛋白降解的胺连接的c3-戊二酰亚胺降解决定子体
JP7168580B2 (ja) * 2017-04-05 2022-11-09 プレジデント アンド フェローズ オブ ハーバード カレッジ 大環状化合物およびその使用
CN110769822A (zh) 2017-06-20 2020-02-07 C4医药公司 用于蛋白降解的n/o-连接的降解决定子和降解决定子体
CN120698985A (zh) 2018-12-20 2025-09-26 C4医药公司 靶向蛋白降解
WO2021233948A1 (en) 2020-05-19 2021-11-25 INSERM (Institut National de la Santé et de la Recherche Médicale) Method to treat a pathogen lung infection
WO2022008464A1 (en) 2020-07-06 2022-01-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Combination of antineoplastic antibiotics and bcl-2 inhibitors for the treatment of npm-1-driven acute myeloid leukemia (aml)
WO2025087879A2 (en) 2023-10-23 2025-05-01 Institut National de la Santé et de la Recherche Médicale Suppressing the pi3kgamma/akt signalling pathway for the treatment of acute myeloid leukemia

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4235871A (en) 1978-02-24 1980-11-25 Papahadjopoulos Demetrios P Method of encapsulating biologically active materials in lipid vesicles
JPS55133364A (en) 1979-04-03 1980-10-17 Mitsubishi Petrochem Co Ltd Preparation of isoxazolidine derivative
DE3643012A1 (de) 1986-12-17 1988-06-30 Hoechst Ag 2,3-disubstituierte isoxazolidine, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
ES2102367T3 (es) 1990-05-18 1997-08-01 Hoechst Ag Amidas de acidos isoxazol-4-carboxilicos y amidas de acidos hidroxialquiliden-cianoaceticos, medicamentos que contienen estos compuestos y su utilizacion.
US5294617A (en) * 1993-04-23 1994-03-15 American Cyanamid Company Angiotensin II receptor blocking 2,3,6 substituted quinazolinones
ATE181735T1 (de) * 1993-05-01 1999-07-15 Merck Patent Gmbh Substituierte 1-phenyl-oxazolidin-2-on derivate, deren herstellung und deren verwendung als adhäsionsrezeptor-antagonisten
SK66696A3 (en) 1993-11-24 1996-11-06 Du Pont Merck Pharma Isoxazoline and isoxazole fibrinogen receptor antagonists
ATE169009T1 (de) 1994-03-09 1998-08-15 Pfizer Isoxazoline verbindung zur hemmung tnf-freigabe
US5514505A (en) * 1995-05-15 1996-05-07 Xerox Corporation Method for obtaining improved image contrast in migration imaging members
DE19539638A1 (de) 1995-10-25 1997-04-30 Hoechst Ag Die Verwendung von Isoxazol- und Crotonsäureamidderivaten zur Behandlung von Krebserkrankungen
US6221865B1 (en) * 1995-11-06 2001-04-24 University Of Pittsburgh Inhibitors of protein isoprenyl transferases
WO1998006694A1 (en) 1996-08-16 1998-02-19 Du Pont Pharmaceuticals Company Amidinophenyl-pyrrolidines, -pyrrolines, and -isoxazolidines and derivatives thereof
WO1998016830A2 (en) 1996-10-16 1998-04-23 The President And Fellows Of Harvard College Droplet assay system
PH11998001072B1 (en) 1997-05-07 2006-11-21 Univ Pittsburgh Inhibitors of protein isoprenyl transferases
AU7105800A (en) 1999-09-01 2001-03-26 Chemrx Advanced Technologies, Inc. Process for synthesizing isoxazolidines
KR100399361B1 (ko) * 1999-11-04 2003-09-26 주식회사 엘지생명과학 캐스파제 억제제 함유 치료제 조성물
WO2002097053A2 (en) 2001-05-30 2002-12-05 The Regents Of The University Of Michigan Small molecule antagonists of bcl2 family proteins
FR2840807B1 (fr) 2002-06-12 2005-03-11 Composition cosmetique de soin et/ou de maquillage, structuree par des polymeres silicones et des organogelateurs, sous forme rigide
ES2382383T3 (es) 2004-06-17 2012-06-07 Infinity Discovery, Inc. Compuestos y procedimientos para inhibir la interacción de proteínas Bcl con componentes de unión
US20060020004A1 (en) * 2004-06-17 2006-01-26 Infinity Pharmaceuticals, Inc. Isoxazolidine compounds for treatment of bacterial infections
TWI403320B (zh) * 2005-12-16 2013-08-01 Infinity Discovery Inc 用於抑制ｂｃｌ蛋白和結合夥伴間之交互作用的化合物及方法

Similar Documents

Publication Publication Date Title
JP2014055156A5 (OSRAM)
JP2010510214A5 (OSRAM)
Huttunen et al. Prodrugs—from serendipity to rational design
Naksuriya et al. Curcumin nanoformulations: a review of pharmaceutical properties and preclinical studies and clinical data related to cancer treatment
RU2468016C2 (ru) СОЕДИНЕНИЯ И СПОСОБЫ ИНГИБИРОВАНИЯ ВЗАИМОДЕЙСТВИЯ БЕЛКОВ Bcl СО СВЯЗЫВАЮЩИМИ ПАРТНЕРАМИ
CY1122527T1 (el) Φαρμακοτεχνικες μορφες νευροενεργων στεροειδων που περιλαμβανουν ενα συμπλοκο αλοπρεγνανολονης και θειοβουτυλαιθερα βητα-κυκλοδεξτρινης
WO2008027445A3 (en) Combination with bis(thiohydrazide amides) for treating cancer
WO2015006740A3 (en) Oligonucleotide-ligand conjugates and process for their preparation
WO2010135396A3 (en) Formulations of 4-amino-2-(2,6-dioxopiperidine-3-yl)isoindoline-1,3-dione
BRPI0814542A2 (pt) Métodos e composições para o tratamento de câncer, tumores e desordens relacionadas a tumores
MX2010009670A (es) Conjugados de paclitaxel polimericos y metodos para tratamiento de cancer.
JP2010001302A5 (OSRAM)
CO7310528A2 (es) Composición farmacéutica recubierta que contiene regorafenib
JP2017517520A5 (OSRAM)
MX2017015879A (es) Composiciones de hidroxipropil beta-ciclodextrina y metodos.
IN2014MU00303A (OSRAM)
PH12014501495B1 (en) Formulations of (+)-2-[1-(3-ethoxy-4-methoxy-phenyl)-2-methanesulfonyl-ethyl]-4-acetyl aminoisoindoline-1,3-dione
HK1254645A1 (zh) 冻乾药物组合物
JP2017511340A5 (OSRAM)
EA201301265A1 (ru) Способ лечения солидных злокачественных опухолей, включая прогрессирующие или метастатические солидные злокачественные опухоли
EP3986398A4 (en) SMALL MOLECULE INHIBITORS INTENDED FOR THE TREATMENT OF CANCER IN A SUBJECT SUFFERING FROM TUMOR WITH HIGH INTERSTITIAL PRESSURE
CL2011002774A1 (es) Combinacion farmaceutica que comprende cabazitaxel y capecitabina, en forma de base, sal, hidrato o solvato; uso para el tratamiento del cancer de mama metastasico.
WO2008102397A3 (en) Colchicine derivatives, process for their preparation and use in the medical field
WO2010088544A8 (en) Methods to treat cancer
WO2015089339A3 (en) Compositions, methods and kits for dna fragmentation and tagmentation