JP2014001165A - Skin cosmetics - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide skin cosmetics that have good fitness to skin, suppress stickiness after use, exhibit excellent moisture retention and wrinkle suppression effects, and achieve excellent spreading.SOLUTION: The skin cosmetics contain (a) 0.0001-0.1 mass% of a compound represented by the formula (I), (b) 1-30 mass% of 3-8C divalent alcohol, and (c) 0.0001-10 mass% of polysaccharide.

Description

  The present invention relates to a skin cosmetic that has good conformability to the skin, suppresses stickiness after use, is excellent in a moisturizing effect and a wrinkle-suppressing effect, and has a good makeup stickiness.

  The surface of human skin is usually protected with a sebum film, and the transpiration of water is appropriately controlled. Keeping the skin moisture moderately is very important from the viewpoint of skin health. If the moisture is insufficient, rough skin and the like are likely to occur. For example, when the sebum film is temporarily removed by face washing, bathing, etc., the moisture of the skin is easily lost. In such a case, it is necessary to supplement the skin with moisture by using a moisturizing cosmetic such as a lotion, milky lotion, cream, or cosmetic liquid.

  Generally, such skin cosmetics are blended with glycerin, 1,3-butylene glycol, polyhydric alcohols such as sorbitol, pyrrolidone carboxylate and the like as moisturizers. However, these humectants have good moisture retention under high humidity, but poor moisture retention under low humidity. Therefore, these moisturizers sometimes have poor moisturizing effects.

  Therefore, various moisturizing ingredients such as chitin (and its derivatives), chitosan (and its derivatives), hyaluronic acid (and its derivatives), etc. Highly moisturizing ingredients have been proposed. However, when these high moisturizing ingredients are blended in cosmetics, the high moisturizing power may cause unpleasant stickiness, and the elongation and familiarity with the skin may be worsened.

  For example, Patent Document 1 describes an external preparation for skin that combines mucopolysaccharide and trehalose to improve stickiness while maintaining a high moisturizing effect. However, this external preparation for skin may not be able to sufficiently suppress stickiness, and further, sufficient performance is not obtained with respect to skin conformability, wrinkle suppression, and the effect of improving makeup flesh.

  On the other hand, skin aging progresses due to dryness, aging, ultraviolet rays, etc., resulting in increased spots, dullness, freckles, reduced skin elasticity, increased wrinkles, and the like. In particular, the increase in wrinkles, which is a remarkable change in appearance, is a symbol of the skin aging phenomenon. Here, it is known that collagen, which accounts for about 70% of the skin dermis, is deeply involved in the formation of wrinkles. For example, collagen is denatured by ultraviolet rays or aging and its function is lowered, or the ability to synthesize collagen in skin fibroblasts is reduced, thereby causing wrinkle formation and skin elasticity. Therefore, promoting the synthesis of collagen to maintain the amount of collagen is effective in preventing and improving wrinkles and improving skin elasticity, and for the purpose of preventing skin aging represented by wrinkles. There has been an active search for components that promote synthesis.

  Among them, the promotion of synthesis of type I collagen, which accounts for about 80% of dermal collagen, is the most important for preventing and improving wrinkles and improving skin elasticity. Type I collagen is completed by first synthesizing a precursor type I procollagen by skin fibroblasts and secreting it out of the cell, and then cleaving both ends of the type I procollagen with an enzyme. . Therefore, promoting the expression level of type I procollagen mRNA gene in dermal skin fibroblasts promotes the synthesis of type I procollagen and leads to the promotion of the synthesis of collagen in the dermis.

  L-ascorbic acid and retinoic acid are mentioned as components having an effect of promoting collagen synthesis. Furthermore, as a collagen synthesis promoter more excellent in terms of safety and stability, for example, Patent Document 2 describes a collagen production promoter using an acidic xylo-oligosaccharide having a uronic acid residue in a xylo-oligosaccharide molecule. ing. However, this collagen production promoter may become sticky after use, and sufficient performance is not obtained with respect to skin conformability and the effect of improving makeup. As other collagen synthesis promoters, a water-containing solvent extract of Seddesmus phytoplankton (Patent Document 3), a winged bean extract (Patent Document 4), a daisies extract (Patent Document 5) and the like have been proposed. These, as well as the collagen production promoter of Patent Document 2, have not been able to obtain sufficient performance in terms of skin compatibility, suppression of stickiness after use, and makeup.

  In addition, as a component that is said to have an effect of promoting collagen synthesis, a compound represented by the formula (I) in the present invention can be mentioned (Non-patent Document 1). The compound represented by the formula (I) has been recognized to promote the synthesis of type I collagen in vitro, and the effectiveness of anti-wrinkles in clinical trials of skin cosmetics containing the compound represented by the formula (I) And safety is recognized.

  However, the skin cosmetics containing the compound represented by the formula (I) have not yet been developed so that sufficient performance can be obtained with respect to the conformability to the skin, the moisturizing effect, and the effect of improving the makeup.

JP-A-6-122621 JP 2004-59478 A JP 2007-186471 A JP 2010-24222 A JP 2009-249366 A

Biosci. Biotechnol. Biochem., 72 (2), 303-311 (2008)

  In view of the above circumstances, an object of the present invention is to provide a skin cosmetic that has good skin adaptability, suppresses stickiness after use, is excellent in a moisturizing effect and a wrinkle suppressing effect, and has a good makeup.

  The inventors of the present invention have made studies to solve the above problems, and have found that (a) a compound represented by the formula (I), (b) a dihydric alcohol having 3 to 8 carbon atoms, and (c) a polysaccharide. It discovered that the target skin cosmetics were obtained by combining at a specific ratio, and came to complete this invention.

  That is, the skin cosmetic of the present invention comprises (a) 0.0001 to 0.1% by mass of the compound represented by the formula (I), and (b) 1 to 30% by mass of a dihydric alcohol having 3 to 8 carbon atoms. (C) A skin cosmetic containing 0.0001 to 10% by mass of a polysaccharide.

  The skin cosmetic composition of the present invention is represented by (d) (d-1) 20 to 100 mol% of a monomer represented by the formula (II), and (d-2) represented by the formula (II) as necessary. The polymer may further contain 0.0001 to 1% by mass of a polymer obtained from 0 to 80% by mol of the monomer copolymerizable with the monomer.

（式中、Ｒ^１は水素原子又はメチル基、Ｒ^２は−（ＣＨ_２）_ｎ−を示し、ｎは１〜４の整数である。）

(In the formula, R ¹ represents a hydrogen atom or a methyl group, R ² represents — (CH ₂ ) _n —, and n is an integer of 1 to 4).

  The skin cosmetic of the present invention has good conformability to the skin, suppresses stickiness after use, is excellent in a moisturizing effect and a wrinkle-suppressing effect, and has an effect that the makeup paste is good.

  Hereinafter, embodiments of the present invention will be described. The skin cosmetic of the present invention contains at least the following components (a) to (c), and further contains the following component (d) as necessary.

[(A) Compound represented by Formula (I)]
Examples of the compound represented by the formula (I) used in the skin cosmetic of the present invention include those obtained by purifying and isolating the extract of Sanguisorba officinalis belonging to the genus Waremokou, or by chemical synthesis. Can be used.
As a commercial product of component (a), Bioland Ltd. “Bio-Zyuglycoxide I”, “SOREX 60”, etc. manufactured by the company can be used.

  (A) component is 0.0001-0.1 mass% with respect to skin cosmetics, Preferably it is 0.001-0.08 mass%, More preferably, it contains in the ratio of 0.003-0.05 mass%. Is done. If it is less than 0.0001% by mass, it may become sticky after use, or the effect of improving the wrinkle-suppressing effect and makeup flakes may be reduced. When it exceeds 0.1% by mass, the skin conformability may be deteriorated or the stability with time may be deteriorated.

[(B) C3-C8 dihydric alcohol]
(B) C3-C8 dihydric alcohol used for the skin cosmetics of this invention is a compound which has two hydroxyl groups in 1 molecule, and is a compound generally called glycols. When the carbon number is less than 3, irritation may be given to the skin, and when the carbon number is 9 or more, the wrinkle suppressing effect may be weakened.

  Specific examples of the divalent alcohol having 3 to 8 carbon atoms include propylene glycol, butylene glycol, diethylene glycol, pentylene glycol, hexylene glycol, dipropylene glycol, heptylene glycol, and octylene glycol. Of these, 1,2-propylene glycol, 1,3-propylene glycol, 1,3-butylene glycol, 1,2-pentylene glycol, and dipropylene glycol are preferable from the viewpoint of usability. One or more of these dihydric alcohols can be used.

  The component (b) is contained in an amount of 1 to 30% by mass, preferably 3 to 25% by mass, and more preferably 5 to 20% by mass with respect to the skin cosmetic. When the amount is less than 1% by mass, the conformability to the skin may be deteriorated, and the effect of suppressing wrinkles and improving the makeup paste may be reduced. If it exceeds 30% by mass, it may become sticky after use.

  Further, the mass ratio (a) / (b) of the component (a) to the component (b) is preferably 1/100 or less, particularly 1/150 or less, in order to sufficiently develop the skin conformability and the wrinkle suppressing effect. Further, it is preferably 1/200 or less.

[(C) polysaccharide]
(C) Polysaccharides used in the skin cosmetics of the present invention include derivatives thereof such as hyaluronic acid, sodium hyaluronate, sodium chondroitin sulfate, sodium dermatan sulfate, sodium acetylated hyaluronate, starch, xanthan gum, Examples include dextrin, fructan, agar, sodium alginate, carrageenan, guar gum, roast bean gum, pectin, quince seed, pullulan, sodium carboxymethylcellulose, hydroxypropylethylcellulose and the like. Of these, sodium hyaluronate, acetylated sodium hyaluronate, xanthan gum, fructan, and hydroxypropylethyl cellulose are preferable from the viewpoint of feeling of use and the like. One or more of these polysaccharides can be used. The (c) polysaccharide does not include (a) the compound represented by the formula (I).

  (C) A component is 0.0001-10 mass% with respect to skin cosmetics, Preferably it is 0.01-5 mass%, More preferably, it contains in the ratio of 0.05-3 mass%. When the amount is less than 0.0001% by mass, the moisturizing effect is not sufficient, and the effect of suppressing wrinkles and improving the makeup paste may be reduced. If it exceeds 10% by mass, it may become sticky after use.

[(D) polymer]
The skin cosmetic of the present invention may contain a polymer of the component (d) in order to improve the effect of suppressing wrinkles and improving the makeup.

  The polymer of component (d) is (d-1) 20 to 100 mol%, preferably 30 to 90 mol% of the monomer represented by formula (II), and (d-2) It is a polymer obtained from 0 to 80 mol%, preferably 10 to 70 mol% of a monomer copolymerizable with the monomers shown.

(D-1) In the monomer represented by the formula (II), R ¹ in the formula represents a hydrogen atom or a methyl group, and a methyl group is preferable from the viewpoint of stability. R ² is - _{(CH 2) n} - indicates, n is an integer of 1 to 4, n = 2 is preferred from easy availability. Specific examples of the monomer represented by the formula (II) include glycerol-1-methacryloyloxyethylene urethane, glycerol-1-methacryloyloxypropylene urethane, and the like.

  As a method for synthesizing the monomer represented by the formula (II), for example, a compound obtained by subjecting a cyclic ketal and (meth) acryloyloxyalkylene isocyanate to a urethanation reaction with water in the presence of a urethanization reaction catalyst is used. Examples thereof include a hydrocyclization reaction in a contained solvent. (Meth) acryloyl represents methacryloyl or acryloyl, and (meth) acrylate represents methacrylate or acrylate.

  The component (d) may be a homopolymer obtained by polymerizing only the monomer (d-1) represented by the formula (II), or the monomer (d-1) represented by the formula (II) A copolymer with another monomer (d-2) capable of copolymerization may be used. As the other copolymerizable monomer (d-2), a known monomer can be used, and a monomer represented by the following formula (III) is preferable. In addition, 1 type (s) or 2 or more types can be used for another monomer (d-2).

In the formula, L ¹ represents —C ₆ H ₄ —, —C ₆ H ₁₀ —, — (C═O) —O—, —O—, — (C═O) NH—, —O— (C═O). )-Or -O- (C = O) -O-, L ² is a linear or branched alkyl group having 10 to 22 carbon atoms, such as decyl group, dodecyl group, tetradodecyl group, hexadecyl group, octadecyl group Group, a docosanyl group, etc., and R ³ represents a hydrogen atom or a methyl group.

  Examples of the monomer represented by the formula (III) include linear or branched decyl (meth) acrylate, dodecyl (meth) acrylate, tetradecyl (meth) acrylate, hexadecyl (meth) acrylate, octadecyl (meth) acrylate, and the like. Examples include alkyl (meth) acrylates and vinyl ester monomers such as vinyl decanoate, vinyl dodecanoate, vinyl hexadecanoate, and vinyl octadecanoate. Among these, octadecyl methacrylate is preferable from the viewpoint of stability.

  In addition, in order to make it easy to handle (d) component, what was diluted with polyhydric alcohols, such as glycerol and 1, 3- butylene glycol, can be used. Moreover, 1 type, or 2 or more types can be used for (d) component.

(C) “Ceracte-L” or “Ceracte-F” manufactured by NOF Corporation can be used as a commercially available component.
“Ceracte-L” includes (d-1) 60 mol% of a monomer represented by the formula (II) wherein R ¹ is a methyl group and R ² is — (CH ₂ ) ₂ —, (d-2) 5% by mass of a copolymer obtained from 40 mol% of a monomer in which L ¹ in the formula (III) is — (C═O) —O—, L ² is an octadecyl group, and R ³ is a methyl group; Glycerin 66.5% by mass, 1,3-butylene glycol 28.5% by mass.
“Ceracte-F” includes (d-1) 60 mol% of a monomer represented by the formula (II) in which R ¹ is a methyl group and R ² is — (CH ₂ ) ₂ —; 2) A copolymer obtained from 40 mol% of a monomer represented by L ¹ in formula (III)-(C = O) -O-, L ² in octadecyl group, and R ³ in methyl group. .

  (D) component is 0.0001-1 mass% with respect to skin cosmetics, Preferably it is 0.001-0.5 mass%, More preferably, it contains in the ratio of 0.01-0.3 mass%. . When the amount is less than 0.0001% by mass, the effect of suppressing wrinkles and the effect of improving the makeup flakes may not be sufficient, and when it exceeds 1% by mass, it may become sticky after use.

The skin cosmetics of the present invention can take various dosage forms, such as cosmetic liquids, emulsions, gels, creams, etc., and any form such as a form impregnated with a non-woven fabric. It may be.
Moreover, it is also possible to mix | blend the additive normally used for cosmetics and a pharmaceutical in the skin cosmetics of this invention in the range which does not impair the effect of this invention.

  Hereinafter, the present invention will be described more specifically with reference to examples and comparative examples.

[Examples 1-6, Comparative Examples 1-4]
Skin cosmetics were prepared at the blending ratios shown in Table 1 by the following method. The common additive components in Table 1 are the 10 components shown in Table 2.
(A) component, (b) component, (c) component, ion-exchanged water, preservative in common additive component, aqueous phase including other components, oil component and surfactant in common additive component The oil phase was mixed with each other, heated to 75 to 80 ° C., mixed with a homomixer, and then cooled to obtain an oil-in-water emulsified cream skin cosmetic. Moreover, about Example 5, 6, (d) component was further mixed and the skin cosmetics of the oil-in-water type emulsification cream were obtained.
As a component (a), Bioland Ltd. containing 80% by mass of the compound represented by the formula (I). “Bio-Ziugglycoside I” manufactured by the company was used. In addition, as a component (d), “Ceracte-L” manufactured by NOF Corporation containing 5% by mass of an effective copolymer is used.

  Using the obtained skin cosmetics, five items were evaluated by the following methods. The results are shown in Table 1.

(1) Familiarity to skin 20 women (30 to 48 years old) were panelists, and the touch when the obtained skin cosmetic was used on the entire face was determined as follows.
2 points: When familiar with skin.
1 point: When familiar with skin, feels slightly worse.
0 point: When it is felt that the familiarity with the skin is bad.

The total score of 20 people was calculated and evaluated as follows.
A: Total score of 35 points or more and 0 points: 0: Skin cosmetics with very good compatibility with skin.
◯: Total score of 25 points or more and less than 35 points, or total score of 35 points or more and 0 point of 1 or more and 2 or less: A skin cosmetic with good skin adaptability.
(Triangle | delta): Total score is 15 points or more and less than 25 points: It is skin cosmetics with slightly good adaptability to skin.
X: The total score is less than 15 points: skin cosmetics that are not so well adapted to the skin.

(2) Stickiness after use Twenty women (30 to 48 years old) were panelists, and the touch after the obtained skin cosmetic was used on the entire face was determined as follows.
2 points: When it feels non-sticky.
1 point: If you feel a little sticky.
0 points: When feeling sticky.

The total score of 20 people was calculated and evaluated as follows.
A: Total score of 35 points or more and 0 points: 0: A skin cosmetic that does not feel sticky.
◯: Total score of 25 points or more and less than 35 points, or total score of 35 points or more and 0 point of 1 or more and 2 or less: Skin cosmetics that hardly feel sticky.
(Triangle | delta): Total score is 15 points or more and less than 25 points: It is skin cosmetics which do not feel stickiness very much.
X: Total score is less than 15 points: skin cosmetic that feels slightly sticky.

(3) Moisturizing effect 20 females (30-48 years old) are panelists, and after using the obtained skin cosmetics on the whole face in the morning of winter (February), the skin condition in the evening is as follows. Judged to.
2 points: When feeling moisturized.
1 point: When a feeling of moisture retention is somewhat felt.
0 point: When there is no moisturizing feeling.

The total score of 20 people was calculated and evaluated as follows.
A: Total score of 35 points or more and 0 points: 0: Skin cosmetic with a very high moisturizing effect.
A: The total score is 25 points or more and less than 35 points, or the total score is 35 points or more and the 0 point is 1 or more and 2 or less: A skin cosmetic with a high moisturizing effect.
(Triangle | delta): A total score is 15 points or more and less than 25 points: It is skin cosmetics with a somewhat high moisturizing effect.
X: The total score is less than 15: skin cosmetics with a low moisturizing effect.

(4) Wrinkle-suppressing effect 20 females (30 to 48 years old) are panelists, and the obtained skin cosmetics are used on the entire face twice a day for two consecutive months, and the skin condition after one month. Was determined as follows.
2 points: When you feel that wrinkles are clearly inconspicuous.
1 point: When wrinkles are slightly inconspicuous.
0 point: When wrinkle suppression effect is not seen.

The total score of 20 people was calculated and evaluated as follows.
A: Total score of 35 points or more and 0 points: 0: A skin cosmetic having a very excellent wrinkle-inhibiting effect.
A: Total score of 25 points or more and less than 35 points, or total score of 35 points or more and 0 point of 1 or more and 2 or less: A skin cosmetic having an excellent wrinkle suppressing effect.
Δ: Total score of 15 points or more and less than 25 points: A skin cosmetic having a slight wrinkle suppressing effect.
X: The total score is less than 15: It is a skin cosmetic that does not have a wrinkle suppressing effect.

(5) Makeup Nourishment 20 females (30 to 48 years old) are panelists, and the obtained skin cosmetics are used twice a day for 1 month on all faces for 1 month later. Judgment was made as follows.
2 points: When the makeup feel is good.
1 point: When the feeling of makeup is slightly good.
0 points: When the makeup feel is not good.

The total score of 20 people was calculated and evaluated as follows.
A: Total score of 35 points or more and 0 points: 0: Skin cosmetic with very good makeup.
◯: Total score of 25 points or more and less than 35 points, or total score of 35 points or more and 0 point of 1 or more and 2 or less: Skin cosmetic with good makeup.
(Triangle | delta): A total score is 15 points or more and less than 25 points: It is a skin cosmetic with a slightly good makeup paste.
X: The total score is less than 20 points, or 0 points is 6 or more: Skin cosmetics that do not have very good makeup.

As shown in the results of Examples 1 to 6, all the creams using the components of the present invention have good conformability to the skin, suppress stickiness after use, and are excellent in moisturizing effect and wrinkle suppressing effect, The effect of improving makeup paste was obtained. On the other hand, in Comparative Examples 1-4, sufficient performance is not obtained.
Specifically, since the component (a) is not contained in Comparative Example 1, sufficient performance is not obtained in conformity to the skin, stickiness after use, wrinkle suppression effect, and makeup glue. In Comparative Example 2, the collagen synthesis accelerator described in Patent Document 2 is included, but since (a) component is not included, it is sufficient for skin conformability, stickiness after use, and makeup paste. Performance has not been obtained. In Comparative Example 3, since the component (b) is not contained, sufficient performance is not obtained in terms of familiarity with the skin, stickiness after use, and makeup paste. In Comparative Example 4, since the component (c) is not included, sufficient performance is not obtained in the moisturizing effect, the wrinkle suppressing effect, and the makeup paste.

[Examples 7 and 8]
Skin cosmetics were prepared at the blending ratios shown in Table 3 by the following method. In addition, common addition components in Table 3 are 10 components shown in Table 4.
(A) component, (b) component, (c) component, ion-exchanged water, and an aqueous phase containing a preservative in the common additive component, and an oil phase containing an oily component and a surfactant in the common additive component, Each was mixed, heated to 75-80 ° C., mixed using a homomixer, and then cooled. Thereafter, the viscosity adjusting agent, the pH adjusting agent, and the component (d) in the commonly added components were mixed to obtain an oil-in-water emulsion skin cosmetic.
As a component (a), Bioland Ltd. containing 60% by mass of the compound represented by the formula (I). “Sorex 60” manufactured by the company was used. In addition, as a component (d), “Ceracte-L” manufactured by NOF Corporation containing 5% by mass of an effective copolymer is used.

  Using the obtained skin cosmetics, five items were evaluated in the same manner as in the above Examples. The results are shown in Table 3.

  As shown in the results of Examples 7 and 8, each of the emulsions using the components of the present invention has good compatibility with the skin, suppresses stickiness after use, and is excellent in a moisturizing effect and a wrinkle suppressing effect. The effect of improving makeup paste was obtained.

[Examples 9 and 10]
Skin cosmetics were prepared at the blending ratios shown in Table 5 by the following method.
(A) component, (b) component, (c) component, ion-exchange water, and antiseptic | preservative were mixed, it cooled, after heating to 75-80 degreeC. Thereafter, component (d) was mixed to obtain a cosmetic skin cosmetic.
As a component (a), Bioland Ltd. containing 80% by mass of the compound represented by the formula (I). “Bio-Ziugglycoside I” manufactured by the company was used. Further, “Ceracte-F” manufactured by NOF Corporation was used as the component (d).

  Using the obtained skin cosmetics, five items were evaluated in the same manner as in the above Examples. The results are shown in Table 5.

  As shown in the results of Examples 9 and 10, all of the cosmetic liquids using the ingredients of the present invention have good compatibility with the skin, suppress stickiness after use, and are excellent in moisturizing effect and wrinkle suppressing effect. The effect of improving the makeup paste was obtained.

  The skin cosmetics of the present invention have good compatibility with the skin, suppress stickiness after use, are excellent in moisturizing effect and wrinkle-suppressing effect, and have a good makeup paste, so skins such as cosmetic liquids, emulsions, gels, creams, etc. It can be suitably used as a cosmetic.

Claims (2)

(A) 0.0001 to 0.1% by mass of a compound represented by the formula (I), (b) 1 to 30% by mass of a dihydric alcohol having 3 to 8 carbon atoms, and (c) 0.0001 of a polysaccharide. Skin cosmetic containing 10% by mass.

(D) (d-1) 20 to 100 mol% of a monomer represented by the formula (II), and (d-2) a monomer 0 copolymerizable with the monomer represented by the formula (II). The skin cosmetic according to claim 1, further comprising 0.0001 to 1% by mass of a polymer obtained from ˜80 mol%.

(In the formula, R ¹ represents a hydrogen atom or a methyl group, R ² represents — (CH ₂ ) _n —, and n is an integer of 1 to 4).