JP2013544812A5 - - Google Patents
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- Publication number
- JP2013544812A5 JP2013544812A5 JP2013537808A JP2013537808A JP2013544812A5 JP 2013544812 A5 JP2013544812 A5 JP 2013544812A5 JP 2013537808 A JP2013537808 A JP 2013537808A JP 2013537808 A JP2013537808 A JP 2013537808A JP 2013544812 A5 JP2013544812 A5 JP 2013544812A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- cycloalkyl
- optionally substituted
- hydrogen
- nhc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC**(*C)C(**)C(*(CCC1)[C@@]1C1=*C(c(cc2)ccc2-c2ccc(*(C)C(C3=CC=C(*(CC4)CC*4C(*C)=O)I(C)=C3)=O)cc2)=C*1C)=O Chemical compound CC**(*C)C(**)C(*(CCC1)[C@@]1C1=*C(c(cc2)ccc2-c2ccc(*(C)C(C3=CC=C(*(CC4)CC*4C(*C)=O)I(C)=C3)=O)cc2)=C*1C)=O 0.000 description 6
- BQUJMOCJNLYVAV-NMHGFXMVSA-N CC(C)[C@@H](C(N(CCC1)C1c1nc(-c(cc2)ccc2-c(c(OC(F)(F)F)c2)cc(Cl)c2NC(c(cc2)cnc2N(CC2)[C@H](C)CN2C(c2c[nH]cn2)=O)=O)c[nH]1)=O)NC(OC)=O Chemical compound CC(C)[C@@H](C(N(CCC1)C1c1nc(-c(cc2)ccc2-c(c(OC(F)(F)F)c2)cc(Cl)c2NC(c(cc2)cnc2N(CC2)[C@H](C)CN2C(c2c[nH]cn2)=O)=O)c[nH]1)=O)NC(OC)=O BQUJMOCJNLYVAV-NMHGFXMVSA-N 0.000 description 1
- KUHMLERCNDMMDA-LQEVUUGDSA-N CC(C)[C@@H](C(N(CCC1)[C@@H]1c1nc(-c(cc2)ccc2-c(c(C(F)(F)F)c2)cc(F)c2NC(c(cc2)cnc2N(CC2)[C@H](C)CN2C([C@@H]2C(C)(C)C2)=O)=O)c[nH]1)=O)NC(OC)=O Chemical compound CC(C)[C@@H](C(N(CCC1)[C@@H]1c1nc(-c(cc2)ccc2-c(c(C(F)(F)F)c2)cc(F)c2NC(c(cc2)cnc2N(CC2)[C@H](C)CN2C([C@@H]2C(C)(C)C2)=O)=O)c[nH]1)=O)NC(OC)=O KUHMLERCNDMMDA-LQEVUUGDSA-N 0.000 description 1
- QESKXMHWUZEWCA-AKGSCHIQSA-N CC(C)[C@@H](C(N(CCC1)[C@@H]1c1nc(-c(cc2)ccc2-c(c(NC(F)(F)F)c2)cc(Cl)c2NC(c(cc2)cnc2N(CC2)[C@H](C)CN2C([C@@H]2C(C)(C)C2)=[U])=O)c[nH]1)=O)NC(OC)=O Chemical compound CC(C)[C@@H](C(N(CCC1)[C@@H]1c1nc(-c(cc2)ccc2-c(c(NC(F)(F)F)c2)cc(Cl)c2NC(c(cc2)cnc2N(CC2)[C@H](C)CN2C([C@@H]2C(C)(C)C2)=[U])=O)c[nH]1)=O)NC(OC)=O QESKXMHWUZEWCA-AKGSCHIQSA-N 0.000 description 1
- GFYYLFBIILMAEZ-VLHAJMFKSA-N CC(C)[C@@H](C(N(CCC1)[C@@H]1c1nc(-c(cc2)ccc2-c(c([U]C(F)(F)F)c2)cc(F)c2NC(c(cc2)cnc2N(C[C@@H]2C)[C@H](C)CN2C([C@@H]2C(C)(C)C2)=O)=O)c[nH]1)=O)NC(OC)=O Chemical compound CC(C)[C@@H](C(N(CCC1)[C@@H]1c1nc(-c(cc2)ccc2-c(c([U]C(F)(F)F)c2)cc(F)c2NC(c(cc2)cnc2N(C[C@@H]2C)[C@H](C)CN2C([C@@H]2C(C)(C)C2)=O)=O)c[nH]1)=O)NC(OC)=O GFYYLFBIILMAEZ-VLHAJMFKSA-N 0.000 description 1
- MARWFYFKAALXOO-ZBDRNGKCSA-N CC(C)[C@@H](C(N(CCC1)[C@@H]1c1nc(-c(cc2)ccc2-c(c([U]C(F)(F)F)c2)cc(F)c2NC(c(cc2)cnc2N(C[C@@H]2C)[C@H](C)CN2C(c2c[nH]cn2)=O)=O)c[nH]1)=O)NC(OC)=O Chemical compound CC(C)[C@@H](C(N(CCC1)[C@@H]1c1nc(-c(cc2)ccc2-c(c([U]C(F)(F)F)c2)cc(F)c2NC(c(cc2)cnc2N(C[C@@H]2C)[C@H](C)CN2C(c2c[nH]cn2)=O)=O)c[nH]1)=O)NC(OC)=O MARWFYFKAALXOO-ZBDRNGKCSA-N 0.000 description 1
- SWHWQCWIEKSFRM-ASZBYZQXSA-N CC(C)[C@@H](C(N(CCC1)[C@@H]1c1nc(-c(cc2)ccc2-c(ccc(NC(c(cc2)cnc2N(C[C@@H]2C)[C@H](C)CN2C([C@@H]2C(C)(C)C2)=O)=O)c2)c2O[Cl]=[IH])c[nH]1)=N)NC(OC)=[U] Chemical compound CC(C)[C@@H](C(N(CCC1)[C@@H]1c1nc(-c(cc2)ccc2-c(ccc(NC(c(cc2)cnc2N(C[C@@H]2C)[C@H](C)CN2C([C@@H]2C(C)(C)C2)=O)=O)c2)c2O[Cl]=[IH])c[nH]1)=N)NC(OC)=[U] SWHWQCWIEKSFRM-ASZBYZQXSA-N 0.000 description 1
- PARLTOCUUHKJIH-HWVSEBKZSA-N CC(C)[C@@H](C(N(CCC1)[C@@H]1c1nc(-c(cc2)ccc2C(/C(/[U]C(F)(F)F)=C\C(\NC(c(cc2)cnc2N(C[C@@H]2C)[C@H](C)CN2C(NC)=O)=O)=C\F)=C)c[nH]1)=O)NC(OC)=O Chemical compound CC(C)[C@@H](C(N(CCC1)[C@@H]1c1nc(-c(cc2)ccc2C(/C(/[U]C(F)(F)F)=C\C(\NC(c(cc2)cnc2N(C[C@@H]2C)[C@H](C)CN2C(NC)=O)=O)=C\F)=C)c[nH]1)=O)NC(OC)=O PARLTOCUUHKJIH-HWVSEBKZSA-N 0.000 description 1
Applications Claiming Priority (7)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41026710P | 2010-11-04 | 2010-11-04 | |
US61/410,267 | 2010-11-04 | ||
US201161444046P | 2011-02-17 | 2011-02-17 | |
US61/444,046 | 2011-02-17 | ||
US201161492267P | 2011-06-01 | 2011-06-01 | |
US61/492,267 | 2011-06-01 | ||
PCT/US2011/059061 WO2012061552A1 (en) | 2010-11-04 | 2011-11-03 | Novel inhibitors of hepatitis c virus |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2013544812A JP2013544812A (ja) | 2013-12-19 |
JP2013544812A5 true JP2013544812A5 (US20080131398A1-20080605-C00009.png) | 2014-11-06 |
JP5891235B2 JP5891235B2 (ja) | 2016-03-22 |
Family
ID=44993923
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013537808A Expired - Fee Related JP5891235B2 (ja) | 2010-11-04 | 2011-11-03 | C型肝炎ウイルスの新規阻害剤 |
Country Status (9)
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2008156620A1 (en) * | 2007-06-12 | 2008-12-24 | Technolines, Llc | High speed and high power laser scribing methods and systems |
DK2455376T3 (en) | 2009-06-11 | 2015-03-02 | Abbvie Bahamas Ltd | Heterocyclic compounds as inhibitors of hepatitis C virus (HCV) |
US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
NZ605440A (en) | 2010-06-10 | 2014-05-30 | Abbvie Bahamas Ltd | Solid compositions comprising an hcv inhibitor |
ES2548286T3 (es) * | 2010-11-04 | 2015-10-15 | Theravance Biopharma R&D Ip, Llc | Nuevos inhibidores del virus de la hepatitis C |
US8552047B2 (en) | 2011-02-07 | 2013-10-08 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US9546160B2 (en) | 2011-05-12 | 2017-01-17 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US10201584B1 (en) | 2011-05-17 | 2019-02-12 | Abbvie Inc. | Compositions and methods for treating HCV |
EP2723732B1 (en) | 2011-06-22 | 2017-01-18 | Purdue Pharma LP | Trpv1 antagonists including dihydroxy substituent and uses thereof |
BR112014010401A8 (pt) | 2011-11-03 | 2017-12-19 | Theravance Inc | Inibidores do vírus da hepatite c rod-like que contêm o fragmento {2-[4-(bifenil-4-il)-1h-imidazo-2-il] pirrolidina-1-carbonilmetil}amina |
US9034832B2 (en) | 2011-12-29 | 2015-05-19 | Abbvie Inc. | Solid compositions |
US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US9206159B2 (en) | 2012-04-25 | 2015-12-08 | Theravance Biopharma R&D Ip, Llc | Piperazine-piperidine compounds as hepatitis C virus inhibitors |
WO2013163270A1 (en) * | 2012-04-25 | 2013-10-31 | Theravance, Inc. | Hepatitis c virus inhibitors |
US8883135B2 (en) | 2012-05-03 | 2014-11-11 | Theravance Biopharma R&D Ip, Llc | Crystalline form of a pyridyl-piperazinyl hepatitis C virus inhibitor |
US11484534B2 (en) | 2013-03-14 | 2022-11-01 | Abbvie Inc. | Methods for treating HCV |
US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
US9775831B2 (en) | 2013-07-17 | 2017-10-03 | Bristol-Myers Squibb Company | Combinations comprising biphenyl derivatives for use in the treatment of HCV |
WO2015103490A1 (en) | 2014-01-03 | 2015-07-09 | Abbvie, Inc. | Solid antiviral dosage forms |
US10617675B2 (en) | 2015-08-06 | 2020-04-14 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
CN105175401A (zh) * | 2015-10-16 | 2015-12-23 | 北京康立生医药技术开发有限公司 | 一种依匹哌唑的制备方法 |
CN112409336B (zh) * | 2017-11-27 | 2021-09-14 | 常州寅盛药业有限公司 | 适于工业化生产的达卡他韦起始原料的合成方法 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0421908D0 (en) * | 2004-10-01 | 2004-11-03 | Angeletti P Ist Richerche Bio | New uses |
DE602006016313D1 (de) * | 2005-09-16 | 2010-09-30 | Arrow Therapeutics Ltd | Biphenylderivate und ihre verwendung bei der behandlung von hepatitis c |
US8303944B2 (en) | 2006-08-11 | 2012-11-06 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7659270B2 (en) | 2006-08-11 | 2010-02-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US8329159B2 (en) | 2006-08-11 | 2012-12-11 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
US7745636B2 (en) | 2006-08-11 | 2010-06-29 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
CN101558059B (zh) * | 2006-08-11 | 2014-12-03 | 百时美施贵宝公司 | 丙型肝炎病毒抑制剂 |
US7910722B2 (en) * | 2007-07-05 | 2011-03-22 | Florida State University Research Foundation | RNAi therapeutic for treatment of hepatitis C infection |
PT2250163E (pt) | 2008-02-12 | 2012-06-01 | Bristol Myers Squibb Co | Inibidores do vírus da hepatite c |
KR20110098779A (ko) | 2008-12-03 | 2011-09-01 | 프레시디오 파마슈티칼스, 인코포레이티드 | Hcv ns5a의 억제제 |
UY32462A (es) | 2009-02-23 | 2010-09-30 | Arrow Therapeutics Ltd | Derivados de bifenilo novedosos para el tratamiento de infección por virus de hepatitis c 644 |
CA2753313A1 (en) | 2009-02-23 | 2010-08-26 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
WO2011031934A1 (en) | 2009-09-11 | 2011-03-17 | Enanta Pharmaceuticals, Inc. | Hepatitis c virus inhibitors |
US8822700B2 (en) | 2009-09-11 | 2014-09-02 | Enanta Pharmaceuticals, Inc. | Hepatitis C virus inhibitors |
EP2512480A4 (en) | 2009-12-14 | 2013-05-15 | Enanta Pharm Inc | HEPATITIS C-VIRUS HEMMER |
US8377980B2 (en) | 2009-12-16 | 2013-02-19 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
EP2575819A4 (en) | 2010-06-04 | 2013-11-27 | Enanta Pharm Inc | INHIBITORS OF HEPATITIS C VIRUS |
ES2548286T3 (es) * | 2010-11-04 | 2015-10-15 | Theravance Biopharma R&D Ip, Llc | Nuevos inhibidores del virus de la hepatitis C |
BR112014010401A8 (pt) | 2011-11-03 | 2017-12-19 | Theravance Inc | Inibidores do vírus da hepatite c rod-like que contêm o fragmento {2-[4-(bifenil-4-il)-1h-imidazo-2-il] pirrolidina-1-carbonilmetil}amina |
-
2011
- 2011-11-03 ES ES11784875.4T patent/ES2548286T3/es active Active
- 2011-11-03 US US13/288,216 patent/US8921372B2/en not_active Expired - Fee Related
- 2011-11-03 EP EP11784875.4A patent/EP2635571B1/en active Active
- 2011-11-03 JP JP2013537808A patent/JP5891235B2/ja not_active Expired - Fee Related
- 2011-11-03 CA CA2814534A patent/CA2814534A1/en not_active Abandoned
- 2011-11-03 CN CN201180053127.4A patent/CN103189371B/zh not_active Expired - Fee Related
- 2011-11-03 WO PCT/US2011/059061 patent/WO2012061552A1/en active Application Filing
- 2011-11-04 TW TW100140412A patent/TW201249827A/zh unknown
- 2011-11-04 AR ARP110104114A patent/AR083757A1/es not_active Application Discontinuation
-
2014
- 2014-11-12 US US14/539,039 patent/US9260414B2/en not_active Expired - Fee Related