JP2013543869A - Ｂ細胞リンパ腫のための併用療法 - Google Patents

Ｂ細胞リンパ腫のための併用療法 Download PDF

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Publication number
JP2013543869A
JP2013543869A JP2013538963A JP2013538963A JP2013543869A JP 2013543869 A JP2013543869 A JP 2013543869A JP 2013538963 A JP2013538963 A JP 2013538963A JP 2013538963 A JP2013538963 A JP 2013538963A JP 2013543869 A JP2013543869 A JP 2013543869A
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antibody
seq
amino acid
acid sequence
cell
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JP2013538963A
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Japanese (ja)
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JP2013543869A5 (https=
Inventor
ロナルド・ハーブスト
エリザベス・ケイ・ウォード
キャスリーン・フィリップス・マッキーバー
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メディミューン，エルエルシー
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Publication of JP2013543869A publication Critical patent/JP2013543869A/ja
Publication of JP2013543869A5 publication Critical patent/JP2013543869A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41—Glycosylation, sialylation, or fucosylation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72—Increased effector function due to an Fc-modification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013538963A 2010-11-15 2011-11-14 Ｂ細胞リンパ腫のための併用療法 Pending JP2013543869A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41377110P 2010-11-15 2010-11-15
US61/413,771 2010-11-15
PCT/US2011/060520 WO2012067981A1 (en) 2010-11-15 2011-11-14 Combination therapy for b cell lymphomas

Publications (2)

Publication Number Publication Date
JP2013543869A true JP2013543869A (ja) 2013-12-09
JP2013543869A5 JP2013543869A5 (https=) 2015-01-15

Family

ID=46084355

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013538963A Pending JP2013543869A (ja) 2010-11-15 2011-11-14 Ｂ細胞リンパ腫のための併用療法

Country Status (11)

Country Link
US (1) US20130330328A1 (https=)
EP (1) EP2640416A4 (https=)
JP (1) JP2013543869A (https=)
KR (1) KR20130130726A (https=)
CN (1) CN103228291A (https=)
AU (1) AU2011329161A1 (https=)
CA (1) CA2817842A1 (https=)
MX (1) MX2013005270A (https=)
RU (1) RU2013127115A (https=)
SG (1) SG190254A1 (https=)
WO (1) WO2012067981A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019519770A (ja) * 2016-05-30 2019-07-11 モルフォシス・アーゲー 患者における抗ｃｄ１９治療の治療的有用性を予測するための方法
JP2020526568A (ja) * 2017-07-10 2020-08-31 インターナショナル−ドラッグ−ディベロップメント−バイオテック 抗ｃｄ２０抗体または化学療法薬と併用して非フコシル化アポトーシス促進性抗ｃｄ１９抗体を用いるｂ細胞悪性の治療
JP2022545041A (ja) * 2019-08-21 2022-10-24 ジョイント－ストック カンパニー “ジェネリウム” Ｃｄ３結合のための相補性決定領域およびそのｃｄｒを含む二重特異性抗原結合分子

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008530142A (ja) * 2005-02-15 2008-08-07 デューク ユニバーシティ 抗ｃｄ１９抗体および腫瘍学における使用
JP2009539413A (ja) * 2006-06-12 2009-11-19 トゥルビオン・ファーマシューティカルズ・インコーポレーテッド エフェクター機能を有する単鎖多価結合タンパク質
JP2010502232A (ja) * 2006-09-08 2010-01-28 メディミューン，エルエルシー ヒト化抗ｃｄ１９抗体ならびに癌、移植および自己免疫疾患の治療におけるその使用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008530142A (ja) * 2005-02-15 2008-08-07 デューク ユニバーシティ 抗ｃｄ１９抗体および腫瘍学における使用
JP2009539413A (ja) * 2006-06-12 2009-11-19 トゥルビオン・ファーマシューティカルズ・インコーポレーテッド エフェクター機能を有する単鎖多価結合タンパク質
JP2010502232A (ja) * 2006-09-08 2010-01-28 メディミューン，エルエルシー ヒト化抗ｃｄ１９抗体ならびに癌、移植および自己免疫疾患の治療におけるその使用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WARD, BETH K. ET AL.: "A glycoengineered anti-CD19 antibody (MEDI-551) is effective as monotherapy or in combination treatm", MOLECULAR CANCER THERAPEUTICS, vol. Vol.8, No.12, Suppl.1., JPN6015038295, 10 December 2009 (2009-12-10), pages 186, ISSN: 0003160310 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019519770A (ja) * 2016-05-30 2019-07-11 モルフォシス・アーゲー 患者における抗ｃｄ１９治療の治療的有用性を予測するための方法
JP7066639B2 (ja) 2016-05-30 2022-05-13 モルフォシス・アーゲー 患者における抗ｃｄ１９治療の治療的有用性を予測するための方法
JP2022119764A (ja) * 2016-05-30 2022-08-17 モルフォシス・アーゲー 患者における抗ｃｄ１９治療の治療的有用性を予測するための方法
JP7511806B2 (ja) 2016-05-30 2024-07-08 インサイト コーポレイション 患者における抗ｃｄ１９治療の治療的有用性を予測するための方法
JP2020526568A (ja) * 2017-07-10 2020-08-31 インターナショナル−ドラッグ−ディベロップメント−バイオテック 抗ｃｄ２０抗体または化学療法薬と併用して非フコシル化アポトーシス促進性抗ｃｄ１９抗体を用いるｂ細胞悪性の治療
JP7279011B2 (ja) 2017-07-10 2023-05-22 インターナショナル－ドラッグ－ディベロップメント－バイオテック 抗ｃｄ２０抗体または化学療法薬と併用して非フコシル化アポトーシス促進性抗ｃｄ１９抗体を用いるｂ細胞悪性の治療
JP2022545041A (ja) * 2019-08-21 2022-10-24 ジョイント－ストック カンパニー “ジェネリウム” Ｃｄ３結合のための相補性決定領域およびそのｃｄｒを含む二重特異性抗原結合分子
JP7366242B2 (ja) 2019-08-21 2023-10-20 ジョイント－ストック カンパニー “ジェネリウム” Ｃｄ３結合のための相補性決定領域およびそのｃｄｒを含む二重特異性抗原結合分子

Also Published As

Publication number Publication date
US20130330328A1 (en) 2013-12-12
EP2640416A4 (en) 2014-04-23
MX2013005270A (es) 2013-10-25
CA2817842A1 (en) 2012-05-24
SG190254A1 (en) 2013-06-28
CN103228291A (zh) 2013-07-31
AU2011329161A1 (en) 2013-06-27
EP2640416A1 (en) 2013-09-25
WO2012067981A1 (en) 2012-05-24
RU2013127115A (ru) 2014-12-27
KR20130130726A (ko) 2013-12-02

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