JP2013543869A - B細胞リンパ腫のための併用療法 - Google Patents

B細胞リンパ腫のための併用療法 Download PDF

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Publication number
JP2013543869A
JP2013543869A JP2013538963A JP2013538963A JP2013543869A JP 2013543869 A JP2013543869 A JP 2013543869A JP 2013538963 A JP2013538963 A JP 2013538963A JP 2013538963 A JP2013538963 A JP 2013538963A JP 2013543869 A JP2013543869 A JP 2013543869A
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antibody
seq
amino acid
acid sequence
cell
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JP2013543869A5 (enExample
Inventor
ロナルド・ハーブスト
エリザベス・ケイ・ウォード
キャスリーン・フィリップス・マッキーバー
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メディミューン,エルエルシー
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/40Immunoglobulins specific features characterized by post-translational modification
    • C07K2317/41Glycosylation, sialylation, or fucosylation
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/72Increased effector function due to an Fc-modification
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732Antibody-dependent cellular cytotoxicity [ADCC]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Oncology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2013538963A 2010-11-15 2011-11-14 B細胞リンパ腫のための併用療法 Pending JP2013543869A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41377110P 2010-11-15 2010-11-15
US61/413,771 2010-11-15
PCT/US2011/060520 WO2012067981A1 (en) 2010-11-15 2011-11-14 Combination therapy for b cell lymphomas

Publications (2)

Publication Number Publication Date
JP2013543869A true JP2013543869A (ja) 2013-12-09
JP2013543869A5 JP2013543869A5 (enExample) 2015-01-15

Family

ID=46084355

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Application Number Title Priority Date Filing Date
JP2013538963A Pending JP2013543869A (ja) 2010-11-15 2011-11-14 B細胞リンパ腫のための併用療法

Country Status (11)

Country Link
US (1) US20130330328A1 (enExample)
EP (1) EP2640416A4 (enExample)
JP (1) JP2013543869A (enExample)
KR (1) KR20130130726A (enExample)
CN (1) CN103228291A (enExample)
AU (1) AU2011329161A1 (enExample)
CA (1) CA2817842A1 (enExample)
MX (1) MX2013005270A (enExample)
RU (1) RU2013127115A (enExample)
SG (1) SG190254A1 (enExample)
WO (1) WO2012067981A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019519770A (ja) * 2016-05-30 2019-07-11 モルフォシス・アーゲー 患者における抗cd19治療の治療的有用性を予測するための方法
JP2020526568A (ja) * 2017-07-10 2020-08-31 インターナショナル−ドラッグ−ディベロップメント−バイオテック 抗cd20抗体または化学療法薬と併用して非フコシル化アポトーシス促進性抗cd19抗体を用いるb細胞悪性の治療
JP2022545041A (ja) * 2019-08-21 2022-10-24 ジョイント-ストック カンパニー “ジェネリウム” Cd3結合のための相補性決定領域およびそのcdrを含む二重特異性抗原結合分子

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008530142A (ja) * 2005-02-15 2008-08-07 デューク ユニバーシティ 抗cd19抗体および腫瘍学における使用
JP2009539413A (ja) * 2006-06-12 2009-11-19 トゥルビオン・ファーマシューティカルズ・インコーポレーテッド エフェクター機能を有する単鎖多価結合タンパク質
JP2010502232A (ja) * 2006-09-08 2010-01-28 メディミューン,エルエルシー ヒト化抗cd19抗体ならびに癌、移植および自己免疫疾患の治療におけるその使用

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2008530142A (ja) * 2005-02-15 2008-08-07 デューク ユニバーシティ 抗cd19抗体および腫瘍学における使用
JP2009539413A (ja) * 2006-06-12 2009-11-19 トゥルビオン・ファーマシューティカルズ・インコーポレーテッド エフェクター機能を有する単鎖多価結合タンパク質
JP2010502232A (ja) * 2006-09-08 2010-01-28 メディミューン,エルエルシー ヒト化抗cd19抗体ならびに癌、移植および自己免疫疾患の治療におけるその使用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
WARD, BETH K. ET AL.: "A glycoengineered anti-CD19 antibody (MEDI-551) is effective as monotherapy or in combination treatm", MOLECULAR CANCER THERAPEUTICS, vol. Vol.8, No.12, Suppl.1., JPN6015038295, 10 December 2009 (2009-12-10), pages 186, ISSN: 0003160310 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019519770A (ja) * 2016-05-30 2019-07-11 モルフォシス・アーゲー 患者における抗cd19治療の治療的有用性を予測するための方法
JP7066639B2 (ja) 2016-05-30 2022-05-13 モルフォシス・アーゲー 患者における抗cd19治療の治療的有用性を予測するための方法
JP2022119764A (ja) * 2016-05-30 2022-08-17 モルフォシス・アーゲー 患者における抗cd19治療の治療的有用性を予測するための方法
JP7511806B2 (ja) 2016-05-30 2024-07-08 インサイト コーポレイション 患者における抗cd19治療の治療的有用性を予測するための方法
JP2020526568A (ja) * 2017-07-10 2020-08-31 インターナショナル−ドラッグ−ディベロップメント−バイオテック 抗cd20抗体または化学療法薬と併用して非フコシル化アポトーシス促進性抗cd19抗体を用いるb細胞悪性の治療
JP7279011B2 (ja) 2017-07-10 2023-05-22 インターナショナル-ドラッグ-ディベロップメント-バイオテック 抗cd20抗体または化学療法薬と併用して非フコシル化アポトーシス促進性抗cd19抗体を用いるb細胞悪性の治療
JP2022545041A (ja) * 2019-08-21 2022-10-24 ジョイント-ストック カンパニー “ジェネリウム” Cd3結合のための相補性決定領域およびそのcdrを含む二重特異性抗原結合分子
JP7366242B2 (ja) 2019-08-21 2023-10-20 ジョイント-ストック カンパニー “ジェネリウム” Cd3結合のための相補性決定領域およびそのcdrを含む二重特異性抗原結合分子

Also Published As

Publication number Publication date
MX2013005270A (es) 2013-10-25
EP2640416A1 (en) 2013-09-25
US20130330328A1 (en) 2013-12-12
AU2011329161A1 (en) 2013-06-27
SG190254A1 (en) 2013-06-28
EP2640416A4 (en) 2014-04-23
RU2013127115A (ru) 2014-12-27
KR20130130726A (ko) 2013-12-02
CN103228291A (zh) 2013-07-31
CA2817842A1 (en) 2012-05-24
WO2012067981A1 (en) 2012-05-24

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