JP2013543861A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2013543861A5 JP2013543861A5 JP2013538319A JP2013538319A JP2013543861A5 JP 2013543861 A5 JP2013543861 A5 JP 2013543861A5 JP 2013538319 A JP2013538319 A JP 2013538319A JP 2013538319 A JP2013538319 A JP 2013538319A JP 2013543861 A5 JP2013543861 A5 JP 2013543861A5
- Authority
- JP
- Japan
- Prior art keywords
- carbon atoms
- compound
- carbon
- alkyl group
- dihydroquinoline
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000004432 carbon atom Chemical group C* 0.000 claims 23
- 125000000217 alkyl group Chemical group 0.000 claims 14
- 150000001875 compounds Chemical class 0.000 claims 14
- 229910052799 carbon Inorganic materials 0.000 claims 13
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 11
- 125000005843 halogen group Chemical group 0.000 claims 9
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 125000003118 aryl group Chemical group 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 6
- 210000000963 osteoblast Anatomy 0.000 claims 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 4
- 210000000130 stem cell Anatomy 0.000 claims 4
- 210000000988 bone and bone Anatomy 0.000 claims 3
- 125000001072 heteroaryl group Chemical group 0.000 claims 3
- 125000005842 heteroatom Chemical group 0.000 claims 3
- 229910052757 nitrogen Inorganic materials 0.000 claims 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 3
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 3
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 claims 3
- 210000004504 adult stem cell Anatomy 0.000 claims 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 claims 2
- 150000001721 carbon Chemical group 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000037147 Hypercalcaemia Diseases 0.000 claims 1
- 201000002980 Hyperparathyroidism Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 208000029725 Metabolic bone disease Diseases 0.000 claims 1
- 206010027452 Metastases to bone Diseases 0.000 claims 1
- 208000010191 Osteitis Deformans Diseases 0.000 claims 1
- 206010031243 Osteogenesis imperfecta Diseases 0.000 claims 1
- 206010031264 Osteonecrosis Diseases 0.000 claims 1
- 206010049088 Osteopenia Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 208000027067 Paget disease of bone Diseases 0.000 claims 1
- 208000027418 Wounds and injury Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 208000016738 bone Paget disease Diseases 0.000 claims 1
- 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 1
- 230000024245 cell differentiation Effects 0.000 claims 1
- 229940125904 compound 1 Drugs 0.000 claims 1
- 229940125782 compound 2 Drugs 0.000 claims 1
- 229940126214 compound 3 Drugs 0.000 claims 1
- 229940125898 compound 5 Drugs 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000003412 degenerative effect Effects 0.000 claims 1
- 230000018109 developmental process Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000008482 dysregulation Effects 0.000 claims 1
- 230000000148 hypercalcaemia Effects 0.000 claims 1
- 208000030915 hypercalcemia disease Diseases 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 208000014674 injury Diseases 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 235000015097 nutrients Nutrition 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 210000002997 osteoclast Anatomy 0.000 claims 1
- 208000005368 osteomalacia Diseases 0.000 claims 1
- 201000001245 periodontitis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 238000001356 surgical procedure Methods 0.000 claims 1
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR1004445 | 2010-11-16 | ||
| FR1004445A FR2967353B1 (fr) | 2010-11-16 | 2010-11-16 | Derives de quinolinone |
| PCT/IB2011/055096 WO2012066478A1 (fr) | 2010-11-16 | 2011-11-15 | Dérivés de quinolinone |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013543861A JP2013543861A (ja) | 2013-12-09 |
| JP2013543861A5 true JP2013543861A5 (enExample) | 2014-11-20 |
| JP5914509B2 JP5914509B2 (ja) | 2016-05-11 |
Family
ID=45346524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013538319A Expired - Fee Related JP5914509B2 (ja) | 2010-11-16 | 2011-11-15 | キノリノン誘導体 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9061997B2 (enExample) |
| EP (1) | EP2640388B1 (enExample) |
| JP (1) | JP5914509B2 (enExample) |
| CA (1) | CA2817388C (enExample) |
| ES (1) | ES2651015T3 (enExample) |
| FR (1) | FR2967353B1 (enExample) |
| WO (1) | WO2012066478A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2967498B1 (fr) * | 2010-11-16 | 2015-01-02 | Centre Nat Rech Scient | Utilisation de derives de quinolinone comme outil de recherche |
| WO2016042112A1 (en) * | 2014-09-23 | 2016-03-24 | Active Biotech Ab | Quinoline carboxamides for use in the treatment of multiple myeloma |
| EP3641757A4 (en) * | 2017-06-23 | 2021-03-24 | New York Society for the Ruptured and Crippled Maintaining the Hospital for Special Surgery | COMPOSITION, USES, AND METHOD OF TREATMENTAL DISC DEGENERATION BY A HEDGEHOG SOUND PATH |
| CN114196623B (zh) * | 2021-11-12 | 2024-01-16 | 青岛大学附属医院 | 喹啉酮化合物作为骨髓间干细胞成骨分化促进剂的应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE52670B1 (en) * | 1981-03-03 | 1988-01-20 | Leo Ab | Heterocyclic carboxamides,compositions containing such compounds,and processes for their preparation |
| SE8301182D0 (sv) * | 1983-03-04 | 1983-03-04 | Haessle Ab | Novel compounds |
| HRP20000904A2 (en) * | 1998-07-06 | 2001-12-31 | Janssen Pharmaceutica Nv | Farnesyl protein transferase inhibitors for treating arthropathies |
| AU2005324492B2 (en) * | 2004-04-23 | 2012-06-07 | Paratek Pharmaceuticals, Inc. | Transcription factor modulating compounds and methods of use thereof |
| CN1955175A (zh) * | 2004-10-28 | 2007-05-02 | 中国医学科学院药物研究所 | 香豆素衍生物及其制法和其药物组合物与用途 |
| WO2007124617A1 (fr) * | 2006-04-28 | 2007-11-08 | Institute Of Mataria Medica, Chinese Academy Of Medical Sciences | Dérivés de coumarine, leurs procédés de préparation, compositions pharmaceutiques et utilisations |
| MX2009000943A (es) * | 2006-07-26 | 2009-02-04 | Novartis Ag | Inhibidores de undecaprenil pirofosfato sintasa. |
| US8183236B2 (en) * | 2007-04-12 | 2012-05-22 | University Of Southern California | Compounds with HIV-1 integrase inhibitory activity and use thereof as anti-HIV/AIDS therapeutics |
-
2010
- 2010-11-16 FR FR1004445A patent/FR2967353B1/fr active Active
-
2011
- 2011-11-15 JP JP2013538319A patent/JP5914509B2/ja not_active Expired - Fee Related
- 2011-11-15 EP EP11794858.8A patent/EP2640388B1/fr not_active Not-in-force
- 2011-11-15 WO PCT/IB2011/055096 patent/WO2012066478A1/fr not_active Ceased
- 2011-11-15 US US13/885,089 patent/US9061997B2/en not_active Expired - Fee Related
- 2011-11-15 ES ES11794858.8T patent/ES2651015T3/es active Active
- 2011-11-15 CA CA2817388A patent/CA2817388C/fr not_active Expired - Fee Related
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US9382228B2 (en) | N-acyl-N′-(pyridin-2-yl) ureas and analogs exhibiting anti-cancer and anti-proliferative activities | |
| AR065876A1 (es) | Compuestos activos para 11 beta -hsd1 | |
| JP2013543861A5 (enExample) | ||
| JP2019213917A (ja) | 骨の成長および修復に使用するための化合物およびマトリックス | |
| AR085683A1 (es) | Compuestos de piridona y aza-piridona y metodos de uso | |
| CO6241112A2 (es) | Sales novedosas de piperazina como antagonistas d3/d2 | |
| PE20121352A1 (es) | Derivados de heteroarilo que contienen n como inhibidores de cinasa jak3 | |
| JP2010523709A5 (enExample) | ||
| CY1110318T1 (el) | Παραγωγα φαινοξυοξικου οξεος | |
| AR070130A1 (es) | Compuestos moduladores de beta-amiloide, un proceso para su obtencion, el uso del compuesto para la fabricacion de un medicamento y dicho medicamento | |
| EA201071298A1 (ru) | Соединение 3-аминокарбазола, фармацевтическая композиция, его содержащая, и способ их получения | |
| JP2010530373A5 (enExample) | ||
| JP2013523802A5 (enExample) | ||
| ES2590929T3 (es) | Derivados de bencilsulfonamida útiles como inhibidores de MOGAT-2 | |
| PE20081159A1 (es) | Inhibidores de las quinasas y metodos para su utilizacion | |
| AR070836A1 (es) | Derivados de carbazol inhibidores de hsp90, composiciones que los contie-nen; utilizacion de los compuestos para preparar medicamentos; un proce-dimiento para la preparacion de los compuestos; medicamentos; y compues-tos intermediarios de sintesis | |
| JP2013508394A5 (enExample) | ||
| AR074352A1 (es) | Acidos naftalen-2-il-aceticos sustituidos, composiciones farmaceuticas que los contienen, y uso de los mismos en el tratamiento de enfermedades alergicas,tales como rinitis, asma y dermatitis atopica. | |
| JP2014505017A5 (enExample) | ||
| RU2014101464A (ru) | Циклопропил-конденсированные-1,3-тиазепины в качестве ингибиторов васе 1 и(или) васе 2 | |
| ES2409404T3 (es) | Compuestos heterocíclicos de fenoximetilo | |
| AU2014258419A2 (en) | Dicarboxylic acid compound | |
| JP2021527660A (ja) | ＲＯＲγｔのモジュレータとしてのフェニル及びピリジニル置換イミダゾール | |
| JP2021508739A (ja) | パントテン酸キナーゼの小分子モジュレーター | |
| JP2018533621A (ja) | カルボラン化合物及びその使用方法 |