JP2013543578A - 光学的血液モニタリングシステム用の血液チャンバ - Google Patents
光学的血液モニタリングシステム用の血液チャンバ Download PDFInfo
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Abstract
【選択図】図8
Description
本発明の第一の目的は、レシオメトリックモデルを介して酸素飽和度を算出するために使用される検出シグナルの予測されるダイナミックレンジ全体にわたって酸素飽和度の正確な測定を促進し、かつ、高いヘマトクリットレベルおよび低いヘマトクリットレベルの両方でそれを行うことである。
Io= 関心のある波長におけるLED光エミッタから印加された強度;
ip= 光検出器での直接的なパイピング経路から受信した強度;
ρ = いくつかの変数v1、v2、v3,・・・・・vnのパイピング関数)
である。
i = 足し合わされ、光検出器でのカレントに統合された総強度シグナル
is= シグナル経路dbに沿ってLED88から到達した光の成分
ip= 光パイピング経路を通ってLED88から到達した光の成分)
である。
ダクティングが存在する場合、式(8)は、ipを各レシオメトリック項isに足すことにより修正されなければならない。ipおよびレシオメトリック項isは比例的に変化しないため、ipの値がレシオメトリック項isと比較して有意である場合、多項式gは解を持たず決定できない。
Claims (17)
- 体外のチューブを流れる血液を光学的にモニタリングするための血液チャンバであって、当該血液チャンバは、内部血流キャビティを通る流れの経路を画定し、該内部血流キャビティは、血液の光学的モニタリングのための平坦な観察エリアを提供し、当該血液チャンバは、
チャンバ本体を有し、該チャンバ本体は、平坦な内壁、および、該平坦な内壁の周囲で伸長する周壁を有し、該平坦な内壁および周壁は、内部血流キャビティの一部分を形成し、
第1のポートおよびチャンネルを有し、該第1のポートおよびチャンネルは、該周壁中の第1の開口部を通じて該内部血流キャビティと流体連結しており、
第2のポートおよびチャンネルを有し、該第2のポートおよびチャンネルは、該周壁中の第2の開口部を通じて該内部血流キャビティと流体連結しており、
かつ観察レンズを有し、該観察レンズは、該チャンバ本体の該平坦な内壁の少なくとも一部分に相当する透明な材料から作られており、それにより、該内部血流キャビティを流れる血液の観察手段を提供し、
該チャンバ本体の少なくとも一部分は、第3の波長(λ3)として定義される波長を有する赤色光を通さない材料から作られており、かつ、
レンズ本体を有し、該レンズ本体は、該チャンバ本体に取り付けられた平坦な内壁を有し、それにより、該チャンバ本体の該平坦な内壁および周壁と一緒になって該内部血流キャビティを形成し、該レンズ本体は、該レンズの該平坦な内壁により該チャンバ本体に取り付けられており、該レンズの該平坦な内壁は、該チャンバ本体の該平坦な内壁に対して実質的に平行であり、そしてまた、あらかじめ定められた一定の距離だけ該チャンバ本体の該平坦な内壁から分離されており、かつ、さらに、該レンズ本体は、観察レンズを有し、該観察レンズは、該レンズ本体の該平坦な内壁の少なくとも一部分に相当する透明な材料から作られており、それにより、該内部血流キャビティを流れる血液の観察手段を提供し、
該血液チャンバの該不透明な部分は、該チャンバ本体をダクトする該第3の波長(λ3)の光を減衰し、かつ、該第3の波長(λ3)のダクトされた光から該レンズを分離する、
前記血液チャンバ。 - 該第3の波長(λ3)が約660nmである、請求項1に記載の血液チャンバ。
- 該チャンバ本体の該観察レンズが、透明なポリカーボネート材料から成形されており、かつ、該チャンバ本体の残りの部分が、青色の付いたポリカーボネート材料から成形されている、請求項1に記載の血液チャンバ。
- 該チャンバ本体の該不透明なポリカーボネート部分が、製造プロセスの間に、該チャンバ本体の該透明なポリカーボネートの観察レンズに対してオーバーモールドされている、請求項3に記載の血液チャンバ。
- 該チャンバ本体の該不透明な部分が、赤色光の全スペクトルを通さない材料から作られている、請求項1に記載の血液チャンバ。
- 該レンズ本体の全体が透明なポリカーボネート材料から成形されている、請求項1に記載の血液チャンバ。
- 該内部流れキャビティが、該レンズの間の観察エリアの周囲に堀を有する、請求項1に記載の血液チャンバ。
- 該第2のポートおよびチャンネルが、該血液チャンバを横断する軸に沿って、該第1のポートおよびチャンネルと軸に関して位置合わせされている、請求項1に記載の血液チャンバ。
- 光学的血液モニタリングシステムであって、当該光学的血液モニタリングシステムは、
体外チューブを有し、該体外チューブは、患者から採取された血液を通すためのものであり、
血液チャンバを有し、該血液チャンバは、該体外チューブを流れる血液を受け取るものであり、該血液チャンバは、内部血流キャビティを通る流れの経路を画定し、かつ、血液の光学的モニタリングのための平坦な観察エリアを提供し、該血液チャンバは、平坦な内壁、および、該平坦な内壁の周囲で伸長する周壁を有し、該平坦な内壁および該周壁は、該内部血流キャビティの一部分を形成し、該血液チャンバは、第1のポートおよびチャンネルを有し、該第1のポートおよびチャンネルは、該周壁中の第1の開口部を通じて該内部血流キャビティと流体連結しており、該血液チャンバは、第2のポートおよびチャンネルを有し、該第2のポートおよびチャンネルは、該周壁中の第2の開口部を通じて該内部血流キャビティと流体連結しており、かつ、該血液チャンバは、観察レンズを有し、該観察レンズは、該チャンバ本体の該平坦な内壁の少なくとも一部分に相当する透明な材料から作られており、それにより、該内部血流キャビティを流れる血液の観察手段を提供し、該チャンバ本体の少なくとも一部分は、第3の波長(λ3)として定義される波長を有する赤色光を通さない材料から作られており、かつ、
レンズ本体を有し、該レンズ本体は、該チャンバ本体に取り付けられているかまたは該チャンバ本体と一体的に形成されている平坦な内壁を有し、それにより、該チャンバ本体の該平坦な内壁および周壁と一緒になって該内部血流キャビティを形成し、該レンズ本体は、該レンズの該平坦な内壁により該チャンバ本体に取り付けられており、該レンズの該平坦な内壁は、該チャンバ本体の該平坦な内壁に対して実質的に平行であり、そしてまた、予め定められた一定のインスタンス(instance)だけ該チャンバ本体の該平坦な内壁から分離されており、かつ、該レンズ本体は、観察レンズを有し、該観察レンズは、該レンズ本体の該平坦な内壁の少なくとも一部分に相当する透明な材料から作られており、それにより、該内部血流キャビティを流れる血液の観察手段を提供し、
センサアセンブリを有し、該センサアセンブリは、該血液チャンバを流れる患者の血液をモニタリングするものであり、該センサアセンブリは、第3の光エミッタを有し、該第3の光エミッタは、該観察レンズ、および、該血液チャンバの該内部血流キャビティを流れる血液を通る該第3の波長(λ3)の赤色光の分解を放出するためのものであり、該センサアセンブリは、第1の光エミッタを有し、該第1の光エミッタは、該観察レンズ、および、該血液チャンバの該内部血流キャビティを流れる血液を通る第1の波長(λ1)の赤外光を放出するためのものであり、かつ、該センサアセンブリは、少なくとも1つの光検出器を有し、該少なくとも1つの光検出器は、該第3(λ3)および第1(λ1)の波長の各々の光の強度を、該光が、該観察レンズ、および該血液チャンバの該血液チャンバを流れる血液を通過した後に、検出するためのものであり、該血液チャンバの該不透明な部分は、該チャンバ本体をダクトする該第3の波長(λ3)の光を減衰し、かつ、該第3の波長(λ3)のダクトされた光から該レンズを分離し、かつ、
コントローラを有し、該コントローラは、レシオメトリックモデルを有し、該レシオメトリックモデルは、少なくとも、該第3の波長(λ3)での強度の検出された値および該第1の波長(λ1)での強度の検出された値の関数として、患者の酸素飽和度を算出するものである、
前記光学的血液モニタリングシステム。 - 該チャンバ本体の該観察レンズが、透明なポリカーボネート材料から成形されており、かつ、該チャンバ本体の残りの部分が、不透明なポリカーボネート材料から成形されており、かつ、さらに、該チャンバ本体の該不透明な部分が、製造プロセスの間に、該チャンバ本体の該透明な観察レンズにオーバーモールドされている、請求項9に記載の発明。
- 該第3の波長(λ3)が約660nmであり、かつ、該第1の波長(λ1)が約810nmである、請求項9に記載の発明。
- 該センサアセンブリが、第2の光エミッタを更に有し、該第2の光エミッタは、該観察レンズ、および、該血液チャンバの該内部血液キャビティを流れる血液を通る第2の波長(λ2)の光を放出するためのものであり、かつ、該センサアセンブリが、少なくとも1つの光検出器を更に有し、該少なくとも1つの光検出器は、該第2の波長(λ2)の光の強度を、該放射線が該血液チャンバの該内部血流キャビティを流れる血液中の該観察レンズを通過した後に、検出するためのものであり、かつ、該コントローラが、少なくとも、該第1の波長(λ1)の強度の検出された値および該第2の波長(λ2)の検出された強度の関数として、患者のヘマトクリット値を算出するためのレシオメトリックモデルを更に有する、請求項9に記載の発明。
- 該第1の波長(λ1)が約829nmであり、かつ、該第2の波長(λ2)が約1300nmである、請求項14に記載の発明。
- 患者のヘマトクリットを決定するためのレシオメトリックモデルが、以下の形式:
HCTは、該レシオメトリックモデルにより決定されるヘマトクリット値であり、
iλ1は、該第1の波長での検出された強度であり、
iλ2は、該第2の波長での検出された強度であり、
Io-λ1は、該血液チャンバに起因する損失を考慮した該血液チャンバに入射する該第1の波長の強度を表す定数であり、
Io-λ2は、該血液チャンバに起因する損失を考慮した該血液チャンバに入射する該第2の波長の光の強度を表す定数であり、かつ、
fは、対数比の計算を適合してHCTを与える関数である。)
である、請求項14に記載の光学的血液モニタ。
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MX341335B (es) | 2016-08-16 |
WO2012033738A1 (en) | 2012-03-15 |
US20120059234A1 (en) | 2012-03-08 |
US9194792B2 (en) | 2015-11-24 |
CA2808252A1 (en) | 2012-03-15 |
EP2613699A1 (en) | 2013-07-17 |
EP2613699B1 (en) | 2020-08-19 |
CA2808252C (en) | 2018-02-27 |
JP5837598B2 (ja) | 2015-12-24 |
AU2011299393A1 (en) | 2013-02-07 |
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AU2011299393B2 (en) | 2014-09-11 |
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