JP2013542980A5 - - Google Patents
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- Publication number
- JP2013542980A5 JP2013542980A5 JP2013539392A JP2013539392A JP2013542980A5 JP 2013542980 A5 JP2013542980 A5 JP 2013542980A5 JP 2013539392 A JP2013539392 A JP 2013539392A JP 2013539392 A JP2013539392 A JP 2013539392A JP 2013542980 A5 JP2013542980 A5 JP 2013542980A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- pharmaceutically acceptable
- acceptable salt
- trifluoromethyl
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 19
- 150000003839 salts Chemical class 0.000 claims description 13
- 239000011780 sodium chloride Substances 0.000 claims description 13
- 125000000217 alkyl group Chemical group 0.000 claims description 12
- 125000004432 carbon atoms Chemical group C* 0.000 claims description 12
- 229910052736 halogen Inorganic materials 0.000 claims description 10
- 150000002367 halogens Chemical class 0.000 claims description 10
- 229910052799 carbon Inorganic materials 0.000 claims description 9
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims description 8
- 229920000728 polyester Polymers 0.000 claims description 8
- 125000003545 alkoxy group Chemical group 0.000 claims description 6
- 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims description 6
- 229910052739 hydrogen Inorganic materials 0.000 claims description 6
- 125000001570 methylene group Chemical group [H]C([H])([*:1])[*:2] 0.000 claims description 6
- -1 monofluoromethyl Chemical group 0.000 claims description 6
- 229910052760 oxygen Inorganic materials 0.000 claims description 6
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 6
- 229910052717 sulfur Inorganic materials 0.000 claims description 6
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 6
- 125000001931 aliphatic group Chemical group 0.000 claims description 3
- 125000002541 furyl group Chemical group 0.000 claims description 3
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims description 3
- 125000002883 imidazolyl group Chemical group 0.000 claims description 3
- 125000001624 naphthyl group Chemical group 0.000 claims description 3
- 125000003373 pyrazinyl group Chemical group 0.000 claims description 3
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 3
- 125000004076 pyridyl group Chemical group 0.000 claims description 3
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 3
- 125000005493 quinolyl group Chemical group 0.000 claims description 3
- 125000001544 thienyl group Chemical group 0.000 claims description 3
- 125000004306 triazinyl group Chemical group 0.000 claims description 3
- 201000010099 disease Diseases 0.000 claims 4
- 206010060945 Bacterial infection Diseases 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- PJLDMMAWNCOMFM-UHFFFAOYSA-N 2-(4-heptylpiperazin-1-yl)-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one Chemical compound C1CN(CCCCCCC)CCN1C1=NC(=O)C2=CC(C(F)(F)F)=CC([N+]([O-])=O)=C2S1 PJLDMMAWNCOMFM-UHFFFAOYSA-N 0.000 claims 1
- SKSIZKIXUNJGRA-UHFFFAOYSA-N 2-(trifluoromethyl)-1,3-benzothiazin-4-one Chemical compound C1=CC=C2SC(C(F)(F)F)=NC(=O)C2=C1 SKSIZKIXUNJGRA-UHFFFAOYSA-N 0.000 claims 1
- BJDZBXGJNBMCAV-UHFFFAOYSA-N 2-[4-(cyclohexylmethyl)piperazin-1-yl]-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one Chemical compound [O-][N+](=O)C1=CC(C(F)(F)F)=CC(C(N=2)=O)=C1SC=2N(CC1)CCN1CC1CCCCC1 BJDZBXGJNBMCAV-UHFFFAOYSA-N 0.000 claims 1
- ITHNASMYIIDIMQ-UHFFFAOYSA-N 2-[4-[3-(4-fluorophenoxy)propyl]piperazin-1-yl]-8-nitro-6-(trifluoromethyl)-1,3-benzothiazin-4-one Chemical compound [O-][N+](=O)C1=CC(C(F)(F)F)=CC(C(N=2)=O)=C1SC=2N(CC1)CCN1CCCOC1=CC=C(F)C=C1 ITHNASMYIIDIMQ-UHFFFAOYSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- 208000006448 Buruli Ulcer Diseases 0.000 claims 1
- 241000186216 Corynebacterium Species 0.000 claims 1
- 206010024229 Leprosy Diseases 0.000 claims 1
- 241000186359 Mycobacterium Species 0.000 claims 1
- 206010066289 Mycobacterium ulcerans infection Diseases 0.000 claims 1
- 241000187654 Nocardia Species 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 201000008827 tuberculosis Diseases 0.000 claims 1
- 0 CCNC*** Chemical compound CCNC*** 0.000 description 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
RUPCT/RU2010/000688 | 2010-11-19 | ||
RU2010000688 | 2010-11-19 | ||
PCT/IB2011/055209 WO2012066518A1 (en) | 2010-11-19 | 2011-11-21 | 2-piperazin-1-yl-4h-1,3-benzothiazin-4-one derivatives and their use for the treatment of mammalian infections |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2013542980A JP2013542980A (ja) | 2013-11-28 |
JP2013542980A5 true JP2013542980A5 (pt-PT) | 2016-03-31 |
JP6061346B2 JP6061346B2 (ja) | 2017-01-18 |
Family
ID=45349249
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013539392A Active JP6061346B2 (ja) | 2010-11-19 | 2011-11-21 | 2−ピペラジン−1−イル−4h−1,3−ベンゾチアジン−4−オン誘導体、および哺乳類の感染症治療へのその使用 |
Country Status (19)
Country | Link |
---|---|
US (1) | US8796264B2 (pt-PT) |
EP (1) | EP2640712B1 (pt-PT) |
JP (1) | JP6061346B2 (pt-PT) |
KR (2) | KR101851774B1 (pt-PT) |
CN (2) | CN107011287A (pt-PT) |
AU (1) | AU2011330742B2 (pt-PT) |
BR (1) | BR112013012280B1 (pt-PT) |
CA (1) | CA2817931C (pt-PT) |
EA (1) | EA023879B1 (pt-PT) |
ES (1) | ES2690728T3 (pt-PT) |
GE (1) | GEP201606545B (pt-PT) |
HU (1) | HUE040152T2 (pt-PT) |
IL (1) | IL226289A (pt-PT) |
LT (1) | LT2640712T (pt-PT) |
PL (1) | PL2640712T3 (pt-PT) |
TR (1) | TR201815010T4 (pt-PT) |
UA (1) | UA109557C2 (pt-PT) |
WO (1) | WO2012066518A1 (pt-PT) |
ZA (1) | ZA201303829B (pt-PT) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103508980B (zh) * | 2012-06-14 | 2016-07-06 | 四川大学 | 苯并噻嗪-4-酮衍生物及其制备方法和用途 |
CN104211708B (zh) * | 2013-05-29 | 2018-08-24 | 中国医学科学院药物研究所 | 苯并噁嗪酮衍生物及其作为抗菌剂的应用 |
KR102320190B1 (ko) | 2014-01-24 | 2021-11-03 | 에이아이 테라퓨틱스, 인코포레이티드 | 아필리모드 조성물 및 이를 사용하기 위한 방법 |
DE102014012546A1 (de) * | 2014-09-26 | 2016-03-31 | Martin-Luther-Universität Halle-Wittenberg | Antimykobakteriell wirksame Substanzen, Verfahren zu ihrer Herstellung und deren Verwendung |
MX2017006015A (es) | 2014-11-07 | 2017-11-17 | Lam Therapeutics Inc | Composiciones para usar en el tratamiento de cancer renal. |
EP3072889A1 (en) * | 2015-03-23 | 2016-09-28 | Ecole Polytechnique Federale De Lausanne (Epfl) | 2-Homopiperazine-1-yl-4H-1,3-benzothiazine-4-one derivatives and process for the preparation of 2-(homo)piperazine 1,3-benzothiazine-4-one hydrochlorides |
RU2752568C2 (ru) * | 2016-09-22 | 2021-07-29 | Ляйбниц-Институт Фюр Натурштофф-Форшунг Унд Инфекционсбиологи Е.Ф. Ханс-Кнёлль Институт (Хки) | Новые антимикробные соединения, их применение для лечения инфекций млекопитающих и новый метаболический механизм |
CN108929329B (zh) * | 2017-05-24 | 2020-12-11 | 中国医学科学院药物研究所 | 2-氮杂环-5-三氟甲基-8-硝基苯并(硫代)吡喃-4-酮类化合物 |
RU2751163C9 (ru) * | 2020-04-06 | 2021-10-20 | Общество С Ограниченной Ответственностью "Ниармедик Плюс" | Фармацевтическая композиция на основе макозинона для лечения туберкулеза, включая его формы с множественной и широкой лекарственной устойчивостью. |
CN111303075A (zh) * | 2020-04-08 | 2020-06-19 | 苏州大学 | 苯并噻嗪酮衍生物及其制备方法与作为抗结核药物的应用 |
KR102409518B1 (ko) | 2020-06-22 | 2022-06-17 | 조은바이오주식회사 | 대량의 하천수를 저장하여 인공양어장을 조성함과 동시에 미세먼지 발생량을 줄여주도록 유도시켜서 대기중의 오염된 공기를 개선시킴과 동시에 비중이 무거운 깨끗한 물 분자를 우선적으로 배출하여 오염된 하천수를 깨끗한 하천수로 정화시키도록 구성되는 자연친화적인 친환경 저수시스템을 이용하여 대량의 전기를 생산하면서 저수지, 호수,댐, 석호,하천,강의 수질을 자연정화시키는 자연친화적인 수질정화 친환경공법 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3470168A (en) * | 1967-03-31 | 1969-09-30 | American Home Prod | 2-substituted-4h-1,3-benzothiazin-4-one derivatives |
US3522247A (en) | 1967-11-07 | 1970-07-28 | Pfizer & Co C | 2-amino-6,7-disubstituted-4h-1,3-benzothiazine-4-ones as bronchodilators |
NZ573833A (en) | 2006-05-24 | 2010-10-29 | Leibniz Inst For Natural Produ | New benzothiazinone derivatives and their use as antibacterial agents |
EP2020406A1 (en) | 2007-07-16 | 2009-02-04 | Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e.V. Hans-Knöll-Institut | New antimicrobial compounds, their synthesis and their use for treatment of mammalian infection |
EP2380886A1 (en) * | 2010-04-23 | 2011-10-26 | Vadim A. Makarov | Process for the preparation of 2-aminosubstituted 1,3-benzothiazine-4-ones |
CN102367239B (zh) * | 2011-07-20 | 2015-10-28 | 沈阳药科大学 | 2-芳基-2,3-二氢-4h-1,3-苯并噻嗪-4-酮衍生物及其用途 |
-
2011
- 2011-11-21 TR TR2018/15010T patent/TR201815010T4/tr unknown
- 2011-11-21 GE GEAP201113122A patent/GEP201606545B/en unknown
- 2011-11-21 CN CN201710192245.2A patent/CN107011287A/zh active Pending
- 2011-11-21 EA EA201390639A patent/EA023879B1/ru not_active IP Right Cessation
- 2011-11-21 KR KR1020177034344A patent/KR101851774B1/ko active IP Right Grant
- 2011-11-21 KR KR1020137015671A patent/KR101871970B1/ko active IP Right Grant
- 2011-11-21 JP JP2013539392A patent/JP6061346B2/ja active Active
- 2011-11-21 LT LTEP11796822.2T patent/LT2640712T/lt unknown
- 2011-11-21 BR BR112013012280-3A patent/BR112013012280B1/pt active IP Right Grant
- 2011-11-21 ES ES11796822.2T patent/ES2690728T3/es active Active
- 2011-11-21 AU AU2011330742A patent/AU2011330742B2/en active Active
- 2011-11-21 CN CN2011800558135A patent/CN103221399A/zh active Pending
- 2011-11-21 CA CA2817931A patent/CA2817931C/en active Active
- 2011-11-21 HU HUE11796822A patent/HUE040152T2/hu unknown
- 2011-11-21 EP EP11796822.2A patent/EP2640712B1/en active Active
- 2011-11-21 US US13/884,825 patent/US8796264B2/en active Active
- 2011-11-21 PL PL11796822T patent/PL2640712T3/pl unknown
- 2011-11-21 UA UAA201307177A patent/UA109557C2/ru unknown
- 2011-11-21 WO PCT/IB2011/055209 patent/WO2012066518A1/en active Application Filing
-
2013
- 2013-05-09 IL IL226289A patent/IL226289A/en active IP Right Grant
- 2013-05-27 ZA ZA2013/03829A patent/ZA201303829B/en unknown
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