JP2013542963A5 - - Google Patents
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- JP2013542963A5 JP2013542963A5 JP2013539140A JP2013539140A JP2013542963A5 JP 2013542963 A5 JP2013542963 A5 JP 2013542963A5 JP 2013539140 A JP2013539140 A JP 2013539140A JP 2013539140 A JP2013539140 A JP 2013539140A JP 2013542963 A5 JP2013542963 A5 JP 2013542963A5
- Authority
- JP
- Japan
- Prior art keywords
- triazolo
- group
- compound
- disorder
- ethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41535610P | 2010-11-19 | 2010-11-19 | |
| DKPA201001045 | 2010-11-19 | ||
| US61/415,356 | 2010-11-19 | ||
| DKPA201001045 | 2010-11-19 | ||
| PCT/DK2011/000136 WO2012065612A1 (en) | 2010-11-19 | 2011-11-18 | Imidazole derivatives as pde10a enzyme inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013542963A JP2013542963A (ja) | 2013-11-28 |
| JP2013542963A5 true JP2013542963A5 (US20070167479A1-20070719-C00034.png) | 2015-01-08 |
| JP5937608B2 JP5937608B2 (ja) | 2016-06-22 |
Family
ID=45217102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013539140A Expired - Fee Related JP5937608B2 (ja) | 2010-11-19 | 2011-11-18 | 酵素ｐｄｅ１０ａ阻害剤としてのイミダゾール誘導体 |
Country Status (31)
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8552045B2 (en) | 2010-11-19 | 2013-10-08 | H. Lundbeck A/S | Tricyclic imidazole compounds as PDE10 inhibitors |
| EP3210984B1 (en) | 2011-01-11 | 2019-06-19 | Sunovion Pharmaceuticals Inc. | Heteroaryl compounds and methods of use thereof |
| WO2013045607A1 (en) * | 2011-09-30 | 2013-04-04 | H. Lundbeck A/S | Quinazoline linked heteroaromatic tricycle derivatives as pde10a enzyme inhibitors |
| WO2013107856A1 (en) * | 2012-01-20 | 2013-07-25 | H. Lundbeck A/S | Imidazole derivatives as pde10a enzyme inhibitors |
| NZ702239A (en) | 2012-06-19 | 2017-01-27 | Sunovion Pharmaceuticals Inc | Heteroaryl compounds and methods of use thereof |
| CN103435617B (zh) * | 2013-08-22 | 2016-04-27 | 南京华安药业有限公司 | 一种6,7-二氢-5H-吡咯并[1,2-a]咪唑-2-甲醛的合成方法 |
| JO3627B1 (ar) | 2015-04-30 | 2020-08-27 | H Lundbeck As | إيميدازو بيرازينونات على هيئة مثبطات pde1 |
| TWI729109B (zh) | 2016-04-12 | 2021-06-01 | 丹麥商Ｈ 朗德貝克公司 | 作爲PDE1抑制劑的1,5-二氫-4H-吡唑并[3,4-d]嘧啶-4-酮和1,5-二氫-4H-吡唑并[4,3-c]吡啶-4-酮 |
| CN109843884B (zh) | 2016-10-18 | 2022-03-04 | H.隆德贝克有限公司 | 作为pde1抑制剂的咪唑并吡嗪酮、吡唑并嘧啶酮和吡唑并吡啶酮 |
| CA3041595A1 (en) | 2016-10-28 | 2018-05-03 | H. Lundbeck A/S | Combination treatments comprising administration of imidazopyrazinones |
| EP3532064B1 (en) | 2016-10-28 | 2020-07-29 | H. Lundbeck A/S | Combination treatments comprising imidazopyrazinones for the treatment of psychiatric and/or cognitive disorders |
| TW202031250A (zh) | 2018-11-06 | 2020-09-01 | 丹麥商Ｈ 朗德貝克公司 | 用於治療負性症狀和認知損傷之pde10a抑制劑 |
| CN109776527A (zh) * | 2019-02-21 | 2019-05-21 | 药雅科技(上海)有限公司 | 一种5-溴-7-氮杂吲哚的合成方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8307865D0 (en) | 1983-03-22 | 1983-04-27 | Fujisawa Pharmaceutical Co | Benzimidazole derivatives |
| US5571775A (en) | 1994-07-11 | 1996-11-05 | Dowelanco | N-aryl[1,2,4]triazolo[1,5-a]pyridine-2-sulfonamide herbicides |
| US20030032579A1 (en) | 2001-04-20 | 2003-02-13 | Pfizer Inc. | Therapeutic use of selective PDE10 inhibitors |
| IL149106A0 (en) | 2001-04-20 | 2002-11-10 | Pfizer Prod Inc | Therapeutic use of selective pde10 inhibitors |
| UA86591C2 (ru) | 2003-06-30 | 2009-05-12 | Алтана Фарма Аг | Пирролодигидроизохинолины как ингибиторы pde10, фармацевтическая композиция на их основе |
| CA2530114A1 (en) | 2003-06-30 | 2005-01-13 | Altana Pharma Ag | Pyrrolo-dihydroisoquinoline derivatives as pde10 inhibitors |
| WO2005012485A2 (en) | 2003-07-31 | 2005-02-10 | Bayer Pharmaceuticals Corporation | Methods for treating diabetes and related disorders using pde10a inhibitors |
| WO2005082883A2 (en) | 2004-02-18 | 2005-09-09 | Pfizer Products Inc. | Tetrahydroisoquinolinyl derivatives of quinazoline and isoquinoline |
| CA2568929A1 (en) | 2004-06-07 | 2005-12-22 | Pfizer Products Inc. | Phosphodiesterase 10 inhibition as treatment for obesity-related and metabolic syndrome-related conditions |
| US20060019975A1 (en) | 2004-07-23 | 2006-01-26 | Pfizer Inc | Novel piperidyl derivatives of quinazoline and isoquinoline |
| WO2006028957A1 (en) | 2004-09-03 | 2006-03-16 | Memory Pharmaceuticals Corporation | 4-substituted 4, 6-dialkoxy-cinnoline derivatives as phospodiesterase 10 inhibitors for the treatment of psychiatric or neurological syndroms |
| TWI501965B (zh) * | 2008-06-20 | 2015-10-01 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之新穎苯基咪唑衍生物 |
| UA102693C2 (ru) * | 2008-06-20 | 2013-08-12 | Х. Луннбек А/С | Производные фенилимидазола как ингибиторы фермента pde10a |
| US8133897B2 (en) * | 2008-06-20 | 2012-03-13 | H. Lundbeck A/S | Phenylimidazole derivatives as PDE10A enzyme inhibitors |
| TW201200516A (en) * | 2009-12-17 | 2012-01-01 | Lundbeck & Co As H | Phenylimidazole derivatives comprising an ethynylene linker as PDE10A enzyme inhibitors |
| TWI481607B (zh) * | 2009-12-17 | 2015-04-21 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑的２－芳基咪唑衍生物 |
| TWI485151B (zh) * | 2009-12-17 | 2015-05-21 | Lundbeck & Co As H | 作為ｐｄｅ１０ａ酵素抑制劑之雜芳香族苯基咪唑衍生物 |
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2011
- 2011-11-14 JO JOP/2011/0339A patent/JO3089B1/ar active
- 2011-11-15 TW TW100141570A patent/TWI541245B/zh not_active IP Right Cessation
- 2011-11-18 GE GEAP201113117A patent/GEP20156346B/en unknown
- 2011-11-18 EP EP11793325.9A patent/EP2640731B9/en active Active
- 2011-11-18 SI SI201130586T patent/SI2640731T1/sl unknown
- 2011-11-18 ES ES11793325.9T patent/ES2547090T3/es active Active
- 2011-11-18 AR ARP110104313A patent/AR083926A1/es unknown
- 2011-11-18 AU AU2011331607A patent/AU2011331607B2/en not_active Ceased
- 2011-11-18 JP JP2013539140A patent/JP5937608B2/ja not_active Expired - Fee Related
- 2011-11-18 DK DK11793325.9T patent/DK2640731T3/en active
- 2011-11-18 HU HUE11793325A patent/HUE025596T2/en unknown
- 2011-11-18 MY MYPI2013001727A patent/MY163327A/en unknown
- 2011-11-18 ME MEP-2015-130A patent/ME02193B/me unknown
- 2011-11-18 PL PL11793325T patent/PL2640731T3/pl unknown
- 2011-11-18 CA CA2817663A patent/CA2817663C/en not_active Expired - Fee Related
- 2011-11-18 BR BR112013012378A patent/BR112013012378A2/pt not_active Application Discontinuation
- 2011-11-18 NZ NZ610353A patent/NZ610353A/en not_active IP Right Cessation
- 2011-11-18 AP AP2013006928A patent/AP3342A/xx active
- 2011-11-18 PT PT117933259T patent/PT2640731E/pt unknown
- 2011-11-18 RS RS20150574A patent/RS54210B1/en unknown
- 2011-11-18 SG SG2013037163A patent/SG190282A1/en unknown
- 2011-11-18 UA UAA201307630A patent/UA112065C2/uk unknown
- 2011-11-18 CN CN201180065325.2A patent/CN103328487B/zh not_active Expired - Fee Related
- 2011-11-18 KR KR1020137012797A patent/KR101916487B1/ko active IP Right Grant
- 2011-11-18 PE PE2013001212A patent/PE20141534A1/es active IP Right Grant
- 2011-11-18 WO PCT/DK2011/000136 patent/WO2012065612A1/en active Application Filing
- 2011-11-18 EA EA201390741A patent/EA027082B1/ru not_active IP Right Cessation
-
2013
- 2013-05-16 GT GT201300130A patent/GT201300130A/es unknown
- 2013-05-16 CR CR20130226A patent/CR20130226A/es unknown
- 2013-05-17 ZA ZA2013/03607A patent/ZA201303607B/en unknown
- 2013-06-18 EC ECSP13012698 patent/ECSP13012698A/es unknown
