JP2013542958A - アンサマイトシン誘導体を含む細胞傷害性剤 - Google Patents
アンサマイトシン誘導体を含む細胞傷害性剤 Download PDFInfo
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- JP2013542958A JP2013542958A JP2013537819A JP2013537819A JP2013542958A JP 2013542958 A JP2013542958 A JP 2013542958A JP 2013537819 A JP2013537819 A JP 2013537819A JP 2013537819 A JP2013537819 A JP 2013537819A JP 2013542958 A JP2013542958 A JP 2013542958A
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- 0 CC(CCCC(C(CC(C(C)C1OC1(C)C(CC(N(C)c1c2)=O)OC(CCOC(CCC(O)ON(C(CC3*)=O)C3=O)O)O)O3)(NC3=O)O)OC)Cc2cc(OC)c1Cl Chemical compound CC(CCCC(C(CC(C(C)C1OC1(C)C(CC(N(C)c1c2)=O)OC(CCOC(CCC(O)ON(C(CC3*)=O)C3=O)O)O)O3)(NC3=O)O)OC)Cc2cc(OC)c1Cl 0.000 description 6
- ICEVRNWQSDYSPA-UHFFFAOYSA-N CCN(C(CC1C2SC2C)=O)C1=O Chemical compound CCN(C(CC1C2SC2C)=O)C1=O ICEVRNWQSDYSPA-UHFFFAOYSA-N 0.000 description 1
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- C07D498/18—Bridged systems
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/16—Peri-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Communicable Diseases (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Cell Biology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Transplantation (AREA)
- Virology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40983110P | 2010-11-03 | 2010-11-03 | |
| US61/409,831 | 2010-11-03 | ||
| PCT/US2011/059131 WO2012061590A1 (en) | 2010-11-03 | 2011-11-03 | Cytotoxic agents comprising new ansamitocin derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013542958A true JP2013542958A (ja) | 2013-11-28 |
| JP2013542958A5 JP2013542958A5 (OSRAM) | 2014-12-18 |
Family
ID=46024826
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013537819A Pending JP2013542958A (ja) | 2010-11-03 | 2011-11-03 | アンサマイトシン誘導体を含む細胞傷害性剤 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US9090629B2 (OSRAM) |
| EP (1) | EP2635301A4 (OSRAM) |
| JP (1) | JP2013542958A (OSRAM) |
| CN (2) | CN103269712B (OSRAM) |
| AU (1) | AU2011323316B2 (OSRAM) |
| BR (1) | BR112013010853A2 (OSRAM) |
| CA (1) | CA2816681A1 (OSRAM) |
| EA (1) | EA201390642A1 (OSRAM) |
| MX (1) | MX2013005046A (OSRAM) |
| WO (1) | WO2012061590A1 (OSRAM) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018521123A (ja) * | 2015-06-09 | 2018-08-02 | エックスディーシーエクスプローラー (シャンハイ) カンパニー リミテッド | 抗体薬物複合体、中間体、その製造方法、薬学的組成物及び応用 |
| JP2019502746A (ja) * | 2016-01-25 | 2019-01-31 | レゲネロン ファーマシューティカルス,インコーポレーテッド | メイタンシノイド誘導体、そのコンジュゲート、及び使用方法 |
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| WO2014089177A2 (en) | 2012-12-04 | 2014-06-12 | Massachusetts Institute Of Technology | Compounds, conjugates and compositions of epipolythiodiketopiperazines and polythiodiketopiperazines |
| CN103933575B (zh) | 2013-01-23 | 2017-09-29 | 上海新理念生物医药科技有限公司 | 一种三齿型连接子及其应用 |
| US9901647B2 (en) | 2013-02-28 | 2018-02-27 | Immunogen, Inc. | Conjugates comprising cell-binding agents and cytotoxic agents |
| WO2014134457A2 (en) * | 2013-02-28 | 2014-09-04 | Immunogen, Inc. | Conjugates comprising cell-binding agents and cytotoxic agents |
| BR112015022585B1 (pt) | 2013-03-15 | 2023-04-04 | Regeneron Pharmaceuticals, Inc | Composto, composição farmacêutica, conjugado droga-anticorpo, e, uso dos mesmos |
| US10208125B2 (en) | 2013-07-15 | 2019-02-19 | University of Pittsburgh—of the Commonwealth System of Higher Education | Anti-mucin 1 binding agents and uses thereof |
| JP6608823B2 (ja) | 2013-08-26 | 2019-11-20 | レゲネロン ファーマシューティカルス,インコーポレーテッド | マクロライドジアステレオマーを含む医薬組成物、その合成方法、及び治療上の使用 |
| EP2881735A1 (en) * | 2013-12-05 | 2015-06-10 | Kittiwake Developments Ltd. | Method for Determining the Concentration of Iron Ions in Hydrocarbon Compositions |
| KR20240142591A (ko) | 2015-03-27 | 2024-09-30 | 리제너론 파아마슈티컬스, 인크. | 메이탄시노이드 유도체, 이의 컨주게이트, 및 사용 방법 |
| CN107849133B (zh) | 2015-05-04 | 2022-08-23 | 西托姆克斯治疗公司 | 抗cd166抗体、可活化抗cd166抗体及其使用方法 |
| CN106279352B (zh) | 2015-05-29 | 2020-05-22 | 上海新理念生物医药科技有限公司 | 海兔毒素10的衍生物及其应用 |
| CN106267225B (zh) | 2015-05-29 | 2020-03-06 | 上海新理念生物医药科技有限公司 | 三马来酰亚胺型连接子及其应用 |
| JP6548751B2 (ja) | 2015-06-08 | 2019-07-24 | シャンドン ダンホン ファーマスーティカル カンパニー リミテッドShandong Danhong Pharmaceutical Co., Ltd. | イミダゾール誘導体及びその中間体の製造及び結晶型 |
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| CN106729743B (zh) * | 2015-11-23 | 2021-09-21 | 四川科伦博泰生物医药股份有限公司 | 抗ErbB2抗体-药物偶联物及其组合物、制备方法和应用 |
| MA47022A (fr) | 2016-02-05 | 2018-12-12 | Immunogen Inc | Procédé efficace de préparation de conjugués agent de liaison cellulaire-agent cytotoxique |
| MA45328A (fr) | 2016-04-01 | 2019-02-06 | Avidity Biosciences Llc | Compositions acide nucléique-polypeptide et utilisations de celles-ci |
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4331598A (en) * | 1979-09-19 | 1982-05-25 | Takeda Chemical Industries, Ltd. | Maytansinoids |
| JPH03161490A (ja) * | 1989-10-25 | 1991-07-11 | Immunogen Inc | メイタンシノイドを含む細胞障害剤及び該細胞障害剤を有効成分とする医薬 |
| JP2005517032A (ja) * | 2001-12-21 | 2005-06-09 | イミュノジェン・インコーポレーテッド | 反応性ポリエチレングリコール部分を持つ細胞毒性薬剤、ポリエチレングリコール連結基を含んでなる細胞毒性コンジュゲート、ならびにその製造方法および使用方法 |
| JP2007527421A (ja) * | 2004-02-23 | 2007-09-27 | ジェネンテック・インコーポレーテッド | 複素環式自壊的リンカーおよび結合体 |
| WO2009134976A1 (en) * | 2008-04-30 | 2009-11-05 | Immunogen, Inc | Potent conjugates and hydrophilic linkers |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030109682A1 (en) * | 2001-09-07 | 2003-06-12 | Daniel Santi | Maytansines and maytansine conjugates |
| US20050276812A1 (en) * | 2004-06-01 | 2005-12-15 | Genentech, Inc. | Antibody-drug conjugates and methods |
| EP1651162B1 (en) | 2003-05-20 | 2015-10-21 | ImmunoGen, Inc. | Improved cytotoxic agents comprising new maytansinoids |
| TR201808537T4 (tr) | 2004-09-23 | 2018-07-23 | Genentech Inc | Sistein değiştirilmiş antikorlar ve konjugatlar. |
| WO2006135371A1 (en) * | 2005-06-09 | 2006-12-21 | Kosan Biosciences Incorporated | Conjugates with reduced adverse systemic effects |
-
2011
- 2011-11-03 CN CN201180062234.3A patent/CN103269712B/zh not_active Expired - Fee Related
- 2011-11-03 MX MX2013005046A patent/MX2013005046A/es unknown
- 2011-11-03 WO PCT/US2011/059131 patent/WO2012061590A1/en not_active Ceased
- 2011-11-03 JP JP2013537819A patent/JP2013542958A/ja active Pending
- 2011-11-03 AU AU2011323316A patent/AU2011323316B2/en not_active Ceased
- 2011-11-03 CA CA2816681A patent/CA2816681A1/en not_active Abandoned
- 2011-11-03 EA EA201390642A patent/EA201390642A1/ru unknown
- 2011-11-03 BR BR112013010853A patent/BR112013010853A2/pt not_active IP Right Cessation
- 2011-11-03 EP EP11838805.7A patent/EP2635301A4/en not_active Withdrawn
- 2011-11-03 CN CN201610728548.7A patent/CN106349254A/zh active Pending
- 2011-11-03 US US13/883,344 patent/US9090629B2/en not_active Expired - Fee Related
-
2015
- 2015-05-22 US US14/719,753 patent/US20160058882A1/en not_active Abandoned
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4331598A (en) * | 1979-09-19 | 1982-05-25 | Takeda Chemical Industries, Ltd. | Maytansinoids |
| JPH03161490A (ja) * | 1989-10-25 | 1991-07-11 | Immunogen Inc | メイタンシノイドを含む細胞障害剤及び該細胞障害剤を有効成分とする医薬 |
| JP2005517032A (ja) * | 2001-12-21 | 2005-06-09 | イミュノジェン・インコーポレーテッド | 反応性ポリエチレングリコール部分を持つ細胞毒性薬剤、ポリエチレングリコール連結基を含んでなる細胞毒性コンジュゲート、ならびにその製造方法および使用方法 |
| JP2007527421A (ja) * | 2004-02-23 | 2007-09-27 | ジェネンテック・インコーポレーテッド | 複素環式自壊的リンカーおよび結合体 |
| WO2009134976A1 (en) * | 2008-04-30 | 2009-11-05 | Immunogen, Inc | Potent conjugates and hydrophilic linkers |
Non-Patent Citations (1)
| Title |
|---|
| JPN J CANCER RES. 1992 JUL;83(7):761-8, JPN6015034866, ISSN: 0003144546 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2018521123A (ja) * | 2015-06-09 | 2018-08-02 | エックスディーシーエクスプローラー (シャンハイ) カンパニー リミテッド | 抗体薬物複合体、中間体、その製造方法、薬学的組成物及び応用 |
| JP2019502746A (ja) * | 2016-01-25 | 2019-01-31 | レゲネロン ファーマシューティカルス,インコーポレーテッド | メイタンシノイド誘導体、そのコンジュゲート、及び使用方法 |
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| CA2816681A1 (en) | 2012-05-10 |
| AU2011323316A9 (en) | 2016-02-18 |
| US9090629B2 (en) | 2015-07-28 |
| EP2635301A1 (en) | 2013-09-11 |
| US20130323268A1 (en) | 2013-12-05 |
| EP2635301A4 (en) | 2016-06-01 |
| US20160058882A1 (en) | 2016-03-03 |
| EA201390642A1 (ru) | 2013-12-30 |
| WO2012061590A1 (en) | 2012-05-10 |
| AU2011323316A1 (en) | 2013-05-09 |
| CN106349254A (zh) | 2017-01-25 |
| CN103269712A (zh) | 2013-08-28 |
| AU2011323316B2 (en) | 2016-02-25 |
| MX2013005046A (es) | 2013-12-12 |
| CN103269712B (zh) | 2016-09-21 |
| BR112013010853A2 (pt) | 2016-08-16 |
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