JP2013541587A - Nedd8活性化酵素阻害剤の投与 - Google Patents

Nedd8活性化酵素阻害剤の投与 Download PDF

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Publication number
JP2013541587A
JP2013541587A JP2013537807A JP2013537807A JP2013541587A JP 2013541587 A JP2013541587 A JP 2013541587A JP 2013537807 A JP2013537807 A JP 2013537807A JP 2013537807 A JP2013537807 A JP 2013537807A JP 2013541587 A JP2013541587 A JP 2013541587A
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Japan
Prior art keywords
mln4924
use according
cancer
day
days
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Pending
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JP2013537807A
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English (en)
Japanese (ja)
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JP2013541587A5 (enExample
Inventor
ブルース ジェイ. デズーベ,
リリ エム. ペトルゼリ,
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Millennium Pharmaceuticals Inc
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Millennium Pharmaceuticals Inc
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Publication date
Application filed by Millennium Pharmaceuticals Inc filed Critical Millennium Pharmaceuticals Inc
Publication of JP2013541587A publication Critical patent/JP2013541587A/ja
Publication of JP2013541587A5 publication Critical patent/JP2013541587A5/ja
Pending legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40Cyclodextrins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/06Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2013537807A 2010-11-05 2011-11-03 Nedd8活性化酵素阻害剤の投与 Pending JP2013541587A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US41047810P 2010-11-05 2010-11-05
US61/410,478 2010-11-05
US201161488240P 2011-05-20 2011-05-20
US61/488,240 2011-05-20
PCT/US2011/059060 WO2012061551A1 (en) 2010-11-05 2011-11-03 Administration of nedd8-activating enzyme inhibitor

Publications (2)

Publication Number Publication Date
JP2013541587A true JP2013541587A (ja) 2013-11-14
JP2013541587A5 JP2013541587A5 (enExample) 2014-12-18

Family

ID=46020229

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013537807A Pending JP2013541587A (ja) 2010-11-05 2011-11-03 Nedd8活性化酵素阻害剤の投与

Country Status (4)

Country Link
US (2) US20120115892A1 (enExample)
EP (1) EP2635287A4 (enExample)
JP (1) JP2013541587A (enExample)
WO (1) WO2012061551A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017111074A1 (ja) * 2015-12-22 2017-06-29 大鵬薬品工業株式会社 ピロロピリミジン化合物による抗腫瘍効果増強剤

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013188881A1 (en) * 2012-06-15 2013-12-19 President And Fellows Of Harvard College Compounds, compositions and methods for treating or preventing neurodegenerative disorders
US9200333B2 (en) 2012-07-25 2015-12-01 Indiana University Research And Technology Corporation Methods for identifying modulators of murine double minute 2
JP6556701B2 (ja) * 2013-05-14 2019-08-07 ミレニアム ファーマシューティカルズ, インコーポレイテッドMillennium Pharmaceuticals, Inc. Nedd8活性化酵素阻害剤及び化学療法剤の投与
EP3103802B1 (en) 2014-06-24 2017-11-08 Taiho Pharmaceutical Co., Ltd. Novel pyrrolopyrimidine compound or salt thereof, pharmaceutical composition containing same, especially agent for prevention and/or treatment of tumors etc based on nae inhibitory effect
CN108210497B (zh) * 2016-12-21 2019-12-20 天津大学 化合物mln4924在制备布尼亚病毒科白蛉病毒属病毒抑制剂的应用
WO2020176643A1 (en) * 2019-02-26 2020-09-03 Millennium Pharmaceuticals, Inc. Compounds useful as adjuvants

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009038701A2 (en) * 2007-09-17 2009-03-26 Schering Corporation Formulation containing cyclin-dependent kinase inhibiting compound and method of treating tumors using the same

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101450533B1 (ko) * 2006-02-02 2014-10-16 밀레니엄 파머슈티컬스 인코퍼레이티드 E1 활성화 효소의 억제제
KR20100066475A (ko) * 2007-08-02 2010-06-17 밀레니엄 파머슈티컬스 인코퍼레이티드 E1 활성화 효소 억제제의 합성 방법
KR20120024715A (ko) * 2009-05-14 2012-03-14 밀레니엄 파머슈티컬스 인코퍼레이티드 ((1s,2s,4r)?4?{4?〔(1s)?2,3?디하이드로?1h?인덴?1?일아미노〕?7h?피롤로〔2,3?d〕피리미딘?7?일}?2?하이드록시사이클로펜틸)메틸 설파메이트의 하이드로클로라이드 염

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009038701A2 (en) * 2007-09-17 2009-03-26 Schering Corporation Formulation containing cyclin-dependent kinase inhibiting compound and method of treating tumors using the same

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
JPN7015002695; 'View of NCT01011530 on 2010_10_18' ClinicalTrials.gov archive , 20101018 *
JPN7015002696; SHAH, Jatin J et al: 'Phase 1 Dose-Escalation Study of MLN4924, a Novel NAE Inhibitor, in Patients with Multiple Myeloma a' 51th ASH ANNUAL MEETING AND EXPOSITION , 20091203 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017111074A1 (ja) * 2015-12-22 2017-06-29 大鵬薬品工業株式会社 ピロロピリミジン化合物による抗腫瘍効果増強剤
JPWO2017111074A1 (ja) * 2015-12-22 2018-05-10 大鵬薬品工業株式会社 ピロロピリミジン化合物による抗腫瘍効果増強剤

Also Published As

Publication number Publication date
US20120115892A1 (en) 2012-05-10
US20140249167A1 (en) 2014-09-04
WO2012061551A1 (en) 2012-05-10
EP2635287A1 (en) 2013-09-11
EP2635287A4 (en) 2014-06-04

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