|
US1014372A
(en)
|
1910-12-01 |
1912-01-09 |
Bush Mfg Company |
Hinge.
|
|
US1013068A
(en)
|
1911-09-09 |
1911-12-26 |
Frederick F Mcintosh |
Single-trigger gun mechanism.
|
|
US2643653A
(en)
*
|
1951-07-19 |
1953-06-30 |
Heidrich John |
Pill injector
|
|
US4458066A
(en)
|
1980-02-29 |
1984-07-03 |
University Patents, Inc. |
Process for preparing polynucleotides
|
|
FR2504010B1
(fr)
|
1981-04-15 |
1985-10-25 |
Sanofi Sa |
Medicaments anticancereux contenant la chaine a de la ricine associee a un anticorps antimelanome et procede pour leur preparation
|
|
US4671958A
(en)
|
1982-03-09 |
1987-06-09 |
Cytogen Corporation |
Antibody conjugates for the delivery of compounds to target sites
|
|
DE3377484D1
(en)
|
1982-04-19 |
1988-09-01 |
Nissan Motor |
Method for controlling reduction ratio of continuously variable transmission with acceleration compensation
|
|
US5272065A
(en)
|
1983-10-20 |
1993-12-21 |
Research Foundation Of State University Of New York |
Regulation of gene expression by employing translational inhibition of MRNA utilizing interfering complementary MRNA
|
|
US4542225A
(en)
|
1984-08-29 |
1985-09-17 |
Dana-Farber Cancer Institute, Inc. |
Acid-cleavable compound
|
|
US4659839A
(en)
|
1984-10-10 |
1987-04-21 |
Mallinckrodt, Inc. |
Coupling agents for radiolabeled antibody fragments
|
|
CA1336076C
(en)
|
1985-01-14 |
1995-06-27 |
Alan R. Fritzberg |
Metal radionuclide labeled proteins for diagnosis and therapy
|
|
US4683195A
(en)
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US4680338A
(en)
|
1985-10-17 |
1987-07-14 |
Immunomedics, Inc. |
Bifunctional linker
|
|
US4699784A
(en)
|
1986-02-25 |
1987-10-13 |
Center For Molecular Medicine & Immunology |
Tumoricidal methotrexate-antibody conjugate
|
|
US5807832A
(en)
|
1987-06-09 |
1998-09-15 |
Biotech Australia Pty Limited |
Oral delivery of biologically active substances bound to vitamin B12
|
|
US5997856A
(en)
|
1988-10-05 |
1999-12-07 |
Chiron Corporation |
Method and compositions for solubilization and stabilization of polypeptides, especially proteins
|
|
US6780613B1
(en)
|
1988-10-28 |
2004-08-24 |
Genentech, Inc. |
Growth hormone variants
|
|
DK0531434T3
(da)
|
1990-05-11 |
2000-01-31 |
Us Health |
Forbedrede Pseudomonas-exotoksiner med lav dyretoksicitet og høj cytocidal aktivitet
|
|
GB9112553D0
(en)
|
1991-06-11 |
1991-07-31 |
Wellcome Found |
Fusion proteins
|
|
ES2109362T3
(es)
|
1991-06-21 |
1998-01-16 |
Univ Cincinnati |
Unas proteinas administrables oralmente y metodo para hacerlas.
|
|
US6613332B1
(en)
|
1991-06-21 |
2003-09-02 |
The University Of Cincinnati |
Oral administration of therapeutic proteins
|
|
ATE314475T1
(de)
|
1992-06-18 |
2006-01-15 |
Us Gov Health & Human Serv |
Rekombinantes pseudomonas exotoxin mit gesteigerter aktivität
|
|
ATE206308T1
(de)
|
1993-02-02 |
2001-10-15 |
Xoma Technology Ltd |
Arzneizusammensetzungen enthaltend ein bakterizides permeabilität erhöhendes protein und ein tensid
|
|
GB9320782D0
(en)
|
1993-10-08 |
1993-12-01 |
Univ Leeds Innovations Ltd |
Stabilising of proteins on solution
|
|
GB9420355D0
(en)
|
1994-10-10 |
1994-11-23 |
Univ Nottingham |
Preparation of protein microspheres, films and coatings
|
|
US5656730A
(en)
|
1995-04-07 |
1997-08-12 |
Enzon, Inc. |
Stabilized monomeric protein compositions
|
|
AU717329B2
(en)
*
|
1995-09-21 |
2000-03-23 |
Quadrant Healthcare (Uk) Limited |
Transcytosis vehicles and enhancers for drug delivery
|
|
US5912014A
(en)
|
1996-03-15 |
1999-06-15 |
Unigene Laboratories, Inc. |
Oral salmon calcitonin pharmaceutical products
|
|
US5922680A
(en)
|
1996-10-23 |
1999-07-13 |
Ferring, B.V. |
Stabilized composition for oral administration of peptides
|
|
WO1999006429A1
(en)
|
1997-08-01 |
1999-02-11 |
Toray Industries, Inc. |
Method for stabilizing useful proteins and useful protein compositions
|
|
US6342611B1
(en)
|
1997-10-10 |
2002-01-29 |
Cytovia, Inc. |
Fluorogenic or fluorescent reporter molecules and their applications for whole-cell fluorescence screening assays for capsases and other enzymes and the use thereof
|
|
US6592847B1
(en)
|
1998-05-14 |
2003-07-15 |
The General Hospital Corporation |
Intramolecularly-quenched near infrared flourescent probes
|
|
US7053200B1
(en)
|
1999-06-01 |
2006-05-30 |
Baylor College Of Medicine |
Compositions and methods for the therapeutic use of an atonal-associated sequence for deafness, osteoarthritis, and abnormal cell proliferation
|
|
DE60031999T2
(de)
|
1999-10-04 |
2007-06-06 |
Novartis Vaccines and Diagnostics, Inc., Emeryville |
Stabilisierte flüssige polypeptid-haltige pharmazeutische zusammensetzungen
|
|
US20030186386A1
(en)
|
2000-02-11 |
2003-10-02 |
Hansen Christian Karsten |
Interleukin 10
|
|
PT1379273E
(pt)
|
2000-11-27 |
2009-11-27 |
Powderject Vaccines Inc |
Adjuvantes à base de ácidos nucleicos
|
|
US6673574B2
(en)
|
2000-11-30 |
2004-01-06 |
Unigene Laboratories Inc. |
Oral delivery of peptides using enzyme-cleavable membrane translocators
|
|
US6573237B2
(en)
|
2001-03-16 |
2003-06-03 |
Eli Lilly And Company |
Protein formulations
|
|
US20050074462A1
(en)
|
2001-05-23 |
2005-04-07 |
Duotol Ab |
Supression of allergic reactions by transdermal administration of allergens conjugated to cholera toxin or fragments thereof
|
|
JP4623625B2
(ja)
|
2003-07-24 |
2011-02-02 |
株式会社AMBiS |
ヘテロ型５量体組換えワクチン
|
|
EP1522585A1
(en)
|
2003-10-09 |
2005-04-13 |
Plant Research International B.V. |
Chimeric carrier molecules for the production of mucosal vaccines
|
|
US20080317761A1
(en)
|
2004-04-28 |
2008-12-25 |
The Trustees Of The University Of Pennsylvania |
Peptide-Mediated Protein Transduction Into Cells of the Hematopoietic Lineage
|
|
WO2006135428A2
(en)
|
2004-10-04 |
2006-12-21 |
Trinity Biosystems, Inc. |
Methods and compositions for inducing an immune response against multiple antigens
|
|
EP1804832A4
(en)
*
|
2004-10-04 |
2008-12-24 |
Trinity Biosystems Inc |
METHOD AND COMPOSITIONS FOR THE NADLESS DELIVERY OF MACROMOLECULES
|
|
US7998930B2
(en)
|
2004-11-04 |
2011-08-16 |
Hanall Biopharma Co., Ltd. |
Modified growth hormones
|
|
PL3006456T3
(pl)
|
2005-07-29 |
2019-05-31 |
The Government Of The Secretary Of Health And Human Services |
Zmutowane egzotoksyny pseudomonas o zmniejszonej antygenowości
|
|
CA2631981A1
(en)
*
|
2005-12-05 |
2007-06-14 |
Trinity Biosystems, Inc. |
Methods and compositions for needleless delivery of binding partners
|
|
EP2010205A2
(en)
|
2006-03-16 |
2009-01-07 |
Trinity Biosystems, Inc. |
Methods for increasing the size of animals using needleless delivery constructs
|
|
US8993295B2
(en)
|
2006-07-20 |
2015-03-31 |
The General Hospital Corporation |
Methods, compositions, and kits for the selective activation of protoxins through combinatorial targeting
|
|
US20090092660A1
(en)
|
2006-08-09 |
2009-04-09 |
Trinity Biosystems, Inc. |
Methods and compositions for needleless delivery of particles
|
|
US20100196277A1
(en)
*
|
2006-10-09 |
2010-08-05 |
The University Of North Carolina At Chapel Hill |
Nanoparticle compositions for controlled delivery of nucleic acids
|
|
WO2008147526A1
(en)
*
|
2007-05-23 |
2008-12-04 |
The Trustees Of The University Of Pennsylvania |
Targeted carriers for intracellular drug delivery
|
|
EP2178559B1
(en)
*
|
2007-07-20 |
2015-06-24 |
The General Hospital Corporation |
Recombinant vibrio cholerae exotoxins
|
|
CN101361968B
(zh)
|
2007-08-06 |
2011-08-03 |
健能隆医药技术（上海）有限公司 |
白介素-22在治疗脂肪肝中的应用
|
|
WO2009026328A2
(en)
|
2007-08-21 |
2009-02-26 |
Immune Disease Institute, Inc. |
Methods of delivery of agents to leukocytes and endothelial cells
|
|
WO2009115531A2
(en)
*
|
2008-03-17 |
2009-09-24 |
Universitätsklinikum Münster |
Yopm as delivery vehicle for cargo molecules and as biological therapeutic for immunomodulation of inflammatory reactions
|
|
WO2009149281A1
(en)
|
2008-06-04 |
2009-12-10 |
The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services |
Immunotoxins and uses thereof
|
|
NO2344540T3
(enExample)
|
2008-10-02 |
2018-04-28 |
|
|
|
WO2011009624A1
(en)
|
2009-07-22 |
2011-01-27 |
Cenix Bioscience Gmbh |
Delivery system and conjugates for compound delivery via naturally occurring intracellular transport routes
|
|
WO2011031441A1
(en)
|
2009-08-28 |
2011-03-17 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Therapy with a chimeric molecule and a pro-apoptotic agent
|
|
EP2616045B1
(en)
|
2010-09-15 |
2017-10-25 |
Randall J. Mrsny |
Systems and methods of delivery of bioactive agents using bacterial toxin-derived transport sequences
|
|
US20140065172A1
(en)
|
2011-01-26 |
2014-03-06 |
Cenix Bioscience Gmbh |
Delivery system and conjugates for compound delivery via naturally occurring intracellular transport routes
|
|
WO2012110596A1
(en)
|
2011-02-16 |
2012-08-23 |
Friedrich-Alexander-Universität Erlangen-Nürnberg |
Fusion protein for the treatment of immunologic or allergic reactions
|
|
CA3070695C
(en)
|
2011-06-29 |
2024-01-23 |
Rani Therapeutics, Llc |
Therapeutic agent preparations for delivery into a lumen of the intestinal tract using a swallowable drug delivery device
|
|
EP2989240A4
(en)
|
2013-04-24 |
2016-10-19 |
Armo Biosciences Inc |
INTERLEUKIN-10 COMPOSITIONS AND USES THEREOF
|
|
AU2014346554B2
(en)
|
2013-11-07 |
2020-06-04 |
Evive Biotechnology (Shanghai) Ltd |
Methods of use for IL-22 in the treatment of gastrointestinal graft vs. host disease
|
|
CN104623637A
(zh)
|
2013-11-07 |
2015-05-20 |
健能隆医药技术（上海）有限公司 |
Il-22二聚体在制备静脉注射药物中的应用
|
|
EP3575312A1
(en)
|
2014-01-27 |
2019-12-04 |
Molecular Templates, Inc. |
De-immunized shiga toxin a subunit effector polypeptides for applications in mammals
|
|
SG11201610183XA
(en)
|
2014-05-07 |
2017-01-27 |
Applied Molecular Transp Llc |
Cholix toxin-derived fusion molecules for oral delivery of biologically active cargo
|
|
CN107106655A
(zh)
|
2014-10-22 |
2017-08-29 |
阿尔莫生物科技股份有限公司 |
使用白细胞介素‑10治疗疾病和病症的方法
|
|
WO2016146833A1
(en)
|
2015-03-19 |
2016-09-22 |
F. Hoffmann-La Roche Ag |
Biomarkers for nad(+)-diphthamide adp ribosyltransferase resistance
|
|
WO2017069958A2
(en)
|
2015-10-09 |
2017-04-27 |
The Brigham And Women's Hospital, Inc. |
Modulation of novel immune checkpoint targets
|
|
US10828318B2
(en)
|
2016-01-06 |
2020-11-10 |
Yeda Research And Development Co. Ltd. |
Compositions and methods for treating malignant, autoimmune and inflammatory diseases
|
|
EP3192805A1
(en)
|
2016-01-15 |
2017-07-19 |
Humanitas Mirasole S.p.A. |
Inhibitors of t cell activation or stimulation and uses thereof
|
|
US11110122B2
(en)
|
2016-06-03 |
2021-09-07 |
New York University |
Methods and reagents for modulating macrophage phenotype
|
|
US10335459B2
(en)
|
2016-06-22 |
2019-07-02 |
Alkermes, Inc. |
Compositions for modulating IL-10 immunostimulatory and anti-inflammatory properties
|
|
EP3554346B1
(en)
|
2016-12-14 |
2024-01-31 |
Biora Therapeutics, Inc. |
Treatment of a disease of the gastrointestinal tract with an immunosuppressant
|
|
CA3045310A1
(en)
|
2016-12-14 |
2018-06-21 |
Progenity, Inc. |
Treatment of a disease of the gastrointestinal tract with a chemokine/chemokine receptor inhibitor
|
|
WO2018183931A1
(en)
|
2017-03-30 |
2018-10-04 |
Progenity Inc. |
Treatment of a disease of the gastrointestinal tract with il-10 or an il-10 agonist
|
|
WO2019173787A1
(en)
|
2018-03-08 |
2019-09-12 |
Applied Molecular Transport Inc. |
Toxin-derived delivery constructs for oral delivery
|