JP2013540826A5 - - Google Patents
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- Publication number
- JP2013540826A5 JP2013540826A5 JP2013536904A JP2013536904A JP2013540826A5 JP 2013540826 A5 JP2013540826 A5 JP 2013540826A5 JP 2013536904 A JP2013536904 A JP 2013536904A JP 2013536904 A JP2013536904 A JP 2013536904A JP 2013540826 A5 JP2013540826 A5 JP 2013540826A5
- Authority
- JP
- Japan
- Prior art keywords
- formulated
- administration
- crofelemer
- daily
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001393 Crofelemer Polymers 0.000 claims description 65
- 229940047615 crofelemer Drugs 0.000 claims description 65
- ADNPLDHMAVUMIW-CUZNLEPHSA-N substance P Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CCCCN)NC(=O)[C@H]1N(CCC1)C(=O)[C@@H](N)CCCN=C(N)N)C1=CC=CC=C1 ADNPLDHMAVUMIW-CUZNLEPHSA-N 0.000 claims description 65
- 206010012735 Diarrhoea Diseases 0.000 claims description 20
- 238000011225 antiretroviral therapy Methods 0.000 claims description 6
- 208000024891 symptom Diseases 0.000 claims description 6
- 208000034347 Faecal incontinence Diseases 0.000 claims description 5
- 230000003247 decreasing effect Effects 0.000 claims description 5
- 208000004998 Abdominal Pain Diseases 0.000 claims description 4
- 230000002550 fecal effect Effects 0.000 claims description 3
- 208000031886 HIV Infections Diseases 0.000 claims description 2
- 208000037357 HIV infectious disease Diseases 0.000 claims description 2
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 claims description 2
- 206010000059 abdominal discomfort Diseases 0.000 claims description 2
- 208000023505 abnormal feces Diseases 0.000 claims description 2
- 208000033519 human immunodeficiency virus infectious disease Diseases 0.000 claims description 2
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims description 2
- 230000006866 deterioration Effects 0.000 claims 1
- 238000000034 method Methods 0.000 description 34
- 230000005713 exacerbation Effects 0.000 description 1
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40862210P | 2010-10-31 | 2010-10-31 | |
| US61/408,622 | 2010-10-31 | ||
| US40933510P | 2010-11-02 | 2010-11-02 | |
| US61/409,335 | 2010-11-02 | ||
| US41624910P | 2010-11-22 | 2010-11-22 | |
| US61/416,249 | 2010-11-22 | ||
| US201161434379P | 2011-01-19 | 2011-01-19 | |
| US61/434,379 | 2011-01-19 | ||
| PCT/US2011/058549 WO2012058664A1 (en) | 2010-10-31 | 2011-10-31 | Methods and compositions for treating hiv-associated diarrhea |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016151656A Division JP6310971B2 (ja) | 2010-10-31 | 2016-08-02 | Ｈｉｖ関連の下痢を治療するための方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013540826A JP2013540826A (ja) | 2013-11-07 |
| JP2013540826A5 true JP2013540826A5 (https=) | 2014-12-18 |
| JP6063385B2 JP6063385B2 (ja) | 2017-01-18 |
Family
ID=45994461
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013536904A Active JP6063385B2 (ja) | 2010-10-31 | 2011-10-31 | Ｈｉｖ関連の下痢を治療するための方法および組成物 |
| JP2016151656A Active JP6310971B2 (ja) | 2010-10-31 | 2016-08-02 | Ｈｉｖ関連の下痢を治療するための方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016151656A Active JP6310971B2 (ja) | 2010-10-31 | 2016-08-02 | Ｈｉｖ関連の下痢を治療するための方法および組成物 |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US8962680B2 (https=) |
| EP (1) | EP2632550B1 (https=) |
| JP (2) | JP6063385B2 (https=) |
| CN (2) | CN107595836A (https=) |
| AU (1) | AU2011320155B2 (https=) |
| BR (1) | BR112013010774A2 (https=) |
| CA (1) | CA2816416C (https=) |
| DK (1) | DK2632550T3 (https=) |
| EC (1) | ECSP13012650A (https=) |
| ES (1) | ES2635435T3 (https=) |
| HK (1) | HK1249036A1 (https=) |
| HU (1) | HUE035393T2 (https=) |
| MX (1) | MX348184B (https=) |
| PE (1) | PE20140036A1 (https=) |
| PH (1) | PH12013500857A1 (https=) |
| PL (1) | PL2632550T3 (https=) |
| PT (1) | PT2632550T (https=) |
| RU (1) | RU2597746C2 (https=) |
| WO (1) | WO2012058664A1 (https=) |
| ZA (1) | ZA201303136B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2241318T1 (sl) | 2006-05-01 | 2013-04-30 | Napo Pharmaceuticals, Inc. | Postopek za zdravljenje sindroma iritabilnega ÄŤrevesa s predominantno obstipacijo |
| ES2616012T3 (es) | 2006-05-01 | 2017-06-09 | Napo Pharmaceuticals, Inc. | Composiciones para tratar o prevenir enfermedad inflamatoria del intestino |
| US20070254050A1 (en) | 2006-05-01 | 2007-11-01 | Quart Barry D | Method for treatment of diarrhea-predominant irritable bowel syndrome |
| CN107595836A (zh) | 2010-10-31 | 2018-01-19 | 纳珀制药公司 | 用于治疗hiv相关性腹泻的方法和组合物 |
| EP2928560A4 (en) * | 2012-12-07 | 2016-06-01 | Salix Pharmaceuticals Inc | METHODS AND COMPOSITIONS FOR THE TREATMENT OF HIV-ASSOCIATED DIARRHEA |
| US11389424B2 (en) | 2017-03-09 | 2022-07-19 | Napo Pharmaceuticals, Inc. | Methods and compositions for treating chemotherapy-induced diarrhea |
| JP7328153B2 (ja) | 2017-05-31 | 2023-08-16 | ナポ ファーマシューティカルズ インク． | 胆汁酸性下痢、小腸切除又は胆嚢除去及び短腸症候群に関連する下痢を治療するための方法及び組成物 |
| US11857510B2 (en) | 2017-05-31 | 2024-01-02 | Napo Pharmaceuticals, Inc. | Methods and compositions for treating congenital diarrhea disorder |
| EP3935581A4 (en) | 2019-03-04 | 2022-11-30 | Iocurrents, Inc. | DATA COMPRESSION AND COMMUNICATION USING MACHINE LEARNING |
| CA3182864A1 (en) * | 2020-06-19 | 2021-12-23 | Lisa A. CONTE | Methods and compositions for treating chemotherapy-induced diarrhea |
| WO2022115481A1 (en) * | 2020-11-24 | 2022-06-02 | Napo Pharmaceuticals, Inc. | Methods and compositions for treating post-acute infection gastrointestinal disorders |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5211944A (en) | 1990-10-12 | 1993-05-18 | Shaman Pharmaceuticals, Inc. | Proanthocyanidin polymers having antiviral activity and methods of obtaining same |
| EP2060183A3 (en) | 1996-10-16 | 2009-06-03 | Napo Pharmaceuticals, Inc. | Enteric formulations of proanthocyanidin polymer antidiarrheal compositions |
| WO2000047062A2 (en) * | 1999-02-01 | 2000-08-17 | Shaman Pharmaceuticals, Inc. | Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same |
| US20040071793A1 (en) | 2002-10-05 | 2004-04-15 | Bobrowski Paul J. | Oral rehydration methods and compositions |
| WO2005074575A2 (en) * | 2004-01-30 | 2005-08-18 | Microbia, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| JP2008546790A (ja) * | 2005-06-22 | 2008-12-25 | ユニバーシティー オブ マサチューセッツ | Ｈｉｖ−１プロテアーゼ阻害剤 |
| CA2633417A1 (en) | 2005-12-15 | 2007-06-21 | Bayer Healthcare Ag | Diaryl ureas for treating virus infections |
| SI2241318T1 (sl) * | 2006-05-01 | 2013-04-30 | Napo Pharmaceuticals, Inc. | Postopek za zdravljenje sindroma iritabilnega ÄŤrevesa s predominantno obstipacijo |
| ES2616012T3 (es) | 2006-05-01 | 2017-06-09 | Napo Pharmaceuticals, Inc. | Composiciones para tratar o prevenir enfermedad inflamatoria del intestino |
| US20070254050A1 (en) | 2006-05-01 | 2007-11-01 | Quart Barry D | Method for treatment of diarrhea-predominant irritable bowel syndrome |
| US20100092479A1 (en) | 2008-08-18 | 2010-04-15 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
| US7928115B2 (en) | 2008-10-02 | 2011-04-19 | Salix Pharmaceuticals, Ltd. | Methods of treating travelers diarrhea and hepatic encephalopathy |
| WO2011024049A2 (en) | 2009-08-26 | 2011-03-03 | Glenmark Pharmaceuticals Ltd | Method for producing proanthocyanidin polymer compositions for pharmaceutical formulations |
| AU2010303577B2 (en) | 2009-10-06 | 2015-10-22 | Napo Pharmaceuticals, Inc. | Methods of treating diseases with proanthocyanidin oligomers such as crofelemer |
| US20110087530A1 (en) | 2009-10-09 | 2011-04-14 | Visa U.S.A. Inc. | Systems and Methods to Provide Loyalty Programs |
| CN107595836A (zh) | 2010-10-31 | 2018-01-19 | 纳珀制药公司 | 用于治疗hiv相关性腹泻的方法和组合物 |
| WO2012101008A1 (en) | 2011-01-27 | 2012-08-02 | Glenmark Pharmaceuticals Limited | Process for the production of proanthocyanidin polymeric composition |
| BR112014015314A2 (pt) | 2011-12-22 | 2017-06-13 | Glenmark Pharmaceuticals Ltd | composição farmacêutica não entérica compreendendo crofelemer |
| EP2928560A4 (en) | 2012-12-07 | 2016-06-01 | Salix Pharmaceuticals Inc | METHODS AND COMPOSITIONS FOR THE TREATMENT OF HIV-ASSOCIATED DIARRHEA |
-
2011
- 2011-10-31 CN CN201711077144.7A patent/CN107595836A/zh active Pending
- 2011-10-31 RU RU2013123794/15A patent/RU2597746C2/ru active
- 2011-10-31 CN CN2011800637391A patent/CN103370101A/zh active Pending
- 2011-10-31 JP JP2013536904A patent/JP6063385B2/ja active Active
- 2011-10-31 PE PE2013000926A patent/PE20140036A1/es not_active Application Discontinuation
- 2011-10-31 PT PT118372499T patent/PT2632550T/pt unknown
- 2011-10-31 EP EP11837249.9A patent/EP2632550B1/en active Active
- 2011-10-31 ES ES11837249.9T patent/ES2635435T3/es active Active
- 2011-10-31 DK DK11837249.9T patent/DK2632550T3/en active
- 2011-10-31 CA CA2816416A patent/CA2816416C/en active Active
- 2011-10-31 PL PL11837249T patent/PL2632550T3/pl unknown
- 2011-10-31 WO PCT/US2011/058549 patent/WO2012058664A1/en not_active Ceased
- 2011-10-31 MX MX2013004873A patent/MX348184B/es active IP Right Grant
- 2011-10-31 US US13/285,397 patent/US8962680B2/en active Active
- 2011-10-31 HU HUE11837249A patent/HUE035393T2/en unknown
- 2011-10-31 BR BR112013010774A patent/BR112013010774A2/pt not_active Application Discontinuation
- 2011-10-31 PH PH1/2013/500857A patent/PH12013500857A1/en unknown
- 2011-10-31 AU AU2011320155A patent/AU2011320155B2/en active Active
- 2011-11-11 US US13/294,307 patent/US20120107370A1/en not_active Abandoned
-
2013
- 2013-04-29 ZA ZA2013/03136A patent/ZA201303136B/en unknown
- 2013-05-31 EC ECSP13012650 patent/ECSP13012650A/es unknown
-
2014
- 2014-06-17 US US14/307,175 patent/US20140294903A1/en not_active Abandoned
-
2015
- 2015-01-15 US US14/597,740 patent/US9585868B2/en active Active
-
2016
- 2016-08-02 JP JP2016151656A patent/JP6310971B2/ja active Active
-
2018
- 2018-07-09 HK HK18108819.2A patent/HK1249036A1/zh unknown
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