CA2816416C - Methods and compositions for treating hiv-associated diarrhea - Google Patents
Methods and compositions for treating hiv-associated diarrhea Download PDFInfo
- Publication number
- CA2816416C CA2816416C CA2816416A CA2816416A CA2816416C CA 2816416 C CA2816416 C CA 2816416C CA 2816416 A CA2816416 A CA 2816416A CA 2816416 A CA2816416 A CA 2816416A CA 2816416 C CA2816416 C CA 2816416C
- Authority
- CA
- Canada
- Prior art keywords
- crofelemer
- per day
- placebo
- day
- diarrhea
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- AIDS & HIV (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Communicable Diseases (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US40862210P | 2010-10-31 | 2010-10-31 | |
| US61/408,622 | 2010-10-31 | ||
| US40933510P | 2010-11-02 | 2010-11-02 | |
| US61/409,335 | 2010-11-02 | ||
| US41624910P | 2010-11-22 | 2010-11-22 | |
| US61/416,249 | 2010-11-22 | ||
| US201161434379P | 2011-01-19 | 2011-01-19 | |
| US61/434,379 | 2011-01-19 | ||
| PCT/US2011/058549 WO2012058664A1 (en) | 2010-10-31 | 2011-10-31 | Methods and compositions for treating hiv-associated diarrhea |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2816416A1 CA2816416A1 (en) | 2012-05-03 |
| CA2816416C true CA2816416C (en) | 2020-02-11 |
Family
ID=45994461
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2816416A Active CA2816416C (en) | 2010-10-31 | 2011-10-31 | Methods and compositions for treating hiv-associated diarrhea |
Country Status (20)
| Country | Link |
|---|---|
| US (4) | US8962680B2 (https=) |
| EP (1) | EP2632550B1 (https=) |
| JP (2) | JP6063385B2 (https=) |
| CN (2) | CN107595836A (https=) |
| AU (1) | AU2011320155B2 (https=) |
| BR (1) | BR112013010774A2 (https=) |
| CA (1) | CA2816416C (https=) |
| DK (1) | DK2632550T3 (https=) |
| EC (1) | ECSP13012650A (https=) |
| ES (1) | ES2635435T3 (https=) |
| HK (1) | HK1249036A1 (https=) |
| HU (1) | HUE035393T2 (https=) |
| MX (1) | MX348184B (https=) |
| PE (1) | PE20140036A1 (https=) |
| PH (1) | PH12013500857A1 (https=) |
| PL (1) | PL2632550T3 (https=) |
| PT (1) | PT2632550T (https=) |
| RU (1) | RU2597746C2 (https=) |
| WO (1) | WO2012058664A1 (https=) |
| ZA (1) | ZA201303136B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI2241318T1 (sl) | 2006-05-01 | 2013-04-30 | Napo Pharmaceuticals, Inc. | Postopek za zdravljenje sindroma iritabilnega ÄŤrevesa s predominantno obstipacijo |
| ES2616012T3 (es) | 2006-05-01 | 2017-06-09 | Napo Pharmaceuticals, Inc. | Composiciones para tratar o prevenir enfermedad inflamatoria del intestino |
| US20070254050A1 (en) | 2006-05-01 | 2007-11-01 | Quart Barry D | Method for treatment of diarrhea-predominant irritable bowel syndrome |
| CN107595836A (zh) | 2010-10-31 | 2018-01-19 | 纳珀制药公司 | 用于治疗hiv相关性腹泻的方法和组合物 |
| EP2928560A4 (en) * | 2012-12-07 | 2016-06-01 | Salix Pharmaceuticals Inc | METHODS AND COMPOSITIONS FOR THE TREATMENT OF HIV-ASSOCIATED DIARRHEA |
| US11389424B2 (en) | 2017-03-09 | 2022-07-19 | Napo Pharmaceuticals, Inc. | Methods and compositions for treating chemotherapy-induced diarrhea |
| JP7328153B2 (ja) | 2017-05-31 | 2023-08-16 | ナポ ファーマシューティカルズ インク． | 胆汁酸性下痢、小腸切除又は胆嚢除去及び短腸症候群に関連する下痢を治療するための方法及び組成物 |
| US11857510B2 (en) | 2017-05-31 | 2024-01-02 | Napo Pharmaceuticals, Inc. | Methods and compositions for treating congenital diarrhea disorder |
| EP3935581A4 (en) | 2019-03-04 | 2022-11-30 | Iocurrents, Inc. | DATA COMPRESSION AND COMMUNICATION USING MACHINE LEARNING |
| CA3182864A1 (en) * | 2020-06-19 | 2021-12-23 | Lisa A. CONTE | Methods and compositions for treating chemotherapy-induced diarrhea |
| WO2022115481A1 (en) * | 2020-11-24 | 2022-06-02 | Napo Pharmaceuticals, Inc. | Methods and compositions for treating post-acute infection gastrointestinal disorders |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5211944A (en) | 1990-10-12 | 1993-05-18 | Shaman Pharmaceuticals, Inc. | Proanthocyanidin polymers having antiviral activity and methods of obtaining same |
| EP2060183A3 (en) | 1996-10-16 | 2009-06-03 | Napo Pharmaceuticals, Inc. | Enteric formulations of proanthocyanidin polymer antidiarrheal compositions |
| WO2000047062A2 (en) * | 1999-02-01 | 2000-08-17 | Shaman Pharmaceuticals, Inc. | Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same |
| US20040071793A1 (en) | 2002-10-05 | 2004-04-15 | Bobrowski Paul J. | Oral rehydration methods and compositions |
| WO2005074575A2 (en) * | 2004-01-30 | 2005-08-18 | Microbia, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| JP2008546790A (ja) * | 2005-06-22 | 2008-12-25 | ユニバーシティー オブ マサチューセッツ | Ｈｉｖ−１プロテアーゼ阻害剤 |
| CA2633417A1 (en) | 2005-12-15 | 2007-06-21 | Bayer Healthcare Ag | Diaryl ureas for treating virus infections |
| SI2241318T1 (sl) * | 2006-05-01 | 2013-04-30 | Napo Pharmaceuticals, Inc. | Postopek za zdravljenje sindroma iritabilnega ÄŤrevesa s predominantno obstipacijo |
| ES2616012T3 (es) | 2006-05-01 | 2017-06-09 | Napo Pharmaceuticals, Inc. | Composiciones para tratar o prevenir enfermedad inflamatoria del intestino |
| US20070254050A1 (en) | 2006-05-01 | 2007-11-01 | Quart Barry D | Method for treatment of diarrhea-predominant irritable bowel syndrome |
| US20100092479A1 (en) | 2008-08-18 | 2010-04-15 | Combinatorx (Singapore) Pte. Ltd. | Compositions and methods for treatment of viral diseases |
| US7928115B2 (en) | 2008-10-02 | 2011-04-19 | Salix Pharmaceuticals, Ltd. | Methods of treating travelers diarrhea and hepatic encephalopathy |
| WO2011024049A2 (en) | 2009-08-26 | 2011-03-03 | Glenmark Pharmaceuticals Ltd | Method for producing proanthocyanidin polymer compositions for pharmaceutical formulations |
| AU2010303577B2 (en) | 2009-10-06 | 2015-10-22 | Napo Pharmaceuticals, Inc. | Methods of treating diseases with proanthocyanidin oligomers such as crofelemer |
| US20110087530A1 (en) | 2009-10-09 | 2011-04-14 | Visa U.S.A. Inc. | Systems and Methods to Provide Loyalty Programs |
| CN107595836A (zh) | 2010-10-31 | 2018-01-19 | 纳珀制药公司 | 用于治疗hiv相关性腹泻的方法和组合物 |
| WO2012101008A1 (en) | 2011-01-27 | 2012-08-02 | Glenmark Pharmaceuticals Limited | Process for the production of proanthocyanidin polymeric composition |
| BR112014015314A2 (pt) | 2011-12-22 | 2017-06-13 | Glenmark Pharmaceuticals Ltd | composição farmacêutica não entérica compreendendo crofelemer |
| EP2928560A4 (en) | 2012-12-07 | 2016-06-01 | Salix Pharmaceuticals Inc | METHODS AND COMPOSITIONS FOR THE TREATMENT OF HIV-ASSOCIATED DIARRHEA |
-
2011
- 2011-10-31 CN CN201711077144.7A patent/CN107595836A/zh active Pending
- 2011-10-31 RU RU2013123794/15A patent/RU2597746C2/ru active
- 2011-10-31 CN CN2011800637391A patent/CN103370101A/zh active Pending
- 2011-10-31 JP JP2013536904A patent/JP6063385B2/ja active Active
- 2011-10-31 PE PE2013000926A patent/PE20140036A1/es not_active Application Discontinuation
- 2011-10-31 PT PT118372499T patent/PT2632550T/pt unknown
- 2011-10-31 EP EP11837249.9A patent/EP2632550B1/en active Active
- 2011-10-31 ES ES11837249.9T patent/ES2635435T3/es active Active
- 2011-10-31 DK DK11837249.9T patent/DK2632550T3/en active
- 2011-10-31 CA CA2816416A patent/CA2816416C/en active Active
- 2011-10-31 PL PL11837249T patent/PL2632550T3/pl unknown
- 2011-10-31 WO PCT/US2011/058549 patent/WO2012058664A1/en not_active Ceased
- 2011-10-31 MX MX2013004873A patent/MX348184B/es active IP Right Grant
- 2011-10-31 US US13/285,397 patent/US8962680B2/en active Active
- 2011-10-31 HU HUE11837249A patent/HUE035393T2/en unknown
- 2011-10-31 BR BR112013010774A patent/BR112013010774A2/pt not_active Application Discontinuation
- 2011-10-31 PH PH1/2013/500857A patent/PH12013500857A1/en unknown
- 2011-10-31 AU AU2011320155A patent/AU2011320155B2/en active Active
- 2011-11-11 US US13/294,307 patent/US20120107370A1/en not_active Abandoned
-
2013
- 2013-04-29 ZA ZA2013/03136A patent/ZA201303136B/en unknown
- 2013-05-31 EC ECSP13012650 patent/ECSP13012650A/es unknown
-
2014
- 2014-06-17 US US14/307,175 patent/US20140294903A1/en not_active Abandoned
-
2015
- 2015-01-15 US US14/597,740 patent/US9585868B2/en active Active
-
2016
- 2016-08-02 JP JP2016151656A patent/JP6310971B2/ja active Active
-
2018
- 2018-07-09 HK HK18108819.2A patent/HK1249036A1/zh unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request |
Effective date: 20160907 |
|
| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 13TH ANNIV.) - STANDARD Year of fee payment: 13 |
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| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20240917 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT DETERMINED COMPLIANT Effective date: 20240917 Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20240917 |
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| MPN | Maintenance fee for patent paid |
Free format text: FEE DESCRIPTION TEXT: MF (PATENT, 14TH ANNIV.) - STANDARD Year of fee payment: 14 |
|
| U00 | Fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U00-U101 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE REQUEST RECEIVED Effective date: 20250908 |
|
| U11 | Full renewal or maintenance fee paid |
Free format text: ST27 STATUS EVENT CODE: A-4-4-U10-U11-U102 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: MAINTENANCE FEE PAYMENT PAID IN FULL Effective date: 20250908 |