CN107595836A - 用于治疗hiv相关性腹泻的方法和组合物 - Google Patents

用于治疗hiv相关性腹泻的方法和组合物 Download PDF

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Publication number
CN107595836A
CN107595836A CN201711077144.7A CN201711077144A CN107595836A CN 107595836 A CN107595836 A CN 107595836A CN 201711077144 A CN201711077144 A CN 201711077144A CN 107595836 A CN107595836 A CN 107595836A
Authority
CN
China
Prior art keywords
crofelemer
day
subject
hiv
medicine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201711077144.7A
Other languages
English (en)
Chinese (zh)
Inventor
W.福布斯
E.博尔泰
S.金
P.查图维迪
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Napo Pharmaceuticals Inc
Original Assignee
Napo Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45994461&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN107595836(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Napo Pharmaceuticals Inc filed Critical Napo Pharmaceuticals Inc
Publication of CN107595836A publication Critical patent/CN107595836A/zh
Pending legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pain & Pain Management (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Plant Substances (AREA)
CN201711077144.7A 2010-10-31 2011-10-31 用于治疗hiv相关性腹泻的方法和组合物 Pending CN107595836A (zh)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US40862210P 2010-10-31 2010-10-31
US61/408622 2010-10-31
US40933510P 2010-11-02 2010-11-02
US61/409335 2010-11-02
US41624910P 2010-11-22 2010-11-22
US61/416249 2010-11-22
US201161434379P 2011-01-19 2011-01-19
US61/434379 2011-01-19
CN2011800637391A CN103370101A (zh) 2010-10-31 2011-10-31 用于治疗hiv相关性腹泻的方法和组合物

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN2011800637391A Division CN103370101A (zh) 2010-10-31 2011-10-31 用于治疗hiv相关性腹泻的方法和组合物

Publications (1)

Publication Number Publication Date
CN107595836A true CN107595836A (zh) 2018-01-19

Family

ID=45994461

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201711077144.7A Pending CN107595836A (zh) 2010-10-31 2011-10-31 用于治疗hiv相关性腹泻的方法和组合物
CN2011800637391A Pending CN103370101A (zh) 2010-10-31 2011-10-31 用于治疗hiv相关性腹泻的方法和组合物

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2011800637391A Pending CN103370101A (zh) 2010-10-31 2011-10-31 用于治疗hiv相关性腹泻的方法和组合物

Country Status (20)

Country Link
US (4) US8962680B2 (https=)
EP (1) EP2632550B1 (https=)
JP (2) JP6063385B2 (https=)
CN (2) CN107595836A (https=)
AU (1) AU2011320155B2 (https=)
BR (1) BR112013010774A2 (https=)
CA (1) CA2816416C (https=)
DK (1) DK2632550T3 (https=)
EC (1) ECSP13012650A (https=)
ES (1) ES2635435T3 (https=)
HK (1) HK1249036A1 (https=)
HU (1) HUE035393T2 (https=)
MX (1) MX348184B (https=)
PE (1) PE20140036A1 (https=)
PH (1) PH12013500857A1 (https=)
PL (1) PL2632550T3 (https=)
PT (1) PT2632550T (https=)
RU (1) RU2597746C2 (https=)
WO (1) WO2012058664A1 (https=)
ZA (1) ZA201303136B (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI2241318T1 (sl) 2006-05-01 2013-04-30 Napo Pharmaceuticals, Inc. Postopek za zdravljenje sindroma iritabilnega ÄŤrevesa s predominantno obstipacijo
ES2616012T3 (es) 2006-05-01 2017-06-09 Napo Pharmaceuticals, Inc. Composiciones para tratar o prevenir enfermedad inflamatoria del intestino
US20070254050A1 (en) 2006-05-01 2007-11-01 Quart Barry D Method for treatment of diarrhea-predominant irritable bowel syndrome
CN107595836A (zh) 2010-10-31 2018-01-19 纳珀制药公司 用于治疗hiv相关性腹泻的方法和组合物
EP2928560A4 (en) * 2012-12-07 2016-06-01 Salix Pharmaceuticals Inc METHODS AND COMPOSITIONS FOR THE TREATMENT OF HIV-ASSOCIATED DIARRHEA
US11389424B2 (en) 2017-03-09 2022-07-19 Napo Pharmaceuticals, Inc. Methods and compositions for treating chemotherapy-induced diarrhea
JP7328153B2 (ja) 2017-05-31 2023-08-16 ナポ ファーマシューティカルズ インク． 胆汁酸性下痢、小腸切除又は胆嚢除去及び短腸症候群に関連する下痢を治療するための方法及び組成物
US11857510B2 (en) 2017-05-31 2024-01-02 Napo Pharmaceuticals, Inc. Methods and compositions for treating congenital diarrhea disorder
EP3935581A4 (en) 2019-03-04 2022-11-30 Iocurrents, Inc. DATA COMPRESSION AND COMMUNICATION USING MACHINE LEARNING
CA3182864A1 (en) * 2020-06-19 2021-12-23 Lisa A. CONTE Methods and compositions for treating chemotherapy-induced diarrhea
WO2022115481A1 (en) * 2020-11-24 2022-06-02 Napo Pharmaceuticals, Inc. Methods and compositions for treating post-acute infection gastrointestinal disorders

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007130893A2 (en) * 2006-05-01 2007-11-15 Napo Pharmaceuticals, Inc. Compositions and methods for treating or preventing inflammatory bowel disease, familial adenomatous polyposis and colon cancer

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5211944A (en) 1990-10-12 1993-05-18 Shaman Pharmaceuticals, Inc. Proanthocyanidin polymers having antiviral activity and methods of obtaining same
EP2060183A3 (en) 1996-10-16 2009-06-03 Napo Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer antidiarrheal compositions
WO2000047062A2 (en) * 1999-02-01 2000-08-17 Shaman Pharmaceuticals, Inc. Enteric formulations of proanthocyanidin polymer dietary supplements and methods for preparing same
US20040071793A1 (en) 2002-10-05 2004-04-15 Bobrowski Paul J. Oral rehydration methods and compositions
WO2005074575A2 (en) * 2004-01-30 2005-08-18 Microbia, Inc. Methods and compositions for the treatment of gastrointestinal disorders
JP2008546790A (ja) * 2005-06-22 2008-12-25 ユニバーシティー オブ マサチューセッツ Ｈｉｖ−１プロテアーゼ阻害剤
CA2633417A1 (en) 2005-12-15 2007-06-21 Bayer Healthcare Ag Diaryl ureas for treating virus infections
SI2241318T1 (sl) * 2006-05-01 2013-04-30 Napo Pharmaceuticals, Inc. Postopek za zdravljenje sindroma iritabilnega ÄŤrevesa s predominantno obstipacijo
US20070254050A1 (en) 2006-05-01 2007-11-01 Quart Barry D Method for treatment of diarrhea-predominant irritable bowel syndrome
US20100092479A1 (en) 2008-08-18 2010-04-15 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
US7928115B2 (en) 2008-10-02 2011-04-19 Salix Pharmaceuticals, Ltd. Methods of treating travelers diarrhea and hepatic encephalopathy
WO2011024049A2 (en) 2009-08-26 2011-03-03 Glenmark Pharmaceuticals Ltd Method for producing proanthocyanidin polymer compositions for pharmaceutical formulations
AU2010303577B2 (en) 2009-10-06 2015-10-22 Napo Pharmaceuticals, Inc. Methods of treating diseases with proanthocyanidin oligomers such as crofelemer
US20110087530A1 (en) 2009-10-09 2011-04-14 Visa U.S.A. Inc. Systems and Methods to Provide Loyalty Programs
CN107595836A (zh) 2010-10-31 2018-01-19 纳珀制药公司 用于治疗hiv相关性腹泻的方法和组合物
WO2012101008A1 (en) 2011-01-27 2012-08-02 Glenmark Pharmaceuticals Limited Process for the production of proanthocyanidin polymeric composition
BR112014015314A2 (pt) 2011-12-22 2017-06-13 Glenmark Pharmaceuticals Ltd composição farmacêutica não entérica compreendendo crofelemer
EP2928560A4 (en) 2012-12-07 2016-06-01 Salix Pharmaceuticals Inc METHODS AND COMPOSITIONS FOR THE TREATMENT OF HIV-ASSOCIATED DIARRHEA

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007130893A2 (en) * 2006-05-01 2007-11-15 Napo Pharmaceuticals, Inc. Compositions and methods for treating or preventing inflammatory bowel disease, familial adenomatous polyposis and colon cancer

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
MARK HOLODNIY 等: "A double blind, randomized, placebo-controlled phase II study to assess the safety and efficacy of orally administered SP-303 for the symptomatic treatment of diarrhea in patients with AIDS", 《THE AMERICAN JOURNAL OF GASTROENTEROLOGY》 *
马燕: "Crofelemer 治疗急性传染性腹泻的II期临床试验启动", 《国外医药（抗生素分册）》 *

Also Published As

Publication number Publication date
US8962680B2 (en) 2015-02-24
EP2632550B1 (en) 2017-05-03
CN103370101A (zh) 2013-10-23
PE20140036A1 (es) 2014-01-31
RU2013123794A (ru) 2014-12-10
WO2012058664A1 (en) 2012-05-03
MX2013004873A (es) 2013-08-21
US20120107370A1 (en) 2012-05-03
MX348184B (es) 2017-06-02
HUE035393T2 (en) 2018-05-02
ES2635435T3 (es) 2017-10-03
DK2632550T3 (en) 2017-08-07
AU2011320155B2 (en) 2016-02-25
CA2816416A1 (en) 2012-05-03
CA2816416C (en) 2020-02-11
US20140294903A1 (en) 2014-10-02
US9585868B2 (en) 2017-03-07
EP2632550A4 (en) 2014-04-23
US20120184605A1 (en) 2012-07-19
ECSP13012650A (es) 2013-10-31
EP2632550A1 (en) 2013-09-04
PH12013500857A1 (en) 2018-01-17
PL2632550T3 (pl) 2017-10-31
JP2017019806A (ja) 2017-01-26
JP6310971B2 (ja) 2018-04-11
JP2013540826A (ja) 2013-11-07
ZA201303136B (en) 2016-01-27
AU2011320155A1 (en) 2013-05-09
HK1249036A1 (zh) 2018-10-26
JP6063385B2 (ja) 2017-01-18
US20150190367A1 (en) 2015-07-09
RU2597746C2 (ru) 2016-09-20
PT2632550T (pt) 2017-08-02
BR112013010774A2 (pt) 2017-03-21

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