JP2013540117A - 腫瘍幹細胞におけるeph受容体発現 - Google Patents

腫瘍幹細胞におけるeph受容体発現 Download PDF

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Publication number
JP2013540117A
JP2013540117A JP2013530753A JP2013530753A JP2013540117A JP 2013540117 A JP2013540117 A JP 2013540117A JP 2013530753 A JP2013530753 A JP 2013530753A JP 2013530753 A JP2013530753 A JP 2013530753A JP 2013540117 A JP2013540117 A JP 2013540117A
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Japan
Prior art keywords
gbm
epha2
cells
csc
ephrina1
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JP2013530753A
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English (en)
Japanese (ja)
Inventor
アンジェロ ルイジ ヴェスコビ
エレーナ ビンダ
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STEMGEN SpA
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STEMGEN SpA
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Publication of JP2013540117A publication Critical patent/JP2013540117A/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Cell Biology (AREA)
  • Oncology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
JP2013530753A 2010-10-01 2011-09-30 腫瘍幹細胞におけるeph受容体発現 Pending JP2013540117A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP10185930A EP2446895A1 (en) 2010-10-01 2010-10-01 EPH receptor expression in tumor stem cells
EP10185930.4 2010-10-01
PCT/EP2011/067114 WO2012042021A1 (en) 2010-10-01 2011-09-30 Eph receptor expression in tumor stem cells

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2015200808A Division JP6523910B2 (ja) 2010-10-01 2015-10-09 腫瘍幹細胞におけるeph受容体発現

Publications (1)

Publication Number Publication Date
JP2013540117A true JP2013540117A (ja) 2013-10-31

Family

ID=43856109

Family Applications (4)

Application Number Title Priority Date Filing Date
JP2013530753A Pending JP2013540117A (ja) 2010-10-01 2011-09-30 腫瘍幹細胞におけるeph受容体発現
JP2015200808A Active JP6523910B2 (ja) 2010-10-01 2015-10-09 腫瘍幹細胞におけるeph受容体発現
JP2017192907A Active JP6618968B2 (ja) 2010-10-01 2017-10-02 腫瘍幹細胞におけるeph受容体発現
JP2019205190A Pending JP2020037579A (ja) 2010-10-01 2019-11-13 腫瘍幹細胞におけるeph受容体発現

Family Applications After (3)

Application Number Title Priority Date Filing Date
JP2015200808A Active JP6523910B2 (ja) 2010-10-01 2015-10-09 腫瘍幹細胞におけるeph受容体発現
JP2017192907A Active JP6618968B2 (ja) 2010-10-01 2017-10-02 腫瘍幹細胞におけるeph受容体発現
JP2019205190A Pending JP2020037579A (ja) 2010-10-01 2019-11-13 腫瘍幹細胞におけるeph受容体発現

Country Status (11)

Country Link
US (1) US9078857B2 (enExample)
EP (2) EP2446895A1 (enExample)
JP (4) JP2013540117A (enExample)
KR (2) KR20130095286A (enExample)
AU (1) AU2011310109B2 (enExample)
CA (1) CA2813101C (enExample)
DK (1) DK2621513T3 (enExample)
ES (1) ES2616444T3 (enExample)
NZ (1) NZ609594A (enExample)
PL (1) PL2621513T3 (enExample)
WO (1) WO2012042021A1 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PH12013501137A1 (en) 2010-12-08 2021-06-02 Abbvie Stemcentrx Llc Novel modulators and methods of use
SA112330278B1 (ar) 2011-02-18 2015-10-09 ستيم سينتركس، انك. مواد ضابطة جديدة وطرق للاستخدام
EP2733206A1 (en) * 2012-11-19 2014-05-21 Naroa LLC Method for the isolation for mammalian stem cells using EphA2 and uses thereof
RU2016119491A (ru) 2013-11-04 2017-12-11 Пфайзер Инк. Конъюгаты антитела к efna4 с лекарственным средством
SMT202100146T1 (it) 2014-04-30 2021-05-07 Pfizer Coniugati di anticorpo anti-ptk7-farmaco
ES2796973T3 (es) 2014-12-10 2020-11-30 Hyperstem Sa Métodos y composiciones para reducir el crecimiento, la migración y la invasividad de células madre de cáncer cerebral y mejorar la supervivencia de pacientes con tumores cerebrales
US10783439B2 (en) * 2015-05-08 2020-09-22 FlowJo, LLC Plugin interface and framework for integrating a remote server with sample data analysis software
WO2017081686A1 (en) 2015-11-10 2017-05-18 B. G. Negev Technologies And Applications Ltd., At Ben-Gurion University Means and methods for reducing tumorigenicity of cancer stem cells
US20240226175A1 (en) * 2020-03-31 2024-07-11 Keio University Therapeutic agent using genome-edited pluripotent stem cell
WO2026022122A1 (en) * 2024-07-23 2026-01-29 Eos Research Sa Checkpoint inhibitors in the treatment of glioblastoma multiforme

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090123371A1 (en) * 2006-03-08 2009-05-14 Wake Forest University Health Sciences Molecular signature of cancer
US20100183618A1 (en) * 2007-08-30 2010-07-22 Daiichi Sankyo Company, Limited Anti-epha2 antibody

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20060130038A (ko) * 2003-10-15 2006-12-18 메디뮨 인코포레이티드 리스테리아에 의거한 EphA2 백신
AU2005277641A1 (en) * 2004-08-16 2006-03-02 Medimmune, Llc Eph receptor Fc variants with enhanced antibody dependent cell-mediated cytotoxicity activity
US20070248628A1 (en) * 2005-12-06 2007-10-25 Keller Lorraine H Immunogens in cancer stem cells

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090123371A1 (en) * 2006-03-08 2009-05-14 Wake Forest University Health Sciences Molecular signature of cancer
US20100183618A1 (en) * 2007-08-30 2010-07-22 Daiichi Sankyo Company, Limited Anti-epha2 antibody

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
JPN6014027355; Int J Oncol, vol.30, p.865-871 (2007) *
JPN6014027357; Mol Cancer Ther, vol.6, no.12, p.3208-3218 (2007) *
JPN6014027359; Mol Cancer Res, vol.3, no.10, p.541-551 (2005) *
JPN6014027361; Oncogene, vol.28, p.1759-1768 (2009) *
JPN6014027363; Cancer Cell, vol.22, p.765-780 (2012) *

Also Published As

Publication number Publication date
AU2011310109A1 (en) 2013-05-02
DK2621513T3 (en) 2017-03-06
JP2018048151A (ja) 2018-03-29
WO2012042021A1 (en) 2012-04-05
EP2621513B1 (en) 2016-12-28
JP6523910B2 (ja) 2019-06-05
CA2813101C (en) 2018-10-30
US9078857B2 (en) 2015-07-14
JP2020037579A (ja) 2020-03-12
JP6618968B2 (ja) 2019-12-11
KR20130095286A (ko) 2013-08-27
KR101719966B1 (ko) 2017-03-24
JP2016094391A (ja) 2016-05-26
PL2621513T3 (pl) 2017-06-30
AU2011310109B2 (en) 2014-11-20
US20120083454A1 (en) 2012-04-05
ES2616444T3 (es) 2017-06-13
NZ609594A (en) 2015-01-30
KR20160027106A (ko) 2016-03-09
EP2621513A1 (en) 2013-08-07
CA2813101A1 (en) 2012-04-05
EP2446895A1 (en) 2012-05-02

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