JP2013537532A - 感染性疾患を治療及び予防する組み合わせ医薬組成物及び方法 - Google Patents
感染性疾患を治療及び予防する組み合わせ医薬組成物及び方法 Download PDFInfo
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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Landscapes
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Applications Claiming Priority (17)
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| RU2010133047/15A RU2517085C2 (ru) | 2010-08-06 | 2010-08-06 | Комплексное лекарственное средство и способ профилактики инфицирования вич, профилактики и лечения заболеваний, вызываемых вич или ассоциированных с вич, в том числе спида |
| RU2010133051/15A RU2505312C2 (ru) | 2010-08-06 | 2010-08-06 | Комплексное лекарственное средство для лечения гриппа различных типов |
| RU2010133050 | 2010-08-06 | ||
| RU2010133053/15A RU2521392C2 (ru) | 2010-08-06 | 2010-08-06 | Комплексное лекарственное средство для лечения вирусных заболеваний и способ лечения вирусных заболеваний |
| RU2010133047 | 2010-08-06 | ||
| RU2010133041 | 2010-08-06 | ||
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| RU2010133043/15A RU2519862C2 (ru) | 2010-08-06 | 2010-08-06 | Комплексное лекарственное средство и способ профилактики и лечения инфекционных вирусных заболеваний |
| RU2010133051 | 2010-08-06 | ||
| RU2010133052 | 2010-08-06 | ||
| RU2010133052/15A RU2500422C2 (ru) | 2010-08-06 | 2010-08-06 | Комплексное лекарственное средство для лечения вирусных инфекций и способ лечения вирусных инфекций |
| RU2010133053 | 2010-08-06 | ||
| RU2010133050/15A RU2502521C2 (ru) | 2010-08-06 | 2010-08-06 | Комплексное лекарственное средство для лечения бактериальных инфекций и способ лечения бактериальных инфекций |
| RU2011127226/15A RU2577299C2 (ru) | 2011-07-04 | 2011-07-04 | Способ лечения инфекционных заболеваний и комплексное лекарственное средство для лечения инфекционных заболеваний |
| RU2011127226 | 2011-07-04 | ||
| PCT/IB2011/002470 WO2012017328A2 (en) | 2010-08-06 | 2011-07-15 | Combination pharmaceutical composition and methods of treating and preventing the infectious diseases |
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| JP2016131741A Division JP2016216478A (ja) | 2010-08-06 | 2016-07-01 | 感染性疾患を治療及び予防する組み合わせ医薬組成物及び方法 |
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| JP2018085391A Withdrawn JP2018135370A (ja) | 2010-08-06 | 2018-04-26 | 感染性疾患を治療及び予防する組み合わせ医薬組成物及び方法 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP2022545178A (ja) * | 2019-08-29 | 2022-10-26 | イリイチ・エプシテイン オレグ | 感染症を治療するための医薬及び方法 |
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| RU2181297C2 (ru) * | 2000-06-20 | 2002-04-20 | Эпштейн Олег Ильич | Способ лечения патологического синдрома и лекарственное средство |
| UA76638C2 (en) * | 2002-08-02 | 2006-08-15 | Oleh Illich Epshtein | Homeopathic medication based on anti-interferon antibodies and method for treating a pathological syndrome associated with interferon |
| RU2309732C1 (ru) * | 2006-03-13 | 2007-11-10 | Олег Ильич Эпштейн | Спрессованная твердая оральная форма лекарственного препарата и способ получения твердой оральной формы лекарственного препарата |
| FR2962652A1 (fr) | 2010-07-15 | 2012-01-20 | Oleg Iliich Epshtein | Composition pharmaceutique d'association et son utilisation dans des procedes pour traiter les maladies ou affections associees a des maladies neurodegeneratives |
| MX2013000543A (es) | 2010-07-15 | 2013-10-28 | Oleg Iliich Epshtein | Un metodo para aumentar el efecto de una forma activa potenciada de un anticuerpo. |
| PH12013500144A1 (en) | 2010-07-21 | 2018-03-21 | Oleg Iliich Epshtein | A method of treating attention deficit hyperactivity disorder |
| FR2962909A1 (fr) | 2010-07-21 | 2012-01-27 | Oleg Iliich Epshtein | Composition pharmaceutique d'association et son utilisation dans des procedes pour traiter les maladies ou affections associees avec une maladie ou affection respiratoire |
| RU2535033C2 (ru) * | 2010-08-06 | 2014-12-10 | Олег Ильич Эпштейн | Лекарственное средство и способ профилактики инфицирования вич, профилактики и лечения заболеваний, вызываемых вич или ассоциированных с вич, в том числе спида |
| CZ2013159A3 (cs) * | 2010-08-06 | 2013-06-12 | Iliich Epshtein@Oleg | Kombinovaná farmaceutická kompozice a zpusoby lécby a prevence infekcních chorob |
| RU2013111962A (ru) | 2013-03-18 | 2014-09-27 | Олег Ильич Эпштейн | Способ определения выраженности модифицирующей активности, ассоциированной с носителем |
| RU2013111961A (ru) | 2013-03-18 | 2014-09-27 | Олег Ильич Эпштейн | Способ определения выраженности модифицирующей активности, ассоциированной с носителем |
| RU2603623C2 (ru) * | 2014-06-06 | 2016-11-27 | Олег Ильич Эпштейн | Ветеринарная композиция и способ улучшения жизнеспособности животных, стимуляции прироста живой массы млекопитающих и птиц, повышения эффективности иммунизации, профилактики и/или лечения инфекционных заболеваний (варианты) |
| DE102020007979A1 (de) | 2020-12-29 | 2022-06-30 | Charité Universitätsmedizin Institut für Mikrobiologie und Infektionsimmunologie | Zusammensetzung zur Behandlung von lnfektionen mit Coronaviren |
| WO2023230249A1 (en) * | 2022-05-25 | 2023-11-30 | Baruch S. Blumberg Institute | Novel hepatoselective polyadenylating polymerases inhibitors and their method of use |
| AU2023275550A1 (en) * | 2022-05-25 | 2024-11-21 | Flagship Pioneering Innovations Vii, Llc | Compositions and methods for modulating cytokines |
| WO2025088452A1 (en) * | 2023-10-24 | 2025-05-01 | Epshtein Oleg Ilyich | Artificial substance and method of its preparation |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090016993A1 (en) * | 2006-12-22 | 2009-01-15 | Shah Rajesh | Medicinal formulation for the treatment for hepatitis c |
| JP2009539827A (ja) * | 2006-06-06 | 2009-11-19 | オレグ イリッチ エプシュテイン | 肥満、真性糖尿病及び耐糖能異常を伴う疾患の治療用薬剤 |
| US20100166762A1 (en) * | 2000-06-20 | 2010-07-01 | Oleg Iliich Epshtein | Method of treating a pathological syndrome |
| JP2013532182A (ja) * | 2010-07-15 | 2013-08-15 | イリイチ・エプシテイン オレグ | 組み合わせ医薬組成物及び神経変性疾患に関連する疾患又は状態を治療する方法 |
| JP2013533268A (ja) * | 2010-07-21 | 2013-08-22 | イリイチ・エプシテイン オレグ | 糖尿病及び代謝障害を治療する組み合わせ医薬組成物及び方法 |
| JP2013533269A (ja) * | 2010-07-21 | 2013-08-22 | イリイチ・エプシテイン オレグ | 組み合わせ医薬組成物及び呼吸器の疾患又は状態に関連する疾患及び状態を治療する方法 |
| JP2013535436A (ja) * | 2010-07-15 | 2013-09-12 | イリイチ・エプシテイン オレグ | 医薬組成物及び治療方法 |
| JP2013536174A (ja) * | 2010-07-21 | 2013-09-19 | イリイチ・エプシテイン オレグ | 組み合わせ医薬組成物並びに回転性めまい、動揺病及び自律神経血管ジストニアを治療する方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4311897A (en) | 1979-08-28 | 1982-01-19 | Union Carbide Corporation | Plasma arc torch and nozzle assembly |
| RU2192888C1 (ru) | 2001-02-15 | 2002-11-20 | Эпштейн Олег Ильич | Лекарственное средство и способ лечения патологического синдрома |
| RU2001134982A (ru) * | 2001-12-26 | 2004-02-20 | Олег Ильич Эпштейн | Способ коррекции иммунного ответа и лекарственное средство |
| UA76640C2 (uk) * | 2002-08-02 | 2006-08-15 | Олєг Ільіч Епштєйн | Спосіб корекції патологічних імунних реакцій та гомеопатичний лікарський засіб |
| UA76641C2 (uk) | 2002-08-02 | 2006-08-15 | Олєг Ільіч Епштєйн | Гомеопатичний лікарський засіб та спосіб лікування захворювань передміхурової залози |
| UA76638C2 (en) * | 2002-08-02 | 2006-08-15 | Oleh Illich Epshtein | Homeopathic medication based on anti-interferon antibodies and method for treating a pathological syndrome associated with interferon |
| GB2414670B (en) | 2003-03-14 | 2008-03-19 | Nutrition Res Inc | Homeopathic formulations useful for treating pain and/or inflammation |
| RU2309732C1 (ru) * | 2006-03-13 | 2007-11-10 | Олег Ильич Эпштейн | Спрессованная твердая оральная форма лекарственного препарата и способ получения твердой оральной формы лекарственного препарата |
| RU2332236C1 (ru) * | 2007-02-02 | 2008-08-27 | Олег Ильич Эпштейн | Лекарственное средство для лечения гриппа у птиц |
| CZ2013159A3 (cs) * | 2010-08-06 | 2013-06-12 | Iliich Epshtein@Oleg | Kombinovaná farmaceutická kompozice a zpusoby lécby a prevence infekcních chorob |
-
2011
- 2011-07-15 CZ CZ20130159A patent/CZ2013159A3/cs unknown
- 2011-07-15 FR FR1156483A patent/FR2963563A1/fr not_active Withdrawn
- 2011-07-15 NZ NZ606993A patent/NZ606993A/en not_active IP Right Cessation
- 2011-07-15 JP JP2013522318A patent/JP2013537532A/ja active Pending
- 2011-07-15 SG SG2013008974A patent/SG187732A1/en unknown
- 2011-07-15 KR KR1020137005740A patent/KR20140012021A/ko not_active Ceased
- 2011-07-15 EP EP11778688.9A patent/EP2601219A2/en not_active Ceased
- 2011-07-15 EA EA201300135A patent/EA030513B1/ru not_active IP Right Cessation
- 2011-07-15 MX MX2013001451A patent/MX368313B/es active IP Right Grant
- 2011-07-15 US US13/135,899 patent/US20130045237A1/en not_active Abandoned
- 2011-07-15 GB GB1303867.4A patent/GB2503066B8/en not_active Expired - Fee Related
- 2011-07-15 ES ES201390022A patent/ES2510940R1/es active Pending
- 2011-07-15 PH PH1/2013/500232A patent/PH12013500232A1/en unknown
- 2011-07-15 BR BR112013002296A patent/BR112013002296A2/pt not_active Application Discontinuation
- 2011-07-15 WO PCT/IB2011/002470 patent/WO2012017328A2/en not_active Ceased
- 2011-07-15 SG SG10201403870XA patent/SG10201403870XA/en unknown
- 2011-07-15 CN CN201180048456XA patent/CN103154030A/zh active Pending
- 2011-07-15 DE DE112011102640T patent/DE112011102640T5/de not_active Withdrawn
- 2011-07-15 PE PE2013000216A patent/PE20131185A1/es not_active Application Discontinuation
- 2011-07-15 AU AU2011287292A patent/AU2011287292B2/en not_active Ceased
- 2011-07-15 GB GB1707875.9A patent/GB2548034B/en not_active Expired - Fee Related
-
2013
- 2013-02-03 IL IL224545A patent/IL224545A/en active IP Right Grant
-
2014
- 2014-07-07 US US14/324,575 patent/US20150023972A1/en not_active Abandoned
- 2014-07-08 US US14/325,455 patent/US20150023980A1/en not_active Abandoned
-
2016
- 2016-07-01 JP JP2016131741A patent/JP2016216478A/ja active Pending
-
2018
- 2018-04-26 JP JP2018085391A patent/JP2018135370A/ja not_active Withdrawn
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100166762A1 (en) * | 2000-06-20 | 2010-07-01 | Oleg Iliich Epshtein | Method of treating a pathological syndrome |
| JP2009539827A (ja) * | 2006-06-06 | 2009-11-19 | オレグ イリッチ エプシュテイン | 肥満、真性糖尿病及び耐糖能異常を伴う疾患の治療用薬剤 |
| US20090016993A1 (en) * | 2006-12-22 | 2009-01-15 | Shah Rajesh | Medicinal formulation for the treatment for hepatitis c |
| JP2013532182A (ja) * | 2010-07-15 | 2013-08-15 | イリイチ・エプシテイン オレグ | 組み合わせ医薬組成物及び神経変性疾患に関連する疾患又は状態を治療する方法 |
| JP2013535436A (ja) * | 2010-07-15 | 2013-09-12 | イリイチ・エプシテイン オレグ | 医薬組成物及び治療方法 |
| JP2013533268A (ja) * | 2010-07-21 | 2013-08-22 | イリイチ・エプシテイン オレグ | 糖尿病及び代謝障害を治療する組み合わせ医薬組成物及び方法 |
| JP2013533269A (ja) * | 2010-07-21 | 2013-08-22 | イリイチ・エプシテイン オレグ | 組み合わせ医薬組成物及び呼吸器の疾患又は状態に関連する疾患及び状態を治療する方法 |
| JP2013536174A (ja) * | 2010-07-21 | 2013-09-19 | イリイチ・エプシテイン オレグ | 組み合わせ医薬組成物並びに回転性めまい、動揺病及び自律神経血管ジストニアを治療する方法 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2022545178A (ja) * | 2019-08-29 | 2022-10-26 | イリイチ・エプシテイン オレグ | 感染症を治療するための医薬及び方法 |
| JP2024156824A (ja) * | 2019-08-29 | 2024-11-06 | イリイチ・エプシテイン オレグ | 感染症を治療するための医薬及び方法 |
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