AU2011287292B2 - Combination pharmaceutical composition and methods of treating and preventing the infectious diseases - Google Patents
Combination pharmaceutical composition and methods of treating and preventing the infectious diseases Download PDFInfo
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- AU2011287292B2 AU2011287292B2 AU2011287292A AU2011287292A AU2011287292B2 AU 2011287292 B2 AU2011287292 B2 AU 2011287292B2 AU 2011287292 A AU2011287292 A AU 2011287292A AU 2011287292 A AU2011287292 A AU 2011287292A AU 2011287292 B2 AU2011287292 B2 AU 2011287292B2
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- C—CHEMISTRY; METALLURGY
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Landscapes
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Applications Claiming Priority (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010133047/15A RU2517085C2 (ru) | 2010-08-06 | 2010-08-06 | Комплексное лекарственное средство и способ профилактики инфицирования вич, профилактики и лечения заболеваний, вызываемых вич или ассоциированных с вич, в том числе спида |
| RU2010133051/15A RU2505312C2 (ru) | 2010-08-06 | 2010-08-06 | Комплексное лекарственное средство для лечения гриппа различных типов |
| RU2010133050 | 2010-08-06 | ||
| RU2010133053/15A RU2521392C2 (ru) | 2010-08-06 | 2010-08-06 | Комплексное лекарственное средство для лечения вирусных заболеваний и способ лечения вирусных заболеваний |
| RU2010133047 | 2010-08-06 | ||
| RU2010133041 | 2010-08-06 | ||
| RU2010133043 | 2010-08-06 | ||
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Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
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| RU2181297C2 (ru) * | 2000-06-20 | 2002-04-20 | Эпштейн Олег Ильич | Способ лечения патологического синдрома и лекарственное средство |
| UA76638C2 (en) * | 2002-08-02 | 2006-08-15 | Oleh Illich Epshtein | Homeopathic medication based on anti-interferon antibodies and method for treating a pathological syndrome associated with interferon |
| RU2309732C1 (ru) * | 2006-03-13 | 2007-11-10 | Олег Ильич Эпштейн | Спрессованная твердая оральная форма лекарственного препарата и способ получения твердой оральной формы лекарственного препарата |
| FR2962652A1 (fr) | 2010-07-15 | 2012-01-20 | Oleg Iliich Epshtein | Composition pharmaceutique d'association et son utilisation dans des procedes pour traiter les maladies ou affections associees a des maladies neurodegeneratives |
| MX2013000543A (es) | 2010-07-15 | 2013-10-28 | Oleg Iliich Epshtein | Un metodo para aumentar el efecto de una forma activa potenciada de un anticuerpo. |
| PH12013500144A1 (en) | 2010-07-21 | 2018-03-21 | Oleg Iliich Epshtein | A method of treating attention deficit hyperactivity disorder |
| FR2962909A1 (fr) | 2010-07-21 | 2012-01-27 | Oleg Iliich Epshtein | Composition pharmaceutique d'association et son utilisation dans des procedes pour traiter les maladies ou affections associees avec une maladie ou affection respiratoire |
| RU2535033C2 (ru) * | 2010-08-06 | 2014-12-10 | Олег Ильич Эпштейн | Лекарственное средство и способ профилактики инфицирования вич, профилактики и лечения заболеваний, вызываемых вич или ассоциированных с вич, в том числе спида |
| CZ2013159A3 (cs) * | 2010-08-06 | 2013-06-12 | Iliich Epshtein@Oleg | Kombinovaná farmaceutická kompozice a zpusoby lécby a prevence infekcních chorob |
| RU2013111962A (ru) | 2013-03-18 | 2014-09-27 | Олег Ильич Эпштейн | Способ определения выраженности модифицирующей активности, ассоциированной с носителем |
| RU2013111961A (ru) | 2013-03-18 | 2014-09-27 | Олег Ильич Эпштейн | Способ определения выраженности модифицирующей активности, ассоциированной с носителем |
| RU2603623C2 (ru) * | 2014-06-06 | 2016-11-27 | Олег Ильич Эпштейн | Ветеринарная композиция и способ улучшения жизнеспособности животных, стимуляции прироста живой массы млекопитающих и птиц, повышения эффективности иммунизации, профилактики и/или лечения инфекционных заболеваний (варианты) |
| CN114375200A (zh) * | 2019-08-29 | 2022-04-19 | 奥列格·伊利奇·爱泼斯坦 | 治疗传染病的药物和方法 |
| DE102020007979A1 (de) | 2020-12-29 | 2022-06-30 | Charité Universitätsmedizin Institut für Mikrobiologie und Infektionsimmunologie | Zusammensetzung zur Behandlung von lnfektionen mit Coronaviren |
| WO2023230249A1 (en) * | 2022-05-25 | 2023-11-30 | Baruch S. Blumberg Institute | Novel hepatoselective polyadenylating polymerases inhibitors and their method of use |
| AU2023275550A1 (en) * | 2022-05-25 | 2024-11-21 | Flagship Pioneering Innovations Vii, Llc | Compositions and methods for modulating cytokines |
| WO2025088452A1 (en) * | 2023-10-24 | 2025-05-01 | Epshtein Oleg Ilyich | Artificial substance and method of its preparation |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003055518A1 (fr) * | 2001-12-26 | 2003-07-10 | Goldberg, Evgeny Danilovich | Procede de traitement d'etats immuno-pathologiques et medicament correspondant |
| EP1550460A1 (en) * | 2002-08-02 | 2005-07-06 | Oleg Iliich Epshtein | Method for correcting immune responses and medicinal agent |
| US20060024307A1 (en) * | 2002-08-02 | 2006-02-02 | Epshteni Oleg I | Media and method for treating pathological syndrome |
| EP1997481A1 (en) * | 2006-03-13 | 2008-12-03 | Oleg Iliich Epshtein | Solid oral form of a medicinal preparation and a method for the production thereof |
| EP2123300A1 (en) * | 2007-02-02 | 2009-11-25 | Dolgovykh, Lyudmila Fedorovna | Medicinal agent for treating bird flu |
| US20100166762A1 (en) * | 2000-06-20 | 2010-07-01 | Oleg Iliich Epshtein | Method of treating a pathological syndrome |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4311897A (en) | 1979-08-28 | 1982-01-19 | Union Carbide Corporation | Plasma arc torch and nozzle assembly |
| RU2192888C1 (ru) | 2001-02-15 | 2002-11-20 | Эпштейн Олег Ильич | Лекарственное средство и способ лечения патологического синдрома |
| UA76641C2 (uk) | 2002-08-02 | 2006-08-15 | Олєг Ільіч Епштєйн | Гомеопатичний лікарський засіб та спосіб лікування захворювань передміхурової залози |
| GB2414670B (en) | 2003-03-14 | 2008-03-19 | Nutrition Res Inc | Homeopathic formulations useful for treating pain and/or inflammation |
| CA2654408C (en) * | 2006-06-06 | 2018-05-08 | Oleg Iliich Epshtein | Medicinal agent for treating fatness, diabetes, and diseases associated with impaired glucose tolerance |
| WO2008078331A1 (en) * | 2006-12-22 | 2008-07-03 | Rajesh Shah | Medicinal formulation for the treatment for hepatitis c |
| EA029400B1 (ru) * | 2010-07-15 | 2018-03-30 | Олег Ильич ЭПШТЕЙН | Фармацевтическая композиция для лечения ожирения и сопутствующих метаболических расстройств и способ лечения |
| FR2962652A1 (fr) * | 2010-07-15 | 2012-01-20 | Oleg Iliich Epshtein | Composition pharmaceutique d'association et son utilisation dans des procedes pour traiter les maladies ou affections associees a des maladies neurodegeneratives |
| FR2962909A1 (fr) * | 2010-07-21 | 2012-01-27 | Oleg Iliich Epshtein | Composition pharmaceutique d'association et son utilisation dans des procedes pour traiter les maladies ou affections associees avec une maladie ou affection respiratoire |
| US20130058981A1 (en) * | 2010-07-21 | 2013-03-07 | Oleg Iliich Epshtein | Combination pharmaceutical compositions and method of treatment of vertigo, kinetosis and vegetative-vascular dystonia |
| CN103118707A (zh) * | 2010-07-21 | 2013-05-22 | 奥列格·伊里奇·爱泼斯坦 | 复合药物组合物及对糖尿病和代谢紊乱进行治疗的方法 |
| CZ2013159A3 (cs) * | 2010-08-06 | 2013-06-12 | Iliich Epshtein@Oleg | Kombinovaná farmaceutická kompozice a zpusoby lécby a prevence infekcních chorob |
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2011
- 2011-07-15 CZ CZ20130159A patent/CZ2013159A3/cs unknown
- 2011-07-15 FR FR1156483A patent/FR2963563A1/fr not_active Withdrawn
- 2011-07-15 NZ NZ606993A patent/NZ606993A/en not_active IP Right Cessation
- 2011-07-15 JP JP2013522318A patent/JP2013537532A/ja active Pending
- 2011-07-15 SG SG2013008974A patent/SG187732A1/en unknown
- 2011-07-15 KR KR1020137005740A patent/KR20140012021A/ko not_active Ceased
- 2011-07-15 EP EP11778688.9A patent/EP2601219A2/en not_active Ceased
- 2011-07-15 EA EA201300135A patent/EA030513B1/ru not_active IP Right Cessation
- 2011-07-15 MX MX2013001451A patent/MX368313B/es active IP Right Grant
- 2011-07-15 US US13/135,899 patent/US20130045237A1/en not_active Abandoned
- 2011-07-15 GB GB1303867.4A patent/GB2503066B8/en not_active Expired - Fee Related
- 2011-07-15 ES ES201390022A patent/ES2510940R1/es active Pending
- 2011-07-15 PH PH1/2013/500232A patent/PH12013500232A1/en unknown
- 2011-07-15 BR BR112013002296A patent/BR112013002296A2/pt not_active Application Discontinuation
- 2011-07-15 WO PCT/IB2011/002470 patent/WO2012017328A2/en not_active Ceased
- 2011-07-15 SG SG10201403870XA patent/SG10201403870XA/en unknown
- 2011-07-15 CN CN201180048456XA patent/CN103154030A/zh active Pending
- 2011-07-15 DE DE112011102640T patent/DE112011102640T5/de not_active Withdrawn
- 2011-07-15 PE PE2013000216A patent/PE20131185A1/es not_active Application Discontinuation
- 2011-07-15 AU AU2011287292A patent/AU2011287292B2/en not_active Ceased
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- 2014-07-07 US US14/324,575 patent/US20150023972A1/en not_active Abandoned
- 2014-07-08 US US14/325,455 patent/US20150023980A1/en not_active Abandoned
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2016
- 2016-07-01 JP JP2016131741A patent/JP2016216478A/ja active Pending
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2018
- 2018-04-26 JP JP2018085391A patent/JP2018135370A/ja not_active Withdrawn
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100166762A1 (en) * | 2000-06-20 | 2010-07-01 | Oleg Iliich Epshtein | Method of treating a pathological syndrome |
| WO2003055518A1 (fr) * | 2001-12-26 | 2003-07-10 | Goldberg, Evgeny Danilovich | Procede de traitement d'etats immuno-pathologiques et medicament correspondant |
| EP1550460A1 (en) * | 2002-08-02 | 2005-07-06 | Oleg Iliich Epshtein | Method for correcting immune responses and medicinal agent |
| US20060024307A1 (en) * | 2002-08-02 | 2006-02-02 | Epshteni Oleg I | Media and method for treating pathological syndrome |
| EP1997481A1 (en) * | 2006-03-13 | 2008-12-03 | Oleg Iliich Epshtein | Solid oral form of a medicinal preparation and a method for the production thereof |
| EP2123300A1 (en) * | 2007-02-02 | 2009-11-25 | Dolgovykh, Lyudmila Fedorovna | Medicinal agent for treating bird flu |
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