JP2013536238A5 - - Google Patents
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- Publication number
- JP2013536238A5 JP2013536238A5 JP2013526087A JP2013526087A JP2013536238A5 JP 2013536238 A5 JP2013536238 A5 JP 2013536238A5 JP 2013526087 A JP2013526087 A JP 2013526087A JP 2013526087 A JP2013526087 A JP 2013526087A JP 2013536238 A5 JP2013536238 A5 JP 2013536238A5
- Authority
- JP
- Japan
- Prior art keywords
- dihydromyricetin
- composition
- gaba
- administered
- ethanol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- KJXSIXMJHKAJOD-LSDHHAIUSA-N (+)-dihydromyricetin Chemical compound C1([C@@H]2[C@H](C(C3=C(O)C=C(O)C=C3O2)=O)O)=CC(O)=C(O)C(O)=C1 KJXSIXMJHKAJOD-LSDHHAIUSA-N 0.000 claims 28
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 20
- KQILIWXGGKGKNX-UHFFFAOYSA-N dihydromyricetin Natural products OC1C(=C(Oc2cc(O)cc(O)c12)c3cc(O)c(O)c(O)c3)O KQILIWXGGKGKNX-UHFFFAOYSA-N 0.000 claims 14
- 229960003692 gamma aminobutyric acid Drugs 0.000 claims 13
- BTCSSZJGUNDROE-UHFFFAOYSA-N gamma-aminobutyric acid Chemical compound NCCCC(O)=O BTCSSZJGUNDROE-UHFFFAOYSA-N 0.000 claims 13
- 208000007848 Alcoholism Diseases 0.000 claims 4
- 206010053164 Alcohol withdrawal syndrome Diseases 0.000 claims 2
- 208000029650 alcohol withdrawal Diseases 0.000 claims 2
- 208000024891 symptom Diseases 0.000 claims 2
- 206010001497 Agitation Diseases 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 206010001584 alcohol abuse Diseases 0.000 claims 1
- 201000007930 alcohol dependence Diseases 0.000 claims 1
- 208000025746 alcohol use disease Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 235000013361 beverage Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 231100000572 poisoning Toxicity 0.000 claims 1
- 230000000607 poisoning effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37652810P | 2010-08-24 | 2010-08-24 | |
| US61/376,528 | 2010-08-24 | ||
| PCT/US2011/048749 WO2012027326A2 (en) | 2010-08-24 | 2011-08-23 | Methods of treating alcohol intoxication, alcohol use disorders and alcohol abuse which comprise the administration of dihydromyricetin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013536238A JP2013536238A (ja) | 2013-09-19 |
| JP2013536238A5 true JP2013536238A5 (enExample) | 2014-10-09 |
Family
ID=45724009
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013526087A Pending JP2013536238A (ja) | 2010-08-24 | 2011-08-23 | ジヒドロミリセチンの投与を含む、アルコール中毒、アルコール使用障害およびアルコール乱用の治療方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20130053435A1 (enExample) |
| EP (1) | EP2608786A4 (enExample) |
| JP (1) | JP2013536238A (enExample) |
| KR (1) | KR20130098347A (enExample) |
| CN (1) | CN103269699A (enExample) |
| AU (1) | AU2011293556A1 (enExample) |
| BR (1) | BR112013003946A2 (enExample) |
| CA (1) | CA2808680A1 (enExample) |
| CL (1) | CL2013000518A1 (enExample) |
| EA (1) | EA201390217A1 (enExample) |
| MX (1) | MX2013002162A (enExample) |
| PH (1) | PH12013500293A1 (enExample) |
| SG (1) | SG187771A1 (enExample) |
| WO (1) | WO2012027326A2 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2014007853A1 (en) * | 2012-07-03 | 2014-01-09 | The Regents Of The University Of California | Dihydromyricetin for the treatment of diseases and disorders of the glutamatergic system |
| CN103772338A (zh) * | 2014-01-10 | 2014-05-07 | 吉首大学 | 真空脉动式制备二氢杨梅素的方法 |
| EP3761979A4 (en) * | 2018-04-06 | 2021-06-30 | Ovid Therapeutics Inc. | USE OF GABOXADOL TO TREAT SUBSTANCE ABUSE |
| CN108567772A (zh) * | 2018-07-24 | 2018-09-25 | 广西师范大学 | 二氢杨梅素的新用途 |
| EP3876926A1 (de) * | 2018-11-05 | 2021-09-15 | Evanium Healthcare GmbH | Alkohol-antidot |
| US20200147032A1 (en) | 2018-11-14 | 2020-05-14 | Robert K. Prud'homme | Dihydromyricetin hot melt extrusion formulations and methods for forming them |
| TW202110437A (zh) * | 2019-05-23 | 2021-03-16 | 美商希諾瓦有限責任公司 | 用於酒精誘發之皮膚潮紅之治療及緩解的組成物及方法 |
| MX2021015457A (es) | 2019-06-14 | 2022-04-06 | Univ Princeton | Formulaciones de dihidromiricetina y un permeabilizante. |
| GR1010117B (el) | 2020-07-14 | 2021-11-08 | Uni Pharma Κλεων Τσετης Φαρμακευτικα Εργαστηρια Αβεε, | Διατροφικο συμπληρωμα για την απο του στοματος χορηγηση συνδυασμου διυδρομυρισετινης, χολινης και μιας ή περισσοτερων βιταμινων με αντιοξειδωτικη δραση, χρησιμων για τη φυσιολογικη λειτουργια του ηπατος |
| CN112546014B (zh) * | 2020-12-15 | 2023-01-31 | 铜仁职业技术学院 | 一种中药解酒护肝泡腾片及其制备方法 |
| CN118354770A (zh) * | 2021-10-07 | 2024-07-16 | 罗特格斯新泽西州立大学 | 具有gabaa受体活性的类黄酮衍生物及使用方法 |
| CN113842461B (zh) * | 2021-11-04 | 2023-08-11 | 杭州诺莘科技有限责任公司 | 用于缓解、治疗酒精中毒、酒后不适的gabaa受体结合物、组合物及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1293825C (zh) * | 2002-08-30 | 2007-01-10 | 广州拜迪生物医药有限公司 | 二氢杨梅树皮素在制备食品、化妆品或药品中的应用 |
| KR20040021927A (ko) * | 2002-09-06 | 2004-03-11 | 차재영 | 호깨나무와 홍삼 추출물을 이용한 건강 보조식품프로헤파-알지의 개발 |
| CN101336978B (zh) * | 2008-08-12 | 2013-01-30 | 西北农林科技大学 | 一种北枳椇总黄酮的提取方法 |
| CN101336987B (zh) * | 2008-08-12 | 2012-04-25 | 西北农林科技大学 | 一种枳椇总黄酮的制备方法 |
-
2011
- 2011-08-23 CA CA2808680A patent/CA2808680A1/en not_active Abandoned
- 2011-08-23 MX MX2013002162A patent/MX2013002162A/es not_active Application Discontinuation
- 2011-08-23 BR BR112013003946A patent/BR112013003946A2/pt not_active IP Right Cessation
- 2011-08-23 EP EP11820493.2A patent/EP2608786A4/en not_active Withdrawn
- 2011-08-23 JP JP2013526087A patent/JP2013536238A/ja active Pending
- 2011-08-23 SG SG2013009576A patent/SG187771A1/en unknown
- 2011-08-23 KR KR1020137007021A patent/KR20130098347A/ko not_active Withdrawn
- 2011-08-23 PH PH1/2013/500293A patent/PH12013500293A1/en unknown
- 2011-08-23 US US13/520,727 patent/US20130053435A1/en not_active Abandoned
- 2011-08-23 EA EA201390217A patent/EA201390217A1/ru unknown
- 2011-08-23 WO PCT/US2011/048749 patent/WO2012027326A2/en not_active Ceased
- 2011-08-23 CN CN201180048110XA patent/CN103269699A/zh active Pending
- 2011-08-23 AU AU2011293556A patent/AU2011293556A1/en not_active Abandoned
-
2013
- 2013-02-22 CL CL2013000518A patent/CL2013000518A1/es unknown
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