JP2013532035A5 - - Google Patents

Info

Publication number

JP2013532035A5

JP2013532035A5 JP2013517408A JP2013517408A JP2013532035A5 JP 2013532035 A5 JP2013532035 A5 JP 2013532035A5 JP 2013517408 A JP2013517408 A JP 2013517408A JP 2013517408 A JP2013517408 A JP 2013517408A JP 2013532035 A5 JP2013532035 A5 JP 2013532035A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

irradiation device

dry pharmaceutical

pharmaceutically acceptable

chitosan

Prior art date

2011-07-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000008194 pharmaceutical composition Substances 0.000 claims 13
• 229920001661 Chitosan Polymers 0.000 claims 8
• 229920000642 polymer Polymers 0.000 claims 7
• ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 claims 6
• 229960002749 aminolevulinic acid Drugs 0.000 claims 5
• 239000000546 pharmaceutical excipient Substances 0.000 claims 5
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 4
• 239000004480 active ingredient Substances 0.000 claims 4
• 229920003086 cellulose ether Polymers 0.000 claims 4
• 238000004108 freeze drying Methods 0.000 claims 3
• 150000003839 salts Chemical class 0.000 claims 3
• 239000002904 solvent Substances 0.000 claims 3
• 210000001215 vagina Anatomy 0.000 claims 3
• -1 5-ALA ester Chemical class 0.000 claims 2
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 2
• 229920002148 Gellan gum Polymers 0.000 claims 2
• 229920001218 Pullulan Polymers 0.000 claims 2
• 239000004373 Pullulan Substances 0.000 claims 2
• 229940072056 alginate Drugs 0.000 claims 2
• 235000010443 alginic acid Nutrition 0.000 claims 2
• 229920000615 alginic acid Polymers 0.000 claims 2
• 235000010418 carrageenan Nutrition 0.000 claims 2
• 239000000679 carrageenan Substances 0.000 claims 2
• 229920001525 carrageenan Polymers 0.000 claims 2
• 229940113118 carrageenan Drugs 0.000 claims 2
• 239000007888 film coating Substances 0.000 claims 2
• 238000009501 film coating Methods 0.000 claims 2
• 235000010492 gellan gum Nutrition 0.000 claims 2
• 239000000216 gellan gum Substances 0.000 claims 2
• 229920002674 hyaluronan Polymers 0.000 claims 2
• 229960003160 hyaluronic acid Drugs 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 239000000203 mixture Substances 0.000 claims 2
• 235000019423 pullulan Nutrition 0.000 claims 2
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
• UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims 2
• 206010008342 Cervix carcinoma Diseases 0.000 claims 1
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
• 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 claims 1
• 201000010881 cervical cancer Diseases 0.000 claims 1
• 210000003679 cervix uteri Anatomy 0.000 claims 1
• 239000002738 chelating agent Substances 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 239000003086 colorant Substances 0.000 claims 1
• 238000003618 dip coating Methods 0.000 claims 1
• 239000007884 disintegrant Substances 0.000 claims 1
• 239000003623 enhancer Substances 0.000 claims 1
• 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 1
• 230000001678 irradiating effect Effects 0.000 claims 1
• 239000007788 liquid Substances 0.000 claims 1
• 230000003232 mucoadhesive effect Effects 0.000 claims 1
• 230000035515 penetration Effects 0.000 claims 1
• 238000002428 photodynamic therapy Methods 0.000 claims 1
• 239000004014 plasticizer Substances 0.000 claims 1
• 239000000843 powder Substances 0.000 claims 1
• 239000002243 precursor Substances 0.000 claims 1
• 238000000935 solvent evaporation Methods 0.000 claims 1
• 238000005507 spraying Methods 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 239000002562 thickening agent Substances 0.000 claims 1