JP2013531983A5 - - Google Patents
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- Publication number
- JP2013531983A5 JP2013531983A5 JP2013514408A JP2013514408A JP2013531983A5 JP 2013531983 A5 JP2013531983 A5 JP 2013531983A5 JP 2013514408 A JP2013514408 A JP 2013514408A JP 2013514408 A JP2013514408 A JP 2013514408A JP 2013531983 A5 JP2013531983 A5 JP 2013531983A5
- Authority
- JP
- Japan
- Prior art keywords
- mixture
- target
- genome
- sequence
- probe
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000523 sample Substances 0.000 claims 34
- 239000000203 mixture Substances 0.000 claims 24
- 238000000034 method Methods 0.000 claims 21
- 108091034117 Oligonucleotide Proteins 0.000 claims 13
- 239000002773 nucleotide Substances 0.000 claims 7
- 125000003729 nucleotide group Chemical group 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 claims 4
- 244000052769 pathogen Species 0.000 claims 3
- 230000001717 pathogenic effect Effects 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 102000054765 polymorphisms of proteins Human genes 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000003252 repetitive effect Effects 0.000 claims 1
- 238000012163 sequencing technique Methods 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 239000003053 toxin Substances 0.000 claims 1
- 231100000765 toxin Toxicity 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35401110P | 2010-06-11 | 2010-06-11 | |
| US61/354,011 | 2010-06-11 | ||
| US37404110P | 2010-08-16 | 2010-08-16 | |
| US61/374,041 | 2010-08-16 | ||
| US201161439167P | 2011-02-03 | 2011-02-03 | |
| US61/439,167 | 2011-02-03 | ||
| PCT/US2011/040106 WO2011156795A2 (en) | 2010-06-11 | 2011-06-10 | Nucleic acids for multiplex organism detection and methods of use and making the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013531983A JP2013531983A (ja) | 2013-08-15 |
| JP2013531983A5 true JP2013531983A5 (enExample) | 2014-09-04 |
Family
ID=45098726
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013514408A Pending JP2013531983A (ja) | 2010-06-11 | 2011-06-10 | 多重生物検出のための核酸ならびにその使用および製造方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20130261196A1 (enExample) |
| EP (1) | EP2580354A4 (enExample) |
| JP (1) | JP2013531983A (enExample) |
| AU (1) | AU2011265205A1 (enExample) |
| SG (1) | SG186987A1 (enExample) |
| WO (1) | WO2011156795A2 (enExample) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9562837B2 (en) | 2006-05-11 | 2017-02-07 | Raindance Technologies, Inc. | Systems for handling microfludic droplets |
| WO2010009365A1 (en) | 2008-07-18 | 2010-01-21 | Raindance Technologies, Inc. | Droplet libraries |
| US12038438B2 (en) | 2008-07-18 | 2024-07-16 | Bio-Rad Laboratories, Inc. | Enzyme quantification |
| US9399797B2 (en) | 2010-02-12 | 2016-07-26 | Raindance Technologies, Inc. | Digital analyte analysis |
| EP4484577A3 (en) | 2010-02-12 | 2025-03-26 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| US10351905B2 (en) * | 2010-02-12 | 2019-07-16 | Bio-Rad Laboratories, Inc. | Digital analyte analysis |
| EP2675819B1 (en) | 2011-02-18 | 2020-04-08 | Bio-Rad Laboratories, Inc. | Compositions and methods for molecular labeling |
| WO2013173774A2 (en) * | 2012-05-18 | 2013-11-21 | Pathogenica, Inc. | Molecular inversion probes |
| WO2013173795A1 (en) * | 2012-05-18 | 2013-11-21 | Pathogenica, Inc. | Realtime sequence based biosurveillance system |
| US9128861B2 (en) | 2013-01-17 | 2015-09-08 | Personalis, Inc. | Methods and systems for genetic analysis |
| AU2014219180A1 (en) * | 2013-02-20 | 2015-10-08 | Emory University | Methods of sequencing nucleic acids in mixtures and compositions related thereto |
| WO2014142831A1 (en) | 2013-03-13 | 2014-09-18 | Illumina, Inc. | Methods and systems for aligning repetitive dna elements |
| WO2014151511A2 (en) * | 2013-03-15 | 2014-09-25 | Abbott Molecular Inc. | Systems and methods for detection of genomic copy number changes |
| US20150141257A1 (en) * | 2013-08-02 | 2015-05-21 | Roche Nimblegen, Inc. | Sequence capture method using specialized capture probes (heatseq) |
| EP3038649B1 (en) * | 2013-08-26 | 2019-09-25 | The Translational Genomics Research Institute | Single molecule-overlapping read analysis for minor variant mutation detection in pathogen samples |
| WO2015031689A1 (en) | 2013-08-30 | 2015-03-05 | Personalis, Inc. | Methods and systems for genomic analysis |
| WO2015071552A1 (en) * | 2013-11-18 | 2015-05-21 | Teknologian Tutkimuskeskus Vtt | Multi-unit probes with high specificity and a method of designing the same |
| CN106414775A (zh) * | 2014-04-11 | 2017-02-15 | 宾夕法尼亚大学董事会 | 用于宏基因组生物标志检测的组合物和方法 |
| US10655188B2 (en) | 2014-06-13 | 2020-05-19 | Q-Linea Ab | Method for determining the identity and antimicrobial susceptibility of a microorganism |
| EP2960818A1 (en) * | 2014-06-24 | 2015-12-30 | Institut Pasteur | Method, device, and computer program for assembling pieces of chromosomes from one or several organisms |
| EP3212808B1 (en) | 2014-10-30 | 2022-03-02 | Personalis, Inc. | Methods for using mosaicism in nucleic acids sampled distal to their origin |
| TWI577803B (zh) * | 2015-01-15 | 2017-04-11 | 昕穎生醫技術股份有限公司 | 多重抗藥性結核病篩檢方法及套組 |
| GB201507026D0 (en) | 2015-04-24 | 2015-06-10 | Linea Ab Q | Medical sample transportation container |
| EP3901279B1 (en) * | 2015-10-18 | 2023-05-17 | Affymetrix, Inc. | Multiallelic genotyping of single nucleotide polymorphisms and indels |
| CA3185611A1 (en) | 2016-03-25 | 2017-09-28 | Karius, Inc. | Synthetic nucleic acid spike-ins |
| GB2554767A (en) | 2016-04-21 | 2018-04-11 | Q Linea Ab | Detecting and characterising a microorganism |
| US11299783B2 (en) | 2016-05-27 | 2022-04-12 | Personalis, Inc. | Methods and systems for genetic analysis |
| US10337051B2 (en) | 2016-06-16 | 2019-07-02 | The Regents Of The University Of California | Methods and compositions for detecting a target RNA |
| EA201990860A1 (ru) | 2016-09-30 | 2019-10-31 | Рнк-направляемые модифицирующие нуклеиновые кислоты ферменты и способы их применения | |
| EA201990861A1 (ru) | 2016-09-30 | 2019-09-30 | Те Риджентс Оф Те Юниверсити Оф Калифорния | Рнк-направляемые модифицирующие нуклеиновые кислоты ферменты и способы их применения |
| US10815525B2 (en) | 2016-12-22 | 2020-10-27 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| US10550429B2 (en) | 2016-12-22 | 2020-02-04 | 10X Genomics, Inc. | Methods and systems for processing polynucleotides |
| EP3630790B1 (en) * | 2017-05-23 | 2023-05-10 | Rutgers, The State University of New Jersey | Target mediatedin situ |
| US11519024B2 (en) | 2017-08-04 | 2022-12-06 | Billiontoone, Inc. | Homologous genomic regions for characterization associated with biological targets |
| SG11202000444PA (en) | 2017-08-04 | 2020-02-27 | Billiontoone Inc | Sequencing output determination and analysis with target-associated molecules in quantification associated with biological targets |
| WO2019028462A1 (en) | 2017-08-04 | 2019-02-07 | Billiontoone, Inc. | TARGET-ASSOCIATED MOLECULES FOR CHARACTERIZATION ASSOCIATED WITH BIOLOGICAL TARGETS |
| US12227753B2 (en) | 2017-11-01 | 2025-02-18 | The Regents Of The University Of California | CasY compositions and methods of use |
| WO2019089808A1 (en) | 2017-11-01 | 2019-05-09 | The Regents Of The University Of California | Class 2 crispr/cas compositions and methods of use |
| AU2018358051B2 (en) | 2017-11-01 | 2025-01-09 | The Regents Of The University Of California | CasZ compositions and methods of use |
| CN112020565B (zh) | 2018-01-05 | 2024-05-24 | 十亿至一公司 | 用于确保基于测序的测定的有效性的质量控制模板 |
| WO2019157529A1 (en) | 2018-02-12 | 2019-08-15 | 10X Genomics, Inc. | Methods characterizing multiple analytes from individual cells or cell populations |
| US11639928B2 (en) | 2018-02-22 | 2023-05-02 | 10X Genomics, Inc. | Methods and systems for characterizing analytes from individual cells or cell populations |
| WO2019169028A1 (en) | 2018-02-28 | 2019-09-06 | 10X Genomics, Inc. | Transcriptome sequencing through random ligation |
| US11702653B2 (en) | 2018-05-21 | 2023-07-18 | Battelle Memorial Institute | Control compositions and methods for sequencing |
| US10801064B2 (en) * | 2018-05-31 | 2020-10-13 | Personalis, Inc. | Compositions, methods and systems for processing or analyzing multi-species nucleic acid samples |
| EP4442836A3 (en) | 2018-08-01 | 2024-12-18 | Mammoth Biosciences, Inc. | Programmable nuclease compositions and methods of use thereof |
| CN113227396A (zh) | 2018-08-06 | 2021-08-06 | 十亿至一公司 | 用于定量生物靶的稀释标签 |
| EP4428234B1 (en) | 2018-11-21 | 2025-12-24 | Karius, Inc. | Direct-to-library methods, systems, and compositions |
| EP3894553B1 (en) | 2018-12-13 | 2025-10-08 | Battelle Memorial Institute | Methods for a quantitative polymerase chain reaction |
| WO2020142754A2 (en) | 2019-01-04 | 2020-07-09 | Mammoth Biosciences, Inc. | Programmable nuclease improvements and compositions and methods for nucleic acid amplification and detection |
| CN113767178A (zh) | 2019-03-11 | 2021-12-07 | 10X基因组学有限公司 | 用于处理光学标签化珠粒的系统和方法 |
| CN111508561B (zh) * | 2019-07-04 | 2024-02-06 | 北京希望组生物科技有限公司 | 同源序列和同源序列中串联重复序列的检测方法、计算机可读介质和应用 |
| CN110592208B (zh) * | 2019-10-08 | 2022-05-03 | 北京诺禾致源科技股份有限公司 | 地中海贫血症三类亚型的捕获探针组合物及其应用方法和应用装置 |
| JP7470787B2 (ja) | 2019-11-05 | 2024-04-18 | パーソナリス，インコーポレイティド | 単一試料からの腫瘍純度の推定 |
| CN120158497A (zh) | 2021-02-23 | 2025-06-17 | 10X基因组学有限公司 | 基于探针的核酸和蛋白质分析 |
| EP4108783B1 (en) * | 2021-06-24 | 2024-02-21 | Miltenyi Biotec B.V. & Co. KG | Spatial sequencing with mictag |
| US12297508B2 (en) | 2021-10-05 | 2025-05-13 | Personalis, Inc. | Customized assays for personalized cancer monitoring |
| AU2023240345A1 (en) | 2022-03-21 | 2024-10-10 | Billion Toone, Inc. | Molecule counting of methylated cell-free dna for treatment monitoring |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030134293A1 (en) * | 1999-11-16 | 2003-07-17 | Zhiping Liu | Method for rapid and accurate identification of microorganisms |
| EP1366192B8 (en) * | 2000-10-24 | 2008-10-29 | The Board of Trustees of the Leland Stanford Junior University | Direct multiplex characterization of genomic dna |
| EP1522853A4 (en) * | 2002-06-24 | 2005-10-19 | Canon Kk | DNA MICROARRAY WITH STANDARD PROBE AND KIT CONTAINING THE MICROARRAY |
| US7618780B2 (en) * | 2004-05-20 | 2009-11-17 | Trillion Genomics Limited | Use of mass labelled probes to detect target nucleic acids using mass spectrometry |
| US20110177960A1 (en) * | 2006-03-10 | 2011-07-21 | Ellen Murphy | Microarray for monitoring gene expression in multiple strains of Streptococcus pneumoniae |
| US7897747B2 (en) * | 2006-05-25 | 2011-03-01 | The Board Of Trustees Of The Leland Stanford Junior University | Method to produce single stranded DNA of defined length and sequence and DNA probes produced thereby |
| JP5908397B2 (ja) * | 2009-06-09 | 2016-04-26 | デフィルス、インコーポレイテッドＤｅｆｙｒｕｓ， Ｉｎｃ． | 病原体感染を予防又は治療するためのインターフェロン投与 |
-
2011
- 2011-06-10 JP JP2013514408A patent/JP2013531983A/ja active Pending
- 2011-06-10 AU AU2011265205A patent/AU2011265205A1/en not_active Abandoned
- 2011-06-10 EP EP11793299.6A patent/EP2580354A4/en not_active Withdrawn
- 2011-06-10 SG SG2013001573A patent/SG186987A1/en unknown
- 2011-06-10 WO PCT/US2011/040106 patent/WO2011156795A2/en not_active Ceased
- 2011-06-10 US US13/703,489 patent/US20130261196A1/en not_active Abandoned
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